-
1
-
-
79957889347
-
The productivity crisis in pharmaceutical R&D
-
Pammolli F., Magazzini L., Riccaboni M. - The productivity crisis in pharmaceutical R&D. - Nature, 10, 428-439, 2011.
-
(2011)
Nature
, vol.10
, pp. 428-439
-
-
Pammolli, F.1
Magazzini, L.2
Riccaboni, M.3
-
2
-
-
0028948839
-
A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
-
Amidon G.L., Lennernas H., Shah V.P., Crison J.R. - A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. - Pharm. Res., 12, 413-420, 1994.
-
(1994)
Pharm. Res.
, vol.12
, pp. 413-420
-
-
Amidon, G.L.1
Lennernas, H.2
Shah, V.P.3
Crison, J.R.4
-
3
-
-
85056967717
-
Stratum corneum bypassed or removed
-
E. Touitou, B.W. Barry Eds., CRC Press, New York
-
Birchall J.C. - Stratum corneum bypassed or removed. - In: Enhancement in Drug Delivery, E. Touitou, B.W. Barry Eds., CRC Press, New York, 2007, p. 337-351.
-
(2007)
Enhancement in Drug Delivery
, pp. 337-351
-
-
Birchall, J.C.1
-
4
-
-
84868206060
-
Microneedles for drug and vaccine delivery
-
Kim Y.C., Park J.H., Prausnitz M.R. - Microneedles for drug and vaccine delivery. -Adv. Drug Deliv. Rev., 64, 1547-68, 2012.
-
(2012)
Adv. Drug Deliv. Rev.
, vol.64
, pp. 1547-1568
-
-
Kim, Y.C.1
Park, J.H.2
Prausnitz, M.R.3
-
5
-
-
33646882359
-
Polymer microneedles for controlled-release drug delivery
-
DOI 10.1007/s11095-006-0028-9
-
Park J., Allen M. G., Prausnitz M.R. Polymer - Microneedles for controlled-release drug delivery. - Pharm. Res., 23, 1008-1019, 2006. (Pubitemid 43781409)
-
(2006)
Pharmaceutical Research
, vol.23
, Issue.5
, pp. 1008-1019
-
-
Park, J.-H.1
Allen, M.G.2
Prausnitz, M.R.3
-
7
-
-
1542268930
-
Lipid vesicles and other colloids as drug carriers on the skin
-
DOI 10.1016/j.addr.2003.10.028, PII S0169409X03002448
-
Cevc G. - Lipid vesicles and other colloids as drug carriers on the skin. - Adv. Drug. Deliv. Rev., 56, 675-711, 2004. (Pubitemid 38326939)
-
(2004)
Advanced Drug Delivery Reviews
, vol.56
, Issue.5
, pp. 675-711
-
-
Cevc, G.1
-
8
-
-
1542328820
-
Skin electroporation for transdermal and topical delivery
-
DOI 10.1016/j.addr.2003.10.027, PII S0169409X03002436
-
Preat V., Vanbever R. - Skin electroporation for transdermal and topical delivery. - Adv. Drug. Deliv. Rev., 56, 659-674, 2004. (Pubitemid 38326938)
-
(2004)
Advanced Drug Delivery Reviews
, vol.56
, Issue.5
, pp. 659-674
-
-
Denet, A.-R.1
Vanbever, R.2
Preat, V.3
-
9
-
-
1542358753
-
Transdermal delivery with a pressure wave
-
Doukas A. - Transdermal delivery with a pressure wave. - Adv. Drug. Deliv. Rev., 56, 559-579, 2004.
-
(2004)
Adv. Drug. Deliv. Rev.
, vol.56
, pp. 559-579
-
-
Doukas, A.1
-
10
-
-
1542328828
-
Low-frequency sonophoresis: A review
-
Mitragotri S., Kost J. - Low-frequency sonophoresis: a review. - Adv. Drug. Deliv. Rev., 56, 589-601, 2004.
-
(2004)
Adv. Drug. Deliv. Rev.
