메뉴 건너뛰기




Volumn 18, Issue 12, 2013, Pages 1536-1547

Inhibition of polyamine oxidase prevented cyclin-dependent kinase inhibitor-induced apoptosis in HCT 116 colon carcinoma cells

Author keywords

Apoptosis; CDK Inhibitors; Colon cancer; Polyamine catabolism

Indexed keywords

N,N' BIS(2,3 BUTADIENYL)PUTRESCINE; POLYAMINE OXIDASE; PURVALANOL; ROSCOVITINE;

EID: 84889096256     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0885-8     Document Type: Article
Times cited : (10)

References (45)
  • 1
    • 1842848009 scopus 로고    scopus 로고
    • Cytotoxic effects of the polyamine oxidase inactivator MDL 72527 to two human colon carcinoma cell lines SW480 and SW620
    • 12484549 10.1023/A:1020863506170 1:CAS:528:DC%2BD38Xot12qsrg%3D
    • Duranton B, Holl V, Schneider Y et al (2002) Cytotoxic effects of the polyamine oxidase inactivator MDL 72527 to two human colon carcinoma cell lines SW480 and SW620. Cell Biol Toxicol 18:381-396
    • (2002) Cell Biol Toxicol , vol.18 , pp. 381-396
    • Duranton, B.1    Holl, V.2    Schneider, Y.3
  • 2
    • 0033595635 scopus 로고    scopus 로고
    • Alteration of pRb/p16/cdk4 regulation in human osteosarcoma
    • 10502725 10.1002/(SICI)1097-0215(19991022)84:5<489: AID-IJC7>3.0.CO;2-D 1:CAS:528:DyaK1MXmslGhsLo%3D
    • Benassi MS, Molendini L, Gamberi G et al (1999) Alteration of pRb/p16/cdk4 regulation in human osteosarcoma. Int J Cancer 84:489-493
    • (1999) Int J Cancer , vol.84 , pp. 489-493
    • Benassi, M.S.1    Molendini, L.2    Gamberi, G.3
  • 3
    • 0029011805 scopus 로고
    • Cell cycle and apoptosis: Common pathways to life and death
    • 7673325 10.1002/jcb.240580206 1:CAS:528:DyaK2MXmtlOnt74%3D
    • King KL, Cidlowski JA (1995) Cell cycle and apoptosis: common pathways to life and death. J Cell Biochem 58:175-180
    • (1995) J Cell Biochem , vol.58 , pp. 175-180
    • King, K.L.1    Cidlowski, J.A.2
  • 4
    • 0037058678 scopus 로고    scopus 로고
    • In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)
    • 12432547 10.1002/ijc.10738 1:CAS:528:DC%2BD38XovVOksL4%3D
    • McClue SJ, Blake D, Clarke R et al (2002) In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine). Int J Cancer 102:463-468
    • (2002) Int J Cancer , vol.102 , pp. 463-468
    • McClue, S.J.1    Blake, D.2    Clarke, R.3
  • 5
    • 0031037714 scopus 로고    scopus 로고
    • Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
    • 9030781 10.1111/j.1432-1033.1997.t01-2-00527.x 1:CAS:528: DyaK2sXhtVWiu7g%3D
    • Meijer L, Borgne A, Mulner O et al (1997) Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem 243:527-536
    • (1997) Eur J Biochem , vol.243 , pp. 527-536
    • Meijer, L.1    Borgne, A.2    Mulner, O.3
  • 6
    • 58149312591 scopus 로고    scopus 로고
    • Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors
    • 18708158 10.1016/j.biocel.2008.07.013 1:CAS:528:DC%2BD1MXns1yjsQ%3D%3D
    • Mohapatra S, Chu B, Zhao X, Djeu J, Cheng JQ, Pledger WJ (2009) Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors. Int J Biochem Cell Biol 41:595-602
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 595-602
    • Mohapatra, S.1    Chu, B.2    Zhao, X.3    Djeu, J.4    Cheng, J.Q.5    Pledger, W.J.6
  • 7
    • 79951807772 scopus 로고    scopus 로고
    • Roscovitine, a selective CDK inhibitor, reduces the basal and estrogen-induced phosphorylation of ER-α in human ER-positive breast cancer cells
