Argonaute 2 sustains the gene expression program driving human monocytic differentiation of acute myeloid leukemia cells

Cell Death and Disease

Volumn 4, Issue 11, 2013, Pages

  Iosue, I ^a,b   Quaranta, R ^a   Masciarelli, S ^a   Fontemaggi, G ^c   Batassa, E M ^b   Bertolami, C ^b   Ottone, T ^d,e   Divona, M ^d,e   Salvatori, B ^f   Padula, F ^a   Fatica, A ^f   Lo Coco, F ^d,e   Nervi, C ^a,b   Fazi, F ^a,b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b San Raffaele Biomedical Park Foundation   (Italy)

^c REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^f SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Acute myeloid leukemia; Argonaute 2; microRNA; Myeloid differentiation

Indexed keywords

ARGONAUTE 2 PROTEIN; CALCITRIOL; LIPOPOLYSACCHARIDE; MICRORNA; MICRORNA 155;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL FATE; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; LEUKEMIA CELL; MONOCYTE; PRIORITY JOURNAL;

ARGONAUTE PROTEINS; BLOTTING, WESTERN; CALCITRIOL; CCAAT-ENHANCER-BINDING PROTEINS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CORE BINDING FACTOR ALPHA 2 SUBUNIT; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICRORNAS; RECEPTORS, CALCITRIOL;

EID: 84889610134     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.452     Document Type: Article

References (62)

