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Volumn 32, Issue 48, 2013, Pages 5481-5491

Targeting cell cycle and hormone receptor pathways in cancer

Author keywords

Cyclin dependent kinase; PD 0332991; Prostate cancer; Retinoblastoma protein; Tumor explants

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; PALBOCICLIB;

EID: 84889087652     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.83     Document Type: Article
Times cited : (93)

References (65)
  • 1
    • 79956103537 scopus 로고    scopus 로고
    • Outsmarting androgen receptor: Creative approaches for targeting aberrant androgen signaling in advanced prostate cancer
    • Knudsen KE, Kelly WK. Outsmarting androgen receptor: Creative approaches for targeting aberrant androgen signaling in advanced prostate cancer. Expert Rev Endocrinol Metab 2011; 6: 483-493
    • (2011) Expert Rev Endocrinol Metab , vol.6 , pp. 483-493
    • Knudsen, K.E.1    Kelly, W.K.2
  • 2
    • 77956453807 scopus 로고    scopus 로고
    • The E2F1/Rb and p53/MDM2 pathways in DNA repair and apoptosis: Understanding the crosstalk to develop novel strategies for prostate cancer radiotherapy
    • Udayakumar T, Shareef MM, Diaz DA, Ahmed MM, Pollack A. The E2F1/Rb and p53/MDM2 pathways in DNA repair and apoptosis: Understanding the crosstalk to develop novel strategies for prostate cancer radiotherapy. Semin Radiat Oncol 2010; 20: 258-266
    • (2010) Semin Radiat Oncol , vol.20 , pp. 258-266
    • Udayakumar, T.1    Shareef, M.M.2    Diaz, D.A.3    Ahmed, M.M.4    Pollack, A.5
  • 3
    • 84857371687 scopus 로고    scopus 로고
    • The AR dependent cell cycle: Mechanisms and cancer relevance
    • Schiewer MJ, Augello MA, Knudsen KE. The AR dependent cell cycle: Mechanisms and cancer relevance. Mol Cell Endocrinol 2012; 352: 34-45
    • (2012) Mol Cell Endocrinol , vol.352 , pp. 34-45
    • Schiewer, M.J.1    Augello, M.A.2    Knudsen, K.E.3
  • 4
    • 21644456228 scopus 로고    scopus 로고
    • Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors
    • Collins I, Garrett MD. Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors. Curr Opin Pharmacol 2005; 5: 366-373
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 366-373
    • Collins, I.1    Garrett, M.D.2
  • 5
    • 70450280886 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitors as potential targeted anticancer agents
    • Diaz-Padilla I, Siu LL, Duran I. Cyclin-dependent kinase inhibitors as potential targeted anticancer agents. Invest New Drugs 2009; 27: 586-594
    • (2009) Invest New Drugs , vol.27 , pp. 586-594
    • Diaz-Padilla, I.1    Siu, L.L.2    Duran, I.3
  • 6
    • 67650777303 scopus 로고    scopus 로고
    • Development of cell-cycle inhibitors for cancer therapy
    • Dickson MA, Schwartz GK. Development of cell-cycle inhibitors for cancer therapy. Curr Oncol 2009; 16: 36-43
    • (2009) Curr Oncol , vol.16 , pp. 36-43
    • Dickson, M.A.1    Schwartz, G.K.2
  • 7
    • 78649658736 scopus 로고    scopus 로고
    • Whether to target single or multiple CDKs for therapy? That is the question
    • Wesierska-Gadek J, Maurer M, Zulehner N, Komina O. Whether to target single or multiple CDKs for therapy? That is the question. J Cell Physiol 2011; 226: 341-349
    • (2011) J Cell Physiol , vol.226 , pp. 341-349
    • Wesierska-Gadek, J.1    Maurer, M.2    Zulehner, N.3    Komina, O.4
  • 8
    • 0031019034 scopus 로고    scopus 로고
    • Flavopiridol (L86-8275): Selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells
    • Drees M, Dengler WA, Roth T, Labonte H, Mayo J, Malspeis L et al. Flavopiridol (L86-8275): Selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells. Clin Cancer Res 1997; 3: 273-279
