Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis

Gut

Volumn 63, Issue 1, 2014, Pages 43-53

  Masterson, Joanne C ^a,b,c,d,e   McNamee, Eóin N ^d,e   Hosford, Lindsay ^a,b,c,d,e   Capocelli, Kelley E ^b,c,e   Ruybal, Joseph ^a,b,c,d,e   Fillon, Sophie A ^a,b,c,d,e   Doyle, Alfred D ^f   Eltzschig, Holger K ^d,e   Rustgi, Anil K ^g   Protheroe, Cheryl A ^f   Lee, Nancy A ^f   Lee, James J ^f   Furuta, Glenn T ^a,b,c,d,e  

^a Section of Pediatric Gastroenterology Hepatology and Nutrition   (United States)

^b Gastrointestinal Eosinophilic Diseases Program   (United States)

^c CHILDREN S HOSPITAL COLORADO   (United States)

^d UNIVERSITY OF COLORADO   (United States)

^e UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^f MAYO GRADUATE SCHOOL   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; EOTAXIN; INTERLEUKIN 13; INTERLEUKIN 5;

ALLERGIC REACTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CELL HYPERPLASIA; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; DEGRANULATION; DISEASE ASSOCIATION; DRUG EFFECT; EOSINOPHILIC ESOPHAGITIS; GENE OVEREXPRESSION; GRANULOCYTE; INTERLEUKIN 5 GENE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIZATION; SQUAMOUS EPITHELIUM; TH1 CELL; TH2 CELL; TRANSGENIC MOUSE;

FOOD ALLERGY; MUCOSAL PATHOLOGY; OESOPHAGEAL DISEASE; OESOPHAGITIS; PAEDIATRIC GASTROENTEROLOGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL MARKERS; DEXAMETHASONE; DISEASE MODELS, ANIMAL; EOSINOPHILIC ESOPHAGITIS; EPITHELIUM; HERPESVIRUS 4, HUMAN; INTERLEUKIN-5; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OXAZOLONE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UP-REGULATION; VIRAL REGULATORY AND ACCESSORY PROTEINS;

EID: 84889678506     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2012-303631     Document Type: Article

References (41)