1. Rosenbauer F, Tenen DG. Transcription factors in myeloid development: Balancing differentiation with transformation. Nat Rev Immunol 2007; 7: 105-117
2. Fazi F, Nervi C. MicroRNA: Basic mechanisms and transcriptional regulatory networks for cell fate determination. Cardiovasc Res 2008; 79: 553-561
3. García P, Frampton J. Hematopoietic lineage commitment: MiRNAs add specificity to a widely expressed transcription factor. Developmental cell 2008; 14: 815-816
4. Chen J, Odenike O, Rowley JD. Leukaemogenesis: More than mutant genes. Nat Rev Cancer 2010; 10: 23-36
5. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, et al. Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group. Ann Intern Med 1985; 103: 620-625
6. Nowak D, Stewart D, Koeffler HP. Differentiation therapy of leukemia: 3 decades of development. Blood 2009; 113: 3655-3665
7. Friedman AD. Transcriptional control of granulocyte and monocyte development. Oncogene 2007; 26: 6816-6828
8. Chendrimada TP, Gregory RI, Kumaraswamy E, Norman J, Cooch N, Nishikura K, et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 2005; 436: 740-744
9. Su H, Trombly MI, Chen J, Wang X. Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Development 2009; 23: 304-317
10. Kawamata T, Tomari Y. Making RISC. Trends Biochem Sci 2010; 35: 368-376
11. Song J-J, Smith SK, Hannon GJ, Joshua-Tor L. Crystal structure of Argonaute and its implications for RISC slicer activity. Science 2004; 305: 1434-1437
12. Frank F, Sonenberg N, Nagar B. Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature 2010; 465: 818-822
13. Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet 2010; 11: 597-610
14. Winter J, Jung S, Keller S, Gregory RI, Diederichs S. Many roads to maturity: MicroRNA biogenesis pathways and their regulation. Nat Cell Biol 2009; 11: 228-234
15. Peters L, Meister G. Argonaute proteins: Mediators of RNA silencing. Mol Cell 2007; 26: 611-623
16. Diederichs S, Haber DA. Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression. Cell 2007; 131: 1097-1108
17. Eulalio A, Huntzinger E, Izaurralde E. Getting to the root of miRNA-mediated gene silencing. Cell 2008; 132: 9-14
18. Meister G. Argonaute proteins: Functional insights and emerging roles. Nat Rev Genet 2013; 14: 447-459
19. Karginov FV, Cheloufi S, Chong MM, Stark A, Smith AD, Hannon GJ. Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases. Mol Cell 2010; 38: 781-788
20. Cheloufi S, Dos Santos CO, Chong MMW, Hannon GJ. A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature 2010; 465: 584-589
21. Gagnon KT, Corey DR. Argonaute and the nuclear RNAs: New pathways for RNA-mediated control of gene expression. Nucleic Acid Therap 2012; 22: 3-16
22. Ahlenstiel CL, Lim HG, Cooper DA, Ishida T, Kelleher AD, Suzuki K. Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells. Nucleic Acids Res 2012; 40: 1579-1595
23. Robb GB, Brown KM, Khurana J, Rana TM. Specific and potent RNAi in the nucleus of human cells. Nat Struct Mol Biol 2005; 12: 133-137
24. Janowski BA, Huffman KE, Schwartz JC, Ram R, Nordsell R, Shames DS, et al. Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. Nat Struct Mol Biol 2006; 13: 787-792
25. Kim DH, Villeneuve LM, Morris KV, Rossi JJ. Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells. Nat Struct Mol Biol 2006; 13: 793-797
26. Zardo G, Ciolfi A, Vian L, Starnes LM, Billi M, Racanicchi S, et al. Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression. Blood 2012; 119: 4034-4046
27. Matsui M, Prakash TP, Corey DR. Transcriptional silencing by single-stranded RNAs targeting a noncoding RNA that overlaps a gene promoter. ACS Chem Biol 2013; 8: 122-126
28. Qi P, Du X. The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine. Modern Pathol 2013; 26: 155-165
29. Batista PJ, Chang HY. Long noncoding RNAs: Cellular address codes in development and disease. Cell 2013; 152: 1298-1307
30. Giles KE, Ghirlando R, Felsenfeld G. Maintenance of a constitutive heterochromatin domain in vertebrates by a Dicer-dependent mechanism. Nat Cell Biol 2010; 12: 94-99; sup pp 1-6
31. Höck J, Meister G. The Argonaute protein family. Genome Biol 2008; 9: 210
32. Alisch RS, Jin P, Epstein M, Caspary T, Warren ST. Argonaute2 is essential for mammalian gastrulation and proper mesoderm formation. PLoS Genet 2007; 3: E227
33. O'Carroll D, Mecklenbrauker I, Das PP, Santana A, Koenig U, Enright AJ, et al. A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev 2007; 21: 1999-2004
34. Bronevetsky Y, Villarino AV, Eisley CJ, Barbeau R, Barczak AJ, Heinz GA, et al. T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med 2013; 210: 417-432