    • (1997) Clin Cancer Res , vol.3 , pp. 273-279
    • Drees, M.1    Dengler, W.A.2    Roth, T.3    Labonte, H.4    Mayo, J.5    Malspeis, L.6
  • 9
    • 0029807115 scopus 로고    scopus 로고
    • Flavopiridol (l86 8275; Nsc 649890), a new kinase inhibitor for tumor therapy
    • Sedlacek H, Czech J, Naik R, Kaur G, Worland P, Losiewicz M et al. Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy. Int J Oncol 1996; 9: 1143-1168
    • (1996) Int J Oncol , vol.9 , pp. 1143-1168
    • Sedlacek, H.1    Czech, J.2    Naik, R.3    Kaur, G.4    Worland, P.5    Losiewicz, M.6
  • 10
    • 0031670668 scopus 로고    scopus 로고
    • Phase i trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms
    • Senderowicz AM, Headlee D, Stinson SF, Lush RM, Kalil N, Villalba L et al. Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms. J Clin Oncol 1998; 16: 2986-2999
    • (1998) J Clin Oncol , vol.16 , pp. 2986-2999
    • Senderowicz, A.M.1    Headlee, D.2    Stinson, S.F.3    Lush, R.M.4    Kalil, N.5    Villalba, L.6
  • 11
    • 10744230675 scopus 로고    scopus 로고
    • A Phase II trial of flavopiridol (NSC #649890) in patients with previously untreated metastatic androgen-independent prostate cancer
    • Liu G, Gandara DR, Lara Jr. PN, Raghavan D, Doroshow JH, Twardowski P et al. A Phase II trial of flavopiridol (NSC #649890) in patients with previously untreated metastatic androgen-independent prostate cancer. Clin Cancer Res 2004; 10: 924-928
    • (2004) Clin Cancer Res , vol.10 , pp. 924-928
    • Liu, G.1    Gandara, D.R.2    Lara Jr., P.N.3    Raghavan, D.4    Doroshow, J.H.5    Twardowski, P.6
  • 13
    • 9444228344 scopus 로고    scopus 로고
    • Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts
    • Fry DW, Harvey PJ, Keller PR, Elliott WL, Meade M, Trachet E et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther 2004; 3: 1427-1438
    • (2004) Mol Cancer Ther , vol.3 , pp. 1427-1438
    • Fry, D.W.1    Harvey, P.J.2    Keller, P.R.3    Elliott, W.L.4    Meade, M.5    Trachet, E.6
  • 15
    • 33748184149 scopus 로고    scopus 로고
    • Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity
    • Marzec M, Kasprzycka M, Lai R, Gladden AB, Wlodarski P, Tomczak E et al. Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity. Blood 2006; 108: 1744-1750
    • (2006) Blood , vol.108 , pp. 1744-1750
    • Marzec, M.1    Kasprzycka, M.2    Lai, R.3    Gladden, A.B.4    Wlodarski, P.5    Tomczak, E.6
  • 16
    • 34548838818 scopus 로고    scopus 로고
    • Pharmacologic inhibition of CDK4/6: Mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia
    • Wang L, Wang J, Blaser BW, Duchemin AM, Kusewitt DF, Liu T et al. Pharmacologic inhibition of CDK4/6: Mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia. Blood 2007; 110: 2075-2083
    • (2007) Blood , vol.110 , pp. 2075-2083
    • Wang, L.1    Wang, J.2    Blaser, B.W.3    Duchemin, A.M.4    Kusewitt, D.F.5    Liu, T.6
  • 17
    • 80052559593 scopus 로고    scopus 로고
    • Deregulation of FGFR1 and CDK6 oncogenic pathways in acute lymphoblastic leukaemia harbouring epigenetic modifications of the MIR9 family
    • Rodriguez-Otero P, Roman-Gomez J, Vilas-Zornoza A, Jose-Eneriz ES, Martin- Palanco V, Rifon J et al. Deregulation of FGFR1 and CDK6 oncogenic pathways in acute lymphoblastic leukaemia harbouring epigenetic modifications of the MIR9 family. Br J Haematol 2011; 155: 73-83
    • (2011) Br J Haematol , vol.155 , pp. 73-83
    • Rodriguez-Otero, P.1    Roman-Gomez, J.2    Vilas-Zornoza, A.3    Jose-Eneriz, E.S.4    Martin- Palanco, V.5    Rifon, J.6
  • 18
    • 48649105786 scopus 로고    scopus 로고
    • A novel therapeutic combination using PD 0332991 and bortezomib: Study in the 5T33MM myeloma model
