Cytokine expression in healthy and inflamed mucosa: Probing the role of eosinophils in the digestive tract

Inflammatory Bowel Diseases

Volumn 11, Issue 8, 2005, Pages 720-726

  Straumann, Alex ^a   Kristl, Jernej ^b   Conus, Sébastien ^b   Vassina, Ekatherina ^b   Spichtin, Hans Peter ^c   Beglinger, Christoph ^d   Simon, Hans Uwe ^b  

^a Kantonsspital ^*  (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c Institute of Clinical Pathology   (Switzerland)

^d UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Cytokine expression pattern; Eosinophilic esophagitis; Eosinophils

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; INTERLEUKIN 5;

ADULT; ARTICLE; BONE MARROW CELL; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; EOSINOPHIL; ESOPHAGITIS; ESOPHAGOGASTRODUODENOSCOPY; ESOPHAGUS MUCOSA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOASSAY; INFLAMMATION; INTESTINE MUCOSA; LEUKOCYTE ACTIVATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE CHARACTERIZATION; TISSUE INJURY; TISSUE SPECIFICITY;

ADOLESCENT; ADULT; BIOPSY, NEEDLE; CASE-CONTROL STUDIES; CYTOKINES; EOSINOPHILIA; EOSINOPHILS; ESOPHAGITIS; ESOPHAGOSCOPY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKINS; MALE; MIDDLE AGED; RECEPTORS, INTERLEUKIN-2; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; TISSUE CULTURE TECHNIQUES;

EID: 24644480082     PISSN: 10780998     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.MIB.0000172557.39767.53     Document Type: Article

References (25)

1. Weller PF. The immunobiology of eosinophils. N Engl J Med. 1991;324: 1110-1118.
2. Cyr MM, Denburg JA. Systemic aspects of allergic disease: the role of the bone marrow. Curr Opin Immunol. 2001;13:727-732.
3. Kato M, Kephart GM, Talley NJ, et al. Eosinophil infiltration and degranulation in normal human tissue. Anat Rec. 1998;252:418-425.
4. Rothenberg ME. Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol. 2004;113:11-28.
5. Lowichik A, Weinberg AG. A quantitative evaluation of mucosal eosinophils in the pediatric gastrointestinal tract. Mod Pathol. 1996;9:110-114.
6. H2-type allergic inflammatory response. J Allergy Clin Immunol. 2001;108:954-961.
7. Reed CE. The natural history of asthma in adults: the problem of irreversibility. J Allergy Clin Immunol. 1999;103:539-547.
8. Straumann A, Spichtin HP, Grize L, et al. Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. Gastroenterology. 2003;125:1660-1669.
9. Attwood SE, Smyrk TC, Demeester TR, et al. Esophageal eosinophilia with dysphagia. A distinct clinicopathologic syndrome. Dig Dis Sci. 1993; 38:109-116.
10. Vitellas KM, Bennett WF, Bova JG, et al. Idiopathic eosinophilic esophagitis. Radiology. 1993;186:789-793.
11. Straumann A, Spichtin HP, Bernoulli R, et al. Idiopathic eosinophilic esophagitis: a frequently overlooked disease with typical clinical aspects and discrete endoscopic findings. Swiss Med Wkly. 1994;124:1419-1429.
12. Rothenberg ME, Mishra A, Collins MH, et al. Pathogenesis and clinical features of eosinophilic esophagitis. J Allergy Clin Immunol. 2001;108: 891-894.
13. Fox VL, Nurko S, Furuta GT. Eosinophilic esophagitis: it's not just kid's stuff. Gastrointest Endosc. 2002;56:260-270.
14. Straumann A, Spichtin HP, Bucher KA, et al. Eosinophilic esophagitis: red on microscopy, white on endoscopy. Digestion. 2004;70:109-116.
15. Simon HU, Plötz S, Simon D, et al. Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Well's syndrome. Eur J Immunol. 2003;33:834-839.
16. Schmid-Grendelmeier P, Altznauer F, Fischer B, et al. Eosinophils express functional IL-13 in eosinophilic inflammatory diseases. J Immunol. 2002; 169:1021-1027.
17. Monici M, Pratesi R, Bernabei P, et al. Natural fluorescence of white blood cells: spectroscopic and imaging study. J Photochem Photobiol B. 1995; 30:29-37.
18. Altznauer F, Martinelli S, Yousefi S, et al. Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils. J Exp Med. 2004;199:1343-1354.
19. Mishra A, Hogan SP, Lee JJ, et al. Fundamental signals that regulate eosinophil homing to the gastrointestinal tract. J Clin Invest. 1999;103: 1719-1727.
20. Moqbel R, Levi-Schaffer F, Kay AB. Cytokine generation by eosinophils. J Allergy Clin Immunol. 1994;94:1183-1188.
21. Mishra A, Rothenberg ME. Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism. Gastroenterology. 2003;125:1419-1427.
22. Defrance T, Carayon P, Billian G, et al. Interleukin 13 is a B cell stimulating factor. J Exp Med. 1994;179:135-143.
23. Nilsson G, Nilsson K. Effects of interleukin (IL)-13 on immediate-early response gene expression, phenotype and differentiation of human mast cells. Comparison with IL-4. Eur J Immunol. 1995;25:870-873.
24. Desreumaux P, Bloget F, Seguy D, et al. Interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 in eosinophilic gastroenteritis. Gastroenterology. 1996;110:768-774.
25. Rothenberg ME. Eosinophilia. N Engl J Med. 1998;338:1592-1600.