Transdermal insulin application system with dissolving microneedles

Diabetes Technology and Therapeutics

Volumn 14, Issue 10, 2012, Pages 891-899

  Ito, Yukako ^a   Nakahigashi, Takuya ^a   Yoshimoto, Naoko ^a   Ueda, Yuriko ^a   Hamasaki, Noriyuki ^a   Takada, Kanji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISSOLVING MICRONEEDLE; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; EQUIPMENT DESIGN; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; NEEDLE; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN PENETRATION;

ADMINISTRATION, CUTANEOUS; ANIMALS; BIOLOGICAL AVAILABILITY; BLOOD GLUCOSE; BLOOD GLUCOSE SELF-MONITORING; DIABETES MELLITUS, TYPE 1; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MICROINJECTIONS; MONITORING, AMBULATORY; NEEDLES; PATIENT SATISFACTION; RATS; RATS, WISTAR; SKIN ABSORPTION;

EID: 84867040734     PISSN: 15209156     EISSN: 15578593     Source Type: Journal    
DOI: 10.1089/dia.2012.0096     Document Type: Article

References (34)

1. Kendall MAF: Needle-free vaccine injection. In: Schafer- Korting M, ed. Handbook of Experimental Pharmacology: Drug Delivery. Berlin: Springer, 2010:193-220.
2. Wermeling DP, Banks SL, Hudson DA, Gill HS, Gupta J, Prausnitz MR, Stinchcomb AL: Microneedles permit transdermal delivery of a skin-impermeant medication to humans. Proc Natl Acad Sci U S A 2008;105:2058-2063.
3. Birchall JC: Stratum corneum bypassed or removed. In: Touitou E, Barry BW, eds. Enhancement in Drug Delivery. New York: CRC Press, 2007:337-351.
4. Cormier M, Johnson B, Ameri M, Nyam K, Libiran L, Zhang DD, Daddona P: Transdermal delivery of desmopressin using a coated microneedle array patch system. J Control Release 2004;97:503-511.
5. Prausnitz RM: Microneedles for transdermal drug delivery. Adv Drug Deliv Rev 2004;56:581-587.
6. Levin G, Gershonowitz A, Sacks H, Stern M, Sherman A, Rudaev S, Zivin I, Phillip M: Transdermal delivery of human growth hormone through RF-microchannels. Pharm Res 2005;22:550-555.
7. Qiu Y, Gao Y, Hu K, Li F: Enhancement of skin permeation of docetaxel: a novel approach combining microneedle and elastic liposomes. J Control Release 2008;129:144-150.
8. Donnelly RF, Morrow DIJ, McCarron PA, Woolfson AD, Morrissey A, Juzenas P, Iani V, McCarthy HO, Moan J: Microneedle mediated intradermal delivery of 5-aminolevulinic acid: potential for enhanced topical photodynamic therapy. J Control Release 2008;129:154-162.
9. Ito Y, Hagiwara E, Saeki A, Sugioka N, Takada K: Feasibility of microneedles for percutaneous absorption of insulin. Eur J Pharm Sci 2006;29:82-88.
10. Ito Y, Murakami A, Maeda T, Sugioka N, Takada K: Evaluation of self-dissolving needles containing low molecular weight heparin (LMWH) in rats. Int J Pharm 2008;349:124-129.
11. Ito Y, Ohashi Y, Shiroyama K, Sugioka N, Takada K: Selfdissolving micropiles for the percutaneous absorption of human growth hormone in rats. Biol Pharm Bull 2008;31: 1631-1633.
12. Ito Y, Yoshimitsu J, Shiroyama K, Sugioka N, Takada K: Selfdissolving microneedles for the percutaneous absorption of EPO in mice. J Drug Target 2006;14:255-262.
13. Ito Y, Saeki A, Shiroyama K, Sugioka N, Takada K: Percutaneous absorption of interferon-β by self-dissolving micropiles. J Drug Target 2008;16:243-249.
14. Ito Y, Ohashi Y, Saeki A, Sugioka N, Takada K: Antihyperglycemic effect of insulin from self-dissolving micropiles in dogs. Chem Pharm Bull 2008;56:243-246.
15. Takada K: Microfabrication derived DDS: from batch to individual production. Drug Discov Ther 2008;2:140-155.
