Glibenclamide reduces pro-inflammatory cytokine production by neutrophils of diabetes patients in response to bacterial infection

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Kewcharoenwong, Chidchamai ^a   Rinchai, Darawan ^a   Utispan, Kusumawadee ^a   Suwannasaen, Duangchan ^a   Bancroft, Gregory J ^b   Ato, Manabu ^c   Lertmemongkolchai, Ganjana ^a  

^a KHON KAEN UNIVERSITY   (Thailand)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; GLIBENCLAMIDE; IL1B PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; INTERLEUKIN 1BETA; INTERLEUKIN 8; METFORMIN;

BIOSYNTHESIS; BURKHOLDERIA PSEUDOMALLEI; CHEMICALLY INDUCED; DIABETES MELLITUS, TYPE 2; DISEASE PREDISPOSITION; HUMAN; IMMUNOLOGY; MELIOIDOSIS; MICROBIOLOGY; NEUTROPHIL; SECRETION (PROCESS); THAILAND;

BURKHOLDERIA PSEUDOMALLEI; DIABETES MELLITUS, TYPE 2; DISEASE SUSCEPTIBILITY; GLYBURIDE; HUMANS; HYPOGLYCEMIC AGENTS; INTERLEUKIN-1BETA; INTERLEUKIN-8; MELIOIDOSIS; METFORMIN; NEUTROPHILS; THAILAND;

EID: 84889584784     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep03363     Document Type: Article

References (41)