    • Menu E, Garcia J, Huang X, Di Liberto M, Toogood PL, Chen I et al. A novel therapeutic combination using PD 0332991 and bortezomib: Study in the 5T33MM myeloma model. Cancer Res 2008; 68: 5519-5523
    • (2008) Cancer Res , vol.68 , pp. 5519-5523
    • Menu, E.1    Garcia, J.2    Huang, X.3    Di Liberto, M.4    Toogood, P.L.5    Chen, I.6
  • 19
    • 33747872306 scopus 로고    scopus 로고
    • A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6
    • Baughn LB, Di Liberto M, Wu K, Toogood PL, Louie T, Gottschalk R et al. A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6. Cancer Res 2006; 66: 7661-7667
    • (2006) Cancer Res , vol.66 , pp. 7661-7667
    • Baughn, L.B.1    Di Liberto, M.2    Wu, K.3    Toogood, P.L.4    Louie, T.5    Gottschalk, R.6
  • 20
    • 76049104235 scopus 로고    scopus 로고
    • PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro
    • Finn RS, Dering J, Conklin D, Kalous O, Cohen DJ, Desai AJ et al. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res 2009; 11: R77
    • (2009) Breast Cancer Res , vol.11
    • Finn, R.S.1    Dering, J.2    Conklin, D.3    Kalous, O.4    Cohen, D.J.5    Desai, A.J.6
  • 21
    • 82055187255 scopus 로고    scopus 로고
    • ERalphadependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer
    • Miller TW, Balko JM, Fox EM, Ghazoui Z, Dunbier A, Anderson H et al. ERalphadependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer. Cancer Discov 2011; 1: 338-351
    • (2011) Cancer Discov , vol.1 , pp. 338-351
    • Miller, T.W.1    Balko, J.M.2    Fox, E.M.3    Ghazoui, Z.4    Dunbier, A.5    Anderson, H.6
  • 23
    • 79960100823 scopus 로고    scopus 로고
    • Therapeutically activating RB: Reestablishing cell cycle control in endocrine therapyresistant breast cancer
    • Thangavel C, Dean JL, Ertel A, Knudsen KE, Aldaz CM, Witkiewicz AK et al. Therapeutically activating RB: Reestablishing cell cycle control in endocrine therapyresistant breast cancer. Endocr Relat Cancer 2011; 18: 333-345
    • (2011) Endocr Relat Cancer , vol.18 , pp. 333-345
    • Thangavel, C.1    Dean, J.L.2    Ertel, A.3    Knudsen, K.E.4    Aldaz, C.M.5    Witkiewicz, A.K.6
  • 24
    • 58849162344 scopus 로고    scopus 로고
    • Advancing bioluminescence imaging technology for the evaluation of anticancer agents in the MDA-MB-435- HAL-Luc mammary fat pad and subrenal capsule tumor models
    • Zhang C, Yan Z, Arango ME, Painter CL, Anderes K. Advancing bioluminescence imaging technology for the evaluation of anticancer agents in the MDA-MB-435- HAL-Luc mammary fat pad and subrenal capsule tumor models. Clin Cancer Res 2009; 15: 238-246
    • (2009) Clin Cancer Res , vol.15 , pp. 238-246
    • Zhang, C.1    Yan, Z.2    Arango, M.E.3    Painter, C.L.4    Anderes, K.5
  • 25
    • 84863230632 scopus 로고    scopus 로고
    • 18F FLT-PET Imaging Does Not Always light up proliferating tumor cells
    • Zhang CC, Yan Z, Li W, Kuszpit K, Painter CL, Zhang Q et al. [18F]FLT-PET imaging does not always light up proliferating tumor cells. Clin Cancer Res 2012; 18: 1303-1312
    • (2012) Clin Cancer Res , vol.18 , pp. 1303-1312
    • Zhang, C.C.1    Yan, Z.2    Li, W.3    Kuszpit, K.4    Painter, C.L.5    Zhang, Q.6
  • 26
    • 79951839895 scopus 로고    scopus 로고
    • A robust highcontent imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators
    • Sutherland JJ, Low J, Blosser W, Dowless M, Engler TA, Stancato LF. A robust highcontent imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators. Mol Cancer Ther 2011; 10: 242-254
    • (2011) Mol Cancer Ther , vol.10 , pp. 242-254
    • Sutherland, J.J.1    Low, J.2    Blosser, W.3    Dowless, M.4    Engler, T.A.5    Stancato, L.F.6