35. Dalton WT, Ahearn MJ, McCredie KB, Freireich EJ, Stass SA, Trujillo JM. HL-60 cell line was derived from a patient with FAB-M2 and not FAB-M3. Blood 1988; 71: 242-247
36. Lanotte M, Martin-Thouvenin V, Najman S, Balerini P, Valensi F, Berger R. NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood 1991; 77: 1080-1086
37. Fazi F, Travaglini L, Carotti D, Palitti F, Diverio D, Alcalay M, et al. Retinoic acid targets DNA-methyltransferases and histone deacetylases during APL blast differentiation in vitro and in vivo. Oncogene 2005; 24: 1820-1830
38. Qi HH, Ongusaha PP, Myllyharju J, Cheng D, Pakkanen O, Shi Y, et al. Prolyl 4-hydroxylation regulates Argonaute 2 stability. Nature 2008; 455: 421-424
39. Fontana L, Pelosi E, Greco P, Racanicchi S, Testa U, Liuzzi F, et al. MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation. Nat Cell Biol 2007; 9: 775-787
40. O'Connell RM, Rao DS, Chaudhuri AA, Boldin MP, Taganov KD, Nicoll J, et al. Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. J Exp Med 2008; 205: 585-594
41. Bousquet M, Harris MH, Zhou B, Lodish HF. MicroRNA miR-125b causes leukemia. Proc Natl Acad Sci USA 2010; 107: 21558-21563
42. Mohri T, Nakajima M, Takagi S, Komagata S, Yokoi T. MicroRNA regulates human vitamin D receptor. Int J cancer 2009; 125: 1328-1333
43. Worm J, Stenvang J, Petri A, Frederiksen KS, Obad S, Elmén J, et al. Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF. Nucleic Acids Res 2009; 37: 5784-5792
44. Bergalet J, Fawal M, Lopez C, Desjobert C, Lamant L, Delsol G, et al. HuR-mediated control of C/EBPbeta mRNA stability and translation in ALK-positive anaplastic large cell lymphomas. Mol Cancer Res 2011; 9: 485-496
45. Salvatori B, Iosue I, Djodji Damas N, Mangiavacchi A, Chiaretti S, Messina M, et al. Critical Role of c-Myc in Acute Myeloid Leukemia Involving Direct Regulation of miR-26a and Histone Methyltransferase EZH2. Genes Cancer 2011; 2: 585-592
46. Salvatori B, Iosue I, Mangiavacchi A, Loddo G, Padula F, Chiaretti S, et al. The micro RNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cells. Cell Death Disease 2012; 3: E413
47. Slezak-Prochazka I, Durmus S, Kroesen B-J, van den Berg A. MicroRNAs, macrocontrol: Regulation of miRNA processing. RNA 2010; 16: 1087-1095
48. D'Ambrogio A, Gu W, Udagawa T, Mello CC, Richter JD. Specific miRNA stabilization by Gld2-catalyzed monoadenylation. Cell Rep 2012; 2: 1537-1545
49. Yin Q, Wang X, McBride J, Fewell C, Flemington E. B-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element. J Biol Chem 2008; 283: 2654-2662
50. Chang S, Wang RH, Akagi K, Kim KA, Martin BK, Cavallone L, et al. Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155. Nat Med 2011; 17: 1275-1282
51. Vargova K, Curik N, Burda P, Basova P, Kulvait V, Pospisil V, et al. MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. Blood 2011; 117: 3816-3825
52. He M, Xu Z, Ding T, Kuang D-M, Zheng L. MicroRNA-155 regulates inflammatory cytokine production in tumor-Associated macrophages via targeting C/EBPbeta. Cell Mol Immunol 2009; 6: 343-352
53. Ruggiero T, Trabucchi M, De Santa F, Zupo S, Harfe BD, McManus MT, et al. LPS induces KH-Type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J 2009; 23: 2898-2908
54. Fleetwood AJ, Lawrence T, Hamilton JA, Cook AD. Granulocyte-macrophage colonystimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: Implications for CSF blockade in inflammation. J Immunol 2007; 178: 5245-5252
55. Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nature reviews. Immunology 2008; 8: 533-544
56. Labeta MO, Durieux JJ, Spagnoli G, Fernandez N, Wijdenes J, Herrmann R. CD14 and tolerance to lipopolysaccharide: Biochemical and functional analysis. Immunology 1993; 80: 415-423
57. Bartel DP. MicroRNAs: Target recognition and regulatory functions. Cell 2009; 136: 215-233
58. Dueck A, Meister G. MicroRNA processing without Dicer. Genome Biol 2010; 11: 123
59. Alemdehy MF, van den Berge IJ, Sanders MA, Cupedo T, Touw IP, Erkeland SJ, et al. Dicer1 deletion in myeloid-committed progenitors causes neutrophil dysplasia and blocks macrophage/dendritic cell development in mice. Blood 2012; 119: 4723-4730
60. Mazumder A, Bose M, Chakraborty A, Chakrabarti S, Bhattacharyya SN. A transient reversal of miRNA-mediated repression controls macrophage activation. EMBO Rep 2013; 14: 1008-1016
61. Cimino G, Fenu S, Travaglini L, Finolezzi E, Mancini M, Nanni M, et al. Sequential valproic acid/all-Trans retinoic acid treatment reprograms differentiation in refractory and high-risk acute myeloid leukemia. Cancer Res 2006; 66: 8903-8911
62. Fazi F, Rosa A, Fatica A, Gelmetti V, De Marchis ML, Nervi C, et al. A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell 2005; 123: 819-831