16. Zhu Q, Zarnitsyn VG, Ye L, Wen Z, Gao Y, Pan L, Skountzou I, Gill HS, Prausnitz MR, Yang C, Compans RW: Immunization by vaccine-coated microneedle arrays protects against influenza virus challenge. Proc Natl Acad Sci U S A 2009;106:7968-7973.
17. Rozis G, Silva S, Benlahrech A, Papagatsias T, Harris J, Gotch F, Dickson G, Patterson S: Langerhans cells are more efficiently tranduced expressing either group C or B fibre protein: implications for mucosal vaccines. Eur J Immunol 2005;35:2617-2626.
18. Furmanov K, Elnekave M, Lehmann D, Clausen BE, Kotton DN, Hovav H: The role of skin-derived dendric cells in CD8 + T cell priming following immunization with lentivectors. J Immunol 2010;184:4889-4897.
19. Ito Y, Yamazaki T, Sugioka N, Takada K: Self-dissolving micropile array tips for percutaneous administration of insulin. J Mater Sci Mater Med 2010;21:835-841.
20. Ito Y, Hasegawa R, Fukushima K, Sugioka N, Takada K: Self-dissolving microarray chip as percutaneous delivery system of protein drug. Biol Pharm Bull 2010;33:683-690.
21. Fukushima K, Ise A, Morita H, Hasegawa R, Ito Y, Sugioka N, Takada K: Two-layered dissolving microneedles for percutaneous delivery of peptide/protein drugs in rats. Pharm Res 2011;28:7-21.
22. Ito Y, Muranao H, Hamasaki N, Fukushima K, Takada K: Incidence of low bioavailability of leuprolide acetate after percutaneous administration to rats by dissolving micro-needles. Int J Pharm 2011;407:126-131.
23. Sheshala R, Kok KP, Tusrida D, Bhavanasi KM, Thakur RRS: Development and validation of HPLC-UV method for the determination of insulin in rat plasma: application to pharmacokinetic study. Chromatographia 2007;66:805-809.
24. Ito Y, Yoshimura M, Tanaka T, Takada K: Effect of lipophilicity on the bioavailability of drugs after percutaneous administration by dissolving microneedles. J Pharm Sci 2012;101:1145-1156.
25. Ito Y, Ise A, Sugioka N, Takada K: Molecular weight dependence on bioavailability of FITC-dextran after administration of self-dissolving micropile to rat skin. Drug Dev Ind Pharm 2010;36:845-851.
26. Donnelly RF, Garland MJ, Morrow DI, Migalska K, Singh TR, Majithiya R, Woolfson AD: Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution. J Control Release 2010;147:333-341.
27. Coulman SA, Birchall JC, Alex A, Pearton M, Hofer B, O'Mahony C, DrexlerW, Povazay B: In vivo, in situ imaging of microneedle insertion into the skin of human volunteers using optical coherence tomography. Pharm Res 2011;28:66-81.
28. Morawski M, Alp ár A, Brückner GA, Fiedler C, Jäger G, Gati J, Stieler T, Arendt T: Chondroitin sulfate proteoglycanbased extracellular matrix in chicken (Gallus domesticus) brain. Brain Res 2009;1275:10-23.
29. Faissner A, Clement A, Lochter A, Streit A, Mandl C, Schachner M: Isolation of a neural chondroitin sulfate proteoglycan with neurite outgrowth promoting properties. J Cell Biol 1994;126:783-799.
30. Umehara Y, Yamada S, Nishimura S, Shioi J, Robakis NK, Sugahara K: Chondroitin sulfate of appican, the proteoglycan form of amyloid precursor protein, produced by C6 glioma cells interacts with heparin-binding neuroregulatory factors. FEBS Lett 2004;557:233-238.
31. Barry B, Williams A: Penetration enhancers. Adv Drug Deliv Rev 2004;56:603-618.
32. Preat V, Vanbever R: Skin electroporation for transdermal and topical delivery. Adv Drug Deliv Rev 2004;56:659-674.
33. Mitragotri S, Kost J: Low-frequency sonophoresis: a review. Adv Drug Deliv Rev 2004;56:589-601.
34. Doukas A: Transdermal delivery with a pressure wave. Adv Drug Deliv Rev 2004;56:559-579.