    • 21328450 10.1002/jcb.23004 1:CAS:528:DC%2BC3MXhvFelurs%3D
    • Wesierska-Gadek J, Gritsch D, Zulehner N, Komina O, Maurer M (2011) Roscovitine, a selective CDK inhibitor, reduces the basal and estrogen-induced phosphorylation of ER-α in human ER-positive breast cancer cells. J Cell Biochem 112:761-772
    • (2011) J Cell Biochem , vol.112 , pp. 761-772
    • Wesierska-Gadek, J.1    Gritsch, D.2    Zulehner, N.3    Komina, O.4    Maurer, M.5
  • 8
    • 76049088795 scopus 로고    scopus 로고
    • Involvement of p21Waf1/Cip1 cleavage during roscovitine-induced apoptosis in non-small cell lung cancer cells
    • 19956888 10.3892/or-00000802 1:CAS:528:DC%2BC3cXoslGntw%3D%3D
    • Zhang T, Jiang T, Zhang F et al (2010) Involvement of p21Waf1/Cip1 cleavage during roscovitine-induced apoptosis in non-small cell lung cancer cells. Oncol Rep 23:239-245
    • (2010) Oncol Rep , vol.23 , pp. 239-245
    • Zhang, T.1    Jiang, T.2    Zhang, F.3
  • 9
    • 23044439051 scopus 로고    scopus 로고
    • Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma
    • 15827128 10.1182/blood-2005-01-0320 1:CAS:528:DC%2BD2MXntVSmsrk%3D
    • Raje N, Kumar S, Hideshima T et al (2005) Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma. Blood 106:1042-1047
    • (2005) Blood , vol.106 , pp. 1042-1047
    • Raje, N.1    Kumar, S.2    Hideshima, T.3
  • 10
    • 84861693009 scopus 로고    scopus 로고
    • Polyamine depletion enhances the roscovitine-induced apoptosis through the activation of mitochondria in HCT116 colon carcinoma cells
    • 21809075 10.1007/s00726-011-1040-x 1:CAS:528:DC%2BC38Xhtlyqurw%3D
    • Arisan ED, Coker A, Palavan-Unsal N (2012) Polyamine depletion enhances the roscovitine-induced apoptosis through the activation of mitochondria in HCT116 colon carcinoma cells. Amino Acids 42:655-665
    • (2012) Amino Acids , vol.42 , pp. 655-665
    • Arisan, E.D.1    Coker, A.2    Palavan-Unsal, N.3
  • 11
    • 0020215250 scopus 로고
    • Polyamine metabolism and function
    • 6814260 1:CAS:528:DyaL38XlvFKiuro%3D
    • Pegg AE, McCann PP (1982) Polyamine metabolism and function. Am J Physiol 243:C212-C221
    • (1982) Am J Physiol , vol.243
    • Pegg, A.E.1    McCann, P.P.2
  • 12
    • 0025325255 scopus 로고
    • Molecular genetics of polyamine synthesis in eukaryotic cells
    • 2187296 10.1016/0968-0004(90)90216-X 1:CAS:528:DyaK3cXitFWmt7w%3D
    • Heby O, Persson L (1990) Molecular genetics of polyamine synthesis in eukaryotic cells. Trends Biochem Sci 15:153-158
    • (1990) Trends Biochem Sci , vol.15 , pp. 153-158
    • Heby, O.1    Persson, L.2
  • 13
    • 0018187647 scopus 로고
    • Interference with S and G2 phase progression by polyamine synthesis inhibitors
    • 627248 10.1016/0014-4827(78)90192-1 1:CAS:528:DyaE1cXhsV2ksb8%3D
    • Heby O, Andersson G, Gray JW (1978) Interference with S and G2 phase progression by polyamine synthesis inhibitors. Exp Cell Res 111:461-464
    • (1978) Exp Cell Res , vol.111 , pp. 461-464
    • Heby, O.1    Andersson, G.2    Gray, J.W.3
  • 14
    • 0017671659 scopus 로고
    • Kinetics of cell proliferation and polyamine synthesis during Ehrlich ascites tumor growth
    • 922727 1:CAS:528:DyaE1cXjsFKnsg%3D%3D
    • Andersson G, Heby O (1977) Kinetics of cell proliferation and polyamine synthesis during Ehrlich ascites tumor growth. Cancer Res 37:4361-4366
    • (1977) Cancer Res , vol.37 , pp. 4361-4366
    • Andersson, G.1    Heby, O.2
