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Volumn 9, Issue 3, 2012, Pages 404-412

Antitumor activity and molecular dynamics simulations of paclitaxel-laden triazine dendrimers

Author keywords

dendrimer; drug delivery; molecular dynamics; paclitaxel; prostate cancer; simulation; triazine; xenografts

Indexed keywords

DENDRIMER; MACROGOL; PACLITAXEL; PRODRUG; TRIAZINE DERIVATIVE;

EID: 84863229418     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp2005017     Document Type: Article
Times cited : (55)

References (50)
  • 1
    • 0031040149 scopus 로고    scopus 로고
    • The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents
    • DOI 10.1146/annurev.med.48.1.353
    • Rowinsky, E. K. The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents Annu. Rev. Med. 1997, 48, 353-374 (Pubitemid 27101837)
    • (1997) Annual Review of Medicine , vol.48 , pp. 353-374
    • Rowinsky, E.K.1
  • 2
    • 25144476858 scopus 로고    scopus 로고
    • Paclitaxel chemotherapy: From empiricism to a mechanism-based formulation strategy
    • Scripture, C. D.; Figg, W. D.; Sparreboom, A. Paclitaxel chemotherapy: from empiricism to a mechanism-based formulation strategy Ther. Clin. Risk Manage. 2005, 1, 107-114
    • (2005) Ther. Clin. Risk Manage. , vol.1 , pp. 107-114
    • Scripture, C.D.1    Figg, W.D.2    Sparreboom, A.3
  • 3
    • 2942562025 scopus 로고    scopus 로고
    • Docetaxel and paclitaxel in the treatment of breast cancer: A review of clinical experience
    • DOI 10.1634/theoncologist.9-suppl-2-24
    • Crown, J.; O'Leary, M.; Ooi, W. S. Docetaxel and paclitaxel in the treatment of breast cancer: a review of clinical experience Oncologist 2004, 9, 24-32 (Pubitemid 38747840)
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 2 , pp. 24-32
    • Crown, J.1    O'Leary, M.2    Ooi, W.-S.3
  • 5
    • 85127651620 scopus 로고
    • Semisynthesis of Taxol and taxotere
    • In; Suffness, M. CRC Press: Boca Raton
    • Holton, R. A.; Biediger, R. J.; Boatman, P. D. Semisynthesis of Taxol and taxotere. In Taxol: science and applications; Suffness, M., Ed.; CRC Press: Boca Raton, 1995; pp 97-121.
    • (1995) Taxol: Science and Applications , pp. 97-121
    • Holton, R.A.1    Biediger, R.J.2    Boatman, P.D.3
  • 6
    • 33646172454 scopus 로고    scopus 로고
    • Novel formulations of taxanes: A review. Old wine in a new bottle?
    • Hennenfent, K. L.; Govindan, R. Novel formulations of taxanes: a review. Old wine in a new bottle? Ann. Oncol. 2006, 17, 735-749
    • (2006) Ann. Oncol. , vol.17 , pp. 735-749
    • Hennenfent, K.L.1    Govindan, R.2
  • 8
    • 0027382066 scopus 로고
    • Cremophor EL solvent for paclitaxel, and toxicity
    • Liebmann, J.; Cook, J. A.; Mitchell, J. B. Cremophor EL solvent for paclitaxel, and toxicity Lancet 1993, 342, 1428
    • (1993) Lancet , vol.342 , pp. 1428
    • Liebmann, J.1    Cook, J.A.2    Mitchell, J.B.3
  • 10
    • 0029921281 scopus 로고    scopus 로고
    • Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle cremophor EL
    • Sparreboom, A.; van Tellingen, O.; Nooijen, W. J.; Beijnen, J. H. Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle Cremophor EL Cancer Res. 1996, 56, 2112-2115 (Pubitemid 26119912)
    • (1996) Cancer Research , vol.56 , Issue.9 , pp. 2112-2115
    • Sparreboom, A.1    Van Teilingen, O.2    Nooijen, W.J.3    Beijnen, J.H.4
  • 11
    • 77649190943 scopus 로고    scopus 로고
    • Preclinical efficacy studies of a novel nanoparticle-based formulation of paclitaxel that out-performs Abraxane
