Cellular effects of purvalanol A: A specific inhibitor of cyclin-dependent kinase activities

International Journal of Cancer

Volumn 97, Issue 6, 2002, Pages 761-769

  Villerbu, Nathalie ^a   Gaben, Anne Marie ^a   Redeuilh, Gérard ^a   Mester, Jan ^a  

^a INSERM   (France)

Author keywords

Cell cycle; Cell death; Cyclin dependent kinase; Proliferation; Transcription

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN E; DNA; ESTRADIOL; LUCIFERASE; PROTEIN P21; PURVALANOL A; RETINOBLASTOMA PROTEIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA SYNTHESIS; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION;

BREAST NEOPLASMS; CELL CYCLE; CELL DIVISION; CELL SURVIVAL; COLONIC NEOPLASMS; CYCLIN D1; CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; ENZYME INHIBITORS; FEMALE; HELA CELLS; HT29 CELLS; HUMANS; METHIONINE; MICROFILAMENT PROTEINS; MUSCLE PROTEINS; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; UTERINE CERVICAL NEOPLASMS;

EID: 0037138452     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10125     Document Type: Article

References (31)

1. Cyclins and cyclin-dependent kinases: A biochemical view
2. D-type cyclins
3. CDK inhibitors: Positive and negative regulators of G1-phase progression
4. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2
5. Caspase 3-mediated cleavage of p21{superWAF1/CIP1/CIP1} associated with the cyclin A/Cdk2 complex is a prerequisite for apoptosis in SK-HEP-cells
6. Induction of p21(CIP1/WAF1/CIP1) and activation of p34(cdc2) involved in retinoic acid-induced apoptosis in human hepatoma Hep3B cells
7. Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines
8. Potent inhibitors of cyclin-dependent kinase 2 induce nuclear accumulation of wild-type p53 and nucleolar fragmentation in human untransformed and tumor-derived cells
9. Cellular effects of olomoucine in human lymphoma cells differing in p53 function
10. Roscovitine induces cell death and morphological changes indicative of apoptosis in MDA-MB-231 breast cancer cells
11. Adenovirus-mediated E2F-1 gene transfer induces an apoptotic response in human gastric carcinoma cells that is enhanced by cyclin dependent kinase inhibitors
12. Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase
13. Cdc2 and Cdk2 kinase activated by transforming growth factor-betal trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells
14. Involvement of cyclin-dependent kinase activities in CD437-induced apoptosis
15. Effects of olomoucine, a selective inhibitor of cyclin-dependent kinases, on cell cycle progression in human cancer cell lines
16. ATP-site directed inhibitors of cyclin-dependent kinases
17. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors
18. Stable luciferase transfected cells for studying steroid receptor biological activity
19. Resistance to TNF-α and adriamycin in the human breast cancer MCF-7 cell line: Relationship to MDR1, MnSOD, and TNF gene expression
20. Sodium butyrate inhibits the phosphorylation of the retinoblastoma gene product in mouse fibroblasts by a transcription-dependent mechanism
21. Oestrogen receptor facilitates the formation of preinitiation complex assembly: Involvement of the general transcription factor TFIIB
22. A model of cell cycle control: Sequential events regulated by growth factors
23. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
24. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
25. Cyclin-dependent kinase 7: At the cross-roads of transcription, DNA repair and cell cycle control?
26. Characterization of alkylating vs. intercalating anticancer drug-induced effects on cell survival, cell cycle kinetic and morphonuclear pattern of 3 neoplastic cell lines growing in vitro
27. Sodium butyrate induces G2 arrest in the human breast cancer cells MDA-MB-231 and renders them competent for DNA re-replication
28. Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
29. Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors
30. Regulation of E2F: A family of transcription factors involved in proliferation control
31. Characterization of a novel cdk1-related kinase