  • 15
    • 0031601569 scopus 로고    scopus 로고
    • Polyamines: An introduction
    • D.M.L. Morgan (eds) Humana Press Clifton
    • Morgan DML (1998) Polyamines: an introduction. In: Morgan DML (ed) Polyamine protocols. Humana Press, Clifton, pp 3-30
    • (1998) Polyamine Protocols , pp. 3-30
    • Morgan, D.M.L.1
  • 16
    • 44649152084 scopus 로고    scopus 로고
    • Ornithine decarboxylase attenuates leukemic chemotherapy drugs-induced cell apoptosis and arrest in human promyelocytic HL-60 cells
    • 18339422 10.1016/j.leukres.2008.01.017 1:CAS:528:DC%2BD1cXntlGgsrY%3D
    • Hsu PC, Hung HC, Liao YF, Liu CC, Tsay GJ, Liu GY (2008) Ornithine decarboxylase attenuates leukemic chemotherapy drugs-induced cell apoptosis and arrest in human promyelocytic HL-60 cells. Leuk Res 32:1530-1540
    • (2008) Leuk Res , vol.32 , pp. 1530-1540
    • Hsu, P.C.1    Hung, H.C.2    Liao, Y.F.3    Liu, C.C.4    Tsay, G.J.5    Liu, G.Y.6
  • 17
    • 21044431877 scopus 로고    scopus 로고
    • Ornithine decarboxylase gene is overexpressed in colorectal carcinoma
    • 15818733 1:CAS:528:DC%2BD2MXksVylsr4%3D
    • Hu HY, Liu XX, Jiang CY et al (2005) Ornithine decarboxylase gene is overexpressed in colorectal carcinoma. World J Gastroenterol 11:2244-2248
    • (2005) World J Gastroenterol , vol.11 , pp. 2244-2248
    • Hu, H.Y.1    Liu, X.X.2    Jiang, C.Y.3
  • 18
    • 0024368618 scopus 로고
    • Polyamine oxidation, programmed cell death, and regulation of melanoma in the murine embryonic limb
    • 2510929 1:CAS:528:DyaK3cXltlSqtg%3D%3D
    • Parchment RE, Pierce GB (1989) Polyamine oxidation, programmed cell death, and regulation of melanoma in the murine embryonic limb. Cancer Res 49:6680-6686
    • (1989) Cancer Res , vol.49 , pp. 6680-6686
    • Parchment, R.E.1    Pierce, G.B.2
  • 19
    • 0027238083 scopus 로고
    • 1-acetyltransferase - The turning point in polyamine metabolism
    • 8500690 1:CAS:528:DyaK3sXks1KitbY%3D
    • 1- acetyltransferase - the turning point in polyamine metabolism. Faseb J 7:653-661
    • (1993) Faseb J , vol.7 , pp. 653-661
    • Casero Jr., R.A.1    Pegg, A.E.2
  • 20
    • 0038419788 scopus 로고    scopus 로고
    • 1-acetylated polyamine oxidase
    • 12660232 10.1074/jbc.M302149200 1:CAS:528:DC%2BD3sXkt1Wjur4%3D
    • 1-acetylated polyamine oxidase. J Biol Chem 278:20514-20525
    • (2003) J Biol Chem , vol.278 , pp. 20514-20525
    • Wu, T.1    Yankovskaya, V.2    McIntire, W.S.3
  • 21
    • 33846786758 scopus 로고    scopus 로고
    • 1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells
    • 17237273 10.1158/1535-7163.MCT-06-0303 1:CAS:528:DC%2BD2sXmsVanug%3D%3D
    • 1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells. Mol Cancer Ther 6:128-137
    • (2007) Mol Cancer Ther , vol.6 , pp. 128-137
    • Allen, W.L.1    McLean, E.G.2    Boyer, J.3
  • 22
    • 84858201928 scopus 로고    scopus 로고
    • Silencing of the polyamine catabolic key enzyme SSAT prevents CDK inhibitor-induced apoptosis in CaCo-2 colon cancer cells
    • 22294330 1:CAS:528:DC%2BC38XjvVaqs78%3D
    • Coker A, Arisan ED, Palavan-Unsal N (2012) Silencing of the polyamine catabolic key enzyme SSAT prevents CDK inhibitor-induced apoptosis in CaCo-2 colon cancer cells. Mol Med Rep 5:1037-1042
    • (2012) Mol Med Rep , vol.5 , pp. 1037-1042
    • Coker, A.1    Arisan, E.D.2    Palavan-Unsal, N.3
  • 23
    • 80051539377 scopus 로고    scopus 로고
