Signalling events underlying platelet aggregation induced by the glycoprotein VI agonist convulxin

European Journal of Biochemistry

Volumn 268, Issue 20, 2001, Pages 5242-5248

  Atkinson, Ben T ^a   Stafford, Margaret J ^b   Pears, Catherine J ^b   Watson, Steve P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Ca2+ secretion; Glycoprotein VI; Platelet; Protein kinase C

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADENOSINE DIPHOSPHATE; COLLAGEN; CONVULXIN; ESTER DERIVATIVE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL)ETHER N,N,N',N' TETRAACETIC ACID; G PROTEIN COUPLED RECEPTOR; GLYCOPROTEIN; PHOSPHOLIPASE C; PROTEIN KINASE C; SNAKE VENOM; THROMBOXANE A2; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CHELATION; CONCENTRATION RESPONSE; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION;

ADENOSINE DIPHOSPHATE; ANIMALS; ANTIGENS, CD36; APYRASE; CROTALID VENOMS; DRUG SYNERGISM; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; INDOLES; INDOMETHACIN; LECTINS, C-TYPE; MICE; PHOSPHATIDIC ACIDS; PLATELET AGGREGATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN KINASE C; SEROTONIN; SIGNAL TRANSDUCTION; THROMBOXANE A2;

EID: 0034791785     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0014-2956.2001.02448.x     Document Type: Article

References (28)

1. More pieces of the platelet activation puzzle slide into place
2. Collagen receptor signalling in platelets: Extending the role of the ITAM
3. Collagen receptor signalling in platelets and megakaryocytes
4. Evidence for two distinct G-protein-coupled ADP receptors mediating platelet activation
5. Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets
6. Molecular basis for ADP-induced platelet activation II: The P2Y1 receptor mediates ADP-induced intracellular calcium mobilisation and shape change in platelets
7. ADP-induced platelet shape change: An investigation of the signalling pathways involved and their dependence on the method of platelet preparation
8. Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice
9. Role of P2Y1 purinoceptor in ADP-induced platelet activation
10. Identification of the platelet ADP receptor targeted by antithrombotic drugs
11. Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation
12. Role of intracellular signaling events in ADP-induced platelet aggregation
13. 2-induced platelet aggregation
14. q protein-coupled receptors does not require an increase in cytosolic calcium for platelet agrregation
15. i protein-coupled receptor and protein kinase C or phospholipase C is required for platelet aggregation
16. Analyses of proteins involved in vesicular trafficking in platelets of mouse models of Hermansky Pudlak syndrome
17. Abnormal expression and subcellular distribution of subunit proteins of the AP-3 adaptor complex lead to platelet storage pool deficiency in the pearl mouse
18. Convulxin, a potent platelet-aggregating protein from Crotalus durissus terrificus venom, specifically binds to platelets
19. Phosphatidylinositol 3,4,5-trisphosphate regulates Ca(2+) entry via Btk in platelets and megakaryocytes without increasing phospholipase C activity
20. Tyrosine phosphorylation of the Fc receptor γ-chain in collagen-stimulated platelets
21. Rapid reactions of platelets studied by a quenched-flow approach: Aggregation kinetics
22. LAT is required for tyrosine phosphorylation of phospholipase Cγ2 and platelet activation by the collagen receptor GPVI
23. 2+ and protein kinase C is the major factor in determining the level of secretion from human platelets
24. i-dependent pathway for an efficient stimulation of phosphoinositide 3-kinase, calcium mobilization, and platelet aggregation
25. Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin
26. A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase
27. A collagen-related peptide regulates phospholipase Cγ2 via phosphatidylinositol 3-kinase in human platelets
28. Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcR γ-chain complex