메뉴 건너뛰기




Volumn , Issue , 2007, Pages 521-540

Combinatorial Synthesis of Alkaloid-like Compounds In Search of Chemical Probes of Protein-Protein Interactions

Author keywords

Alkaloid biosynthesis; Alkaloid natural products; Alkaloid synthesis; Bcl 2; Bcl XL; in silico studies; Indoline alkaloid; Modern alkaloids; Protein protein interactions; Small molecule binders

Indexed keywords


EID: 84889330223     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527621071.ch17     Document Type: Chapter
Times cited : (2)

References (37)
  • 1
    • 33644846857 scopus 로고    scopus 로고
    • Small molecules: the missing link in the central dogma.
    • Schreiber, S. L. (2005) Small molecules: the missing link in the central dogma. Nature Chemical Biology, 1, 64-66.
    • (2005) Nature Chemical Biology , vol.1 , pp. 64-66
    • Schreiber, S.L.1
  • 2
    • 0037416141 scopus 로고    scopus 로고
    • The small-molecule approach to biology
    • Chemical and Engineering News
    • Schreiber, S. L. (2003) The small-molecule approach to biology. Chemical and Engineering News, 51-61.
    • (2003) , pp. 51-61
    • Schreiber, S.L.1
  • 3
    • 25644454404 scopus 로고    scopus 로고
    • Pharmaceuticals: a new grammar for drug discovery
    • Fishman, M. C. and Porter, J. A. (2005) Pharmaceuticals: a new grammar for drug discovery. Nature, 437, 491-493.
    • (2005) Nature , vol.437 , pp. 491-493
    • Fishman, M.C.1    Porter, J.A.2
  • 4
    • 33646372429 scopus 로고    scopus 로고
    • Chemical intervention in signalling networks: recent advances and applications
    • Tate, E. W. (2006) Chemical intervention in signalling networks: recent advances and applications. Signal Transduction, 6, 144-159.
    • (2006) Signal Transduction , vol.6 , pp. 144-159
    • Tate, E.W.1
  • 5
    • 20444383859 scopus 로고    scopus 로고
    • Protein phosphorylation in signaling-50 years and counting
    • Pawson, T. and Scott, J. D. (2005) Protein phosphorylation in signaling-50 years and counting. Trends in Biochemical Sciences, 30, 286-290.
    • (2005) Trends in Biochemical Sciences , vol.30 , pp. 286-290
    • Pawson, T.1    Scott, J.D.2
  • 6
    • 3142781225 scopus 로고    scopus 로고
    • Small-molecule inhibitors of protein-protein interactions: progressing towards the dream
    • Arkin, M. R. and Wells, J. A. (2004) Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nature Reviews Drug Discovery, 3, 301-317.
    • (2004) Nature Reviews Drug Discovery , vol.3 , pp. 301-317
    • Arkin, M.R.1    Wells, J.A.2
  • 7
    • 20444376940 scopus 로고    scopus 로고
    • Protein-protein interactions and cancer: small molecules going in for the kill
    • Arkin, M. (2005) Protein-protein interactions and cancer: small molecules going in for the kill. Current Opinion in Chemical Biology, 9, 317-324.
    • (2005) Current Opinion in Chemical Biology , vol.9 , pp. 317-324
    • Arkin, M.1
  • 8
    • 28544443984 scopus 로고    scopus 로고
    • Promoting apoptosis as a strategy for cancer drug discovery
    • Fesik, S. W. (2005) Promoting apoptosis as a strategy for cancer drug discovery. Nature Reviews Cancer, 5, 876-885.
    • (2005) Nature Reviews Cancer , vol.5 , pp. 876-885
    • Fesik, S.W.1
  • 9
    • 33745198390 scopus 로고    scopus 로고
    • X-linked inhibitor of apoptosis antagonism: strategies in cancer treatment
    • Cheung, H. H., LaCasse, E. C., Korneluk, R. G. (2006) X-linked inhibitor of apoptosis antagonism: strategies in cancer treatment. Clinical Cancer Research, 12, 3238-3242.
    • (2006) Clinical Cancer Research , vol.12 , pp. 3238-3242
    • Cheung, H.H.1    LaCasse, E.C.2    Korneluk, R.G.3
  • 11
    • 0346880501 scopus 로고    scopus 로고
    • The inhibitors of apoptosis: there is more to life than Bcl2.
    • Liston, P., Fong, W. G., Korneluk, R. G. (2003) The inhibitors of apoptosis: there is more to life than Bcl2. Oncogene, 22, 8568-8580.
    • (2003) Oncogene , vol.22 , pp. 8568-8580
    • Liston, P.1    Fong, W.G.2    Korneluk, R.G.3
  • 12
    • 33745953139 scopus 로고    scopus 로고
    • BCL-2 in the crosshairs: tipping the balance of life and death.
    • Walensky, L. D. (2006) BCL-2 in the crosshairs: tipping the balance of life and death. Cell Death and Differentiation, 13, 1339-1350.
