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Volumn 65, Issue 12, 2013, Pages 3107-3119

Deletion of the transforming growth factor β Receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

EID: 84889058563     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.38122     Document Type: Article
Times cited : (160)

References (44)
  • 1
    • 33344467770 scopus 로고    scopus 로고
    • Osteoarthritis of the knee
    • [published erratum appears in N Engl J Med 2006;354:2520].
    • Felson DT,. Osteoarthritis of the knee [published erratum appears in N Engl J Med 2006;354:2520]. N Engl J Med 2006; 354: 841-8.
    • (2006) N Engl J Med , vol.354 , pp. 841-848
    • Felson, D.T.1
  • 4
    • 0035795409 scopus 로고    scopus 로고
    • TGF-β/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
    • Yang X, Chen L, Xu X, Li C, Huang C, Deng CX,. TGF-β/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol 2001; 153: 35-46.
    • (2001) J Cell Biol , vol.153 , pp. 35-46
    • Yang, X.1    Chen, L.2    Xu, X.3    Li, C.4    Huang, C.5    Deng, C.X.6
  • 5
    • 58149097603 scopus 로고    scopus 로고
    • Activation of β-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult β-catenin conditional activation mice
    • Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, et al. Activation of β-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult β-catenin conditional activation mice. J Bone Miner Res 2009; 24: 12-21.
    • (2009) J Bone Miner Res , vol.24 , pp. 12-21
    • Zhu, M.1    Tang, D.2    Wu, Q.3    Hao, S.4    Chen, M.5    Xie, C.6
  • 6
    • 71549136203 scopus 로고    scopus 로고
    • Modulating Hedgehog signaling can attenuate the severity of osteoarthritis
    • Lin AC, Seeto BL, Bartoszko JM, Khoury MA, Whetstone H, Ho L, et al. Modulating Hedgehog signaling can attenuate the severity of osteoarthritis. Nat Med 2009; 15: 1421-5.
    • (2009) Nat Med , vol.15 , pp. 1421-1425
    • Lin, A.C.1    Seeto, B.L.2    Bartoszko, J.M.3    Khoury, M.A.4    Whetstone, H.5    Ho, L.6
  • 7
    • 77953208836 scopus 로고    scopus 로고
    • Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development
    • Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, et al. Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development. Nat Med 2010; 16: 678-86.
    • (2010) Nat Med , vol.16 , pp. 678-686
    • Saito, T.1    Fukai, A.2    Mabuchi, A.3    Ikeda, T.4    Yano, F.5    Ohba, S.6
  • 8
    • 77953183739 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction
    • Yang S, Kim J, Ryu JH, Oh H, Chun CH, Kim BJ, et al. Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction. Nat Med 2010; 16: 687-93.
    • (2010) Nat Med , vol.16 , pp. 687-693
    • Yang, S.1    Kim, J.2    Ryu, J.H.3    Oh, H.4    Chun, C.H.5    Kim, B.J.6
  • 10
    • 0030727351 scopus 로고    scopus 로고
    • Expression of a truncated, kinase-defective TGF-β type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis
    • Serra R, Johnson M, Filvaroff EH, LaBorde J, Sheehan DM, Derynck R, et al. Expression of a truncated, kinase-defective TGF-β type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J Cell Biol 1997; 139: 541-52.
    • (1997) J Cell Biol , vol.139 , pp. 541-552
    • Serra, R.1    Johnson, M.2    Filvaroff, E.H.3    Laborde, J.4    Sheehan, D.M.5    Derynck, R.6
  • 12
  • 14
    • 80052479068 scopus 로고    scopus 로고
    • Contribution of proteoglycan osmotic swelling pressure to the compressive properties of articular cartilage
    • Han EH, Chen SS, Klisch SM, Sah RL,. Contribution of proteoglycan osmotic swelling pressure to the compressive properties of articular cartilage. Biophys J 2011; 101: 916-24.
    • (2011) Biophys J , vol.101 , pp. 916-924
    • Han, E.H.1    Chen, S.S.2    Klisch, S.M.3    Sah, R.L.4
  • 15
    • 0030891983 scopus 로고    scopus 로고
    • Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage
    • Billinghurst RC, Dahlberg L, Ionescu M, Reiner A, Bourne R, Rorabeck C, et al. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest 1997; 99: 1534-45.
    • (1997) J Clin Invest , vol.99 , pp. 1534-1545
    • Billinghurst, R.C.1    Dahlberg, L.2    Ionescu, M.3    Reiner, A.4    Bourne, R.5    Rorabeck, C.6
  • 16
    • 26844518429 scopus 로고    scopus 로고
    • Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions
    • Roach HI, Yamada N, Cheung KS, Tilley S, Clarke NM, Oreffo RO, et al. Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. Arthritis Rheum 2005; 52: 3110-24.
    • (2005) Arthritis Rheum , vol.52 , pp. 3110-3124