, vol.56
, pp. 589-601
-
-
Mitragotri, S.1
Kost, J.2
-
11
-
-
1242308254
-
Current status and future potential of transdermal drug delivery
-
Prausnitz M.R., Mitragotri S., Langer R. - Current status and future potential of transdermal drug delivery. - Nat. Rev. Drug Discov., 3, 115-24, 2004. (Pubitemid 38239773)
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, Issue.2
, pp. 115-124
-
-
Prausnitz, M.R.1
Mitragotri, S.2
Langer, R.3
-
12
-
-
18144406466
-
In vitro and in vivo characterization of MEMS microneedles
-
DOI 10.1007/s10544-005-6171-y
-
Teo M.A.L., Shearwood C., Ng K.C., Lu J., Moochhala S. - In vitro and in vivo characterization of MEMS microneedles. - Biomed. Microdevices, 7, 47-52, 2005. (Pubitemid 40613130)
-
(2005)
Biomedical Microdevices
, vol.7
, Issue.1
, pp. 47-52
-
-
Ling, T.M.A.1
Shearwood, C.2
Ng, K.C.3
Lu, J.4
Moochhala, S.5
-
13
-
-
0036007129
-
Macroflux microprojection array patch technology: A new and efficient approach for intracutaneous immunization
-
DOI 10.1023/A:1013607400040
-
Matriano J.A., Cormier M., Johnson J., Young W.A., Buttery M., Nyam K., Daddona P.E. - Macroflux microprojection array patch technology: a new and efficient approach for intracutaneous immunization. - Pharm. Res., 19, 63-70, 2002. (Pubitemid 34075108)
-
(2002)
Pharmaceutical Research
, vol.19
, Issue.1
, pp. 63-70
-
-
Matriano, J.A.1
Cormier, M.2
Johnson, J.3
Young, W.A.4
Buttery, M.5
Nyam, K.6
Daddona, P.E.7
-
14
-
-
0031852494
-
Microfabricated microneedles: A novel approach to transdermal drug delivery
-
Henry S.D., McAllis V., Prausnitz M.G. - Microfabricated microneedles: A novel approach to transdermal drug delivery. - J. Pharm. Sci., 87, 922-925, 1998.
-
(1998)
J. Pharm. Sci.
, vol.87
, pp. 922-925
-
-
Henry, S.D.1
McAllis, V.2
Prausnitz, M.G.3
-
15
-
-
70649085278
-
Microfabrication derived DDS: From batch to individual production
-
Takada K. - Microfabrication derived DDS: from batch to individual production. - Drug Discov. Then, 2, 140-155, 2008.
-
(2008)
Drug Discov. Then
, vol.2
, pp. 140-155
-
-
Takada, K.1
-
16
-
-
75149140424
-
Effect of transdermal teriparatide administration on bone mineral density in postmenopausal women
-
Cosman F., Lane N.E., Bolognese M., Zanchetta J., Garcia-Hernandez P.A., Sees K., Matriano J.A., Gaumer K., Daddona P.E. - Effect of transdermal teriparatide administration on bone mineral density in postmenopausal women -. J. Clin. Endocrin. Metab., 95, 151-158, 2010.
-
(2010)
J. Clin. Endocrin. Metab.
, vol.95
, pp. 151-158
-
-
Cosman, F.1
Lane, N.E.2
Bolognese, M.3
Zanchetta, J.4
Garcia-Hernandez, P.A.5
Sees, K.6
Matriano, J.A.7
Gaumer, K.8
Daddona, P.E.9
-
17
-
-
67349228237
-
Chondroitin sulfate proteoglycan-based extracellular matrix in chicken (Gallus domesticus) brain
-
Morawski M., Alpár A. Brückner G., Fiedler A., Jäger C., Gati G., Stieler J.T., Arendt T. - Chondroitin sulfate proteoglycan-based extracellular matrix in chicken (Gallus domesticus) brain. - Brain Res., 1275, 10-23, 2009.
-
(2009)
Brain Res.
, vol.1275
, pp. 10-23
-
-
Morawski, M.1
Alpár, A.2
Brückner, G.3
Fiedler, A.4
Jäger, C.5
Gati, G.6
Stieler, J.T.7
Arendt, T.8
-
18
-
-
0028103938
-
Isolation of a neural chondroitin sulfate proteoglycan with neurite outgrowth promoting properties
-
DOI 10.1083/jcb.126.3.783
-
Faissner A., Clement A., Lochter A., Streit A., Mandl C., Schachner M. - Isolation of a neural chondmitin sulfate proteoglycan with neurite outgrowth promoting properties. - J. Cell. Biol., 126, 783-799, 1994. (Pubitemid 24241390)
-
(1994)
Journal of Cell Biology
, vol.126
, Issue.3
, pp. 783-799
-
-
Faissner, A.1
Clement, A.2
Lochter, A.3
Streit, A.4
Mandl, C.5
Schachner, M.6
-
19
-
-
1642532368
-
Chondroitin sulfate of appican, the proteoglycan form of amyloid precursor protein, produced by C6 glioma cells interacts with heparin-binding neuroregulatory factors
-
DOI 10.1016/S0014-5793(03)01506-0
-
Umehara Y., Yamada S., Nishimura S., Shioi J., Robakis N.K., Sugahara K. - Chondroitin sulfate of appican, the proteoglycan form of amyloid precursor protein, produced by C6 glioma cells interacts with heparin-binding neuroregulatory factors. - FEBS Lett., 557, 233-238, 2004. (Pubitemid 38115901)
-
(2004)
FEBS Letters
, vol.557
, Issue.1-3
, pp. 233-238
-
-
Umehara, Y.1
Yamada, S.2
Nishimura, S.3
Shioi, J.4
Robakis, N.K.5
Sugahara, K.6
-
20
-
-
0034726616
-
Chondroitin sulfate proteoglycan expression pattern in hippocampal development: Potential regulation of axon tract formation
-
Wilson T.M., Snow D.M. - Chondroitin sulfate proteoglycan expression pattern in hippocampal development: potential regulation of axon tract formation. - J. Comp. Neurol., 424, 532-546, 2000.