    • (2006) Cell Death and Differentiation , vol.13 , pp. 1339-1350
    • Walensky, L.D.1
  • 16
    • 0347626109 scopus 로고    scopus 로고
    • Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2 family proteins
    • Leone, M., Zhai, D., Sareth, S., Kitada, S., Reed, J. C., Pellecchia, M. (2003) Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2 family proteins. Cancer Research, 63, 8118-8121.
    • (2003) Cancer Research , vol.63 , pp. 8118-8121
    • Leone, M.1    Zhai, D.2    Sareth, S.3    Kitada, S.4    Reed, J.C.5    Pellecchia, M.6
  • 17
    • 0036008083 scopus 로고    scopus 로고
    • Diversity-oriented organic synthesis and proteomics: new frontiers for chemistry & biology Chemistry and Biology
    • Schreiber, S. L., Nicolaou, K. C., Davies, K. (2002) Diversity-oriented organic synthesis and proteomics: new frontiers for chemistry & biology Chemistry and Biology, 9, 1-2.
    • (2002) , vol.9 , pp. 1-2
    • Schreiber, S.L.1    Nicolaou, K.C.2    Davies, K.3
  • 18
    • 33644839988 scopus 로고    scopus 로고
    • Diversity-oriented synthesis: exploring the intersections between chemistry and biology
    • Tan, D. S. (2005) Diversity-oriented synthesis: exploring the intersections between chemistry and biology. Nature Chemical Biology, 1, 74-84.
    • (2005) Nature Chemical Biology , vol.1 , pp. 74-84
    • Tan, D.S.1
  • 19
    • 14144251136 scopus 로고    scopus 로고
    • Exploring new chemical space by stereocontrolled diversity-oriented synthesis
    • Arya, P., Joseph, R., Gan, Z. H., Rakic, B. (2005) Exploring new chemical space by stereocontrolled diversity-oriented synthesis. Chemistry and Biology, 12, 163-180.
    • (2005) Chemistry and Biology , vol.12 , pp. 163-180
    • Arya, P.1    Joseph, R.2    Gan, Z.H.3    Rakic, B.4
  • 20
    • 20444420189 scopus 로고    scopus 로고
    • Natural product-like chemical space: search for chemical dissectors of macromolecular interactions
    • Reayi, A. and Arya, P. (2005) Natural product-like chemical space: search for chemical dissectors of macromolecular interactions. Current Opinion in Chemical Biology, 9, 240-247.
    • (2005) Current Opinion in Chemical Biology , vol.9 , pp. 240-247
    • Reayi, A.1    Arya, P.2
  • 21
    • 20444378945 scopus 로고    scopus 로고
    • The principle of complementarity: chemical versus biological space
    • Haggarty, S. J. (2005) The principle of complementarity: chemical versus biological space. Current Opinion in Chemical Biology, 9, 296-303.
    • (2005) Current Opinion in Chemical Biology , vol.9 , pp. 296-303
    • Haggarty, S.J.1
  • 25
    • 0942289835 scopus 로고    scopus 로고
    • A solid phase library synthesis of hydroxyindoline-derived tricyclic derivatives by Mitsunobu approach
    • Arya, P., Wei, C.-Q., Barnes, M. L., Daroszewska, M. (2004) A solid phase library synthesis of hydroxyindoline-derived tricyclic derivatives by Mitsunobu approach. Journal of Combinatorial Chemistry, 6, 65-72.
    • (2004) Journal of Combinatorial Chemistry , vol.6 , pp. 65-72
    • Arya, P.1    Wei, C.-Q.2    Barnes, M.L.3    Daroszewska, M.4
  • 26
    • 14844300078 scopus 로고    scopus 로고
    • Stereocontrolled solid-phase synthesis of a 90-member library of indoline-alkaloid-like polycyclics from an enantioriched aminoindoline scaffold
    • Gan, Z., Reddy, P. T., Quevillon, S., Couve-Bonnaire, S., Arya, P. (2005) Stereocontrolled solid-phase synthesis of a 90-member library of indoline-alkaloid-like polycyclics from an enantioriched aminoindoline scaffold. Angewandte Chemie, International Edition, 44, 1366-1368.
    • (2005) Angewandte Chemie, International Edition , vol.44 , pp. 1366-1368
    • Gan, Z.1    Reddy, P.T.2    Quevillon, S.3    Couve-Bonnaire, S.4    Arya, P.5
  • 27
    • 33845267229 scopus 로고    scopus 로고
    • Solution-and solid-phase, modular approaches for obtaining different natural product-like polycyclic architectures from an aminoindoline scaffold for combinatorial chemistry
    • Reddy, P. T., Quevillon, S., Gan, Z., Forbes, N., Leek, D. M., Arya, P. (2006) Solution-and solid-phase, modular approaches for obtaining different natural product-like polycyclic architectures from an aminoindoline scaffold for combinatorial chemistry. Journal ofCombinatorial Chemistry, 8, 856-871.