    • Feng, Z.; Zhao, G.; Yu, L.; Gough, D.; Howell, S. B. Preclinical efficacy studies of a novel nanoparticle-based formulation of paclitaxel that out-performs Abraxane Cancer Chemother. Pharmacol. 2010, 65, 923-930
    • (2010) Cancer Chemother. Pharmacol. , vol.65 , pp. 923-930
    • Feng, Z.1    Zhao, G.2    Yu, L.3    Gough, D.4    Howell, S.B.5
  • 13
    • 8444230023 scopus 로고    scopus 로고
    • Antitumor activity of hydrophilic paclitaxel copolymer prodrug using locoregional delivery in human orthotopic non-small cell lung cancer xenograft models
    • DOI 10.1158/1078-0432.CCR-04-0334
    • Zou, Y.; Fu, H.; Ghosh, S.; Farquhar, D.; Klostergaard, J. Antitumor activity of hydrophilic paclitaxel copolymer prodrug using locoregional delivery in human orthotopic nonsmall cell lung cancer xenograft models Clin. Cancer Res. 2004, 10, 7382-7391 (Pubitemid 39487728)
    • (2004) Clinical Cancer Research , vol.10 , Issue.21 , pp. 7382-7391
    • Zou, Y.1    Fu, H.2    Ghosh, S.3    Farquhar, D.4    Klostergaard, J.5
  • 14
    • 77955252647 scopus 로고    scopus 로고
    • HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release
    • Etrych, T.; Sírová, M.; Starovoytova, L.; Ríhová, B.; Ulbrich, K. HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release Mol. Pharmaceutics 2010, 7, 1015-1026
    • (2010) Mol. Pharmaceutics , vol.7 , pp. 1015-1026
    • Etrych, T.1    Sírová, M.2    Starovoytova, L.3    Ríhová, B.4    Ulbrich, K.5
  • 15
    • 33846547612 scopus 로고    scopus 로고
    • Complete regression of xenografted human carcinomas by a paclitaxel-carboxymethyl dextran conjugate (AZ10992)
    • DOI 10.1016/j.jconrel.2006.10.009, PII S0168365906005724
    • Sugahara, S.; Kajiki, M.; Kuriyama, H.; Kobayashi, T. R. Complete regression of xenografted human carcinomas by a paclitaxel-carboxymethyl dextran conjugate (AZ10992) J. Controlled Release 2007, 117, 40-50 (Pubitemid 46161869)
    • (2007) Journal of Controlled Release , vol.117 , Issue.1 , pp. 40-50
    • Sugahara, S.-i.1    Kajiki, M.2    Kuriyama, H.3    Kobayashi, T.-r.4
  • 17
    • 17844400324 scopus 로고    scopus 로고
    • In vivo pharmacokinetic and tissue distribution studies in mice of alternative formulations for local and systemic delivery of paclitaxel: Gel, film, prodrug, liposomes and micelles
    • DOI 10.2174/1567201052772852
    • Dhanikula, A. B.; Singh, D. R.; Panchagnula, R. In vivo pharmacokinetic and tissue distribution studies in mice of alternative formulations for local and systemic delivery of paclitaxel: gel, film, prodrug, liposomes and micelles Curr. Drug Delivery 2005, 2, 35-44 (Pubitemid 40590919)
    • (2005) Current Drug Delivery , vol.2 , Issue.1 , pp. 35-44
    • Dhanikula, A.B.1    Singh, D.R.2    Panchagnula, R.3
  • 18
    • 77954871375 scopus 로고    scopus 로고
    • Novel nanoassemblies composed of squalenoyl-paclitaxel derivatives: Synthesis, characterization, and biological evaluation
    • Dosio, F.; Reddy, L. H.; Ferrero, A.; Stella, B.; Cattel, L.; Couvreur, P. Novel nanoassemblies composed of squalenoyl-paclitaxel derivatives: synthesis, characterization, and biological evaluation Bioconjugate Chem. 2010, 21, 1349-1361
    • (2010) Bioconjugate Chem. , vol.21 , pp. 1349-1361
    • Dosio, F.1    Reddy, L.H.2    Ferrero, A.3    Stella, B.4    Cattel, L.5    Couvreur, P.6
  • 20
    • 0038387390 scopus 로고    scopus 로고
    • The dawning era of polymer therapeutics
    • DOI 10.1038/nrd1088
    • Duncan, R. The dawning era of polymer therapeutics Nat. Rev. Drug Discovery 2003, 2, 347-360 (Pubitemid 37361705)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.5 , pp. 347-360
