Novel model of TH2-polarized chronic ileitis: The SAMPl mouse

Inflammatory Bowel Diseases

Volumn 16, Issue 5, 2010, Pages 743-752

  McNamee, Eoin N ^a   Wermers, Joshua D ^a   Masterson, Joanne C ^b   Collins, Colm B ^a   Matthew, D P ^a   Lebsack, B A ^a   Fillon, Sophie ^a   Robinson, Zachary D ^a   Grenawalt, Joanna ^a   Lee, James J ^c   Jedlicka, Paul ^d   Furuta, Glenn T ^b   Rivera Nieves, Jesús ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Crohn's disease; Polarization; SAMP1; TH2

Indexed keywords

CD19 ANTIGEN; DEXAMETHASONE; HERMES ANTIGEN; L SELECTIN; TRANSCRIPTION FACTOR; CYTOKINE; MESSENGER RNA; TRANSCRIPTION FACTOR GATA 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL POLARITY; CHRONIC DISEASE; CONTROLLED STUDY; DISEASE COURSE; EOSINOPHILIA; FEMALE; FLOW CYTOMETRY; HISTOLOGY; HISTOPATHOLOGY; ILEITIS; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENESCENCE ACCELERATED MOUSE; TH1 CELL; TH2 CELL; TIME; ANIMAL; CELL CULTURE; CROHN DISEASE; DISEASE MODEL; DRUG EFFECT; EOSINOPHIL; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PATHOLOGY;

ANIMALS; CELLS, CULTURED; CROHN DISEASE; CYTOKINES; DEXAMETHASONE; DISEASE MODELS, ANIMAL; EOSINOPHILS; FEMALE; FLOW CYTOMETRY; GATA3 TRANSCRIPTION FACTOR; ILEITIS; IMMUNOLOGIC MEMORY; MICE; MICE, MUTANT STRAINS; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TH1 CELLS; TH2 CELLS;

EID: 77950640810     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21148     Document Type: Article

References (34)

1. Crohn BB, Ginzburg L, Oppenheimer GD. Regional ileitis: a pathological and clinical entity. JAMA. 1932; 251: 73-79.
2. Blumberg RS, Saubermann LJ, Strober W. Animal models of mucosal inflammation and their relation to human inflammatory bowel, disease. Curr Opin Immunol. 1999; 11:648-656.
3. Strober W, Fuss IJ, Blumberg RS. The immunology of mucosal models of inflammation. Annu Rev Immunol. 2002; 20: 495-549.
4. Elson. CO, Sartor RB, Tennyson. GS, et al. Experimental models of inflammatory bowel disease. Gastroenterology. 1995; 109: 1344-1367.
5. 5. Matsumoto S, Okabe Y, Setoyama H, et al. Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/ Yit strain. Gut. 1998; 43: 71-78. (Pubitemid 28335492)
6. 6. Takeda T, Hosokawa M, Takeshita S, et al. A new murine model of accelerated senescence. Mech Ageing Dev. 1981; 17: 183-194. (Pubitemid 12204873)
7. Strober W, Nakamura K, Kitani A. The SAM.P1/Yit mouse: another step closer to modeling human inflammatory bowel disease. J Clin Invest. 2001; 107: 667-670.
8. Burns RC, Rivera-Nieves J, Moskaluk CA, et al. Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/ Yit adoptive transfer model of Crohn's disease in mice. Gastroenterology. 2001; 121: 1428-1436.
9. Lee JJ, McGarry MP, Farmer SC, et al. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. J Exp Med. 1997;185: 2143-2156.
10. 10. Kosiewicz MM, Nast CC, Krishnan A, et al. Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease. J Clin Invest. 2001;107: 695-702. (Pubitemid 32225355)
11. 11. Kang SG, Piniecki RJ, Hogenesch H, et al. Identification of a chemokine network that recruits FoxP3(+) regulatory T cells into chronically inflamed intestine. Gastroenterology. 2007:132: 966-981. (Pubitemid 46454268)
12. Bamias G, Martin C, Mishina M, et al. Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation. Gastroenterology. 2005;128: 654-666.
13. Madara JL, Podolsky DK, King NW, et al. Characterization of spontaneous colitis in cotton-top tamarins (Saguinus oedipus) and its response to sulfasalazine. Gastroenterology. 1985; 88: 13-19.
14. 14. Brandwein SL, McCabe RP, Cong Y, et al. Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial, flora. J Immunol. 1997; 159:44-52. (Pubitemid 127493683)
15. Rivera-Nieves J, Bamias G, Vidrien A, et al. Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis. Gastroenterology. 2003; 124: 972-982.
16. 16. Olson TS, Bamias G, Naganuma M, et al. Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease. J Clin Invest. 2004; 114: 389-398. (Pubitemid 39071611)
17. Lanzavecchia A, Sallusto F. Understanding the generation and function of memory T cell subsets. Curr Opin Immunol. 2005; 17: 326-332.
18. 18. Sallusto F, Lenig D, Forster R, et al. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999; 401: 708-712. (Pubitemid 129515761)
19. Sartor RB. Cytokines in intestinal inflammation: pathophysiological and clinical considerations. Gastroenterology. 1994; 106: 533-539.
20. Marini M, Bamias G, Rivera-Nieves J, et al. TNF-alpha neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal, epithelial cell apoptosis. Proc Natl Acad Sci U S A. 2003; 100: 8366-8371.
21. Fuss IJ, Neurath M, Boirivant M, et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL5. J Immunol. 1996; 157: 1261-1270.
22. 22. Monteleone G, Biancone L, Marasco R, et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal, lamina propria mononuclear cells. Gastroenterology. 1997;112:1169-1178. (Pubitemid 27157528)
23. Targan SR, Hanauer SB, van Deventer SJ, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med. 1997; 337: 1029-1035.
24. Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology. 1998; 115: 182-205.
25. 25. Rutgeerts P, Sandborn WJ, Feagan. BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2005; 353: 2462-2476. (Pubitemid 41770166)
26. Spencer DM, Veldman GM, Banerjee S, et al. Distinct inflammatory mechanisms mediate early versus late colitis in mice. Gastroenterology. 2002; 122: 94-105.
27. Dubucquoi S, Janin A, Klein O, et al. Activated eosinophils and interleukin 5 expression in early recurrence of Crohn's disease. Gut. 1995; 37: 242-246.
28. Takedatsu H, Mitsuyama K, Matsumoto S, et al. Interleukin-5 participates in the pathogenesis of ileitis in SAM.P1/Ylt mice. Eur J Immunol. 2004; 34: 1561-1569.
29. Rothenberg ME, Mishra A, Brandt EB, et al. Gastrointestinal eosinophils. Immunol Rev. 2001; 179: 139-155.
30. Furuta GT, Forbes D, Boey C, et al. Eosinophilic gastrointestinal diseases (EGIDs). J Pediatr Gastroenterol Nutr. 2008; 47: 234-238.
31. Heller F, Florian. P, Bojarski C, et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology. 2005; 129: 550-564.
32. Fuss IJ, Strober W. The role of IL-13 and NK T cells in experimental and human ulcerative colitis. Mucosal Immunol. 2008;1(suppl 1):S31-33.
33. 33. Inoue S, Matsumoto T, Iida M, et al. Characterization of cytokine expression in the rectal mucosa of ulcerative colitis: correlation with disease activity. Am J Gastroenterol. 1999; 94: 2441-2446. (Pubitemid 29420671)
34. Vainer B, Nielsen OH, Hendel J, et al. Colonic expression and synthesis of interleukin 13 and interleukin 15 in inflammatory bowel disease. Cytokine. 2000; 12: 1531-1536.