  • 27
    • 79955469668 scopus 로고    scopus 로고
    • A bioinformatical and functional approach to identify novel strategies for chemoprevention of colorectal cancer
    • Heijink DM, Fehrmann RS, de Vries EG, Koornstra JJ, Oosterhuis D, van der Zee AG et al. A bioinformatical and functional approach to identify novel strategies for chemoprevention of colorectal cancer. Oncogene 2011; 30: 2026-2036
    • (2011) Oncogene , vol.30 , pp. 2026-2036
    • Heijink, D.M.1    Fehrmann, R.S.2    De Vries, E.G.3    Koornstra, J.J.4    Oosterhuis, D.5    Van Der Zee, A.G.6
  • 28
    • 78049250336 scopus 로고    scopus 로고
    • Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss
    • Cole AM, Myant K, Reed KR, Ridgway RA, Athineos D, Van den Brink GR et al. Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. Cancer Res 2010; 70: 8149-8158
    • (2010) Cancer Res , vol.70 , pp. 8149-8158
    • Cole, A.M.1    Myant, K.2    Reed, K.R.3    Ridgway, R.A.4    Athineos, D.5    Van Den Brink, G.R.6
  • 29
    • 77954279920 scopus 로고    scopus 로고
    • A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma
    • Puyol M, Martin A, Dubus P, Mulero F, Pizcueta P, Khan G et al. A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell 2010; 18: 63-73
    • (2010) Cancer Cell , vol.18 , pp. 63-73
    • Puyol, M.1    Martin, A.2    Dubus, P.3    Mulero, F.4    Pizcueta, P.5    Khan, G.6
  • 30
    • 79960334239 scopus 로고    scopus 로고
    • Early G cyclindependent kinases as prognostic markers and potential therapeutic targets in esophageal adenocarcinoma
    • Ismail A, Bandla S, Reveiller M, Toia L, Zhou Z, Gooding WE et al. Early G cyclindependent kinases as prognostic markers and potential therapeutic targets in esophageal adenocarcinoma. Clin Cancer Res 2011; 17: 4513-4522
    • (2011) Clin Cancer Res , vol.17 , pp. 4513-4522
    • Ismail, A.1    Bandla, S.2    Reveiller, M.3    Toia, L.4    Zhou, Z.5    Gooding, W.E.6
  • 32
    • 77951082119 scopus 로고    scopus 로고
    • Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts
    • Michaud K, Solomon DA, Oermann E, Kim JS, Zhong WZ, Prados MD et al. Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts. Cancer Res 2010; 70: 3228-3238
    • (2010) Cancer Res , vol.70 , pp. 3228-3238
    • Michaud, K.1    Solomon, D.A.2    Oermann, E.3    Kim, J.S.4    Zhong, W.Z.5    Prados, M.D.6
  • 33
    • 79958149971 scopus 로고    scopus 로고
    • Phase i study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (schedule 2/1
    • Schwartz GK, LoRusso PM, Dickson MA, Randolph SS, Shaik MN, Wilner KD et al. Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (schedule 2/1). Br J Cancer 2011; 104: 1862-1868
    • (2011) Br J Cancer , pp. 104
    • Schwartz, G.K.1    Lorusso, P.M.2    Dickson, M.A.3    Randolph, S.S.4    Shaik, M.N.5    Wilner, K.D.6
  • 34
    • 84861210266 scopus 로고    scopus 로고
    • Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma
    • Leonard JP, Lacasce AS, Smith MR, Noy A, Chirieac LR, Rodig SJ et al. Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma. Blood 2012; 119: 4597-4607
    • (2012) Blood , vol.119 , pp. 4597-4607
    • Leonard, J.P.1    Lacasce, A.S.2    Smith, M.R.3    Noy, A.4    Chirieac, L.R.5    Rodig, S.J.6
  • 35
    • 84855983664 scopus 로고    scopus 로고
    • Phase I, dose-escalation trial of the oral cyclin-dependent kinase 4/6 inhibitor PD 0332991, administered using a 21-day schedule in patients with advanced cancer
    • Flaherty KT, Lorusso PM, Demichele A, Abramson VG, Courtney R, Randolph SS et al. Phase I, dose-escalation trial of the oral cyclin-dependent kinase 4/6 inhibitor PD 0332991, administered using a 21-day schedule in patients with advanced cancer. Clin Cancer Res 2012; 18: 568-576