    • Duncan, R.1
  • 21
    • 33644593095 scopus 로고    scopus 로고
    • PAMAM dendrimer-based multifunctional conjugate for cancer therapy: Synthesis, characterization, and functionality
    • Majoros, I. J.; Myc, A.; Thomas, T.; Mehta, C. B.; Baker, J. R. PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionality Biomacromolecules 2006, 7, 572-579
    • (2006) Biomacromolecules , vol.7 , pp. 572-579
    • Majoros, I.J.1    Myc, A.2    Thomas, T.3    Mehta, C.B.4    Baker, J.R.5
  • 22
    • 28644434579 scopus 로고    scopus 로고
    • Designing dendrimers for biological applications
    • DOI 10.1038/nbt1171
    • Lee, C. C.; MacKay, J. A.; Fréchet, J. M.; Szoka, F. C. Designing dendrimers for biological applications Nat. Biotechnol. 2005, 23, 1517-1526 (Pubitemid 41752929)
    • (2005) Nature Biotechnology , vol.23 , Issue.12 , pp. 1517-1526
    • Lee, C.C.1    MacKay, J.A.2    Frechet, J.M.J.3    Szoka, F.C.4
  • 23
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Matsumura, Y.; Maeda, H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs Cancer Res. 1986, 6, 6387-6392 (Pubitemid 17221789)
    • (1986) Cancer Research , vol.46 , Issue.12 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 24
    • 77955258060 scopus 로고    scopus 로고
    • EPR effect based drug design and clinical outlook for enhanced cancer chemotherapy
    • Maeda, H.; Matsumura, Y. EPR effect based drug design and clinical outlook for enhanced cancer chemotherapy Adv. Drug Delivery Rev. 2011, 63, 129-130
    • (2011) Adv. Drug Delivery Rev. , vol.63 , pp. 129-130
    • Maeda, H.1    Matsumura, Y.2
  • 25
    • 0141629661 scopus 로고    scopus 로고
    • Chemoselective building blocks for dendrimers from relative reactivity data
    • DOI 10.1021/ol0347491
    • Steffensen, M. B.; Simanek, E. E. Chemoselective building blocks for dendrimers from relative reactivity data Org. Lett. 2003, 5, 2359-2361 (Pubitemid 37161925)
    • (2003) Organic Letters , vol.5 , Issue.13 , pp. 2359-2361
    • Steffensen, M.B.1    Simanek, E.E.2
  • 26
  • 27
    • 77949802553 scopus 로고    scopus 로고
    • Synthesis of odd generation triazine dendrimers using a divergent, macromonomer approach
    • Lim, J.; Mintzer, M. A.; Perez, L. M.; Simanek, E. E. Synthesis of odd generation triazine dendrimers using a divergent, macromonomer approach Org. Lett. 2010, 12, 1148-1151
    • (2010) Org. Lett. , vol.12 , pp. 1148-1151
    • Lim, J.1    Mintzer, M.A.2    Perez, L.M.3    Simanek, E.E.4
  • 28
    • 6044260213 scopus 로고    scopus 로고
    • Synthesis and manipulation of orthogonally protected dendrimers: Building blocks for library synthesis
    • DOI 10.1002/anie.200460031
    • Steffensen, M. B.; Simanek, E. E. Synthesis and manipulation of orthogonally protected dendrimers: building blocks for library synthesis Angew. Chem., Int. Ed. 2004, 43, 5178-5180 (Pubitemid 39382535)
    • (2004) Angewandte Chemie - International Edition , vol.43 , Issue.39 , pp. 5178-5180
    • Steffensen, M.B.1    Simanek, E.E.2
  • 29
    • 71249089119 scopus 로고    scopus 로고
    • Design, synthesis, characterization, and biological evaluation of triazine dendrimers bearing paclitaxel using ester and ester/disulfide linkages
    • Lim, J.; Chouai, A.; Lo, S. -T; Liu, W.; Sun, X.; Simanek, E. E. Design, synthesis, characterization, and biological evaluation of triazine dendrimers bearing paclitaxel using ester and ester/disulfide linkages Bioconjugate Chem. 2009, 20, 2154-2161