    • Transcriptional modulation of apoptosis regulators by roscovitine and related compounds
    • 21505869 10.1007/s10495-011-0603-3
    • Garrofé-Ochoa X, Cosialls AM, Ribas J, Gil J, Boix J (2011) Transcriptional modulation of apoptosis regulators by roscovitine and related compounds. Apoptosis 16(7):660-670
    • (2011) Apoptosis , vol.16 , Issue.7 , pp. 660-670
    • Garrofé-Ochoa, X.1    Cosialls, A.M.2    Ribas, J.3    Gil, J.4    Boix, J.5
  • 24
    • 33845907631 scopus 로고    scopus 로고
    • A cost effective non-commercial ECL-solution for Western blot detections yielding strong signals and low background
    • 17141265 10.1016/j.jim.2006.07.027 1:CAS:528:DC%2BD2sXisVKisA%3D%3D
    • Haan C, Behrmann I (2007) A cost effective non-commercial ECL-solution for Western blot detections yielding strong signals and low background. J Immunol Methods 318:11-19
    • (2007) J Immunol Methods , vol.318 , pp. 11-19
    • Haan, C.1    Behrmann, I.2
  • 25
    • 0041324624 scopus 로고    scopus 로고
    • Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms
    • 12819936 10.1007/s00280-003-0624-x 1:CAS:528:DC%2BD3sXlt1Oisbg%3D
    • Senderowicz AM (2003) Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms. Cancer Chemother Pharmacol 52:S61-S73
    • (2003) Cancer Chemother Pharmacol , vol.52
    • Senderowicz, A.M.1
  • 26
    • 69149107714 scopus 로고    scopus 로고
    • Roscovitine differentially affects asynchronously growing and synchronized human MCF-7 breast cancer cells
    • 19723062 10.1111/j.1749-6632.2009.04717.x 1:CAS:528:DC%2BD1MXht1SntbvE
    • Maurer M, Komina O, Wesierska-Gadek J (2009) Roscovitine differentially affects asynchronously growing and synchronized human MCF-7 breast cancer cells. Ann N Y Acad Sci 1171:250-256
    • (2009) Ann N y Acad Sci , vol.1171 , pp. 250-256
    • Maurer, M.1    Komina, O.2    Wesierska-Gadek, J.3
  • 27
    • 0037138452 scopus 로고    scopus 로고
    • Cellular effects of purvalanol A: A specific inhibitor of cyclin-dependent kinase activities
    • 11857351 10.1002/ijc.10125 1:CAS:528:DC%2BD38XhtVShsrg%3D
    • Villerbu N, Gaben AM, Redeuilh G, Mester J (2002) Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities. Int J Cancer 97:761-769
    • (2002) Int J Cancer , vol.97 , pp. 761-769
    • Villerbu, N.1    Gaben, A.M.2    Redeuilh, G.3    Mester, J.4
  • 28
    • 58149237962 scopus 로고    scopus 로고
    • Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells
    • 18777593 10.3748/wjg.14.5162 1:CAS:528:DC%2BD1MXmtVClsA%3D%3D
    • Abaza MS, Bahman AM, Al-Attiyah RJ (2008) Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells. World J Gastroenterol 14:5162-5175
    • (2008) World J Gastroenterol , vol.14 , pp. 5162-5175
    • Abaza, M.S.1    Bahman, A.M.2    Al-Attiyah, R.J.3
  • 29
    • 12344299194 scopus 로고    scopus 로고
    • Cell cycle arrest induced in human breast cancer cells by cyclin-dependent kinase inhibitors: A comparison of the effects exerted by roscovitine and olomoucine
    • 15591654 10.1211/0022357023277 1:CAS:528:DC%2BD2MXisVeit7o%3D
    • Wesierska-Gadek J, Gueorguieva M, Wojciechowski J, Horky M (2004) Cell cycle arrest induced in human breast cancer cells by cyclin-dependent kinase inhibitors: a comparison of the effects exerted by roscovitine and olomoucine. Pol J Pharmacol 56:635-641
    • (2004) Pol J Pharmacol , vol.56 , pp. 635-641
    • Wesierska-Gadek, J.1    Gueorguieva, M.2    Wojciechowski, J.3    Horky, M.4