1. Liacouras CA, Furuta GT, Hirano I, et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol 2011;128:3-20 e6; quiz 1-2.
2. Masterson JC, Furuta GT, Lee JJ. Update on clinical and immunological features of eosinophilic gastrointestinal diseases. Curr Opin Gastroenterol 2011;27:515-22.
3. Akei HS, Mishra A, Blanchard C, et al. Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice. Gastroenterology 2005;129:985-94. (Pubitemid 41242689)
4. Mishra A, Hogan SP, Brandt EB, et al. An etiological role for aeroallergens and eosinophils in experimental esophagitis. J Clin Invest 2001;107:83-90. (Pubitemid 32047417)
5. Mishra A, Hogan SP, Brandt EB, et al. IL-5 promotes eosinophil trafficking to the esophagus. J Immunol 2002;168:2464-9. (Pubitemid 34171851)
6. Rajavelu P, Rayapudi M, Moffitt M, et al. Significance of para-esophageal lymph nodes in food or aeroallergen-induced iNKT cell-mediated experimental eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol 2012;302:G645-54.
7. Rubinstein E, Cho JY, Rosenthal P, et al. Siglec-F inhibition reduces esophageal eosinophilia and angiogenesis in a mouse model of eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2011;53:409-16.
8. Gonsalves N, Yang GY, Doerfler B, et al. Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors. Gastroenterology 2012;142:1451-9 e1.
9. Spergel JM, Andrews T, Brown-Whitehorn TF, et al. Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol 2005;95:336-43. (Pubitemid 41483727)
10. Assa'ad AH, Gupta SK, Collins MH, et al. An antibody against IL-5 reduces numbers of esophageal intraepithelial eosinophils in children with eosinophilic esophagitis. Gastroenterology 2011;141:1593-604.
11. Blanchard C, Wang N, Stringer KF, et al. Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J Clin Invest 2006;116:536-47. (Pubitemid 43228372)
12. Spergel JM, Rothenberg ME, Collins MH, et al. Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol 2012;129:456-63; 63 e1-3.
13. Stein ML, Collins MH, Villanueva JM, et al. Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis. J Allergy Clin Immunol 2006;118:1312-19. (Pubitemid 44872890)
14. Straumann A, Bauer M, Fischer B, et al. Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response. J Allergy Clin Immunol 2001;108:954-61. (Pubitemid 33151548)
15. Mavi P, Rajavelu P, Rayapudi M, et al. Esophageal functional impairments in experimental eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol 2012;302:G1347-55.
16. Mishra A, Wang M, Pemmaraju VR, et al. Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia. Gastroenterology 2008;134:204-14. (Pubitemid 350309313)
17. Nakagawa H, Wang TC, Zukerberg L, et al. The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach. Oncogene 1997;14:1185-90. (Pubitemid 27141920)
18. Lee NA, McGarry MP, Larson KA, et al. Expression of IL-5 in thymocytes/T cells leads to the development of a massive eosinophilia, extramedullary eosinophilopoiesis, and unique histopathologies. J Immunol 1997;158:1332-44. (Pubitemid 127469959)
19. Nakagawa H, Inomoto T, Rustgi AK. A CACCC box-like cis-regulatory element of the Epstein-Barr virus ED-L2 promoter interacts with a novel transcriptional factor in tissue-specific squamous epithelia. J Biol Chem 1997;272:16688-99. (Pubitemid 27276503)
20. Wirtz S, Neufert C, Weigmann B, et al. Chemically induced mouse models of intestinal inflammation. Nat Protoc 2007;2:541-6. (Pubitemid 47040018)
21. Masterson JC, McNamee EN, Jedlicka P, et al. CCR3 blockade attenuates eosinophilic ileitis and associated remodeling. Am J Pathol 2011;179:2302-14.
22. McNamee EN, Wermers JD, Masterson JC, et al. Novel model of TH2-polarized chronic ileitis: the SAMP1 mouse. Inflamm Bowel Dis 2010;16:743-52.
23. McNamee EN, Masterson JC, Jedlicka P, et al. Interleukin 37 expression protects mice from colitis. Proc Natl Acad Sci U S A 2011;108:16711-16.
24. McNamee EN, Masterson JC, Jedlicka P, et al. Ectopic lymphoid tissue alters the chemokine gradient, increases lymphocyte retention and exacerbates murine ileitis. Gut 2013;62:53-62.
25. Ochkur SI, Jacobsen EA, Protheroe CA, et al. Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma. J Immunol 2007;178:7879-89. (Pubitemid 46898060)
26. Boirivant M, Fuss IJ, Chu A, et al. Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med 1998;188:1929-39. (Pubitemid 28536780)
27. Man MQ, Hatano Y, Lee SH, et al. Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges. J Invest Dermatol 2008;128:79-86. (Pubitemid 350249387)
28. Furuta GT, Liacouras CA, Collins MH, et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology 2007;133:1342-63.
29. Flood-Page P, Menzies-Gow A, Phipps S, et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest 2003;112:1029-36. (Pubitemid 38056318)
30. Justice JP, Borchers MT, Crosby JR, et al. Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathology. Am J Physiol Lung Cell Mol Physiol 2003;284:L169-78. (Pubitemid 35471270)
31. Lee JJ, Dimina D, Macias MP, et al. Defining a link with asthma in mice congenitally deficient in eosinophils. Science 2004;305:1773-6. (Pubitemid 39249644)
32. Bhattacharya B, Carlsten J, Sabo E, et al. Increased expression of eotaxin-3 distinguishes between eosinophilic esophagitis and gastroesophageal reflux disease. Hum Pathol 2007;38:1744-53. (Pubitemid 350179935)
33. Lucendo AJ, De Rezende L, Comas C, et al. Treatment with topical steroids downregulates IL-5, eotaxin-1/CCL11, and eotaxin-3/CCL26 gene expression in eosinophilic esophagitis. Am J Gastroenterol 2008;103:2184-93.
34. Wu CA, Peluso JJ, Zhu L, et al. Bronchial epithelial cells produce IL-5: implications for local immune responses in the airways. Cell Immunol 2010;264:32-41.
35. Blanchard C, Stucke EM, Rodriguez-Jimenez B, et al. A striking local esophageal cytokine expression profile in eosinophilic esophagitis. J Allergy Clin Immunol 2011;127:208-17; 17 e1-7.
36. Straumann A, Kristl J, Conus S, et al. Cytokine expression in healthy and inflamed mucosa: probing the role of eosinophils in the digestive tract. Inflamm Bowel Dis 2005;11:720-6. (Pubitemid 41271175)
37. Zuo L, Fulkerson PC, Finkelman FD, et al. IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathway. J Immunol 2010;185:660-9.
38. Blanchard C, Mingler MK, Vicario M, et al. IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids. J Allergy Clin Immunol 2007;120:1292-300. (Pubitemid 350225686)
39. Straumann A, Conus S, Degen L, et al. Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis. Gastroenterology 2010;139:1526-37; 37 e1.
40. Straumann A, Conus S, Grzonka P, et al. Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial. Gut 2010;59:21-30.
41. Conus S, Straumann A, Bettler E, et al. Mepolizumab does not alter levels of eosinophils, T cells, and mast cells in the duodenal mucosa in eosinophilic esophagitis. J Allergy Clin Immunol 2010;126:175-7.