    • (2009) Bioconjugate Chem. , vol.20 , pp. 2154-2161
    • Lim, J.1    Chouai, A.2    Lo, S.-T.3    Liu, W.4    Sun, X.5    Simanek, E.E.6
  • 31
    • 0033375310 scopus 로고    scopus 로고
    • Enhanced efficacy of a novel controlled release paclitaxel formulation (PACLIMER delivery system) for local-regional therapy of lung cancer tumor nodules in mice
    • Harper, E.; Dang, W.; Lapidus, R. G.; Garver, R. I., Jr. Enhanced efficacy of a novel controlled release paclitaxel formulation (PACLIMER delivery system) for local-regional therapy of lung cancer tumor nodules in mice Clin. Cancer Res. 1999, 5, 4242-4248 (Pubitemid 30013811)
    • (1999) Clinical Cancer Research , vol.5 , Issue.12 , pp. 4242-4248
    • Harper, E.1    Dang, W.2    Lapidus, R.G.3    Garver Jr., R.I.4
  • 33
    • 33745458519 scopus 로고    scopus 로고
    • Albumin-bound paclitaxel: A next-generation taxane
    • DOI 10.1517/14656566.7.8.1041
    • Gradishar, W. J. Albumin-bound paclitaxel: a next-generation taxane Expert Opin. Pharmacother. 2006, 7, 1041-1053 (Pubitemid 43949942)
    • (2006) Expert Opinion on Pharmacotherapy , vol.7 , Issue.8 , pp. 1041-1053
    • Gradishar, W.J.1
  • 34
    • 33644753906 scopus 로고    scopus 로고
    • Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel
    • DOI 10.1158/1078-0432.CCR-05-1634
    • Desai, N.; Trieu, V.; Yao, Z.; Louie, L.; Ci, S.; Yang, A.; Tao, C.; De, T.; Beals, B.; Dykes, D.; Noker, P.; Yao, R.; Labao, E.; Hawkins, M.; Soon-Shiong, P. Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel Clin. Cancer Res. 2006, 12, 1317-1324 (Pubitemid 43342524)
    • (2006) Clinical Cancer Research , vol.12 , Issue.4 , pp. 1317-1324
    • Desai, N.1    Trieu, V.2    Yao, Z.3    Louie, L.4    Ci, S.5    Yang, A.6    Tao, C.7    De, T.8    Beals, B.9    Dykes, D.10    Noker, P.11    Yao, R.12    Labao, E.13    Hawkins, M.14    Soon-Shiong, P.15
  • 35
    • 77955247075 scopus 로고    scopus 로고
    • Biological assessment of triazine dendrimer: Toxicological profiles, solution behavior, biodistribution, drug release and efficacy in a PEGylated, paclitaxel construct
    • Lo, S. T.; Stern, S.; Clogston, J. D.; Zheng, J.; Adiseshaiah, P. P.; Dobrovolskaia, M.; Lim, J.; Patri, A. K.; Sun, X.; Simanek, E. E. Biological assessment of triazine dendrimer: toxicological profiles, solution behavior, biodistribution, drug release and efficacy in a PEGylated, paclitaxel construct Mol. Pharmaceutics 2010, 7, 993-1006
    • (2010) Mol. Pharmaceutics , vol.7 , pp. 993-1006
    • Lo, S.T.1    Stern, S.2    Clogston, J.D.3    Zheng, J.4    Adiseshaiah, P.P.5    Dobrovolskaia, M.6    Lim, J.7    Patri, A.K.8    Sun, X.9    Simanek, E.E.10
  • 36
    • 79958176375 scopus 로고    scopus 로고
    • Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery
    • Cheng, R.; Feng, F.; Meng, F.; Deng, C.; Feijen, J.; Zhong, Z. Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery J. Controlled Release 2011, 152, 2-12
    • (2011) J. Controlled Release , vol.152 , pp. 2-12
    • Cheng, R.1    Feng, F.2    Meng, F.3    Deng, C.4    Feijen, J.5    Zhong, Z.6
  • 37
    • 77950102895 scopus 로고    scopus 로고
    • Computational insights into the interactions between DNA and siRNA with "rigid" and "flexible" triazine dendrimers
    • Pavan, G. M.; Mintzer, M. A.; Simanek, E. E.; Merkel, O. M.; Kissel, T.; Danani, A. Computational insights into the interactions between DNA and siRNA with "rigid" and "flexible" triazine dendrimers Biomacromolecules 2010, 11, 721-730
    • (2010) Biomacromolecules , vol.11 , pp. 721-730