  • 30
    • 57149083267 scopus 로고    scopus 로고
    • Roscovitine up-regulates p53 protein and induces apoptosis in human HeLaS(3) cervix carcinoma cells
    • 18846503 10.1002/jcb.21903 1:CAS:528:DC%2BD1cXhsFWgt77O
    • Wesierska-Gadek J, Wandl S, Kramer MP, Pickem C, Krystof V, Hajek SB (2008) Roscovitine up-regulates p53 protein and induces apoptosis in human HeLaS(3) cervix carcinoma cells. J Cell Biochem 105:1161-1171
    • (2008) J Cell Biochem , vol.105 , pp. 1161-1171
    • Wesierska-Gadek, J.1    Wandl, S.2    Kramer, M.P.3    Pickem, C.4    Krystof, V.5    Hajek, S.B.6
  • 31
    • 0037136718 scopus 로고    scopus 로고
    • P42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol
    • 12226745 10.1038/sj.onc.1205908 1:CAS:528:DC%2BD38XmvVOqtr8%3D
    • Knockaert M, Lenormand P, Gray N, Schultz P, Pouyssegur J, Meijer L (2002) p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol. Oncogene 21:6413-6424
    • (2002) Oncogene , vol.21 , pp. 6413-6424
    • Knockaert, M.1    Lenormand, P.2    Gray, N.3    Schultz, P.4    Pouyssegur, J.5    Meijer, L.6
  • 32
    • 0035525733 scopus 로고    scopus 로고
    • Cellular stress response and apoptosis in cancer therapy
    • 11675328 10.1182/blood.V98.9.2603 1:CAS:528:DC%2BD3MXotVegs7o%3D
    • Herr I, Debatin KM (2001) Cellular stress response and apoptosis in cancer therapy. Blood 98:2603-2614
    • (2001) Blood , vol.98 , pp. 2603-2614
    • Herr, I.1    Debatin, K.M.2
  • 33
    • 11144316653 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor roscovitine induces apoptosis in chronic lymphocytic leukemia cells
    • 14973497 10.1038/sj.leu.2403295 1:CAS:528:DC%2BD2cXisVyru70%3D
    • Hahntow IN, Schneller F, Oelsner M et al (2004) Cyclin-dependent kinase inhibitor roscovitine induces apoptosis in chronic lymphocytic leukemia cells. Leukemia 18:747-755
    • (2004) Leukemia , vol.18 , pp. 747-755
    • Hahntow, I.N.1    Schneller, F.2    Oelsner, M.3
  • 34
    • 28044452862 scopus 로고    scopus 로고
    • Potentiation of the lethality of the histone deacetylase inhibitor LAQ824 by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells
    • 16275999 10.1158/1535-7163.MCT-05-0157 1:CAS:528:DC%2BD2MXhtFyrtLjK
    • Rosato RR, Almenara JA, Maggio SC et al (2005) Potentiation of the lethality of the histone deacetylase inhibitor LAQ824 by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells. Mol Cancer Ther 4:1772-1785
    • (2005) Mol Cancer Ther , vol.4 , pp. 1772-1785
    • Rosato, R.R.1    Almenara, J.A.2    Maggio, S.C.3
  • 35
    • 0026788035 scopus 로고
    • Polyamines as a chemotaxonomic marker in bacterial systematics
    • 1524675 10.3109/10408419209113518 1:CAS:528:DyaK3sXns1Knsg%3D%3D
    • Hamana K, Matsuzaki S (1992) Polyamines as a chemotaxonomic marker in bacterial systematics. Crit Rev Microbiol 18:261-283
    • (1992) Crit Rev Microbiol , vol.18 , pp. 261-283
    • Hamana, K.1    Matsuzaki, S.2
  • 36
    • 0025183915 scopus 로고
    • Colonic polyamine content and ornithine decarboxylase activity as markers for adenomas
    • 2208006 10.1002/1097-0142(19901001)66:7<1539: AID-CNCR2820660718>3. 0.CO;2-Z 1:STN:280:DyaK3M%2Fgtlymtw%3D%3D
    • McGarrity TJ, Peiffer LP, Bartholomew MJ, Pegg AE (1990) Colonic polyamine content and ornithine decarboxylase activity as markers for adenomas. Cancer 66:1539-1543
    • (1990) Cancer , vol.66 , pp. 1539-1543