1. Joshi, N., Caputo, G. M., Weitekamp, M. R. & Karchmer, A. W. Infections in Patients with Diabetes Mellitus. New England Journal of Medicine 341, 1906-1912 (1999)
2. Shah, B. R. & Hux, J. E. Quantifying the Risk of Infectious Diseases for People With Diabetes. Diabetes Care 26, 510-513 (2003) (Pubitemid 36929083)
3. Koh, G., Peacock, S. J., Poll, T. & Wiersinga, W. J. The impact of diabetes on the pathogenesis of sepsis. European Journal of Clinical Microbiology & Infectious Diseases, 1-10 (2011)
4. Suputtamongkol, Y. et al. Risk factors for melioidosis and bacteremic melioidosis. Clin Infect Dis 29, 408-413 (1999) (Pubitemid 29380208)
5. Cheng, A. C. & Currie, B. J. Melioidosis: Epidemiology, Pathophysiology, and Management. Clin. Microbiol. Rev. 18, 383-416 (2005) (Pubitemid 40548298)
6. White, N. J. Melioidosis. Lancet 361, 1715-1722 (2003)
7. Easton,A., Haque, A., Chu, K., Lukaszewski, R.&Bancroft, G. J.ACritical Role for Neutrophils in Resistance to Experimental Infection with Burkholderia pseudomallei. Journal of Infectious Diseases 195, 99-107 (2007) (Pubitemid 44958231)
8. Reckseidler-Zenteno, S. L., DeVinney, R. & Woods, D. E. The Capsular Polysaccharide of Burkholderia pseudomallei Contributes to Survival in Serum by Reducing Complement Factor C3b Deposition. Infect. Immun. 73, 1106-1115 (2005) (Pubitemid 40165771)
9. Chanchamroen, S., Kewcharoenwong, C., Susaengrat, W., Ato, M. & Lertmemongkolchai, G. Human Polymorphonuclear Neutrophil Responses to Burkholderia pseudomallei in Healthy and Diabetic Subjects. Infect. Immun. 77, 456-463 (2009)
10. Nathan, C. Neutrophils and immunity: Challenges and opportunities. Nat Rev Immunol 6, 173-182 (2006) (Pubitemid 43290987)
11. Wiersinga, W. J. et al. Toll-Like Receptor 2 Impairs Host Defense in Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis). PLoS Med 4, e248 (2007)
12. Wiersinga, W. J., Wieland, C. W., Roelofs, J. J. T. H. & van der Poll, T. MyD88 Dependent Signaling Contributes to Protective Host Defense against Burkholderia pseudomallei. PLoS ONE 3, e3494 (2008)
13. Bryant, C. & Fitzgerald, K. A. Molecular mechanisms involved in inflammasome activation. Trends Cell Biol 19, 455-464 (2009)
14. Schroder, K., Zhou, R. & Tschopp, J. The NLRP3 Inflammasome: A Sensor for Metabolic Danger Science 327, 296-300 (2010)
15. Donath, M. Y. & Shoelson, S. E. Type 2 diabetes as an inflammatory disease. Nature reviews. Immunology 11, 98-107 (2011)
16. Ehses, J. A. et al. Increased Number of Islet-Associated Macrophages in Type 2 Diabetes. Diabetes 56, 2356-2370 (2007) (Pubitemid 47358243)
17. Sunil, Y., Ramadori, G. & Raddatzc, D. Influence of NFkappaB inhibitors on IL-1beta-induced chemokine CXCL8 and-10 expression levels in intestinal epithelial cell lines: Glucocorticoid ineffectiveness and paradoxical effect of PDTC. Int J Colorectal Dis 25, 323-333 (2010)
18. Breitbach, K. et al. Caspase-1 Mediates Resistance in Murine Melioidosis. Infect. Immun. 77, 1589-1595 (2009)
19. Oncul, O. et al. Effect of the function of polymorphonuclear leukocytes and interleukin-1 beta on wound healing in patients with diabetic foot infections. Journal of Infection 54, 250-256 (2007) (Pubitemid 46238168)
20. Andreasen, A. et al. Type 2 diabetes mellitus is associated with impaired cytokine response and adhesion molecule expression in human endotoxemia. Intensive Care Medicine 36, 1548-1555 (2010)
21. Lamkanfi, M. et al. Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. J Cell Biol 187, 61-70 (2009)
22. Rinchai, D. et al. Production of interleukin-27 by human neutrophils regulates their function during bacterial infection. Eur J Immunol 42, 3280-3290 (2012)
23. Dinarello, C. A. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117, 3720-3732 (2011)
24. Jonsson, A.,Hallengren, B., Rydberg, T.&Melander, A. Effects and serum levels of glibenclamide and its active metabolites in patients with type 2 diabetes. Diabetes Obes Metab 3, 403-409 (2001) (Pubitemid 34030858)
25. DeFronzo, R. A. Pharmacologic Therapy for Type 2 Diabetes Mellitus. Annals of Internal Medicine 133, 73-74 (2000) (Pubitemid 30432548)
26. Hatanaka, E., Monteagudo, P. T., Marrocos, M. S. M. & Campa, A. Neutrophils and monocytes as potentially important sources of proinflammatory cytokines in diabetes. Clinical & Experimental Immunology 146, 443-447 (2006) (Pubitemid 44722162)
27. Morris, J. et al. Burkholderia pseudomallei Triggers Altered Inflammatory Profiles in a Whole-Blood Model of Type 2 Diabetes-Melioidosis Comorbidity. Infection and Immunity 80, 2089-2099 (2012)
28. Miao, E. A. et al. Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proceedings of the National Academy of Sciences 107, 3076-3080 (2010)
29. Ceballos-Olvera, I., Sahoo, M.,Miller, M. A., Barrio, L. d. & Re, F. Inflammasomedependent Pyroptosis and IL-18 Protect against Burkholderia pseudomallei Lung Infection while IL-1b Is Deleterious. PLoS Pathog 7, e1002452 (2011)
30. Sun, G. W., Lu, J., Pervaiz, S., Cao, W. P. & Gan, Y.-H. Caspase-1 dependent macrophage death induced by Burkholderia pseudomallei. Cellular Microbiology 7, 1447-1458 (2005) (Pubitemid 41335248)
31. Hertting, O. et al. Enhanced chemokine response in experimental acute Escherichia coli pyelonephritis in IL-1b-deficient mice. Clinical & Experimental Immunology 131, 225-233 (2003) (Pubitemid 36205132)
32. Opal, S. M. et al. Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: A phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit Care Med 25, 1115-1124 (1997) (Pubitemid 27310249)
33. Hodgson, K. A., Govan, B. L., Walduck, A. K., Ketheesan, N. & Morris, J. L. Impaired Early Cytokine Responses at the Site of Infection in a Murine Model of Type 2 Diabetes and Melioidosis Comorbidity. Infection and Immunity 81, 470-477 (2013)
34. Winters, M. P. et al. Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor. Bioorganic & Medicinal Chemistry Letters 18, 1926-1930 (2008) (Pubitemid 351380887)
35. Spiller, F. et al. Hydrogen Sulfide Improves Neutrophil Migration and Survival in Sepsis via K 1 ATP Channel Activation. Am. J. Respir. Crit. Care Med. 182, 360-368 (2010)
36. Koh, G. C. K. W. et al. Glyburide Is Anti-inflammatory and Associated with Reduced Mortality in Melioidosis. Clinical Infectious Diseases 52, 717-725 (2011)
37. Shaw, R. J. et al. The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin. Science 310, 1642-1646 (2005) (Pubitemid 41780780)
38. Wen, H. et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 12, 408-415 (2011)
39. Alberti, K. G. & Zimmet, P. Z. Definition, diagnosis and classification of diabetes mellitus and its complications. in Report of WHO consultation: Part 1 Diagnosis and classification of diabetes mellitus. Diabet Med 15, 539-553 (1998) (Pubitemid 28319935)
40. Niopas, I.&Daftsios, A. C. A validated high-performance liquid chromatographic method for the determination of glibenclamide in human plasma and its application to pharmacokinetic studies. Journal of Pharmaceutical and Biomedical Analysis 28, 653-657 (2002) (Pubitemid 34465632)
41. Bailey, C. J. & Turner, R. C. Metformin. New England Journal of Medicine 334, 574-579 (1996)