Application of in vitro biopharmaceutical methods in development of immediate release oral dosage forms intended for paediatric patients

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 3 PART B, 2013, Pages 833-842

  Batchelor, Hannah K ^a   Kendall, Richard ^b   Desset Brethes, Sabine ^c   Alex, Rainer ^d   Ernest, Terry B ^e  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b MSD   (United Kingdom)

^c NOVARTIS PHARMA AG   (Switzerland)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

^e GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Absorption; Bioavailability; Biopharmaceutics; Dissolution; Paediatric; Permeability; Solubility

Indexed keywords

BILE SALT; EXCIPIENT;

BILE; BILE SECRETION; CLINICAL STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DOSAGE FORM; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG SAFETY; DRUG SOLUBILITY; HUMAN; IMMEDIATE DRUG RELEASE; IN VITRO STUDY; INTESTINE FLUID; PHARMACEUTICS; PHARMACOKINETICS; REVIEW; STOMACH CONTENT; STOMACH JUICE; STOMACH PH;

(UNITED STATES) FOOD AND DRUG ADMINISTRATION; ABSORPTION; BCS; BIOAVAILABILITY; BIOPHARMACEUTICS; BIOPHARMACEUTICS CLASSIFICATION SYSTEM; DISSOLUTION; EMA; EUROPEAN MEDICINES AGENCY; FASSIF; FASTED STATE SIMULATED INTESTINAL FLUID; FDA; FED STATE SIMULATED INTESTINAL FLUID; FESSIF; GASTROINTESTINAL; GI; IN VITRO IN VIVO RELATIONSHIP; IVIVR; MAD; MAXIMUM ABSORBABLE DOSE; P-GLYCOPROTEIN; P-GP; PAEDIATRIC; PBPK; PERMEABILITY; PHARMACOKINETIC; PHYSIOLOGICALLY BASED PHARMACOKINETIC; PK; SGF; SIMULATED GASTRIC FLUID; SOLUBILITY; UNITED STATES PHARMACOPOEIA; USP;

ABSORPTION; ADMINISTRATION, ORAL; ADULT; BIOPHARMACEUTICS; CHEMISTRY, PHARMACEUTICAL; CHILD; COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; FOOD-DRUG INTERACTIONS; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; PEDIATRICS; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 84889090166     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.04.015     Document Type: Review

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