    • Pavan, G.M.1    Mintzer, M.A.2    Simanek, E.E.3    Merkel, O.M.4    Kissel, T.5    Danani, A.6
  • 40
    • 79851495066 scopus 로고    scopus 로고
    • Generation-dependent molecular recognition controls self-assembly in supramolecular dendron-virus complexes
    • Doni, D.; Kostiainen, M. A.; Danani, A.; Pavan, G. M. Generation-dependent molecular recognition controls self-assembly in supramolecular dendron-virus complexes Nano Lett. 2011, 11, 723-728
    • (2011) Nano Lett. , vol.11 , pp. 723-728
    • Doni, D.1    Kostiainen, M.A.2    Danani, A.3    Pavan, G.M.4
  • 41
    • 77951821505 scopus 로고    scopus 로고
    • Computational approach for understanding the interactions of UV-degradable dendrons with DNA and siRNA
    • Pavan, G. M.; Kostiainen, M. A.; Danani, A. Computational approach for understanding the interactions of UV-degradable dendrons with DNA and siRNA J. Phys. Chem. B 2010, 114, 5686-5693
    • (2010) J. Phys. Chem. B , vol.114 , pp. 5686-5693
    • Pavan, G.M.1    Kostiainen, M.A.2    Danani, A.3
  • 44
    • 33846823909 scopus 로고
    • Particle mesh Ewald: An N·log(N) method for Ewald sums in large systems
    • Darden, T.; York, D.; Pedersen, L. Particle mesh Ewald: An N·log(N) method for Ewald sums in large systems J. Chem. Phys. 1993, 98, 10089-10092
    • (1993) J. Chem. Phys. , vol.98 , pp. 10089-10092
    • Darden, T.1    York, D.2    Pedersen, L.3
  • 45
    • 33646940952 scopus 로고
    • Numerical integration of the Cartesian equations of motion of a system with constraints: Molecular dynamics of n-alkanes
    • Ryckaert, J. P.; Ciccotti, G.; Berendsen, H. J. C. Numerical integration of the Cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes J. Comput. Phys. 1977, 23, 327-341
    • (1977) J. Comput. Phys. , vol.23 , pp. 327-341
    • Ryckaert, J.P.1    Ciccotti, G.2    Berendsen, H.J.C.3
  • 46
    • 0035871686 scopus 로고    scopus 로고
    • A fast SHAKE algorithm to solve distance constraint equations for small molecules in molecular dynamics simulations
    • DOI 10.1002/1096-987X(20010415)22:5<501::AID-JCC1021>3.0.CO;2-V
    • Krautler, V.; Van Gunsteren, W. F.; Hunenberger, P. H. A fast SHAKE algorithm to solve distance constraint equations for small molecules in molecular dynamics simulations J. Comput. Chem. 2001, 22, 501-508 (Pubitemid 32291686)
    • (2001) Journal of Computational Chemistry , vol.22 , Issue.5 , pp. 501-508
    • Krautler, V.1    Van Gunsteren, W.F.2    Hunenberger, P.H.3
  • 49
    • 0000043930 scopus 로고    scopus 로고
    • Solvation free energy of biomacromolecules: Parameters for a modified generalized born model consistent with the AMBER force field
    • Jayaram, B.; Sprous, D.; Beveridge, D. L. Solvation free energy of biomacromolecules: Parameters for a modified generalized Born model consistent with the AMBER force field J. Phys. Chem. B 1998, 102, 9571-9576 (Pubitemid 128611876)
    • (1998) Journal of Physical Chemistry B , vol.102 , Issue.47 , pp. 9571-9576
    • Jayaram, B.1    Sprous, D.2    Beveridge, D.L.3
  • 50
    • 0028173135 scopus 로고
    • Calculation of electrostatic effects at the amino terminus of an α helix
    • Sitkoff, D.; Lockhart, D. J.; Sharp, K. A.; Honig, B. Calculation of electrostatic effects at the amino terminus of an alpha helix Biophys. J. 1994, 67, 2251-2260 (Pubitemid 24369647)
    • (1994) Biophysical Journal , vol.67 , Issue.6 , pp. 2251-2260
    • Sitkoff, D.1    Lockhart, D.J.2    Sharp, K.A.3    Honig, B.4


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