-
(2000)
J. Comp. Neurol.
, vol.424
, pp. 532-546
-
-
Wilson, T.M.1
Snow, D.M.2
-
21
-
-
0029278168
-
Cross-linked chondroitin sulfate: Characterization for drug delivery purposes
-
Sintov A., Di-Capua N., Rubinstein A. - Cross-linked chondroitin sulfate: characterization for drug delivery purposes. - Biomaterials., 16, 473-478,1995.
-
(1995)
Biomaterials
, vol.16
, pp. 473-478
-
-
Sintov, A.1
Di-Capua, N.2
Rubinstein, A.3
-
22
-
-
32944479453
-
Oral sustained delivery of diclofenac sodium using calcium chondroitin sulfate matrix
-
Tsai F.M., Chiang L.Y., Wang F.L., Huang W.G., Wu C.P. - Oral sustained delivery of diclofenac sodium using calcium chondroitin sulfate matrix. - J. Biomater. Sci. Polym. Ed., 16, 1319-1331, 2005.
-
(2005)
J. Biomater. Sci. Polym. Ed.
, vol.16
, pp. 1319-1331
-
-
Tsai, F.M.1
Chiang, L.Y.2
Wang, F.L.3
Huang, W.G.4
Wu, C.P.5
-
23
-
-
84867040734
-
Transdermal insulin application system with dissolving microneedles
-
Ito Y., Nakahigashi T., Yoshimoto N., Ueda Yu., Hamasaki N., Takada K. - Transdermal insulin application system with dissolving microneedles. - Diabetes. Technol. Ther., 14, 891-899, 2012.
-
(2012)
Diabetes. Technol. Ther.
, vol.14
, pp. 891-899
-
-
Ito, Y.1
Nakahigashi, T.2
Yoshimoto, N.3
Ueda, Yu.4
Hamasaki, N.5
Takada, K.6
-
24
-
-
85027919002
-
Two-layered dissolving microneedles for percutaneous delivery of peptide/protein drugs in rats
-
Fukushima K., Ise A., Morita H., Hasegawa R., Ito Y., Sugioka N., Takada K. - Two-layered dissolving microneedles for percutaneous delivery of peptide/protein drugs in rats. - Pharm. Res., 28, 7-21, 2011.
-
(2011)
Pharm. Res.
, vol.28
, pp. 7-21
-
-
Fukushima, K.1
Ise, A.2
Morita, H.3
Hasegawa, R.4
Ito, Y.5
Sugioka, N.6
Takada, K.7
-
25
-
-
77950876751
-
Self-dissolving microarray chip as percutaneous delivery system of protein drug
-
Ito Y., Hasegawa R., Fukushima K., Sugioka N., Takada K. - Self-dissolving microarray chip as percutaneous delivery system of protein drug. - Biol. Pharm. Bull., 33, 683-690, 2010.
-
(2010)
Biol. Pharm. Bull.
, vol.33
, pp. 683-690
-
-
Ito, Y.1
Hasegawa, R.2
Fukushima, K.3
Sugioka, N.4
Takada, K.5
-
26
-
-
41549116858
-
Percutaneous absorption of interferon-a by self-dissolving micropiles
-
Ito Y., Saeki A., Shiroyama K., Sugioka N., Takada K. - Percutaneous absorption of interferon-a by self-dissolving micropiles. - J. Drug. Target., 16, 243-249, 2008.