    • McGarrity, T.J.1    Peiffer, L.P.2    Bartholomew, M.J.3    Pegg, A.E.4
  • 37
    • 0023881236 scopus 로고
    • Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy
    • 3123052 1:CAS:528:DyaL1cXht1eqs7w%3D
    • Pegg AE (1988) Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. Cancer Res 48:759-774
    • (1988) Cancer Res , vol.48 , pp. 759-774
    • Pegg, A.E.1
  • 39
    • 0035503697 scopus 로고    scopus 로고
    • Polyamine depletion in human melanoma cells leads to G1 arrest associated with induction of p21WAF1/CIP1/SDI1, changes in the expression of p21-regulated genes, and a senescence-like phenotype
    • 11691789 1:CAS:528:DC%2BD3MXotlakur4%3D
    • Kramer DL, Chang BD, Chen Y et al (2001) Polyamine depletion in human melanoma cells leads to G1 arrest associated with induction of p21WAF1/CIP1/SDI1, changes in the expression of p21-regulated genes, and a senescence-like phenotype. Cancer Res 61:7754-7762
    • (2001) Cancer Res , vol.61 , pp. 7754-7762
    • Kramer, D.L.1    Chang, B.D.2    Chen, Y.3
  • 40
    • 0035804314 scopus 로고    scopus 로고
    • Terminally alkylated polyamine analogues as chemotherapeutic agents
    • 11141084 10.1021/jm000084m 1:CAS:528:DC%2BD3cXptVOmu78%3D
    • Casero RA Jr, Woster PM (2001) Terminally alkylated polyamine analogues as chemotherapeutic agents. J Med Chem 44:1-26
    • (2001) J Med Chem , vol.44 , pp. 1-26
    • Casero Jr., R.A.1    Woster, P.M.2
  • 42
    • 0021957073 scopus 로고
    • Specific inhibition of polyamine oxidase in vivo is a method for the elucidation of its physiological role
    • 3967048 10.1016/0304-4165(85)90251-X 1:CAS:528:DyaL2MXhsVKrsbY%3D
    • Bolkenius FN, Bey P, Seiler N (1985) Specific inhibition of polyamine oxidase in vivo is a method for the elucidation of its physiological role. Biochim Biophys Acta 838:69-76
    • (1985) Biochim Biophys Acta , vol.838 , pp. 69-76
    • Bolkenius, F.N.1    Bey, P.2    Seiler, N.3
  • 43
    • 0030684153 scopus 로고    scopus 로고
    • Rapid induction of apoptosis by deregulated uptake of polyamine analogues
    • 9359869 1:CAS:528:DyaK2sXotVWms7k%3D
    • Hu RH, Pegg AE (1997) Rapid induction of apoptosis by deregulated uptake of polyamine analogues. Biochem J 328:307-316
    • (1997) Biochem J , vol.328 , pp. 307-316
    • Hu, R.H.1    Pegg, A.E.2
  • 44
    • 0001547001 scopus 로고    scopus 로고
    • The role of polyamine catabolism in polyamine analogue-induced programmed cell death
    • 9326648 10.1073/pnas.94.21.11557 1:CAS:528:DyaK2sXmslaqtr4%3D
    • Ha HC, Woster PM, Yager JD, Casero RA Jr (1997) The role of polyamine catabolism in polyamine analogue-induced programmed cell death. Proc Natl Acad Sci USA 94:11557-11562
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 11557-11562
    • Ha, H.C.1    Woster, P.M.2    Yager, J.D.3    Casero Jr., R.A.4
  • 45
    • 0033214906 scopus 로고    scopus 로고
    • The polyamine oxidase inhibitor MDL-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects
    • 10519408 1:CAS:528:DyaK1MXmslWktbw%3D
    • Dai H, Kramer DL, Yang C, Murti KG, Porter CW, Cleveland JL (1999) The polyamine oxidase inhibitor MDL-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects. Cancer Res 59:4944-4954
    • (1999) Cancer Res , vol.59 , pp. 4944-4954
    • Dai, H.1    Kramer, D.L.2    Yang, C.3    Murti, K.G.4    Porter, C.W.5    Cleveland, J.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.