    • (2012) Clin Cancer Res , vol.18 , pp. 568-576
    • Flaherty, K.T.1    Lorusso, P.M.2    Demichele, A.3    Abramson, V.G.4    Courtney, R.5    Randolph, S.S.6
  • 36
    • 77954757207 scopus 로고    scopus 로고
    • Therapeutic CDK4/6 inhibition in breast cancer: Key mechanisms of response and failure
    • Dean JL, Thangavel C, McClendon AK, Reed CA, Knudsen ES. Therapeutic CDK4/6 inhibition in breast cancer: Key mechanisms of response and failure. Oncogene 2010; 29: 4018-4032
    • (2010) Oncogene , vol.29 , pp. 4018-4032
    • Dean, J.L.1    Thangavel, C.2    McClendon, A.K.3    Reed, C.A.4    Knudsen, E.S.5
  • 37
    • 79952710710 scopus 로고    scopus 로고
    • Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer
    • Konecny GE, Winterhoff B, Kolarova T, Qi J, Manivong K, Dering J et al. Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer. Clin Cancer Res 2011; 17: 1591-1602
    • (2011) Clin Cancer Res , vol.17 , pp. 1591-1602
    • Konecny, G.E.1    Winterhoff, B.2    Kolarova, T.3    Qi, J.4    Manivong, K.5    Dering, J.6
  • 38
    • 50149120366 scopus 로고    scopus 로고
    • Cellular mechanisms of tumour suppression by the retinoblastoma gene
    • Burkhart DL, Sage J. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer 2008; 8: 671-682
    • (2008) Nat Rev Cancer , vol.8 , pp. 671-682
    • Burkhart, D.L.1    Sage, J.2
  • 39
    • 50149084928 scopus 로고    scopus 로고
    • Tailoring to RB: Tumour suppressor status and therapeutic response
    • Knudsen ES, Knudsen KE. Tailoring to RB: Tumour suppressor status and therapeutic response. Nat Rev Cancer 2008; 8: 714-724
    • (2008) Nat Rev Cancer , vol.8 , pp. 714-724
    • Knudsen, E.S.1    Knudsen, K.E.2
  • 41
    • 81255205373 scopus 로고    scopus 로고
    • A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells
    • Anders L, Ke N, Hydbring P, Choi YJ, Widlund HR, Chick JM et al. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell 2011; 20: 620-634
    • (2011) Cancer Cell , vol.20 , pp. 620-634
    • Anders, L.1    Ke, N.2    Hydbring, P.3    Choi, Y.J.4    Widlund, H.R.5    Chick, J.M.6
  • 42
    • 79958254560 scopus 로고    scopus 로고
    • A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers
    • Jirawatnotai S, Hu Y, Michowski W, Elias JE, Becks L, Bienvenu F et al. A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature 2011; 474: 230-234
    • (2011) Nature , vol.474 , pp. 230-234
    • Jirawatnotai, S.1    Hu, Y.2    Michowski, W.3    Elias, J.E.4    Becks, L.5    Bienvenu, F.6
  • 43
    • 79953153894 scopus 로고    scopus 로고
    • Cyclin D1 is a selective modifier of androgen-dependent signaling and androgen receptor function
    • Comstock CE, Augello MA, Schiewer MJ, Karch J, Burd CJ, Ertel A et al. Cyclin D1 is a selective modifier of androgen-dependent signaling and androgen receptor function. J Biol Chem 2011; 286: 8117-8127
    • (2011) J Biol Chem , vol.286 , pp. 8117-8127
    • Comstock, C.E.1    Augello, M.A.2    Schiewer, M.J.3    Karch, J.4    Burd, C.J.5    Ertel, A.6
  • 44
    • 84860343387 scopus 로고    scopus 로고
    • MTOR is a selective effector of the radiation therapy response in androgen receptorpositive prostate cancer
    • Schiewer MJ, Den R, Hoang DT, Augello MA, Lawrence YR, Dicker AP et al. mTOR is a selective effector of the radiation therapy response in androgen receptorpositive prostate cancer. Endocr Relat Cancer 2012; 19: 1-12
    • (2012) Endocr Relat Cancer , vol.19 , pp. 1-12
    • Schiewer, M.J.1    Den Hoang R, D.T.2    Augello, M.A.3    Lawrence, Y.R.4    Dicker, A.P.5
  • 45
    • 84863013857 scopus 로고    scopus 로고