-
(2008)
J. Drug. Target.
, vol.16
, pp. 243-249
-
-
Ito, Y.1
Saeki, A.2
Shiroyama, K.3
Sugioka, N.4
Takada, K.5
-
27
-
-
0031945584
-
Use of dermal equivalent and skin equivalent models for in vitro cutaneous irritation testing of cosmetic products: Comparison with in vivo human data
-
Augustin C., Collombel C., Damour O. - Use of dermal equivalent and skin equivalent models for in vitro cutaneous irritation testing of cosmetic products: comparison with in vivo human data. - Cutan. Ocul. Toxicol., 17, 5-17, 1998. (Pubitemid 28191466)
-
(1998)
Journal of Toxicology - Cutaneous and Ocular Toxicology
, vol.17
, Issue.1
, pp. 5-17
-
-
Augustin, C.1
Collombel, C.2
Damour, O.3
-
28
-
-
0028961139
-
Use of human skin recombinants as an in vitro model for testing the irritation potential of cutaneous irritants
-
Ponec M., Kempenaar J. - Use of human skin recombinants as an in vitro model for testing the irritation potential of cutaneous irritants - Skin Pharmacol., 8, 49-59, 1995.
-
(1995)
Skin Pharmacol.
, vol.8
, pp. 49-59
-
-
Ponec, M.1
Kempenaar, J.2
-
29
-
-
77957181690
-
Release of arachidonic and linoleic acid metabolites in skin organ cultures as characteristics of in vitro skin irritancy
-
Van de Sandt J.J.M., Maas W.J.M., Doornink P.C., Rutten A. A.J.J.L. - Release of arachidonic and linoleic acid metabolites in skin organ cultures as characteristics of in vitro skin irritancy. - Fundam. Appl. Toxicol., 25, 20-28, 1995.
-
(1995)
Fundam. Appl. Toxicol.
, vol.25
, pp. 20-28
-
-
Van De Sandt, J.J.M.1
Maas, W.J.M.2
Doornink, P.C.3
Rutten, A.A.J.J.L.4
-
30
-
-
0027983042
-
In vitro skin irritation testing of petroleum-based compounds in reconstituted human skin models
-
Koschier F.J., Roth R.N., Stephens T.J., Spence E.T., Duke M.A. - In vitro skin irritation testing of petroleum-based compounds in reconstituted human skin models. - Cutan. Ocul. Toxicol., 13, 23-37, 1994.
-
(1994)
Cutan. Ocul. Toxicol.
, vol.13
, pp. 23-37
-
-
Koschier, F.J.1
Roth, R.N.2
Stephens, T.J.3
Spence, E.T.4
Duke, M.A.5
-
31
-
-
80052261353
-
Kinetics of skin resealing after insertion of microneedles in human subjects
-
Gupta J., Gill H.S., Andrews S.N., Prausnitz M.R. - Kinetics of skin resealing after insertion of microneedles in human subjects. - J. Cont. Rel., 154, 148-155, 2011.
-
(2011)
J. Cont. Rel.
, vol.154
, pp. 148-155
-
-
Gupta, J.1
Gill, H.S.2
Andrews, S.N.3
Prausnitz, M.R.4
-
32
-
-
0014763674
-
Inter-species correction of plasma concentration history of methotrexate
-
Dedrick R.L., Bischoff K.B., Zaharko D.S. - Inter-species correction of plasma concentration history of methotrexate. - Cancer. Chemother. Rep., 54, 95-102, 1970.
-
(1970)
Cancer. Chemother. Rep.
, vol.54
, pp. 95-102
-
-
Dedrick, R.L.1
Bischoff, K.B.2
Zaharko, D.S.3
-
33
-
-
84862629947
-
A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens
-
Matsuo A., Yokota Y., Zhai Y., Quan Y., Kamiyama F., Mukai Y., Okada N., Nakagawa S. - A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens. - J. Con. Rel., 161, 10-17, 2012.
-
(2012)
J. Con. Rel.
, vol.161
, pp. 10-17
-
-
Matsuo, A.1
Yokota, Y.2
Zhai, Y.3
Quan, Y.4
Kamiyama, F.5
Mukai, Y.6
Okada, N.7
Nakagawa, S.8
-
34
-
-
84872192459
-
Method to increase the systemically delivered amount of drug from dissolving microneedles
-
Ito Y., Hamazaki N., Takada K. - Method to increase the systemically delivered amount of drug from dissolving microneedles. - Chem. Pharm. Bull., 61, 8-15, 2013.
-
(2013)
Chem. Pharm. Bull.
, vol.61
, pp. 8-15
-
-
Ito, Y.1
Hamazaki, N.2
Takada, K.3
|