    • (2006) Journal ofCombinatorial Chemistry , vol.8 , pp. 856-871
    • Reddy, P.T.1    Quevillon, S.2    Gan, Z.3    Forbes, N.4    Leek, D.M.5    Arya, P.6
  • 28
    • 33750075769 scopus 로고    scopus 로고
    • Part 1. Modular approach to obtaining diverse tetrahydroquinoline-derived polycyclic skeletons for use in high-throughput generation of natural-product-like chemical probes
    • Prakesch, M., Sharma, U., Sharma, M., Khadem, S., Leek, D. M., Arya, P. (2006) Part 1. Modular approach to obtaining diverse tetrahydroquinoline-derived polycyclic skeletons for use in high-throughput generation of natural-product-like chemical probes. Journal ofCombinatorial Chemistry, 8, 715-734.
    • (2006) Journal ofCombinatorial Chemistry , vol.8 , pp. 715-734
    • Prakesch, M.1    Sharma, U.2    Sharma, M.3    Khadem, S.4    Leek, D.M.5    Arya, P.6
  • 29
    • 33750074465 scopus 로고    scopus 로고
    • Part 2: Building diverse natural-product-like architectures from a tetrahydroaminoquinoline scaffold. modular solution-and solid-phase approaches for use in high-throughput generation of chemical probes.
    • Sharma, U., Srivastava, S., Prakesch, M., Sharma, M., Leek, D. M., Arya, P. (2006) Part 2: Building diverse natural-product-like architectures from a tetrahydroaminoquinoline scaffold. modular solution-and solid-phase approaches for use in high-throughput generation of chemical probes. Journal ofCombinatorial Chemistry, 8, 735-761.
    • (2006) Journal ofCombinatorial Chemistry , vol.8 , pp. 735-761
    • Sharma, U.1    Srivastava, S.2    Prakesch, M.3    Sharma, M.4    Leek, D.M.5    Arya, P.6
  • 30
    • 33750045751 scopus 로고    scopus 로고
    • Part 3. A novel stereocontrolled, in situ, solution-and solid-phase, aza michael approach for high-throughput generation of tetrahydroaminoquinoline-derived natural-product-like architectures.
    • Prakesch, M., Srivastava, S., Leek, D. M., Arya, P. (2006) Part 3. A novel stereocontrolled, in situ, solution-and solid-phase, aza michael approach for high-throughput generation of tetrahydroaminoquinoline-derived natural-product-like architectures. Journal ofCombinatorial Chemistry, 8, 762-773.
    • (2006) Journal ofCombinatorial Chemistry , vol.8 , pp. 762-773
    • Prakesch, M.1    Srivastava, S.2    Leek, D.M.3    Arya, P.4
  • 32
    • 33144479535 scopus 로고    scopus 로고
    • Structural model of the BCL-w-BID peptide complex and its interactions with phospholipids micelles.
    • Denisov, A. Y., Chen, G., Sprules, T., Moldoveanu, T., Beauparlant, P., Gehring, K. (2006) Structural model of the BCL-w-BID peptide complex and its interactions with phospholipids micelles. Biochemistry, 45, 2250-2256.
    • (2006) Biochemistry , vol.45 , pp. 2250-2256
    • Denisov, A.Y.1    Chen, G.2    Sprules, T.3    Moldoveanu, T.4    Beauparlant, P.5    Gehring, K.6
  • 33
    • 84889489006 scopus 로고    scopus 로고
    • The Discovery of Natural Product-Inspired Chemical Probes of Bcl-XL and Mcl-l
    • Submitted
    • Prakesch, M. Denisov, A. Yu., Naim, M., Gehring, K., Arya, P. (2007) The Discovery of Natural Product-Inspired Chemical Probes of Bcl-XL and Mcl-l. Submitted.
    • (2007)
    • Prakesch, M.1    Denisov, A.Y.2    Naim, M.3    Gehring, K.4    Arya, P.5
  • 35
    • 8444220527 scopus 로고    scopus 로고
    • Molecular mechanisms of caspase regulation during apoptosis.
    • Riedl, S. J. and Shi, Y. (2004) Molecular mechanisms of caspase regulation during apoptosis. Nature Reviews Molecular Cell Biology, 5, 897-907.
    • (2004) Nature Reviews Molecular Cell Biology , vol.5 , pp. 897-907
    • Riedl, S.J.1    Shi, Y.2
  • 37
    • 84889368837 scopus 로고    scopus 로고
    • Unpublished results
    • This work was presented as a poster at the Quebec-Ontario Minisymposium, University of Western Ontario, London, Ontario, November 3-6, 2006
    • Foster, T.L., Korneluk, R.G., MacKenzie, A. E., Prakesch, M., Reddy, P.T., Reddy, R.R., Arya, P. (2006) Unpublished results [This work was presented as a poster at the Quebec-Ontario Minisymposium, University of Western Ontario, London, Ontario, November 3-6, 2006.].
    • (2006)
    • Foster, T.L.1    Korneluk, R.G.2    MacKenzie, A.E.3    Prakesch, M.4    Reddy, P.T.5    Reddy, R.R.6    Arya, P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.