    • Modeling a lethal prostate cancer variant with small-cell carcinoma features
    • Tzelepi V, Zhang J, Lu JF, Kleb B, Wu G, Wan X et al. Modeling a lethal prostate cancer variant with small-cell carcinoma features. Clin Cancer Res 2011; 18: 666-677
    • (2011) Clin Cancer Res , vol.18 , pp. 666-677
    • Tzelepi, V.1    Zhang, J.2    Lu, J.F.3    Kleb, B.4    Wu, G.5    Wan, X.6
  • 46
    • 78649888666 scopus 로고    scopus 로고
    • The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression
    • Sharma A, Yeow WS, Ertel A, Coleman I, Clegg N, Thangavel C et al. The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression. J Clin Invest 2010; 120: 4478-4492
    • (2010) J Clin Invest , vol.120 , pp. 4478-4492
    • Sharma, A.1    Yeow, W.S.2    Ertel, A.3    Coleman, I.4    Clegg, N.5    Thangavel, C.6
  • 47
    • 80053078529 scopus 로고    scopus 로고
    • Common gene rearrangements in prostate cancer
    • Rubin MA, Maher CA, Chinnaiyan AM. Common gene rearrangements in prostate cancer. J Clin Oncol 2011; 29: 3659-3668
    • (2011) J Clin Oncol , vol.29 , pp. 3659-3668
    • Rubin, M.A.1    Maher, C.A.2    Chinnaiyan, A.M.3
  • 48
    • 77951679998 scopus 로고    scopus 로고
    • Proliferative suppression by CDK4/6 inhibition: Complex function of the retinoblastoma pathway in liver tissue and hepatoma cells
    • Rivadeneira DB, Mayhew CN, Thangavel C, Sotillo E, Reed CA, Grana X et al. Proliferative suppression by CDK4/6 inhibition: Complex function of the retinoblastoma pathway in liver tissue and hepatoma cells. Gastroenterology 2010; 138: 1920-1930
    • (2010) Gastroenterology , pp. 138
    • Rivadeneira, D.B.1    Mayhew, C.N.2    Thangavel, C.3    Sotillo, E.4    Reed, C.A.5    Grana, X.6
  • 49
    • 84863335299 scopus 로고    scopus 로고
    • Evidence for efficacy of new Hsp90 inhibitors revealed by ex vivo culture of human prostate tumors
    • Centenera MM, Gillis JL, Hanson A, Jindal S, Taylor RA, Risbridger G et al. Evidence for efficacy of new Hsp90 inhibitors revealed by ex vivo culture of human prostate tumors. Clin Cancer Res 2012; 18: 3562-3570
    • (2012) Clin Cancer Res , vol.18 , pp. 3562-3570
    • Centenera, M.M.1    Gillis, J.L.2    Hanson, A.3    Jindal, S.4    Taylor, R.A.5    Risbridger, G.6
  • 51
    • 0034650587 scopus 로고    scopus 로고
    • Prognostic significance of p16 and CDK4 proteins in localized prostate carcinoma
    • Halvorsen OJ, Hostmark J, Haukaas S, Hoisaeter PA, Akslen LA. Prognostic significance of p16 and CDK4 proteins in localized prostate carcinoma. Cancer 2000; 88: 416-424
    • (2000) Cancer , vol.88 , pp. 416-424
    • Halvorsen, O.J.1    Hostmark, J.2    Haukaas, S.3    Hoisaeter, P.A.4    Akslen, L.A.5
  • 52
    • 79958802353 scopus 로고    scopus 로고
    • Pharmacotherapeutic management of locally advanced prostate cancer: Current status
    • Martin JM, Supiot S, Berthold DR. Pharmacotherapeutic management of locally advanced prostate cancer: Current status. Drugs 2011; 71: 1019-1041
    • (2011) Drugs , vol.71 , pp. 1019-1041
    • Martin, J.M.1    Supiot, S.2    Berthold, D.R.3
  • 53
    • 7944231428 scopus 로고    scopus 로고
    • The crystal structure of human CDK7 and its protein recognition properties
    • Lolli G, Lowe ED, Brown NR, Johnson LN. The crystal structure of human CDK7 and its protein recognition properties. Structure 2004; 12: 2067-2079
    • (2004) Structure , vol.12 , pp. 2067-2079
    • Lolli, G.1    Lowe, E.D.2    Brown, N.R.3    Johnson, L.N.4
  • 56
    • 0032541640 scopus 로고    scopus 로고
    • Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d
    • Brotherton DH, Dhanaraj V, Wick S, Brizuela L, Domaille PJ, Volyanik E et al. Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d. Nature 1998; 395: 244-250
