Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 7, 2013, Pages 2478-2483

  Chang, Fang Yuan ^a   Brady, Sean F ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Antitumor; Bisindole alkaloid; Indenotryptoline; Uncultured microbes

Indexed keywords

ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; BORREGOMYCIN A; BORREGOMYCIN B; BORREGOMYCIN C; BORREGOMYCIN D; DNA; INDOLOTRYPTOLINE; TRYPTOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIMERIZATION; DNA LIBRARY; GENE CLUSTER; GENE EXPRESSION; GENETIC SCREENING; HUMAN; HUMAN CELL; METAGENOME; METAGENOMICS; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; STREPTOMYCES ALBUS;

5-HYDROXYTRYPTOPHAN; BASE SEQUENCE; BIOLOGICAL AGENTS; BIOSYNTHETIC PATHWAYS; CARBOLINES; DIMERIZATION; DNA PRIMERS; DRUG DISCOVERY; GENE LIBRARY; GENETIC TESTING; MASS SPECTROMETRY; METAGENOME; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MULTIGENE FAMILY; PHOSPHOPROTEIN PHOSPHATASES; PHYLOGENY; SEQUENCE ANALYSIS, DNA; SOIL; STREPTOMYCES;

EID: 84873727524     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1218073110     Document Type: Article

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