    • (1998) Nature , vol.395 , pp. 244-250
    • Brotherton, D.H.1    Dhanaraj, V.2    Wick, S.3    Brizuela, L.4    Domaille, P.J.5    Volyanik, E.6
  • 57
    • 33745676300 scopus 로고    scopus 로고
    • Toward understanding the structural basis of cyclindependent kinase 6 specific inhibition
    • Lu H, Schulze-Gahmen U. Toward understanding the structural basis of cyclindependent kinase 6 specific inhibition. J Med Chem 2006; 49: 3826-3831
    • (2006) J Med Chem , vol.49 , pp. 3826-3831
    • Lu, H.1    Schulze-Gahmen, U.2
  • 58
    • 17044389775 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 6 associates with the androgen receptor and enhances its transcriptional activity in prostate cancer cells
    • Lim JT, Mansukhani M, Weinstein IB. Cyclin-dependent kinase 6 associates with the androgen receptor and enhances its transcriptional activity in prostate cancer cells. Proc Natl Acad Sci USA 2005; 102: 5156-5161
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 5156-5161
    • Lim, J.T.1    Mansukhani, M.2    Weinstein, I.B.3
  • 59
    • 80054051518 scopus 로고    scopus 로고
    • Time to stratify? the retinoblastoma protein in castrate-resistant prostate cancer
    • Aparicio A, Den RB, Knudsen KE. Time to stratify? The retinoblastoma protein in castrate-resistant prostate cancer. Nat Rev Urol 2011; 8: 562-568
    • (2011) Nat Rev Urol , vol.8 , pp. 562-568
    • Aparicio, A.1    Den Knudsen, K.E.2
  • 60
    • 67650758019 scopus 로고    scopus 로고
    • Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
    • Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J et al. Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell 2009; 138: 245-256
    • (2009) Cell , vol.138 , pp. 245-256
    • Wang, Q.1    Li, W.2    Zhang, Y.3    Yuan, X.4    Xu, K.5    Yu, J.6
  • 61
    • 80052248026 scopus 로고    scopus 로고
    • New hormonal therapies for castration-resistant prostate cancer
    • Mostaghel EA, Plymate S. New hormonal therapies for castration-resistant prostate cancer. Endocrinol Metab Clin North Am 2011; 40: 625-642
    • (2011) Endocrinol Metab Clin North Am , vol.40 , pp. 625-642
    • Mostaghel, E.A.1    Plymate, S.2
  • 62
    • 77958064975 scopus 로고    scopus 로고
    • Cyclin-dependent kinases (cdks) and the DNA damage response: Rationale for cdk inhibitor-chemotherapy combinations as an anticancer strategy for solid tumors
    • Johnson N, Shapiro GI. Cyclin-dependent kinases (cdks) and the DNA damage response: Rationale for cdk inhibitor-chemotherapy combinations as an anticancer strategy for solid tumors. Expert Opin Ther Targets 2010; 14: 1199-1212
    • (2010) Expert Opin Ther Targets , vol.14 , pp. 1199-1212
    • Johnson, N.1    Shapiro, G.I.2
  • 63
    • 0032493489 scopus 로고    scopus 로고
    • Multiple G1 regulatory elements control the androgen-dependent proliferation of prostatic carcinoma cells
    • Knudsen KE, Arden KC, Cavenee WK. Multiple G1 regulatory elements control the androgen-dependent proliferation of prostatic carcinoma cells. J Biol Chem 1998; 273: 20213-20222
    • (1998) J Biol Chem , vol.273 , pp. 20213-20222
    • Knudsen, K.E.1    Arden, K.C.2    Cavenee, W.K.3
  • 64
    • 70450242775 scopus 로고    scopus 로고
    • A method of estimation of the cell doubling time on the basis of cell culture monitoring data
    • Korzynska A, Zychowicz M. A method of estimation of the cell doubling time on the basis of cell culture monitoring data. Biocybernet Biomed Engineer 2008; 28: 75-82
    • (2008) Biocybernet Biomed Engineer , vol.28 , pp. 75-82
    • Korzynska, A.1    Zychowicz, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.