    • Roach, H.I.1    Yamada, N.2    Cheung, K.S.3    Tilley, S.4    Clarke, N.M.5    Oreffo, R.O.6
  • 17
    • 0035165385 scopus 로고    scopus 로고
    • Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice
    • Neuhold LA, Killar L, Zhao W, Sung ML, Warner L, Kulik J, et al. Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. J Clin Invest 2001; 107: 35-44.
    • (2001) J Clin Invest , vol.107 , pp. 35-44
    • Neuhold, L.A.1    Killar, L.2    Zhao, W.3    Sung, M.L.4    Warner, L.5    Kulik, J.6
  • 19
    • 15844413814 scopus 로고    scopus 로고
    • Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
    • Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T, Ma HL, et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 2005; 434: 644-8.
    • (2005) Nature , vol.434 , pp. 644-648
    • Glasson, S.S.1    Askew, R.2    Sheppard, B.3    Carito, B.4    Blanchet, T.5    Ma, H.L.6
  • 20
    • 36048985974 scopus 로고    scopus 로고
    • Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis
    • Majumdar MK, Askew R, Schelling S, Stedman N, Blanchet T, Hopkins B, et al. Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis. Arthritis Rheum 2007; 56: 3670-4.
    • (2007) Arthritis Rheum , vol.56 , pp. 3670-3674
    • Majumdar, M.K.1    Askew, R.2    Schelling, S.3    Stedman, N.4    Blanchet, T.5    Hopkins, B.6
  • 22
    • 33846815207 scopus 로고    scopus 로고
    • Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase
    • Chen M, Lichtler AC, Sheu TJ, Xie C, Zhang X, O'Keefe RJ, et al. Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis 2007; 45: 44-50.
    • (2007) Genesis , vol.45 , pp. 44-50
    • Chen, M.1    Lichtler, A.C.2    Sheu, T.J.3    Xie, C.4    Zhang, X.5    O'Keefe, R.J.6
  • 24
    • 0030032444 scopus 로고    scopus 로고
    • Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage
    • Mitchell PG, Magna HA, Reeves LM, Lopresti-Morrow LL, Yocum SA, Rosner PJ, et al. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J Clin Invest 1996; 97: 761-8.
    • (1996) J Clin Invest , vol.97 , pp. 761-768
    • Mitchell, P.G.1    Magna, H.A.2    Reeves, L.M.3    Lopresti-Morrow, L.L.4    Yocum, S.A.5    Rosner, P.J.6
  • 25
    • 0036199441 scopus 로고    scopus 로고
    • Conditional inactivation of the TGF-β type II receptor using Cre:Lox
    • Chytil A, Magnuson MA, Wright CV, Moses HL,. Conditional inactivation of the TGF-β type II receptor using Cre:Lox. Genesis 2002; 32: 73-5.
    • (2002) Genesis , vol.32 , pp. 73-75
    • Chytil, A.1    Magnuson, M.A.2    Wright, C.V.3    Moses, H.L.4
  • 26
    • 67349155506 scopus 로고    scopus 로고
    • Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues
    • McCulloch DR, Le Goff C, Bhatt S, Dixon LJ, Sandy JD, Apte SS,. Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues. Gene Expr Patterns 2009; 9: 314-23.
    • (2009) Gene Expr Patterns , vol.9 , pp. 314-323
    • McCulloch, D.R.1    Le Goff, C.2    Bhatt, S.3    Dixon, L.J.4    Sandy, J.D.5    Apte, S.S.6
  • 27
    • 34249846564 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2
    • Wang Q, Wei XC, Zhu TH, Zhang M, Shen R, Xing LP, et al. Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2. J Biol Chem 2007; 282: 10742-8.
    • (2007) J Biol Chem , vol.282 , pp. 10742-10748
    • Wang, Q.1    Wei, X.C.2    Zhu, T.H.3    Zhang, M.4    Shen, R.5    Xing, L.P.6
  • 28
    • 33645647676 scopus 로고    scopus 로고
    • Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation
    • Shen R, Chen M, Wang YJ, Kaneki H, Xing L, O'Keefe RJ, et al. Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation. J Biol Chem 2006; 281: 3569-76.
    • (2006) J Biol Chem , vol.281 , pp. 3569-3576
    • Shen, R.1    Chen, M.2    Wang, Y.J.3    Kaneki, H.4    Xing, L.5    O'Keefe, R.J.6
  • 29
    • 67650538541 scopus 로고    scopus 로고
    • PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation
    • Zhang M, Xie R, Hou W, Wang B, Shen R, Wang X, et al. PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation. J Cell Sci 2009; 122: 1382-9.
    • (2009) J Cell Sci , vol.122 , pp. 1382-1389
    • Zhang, M.1    Xie, R.2    Hou, W.3    Wang, B.4    Shen, R.5    Wang, X.6
  • 30
    • 77956924858 scopus 로고    scopus 로고
    • The OARSI histopathology initiative - Recommendations for histological assessments of osteoarthritis in the mouse
    • Glasson SS, Chambers MG, Van Den Berg WB, Little CB,. The OARSI histopathology initiative-recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage 2010; 18 Suppl 3: S17-23.
    • (2010) Osteoarthritis Cartilage , vol.18 , Issue.SUPPL. 3
    • Glasson, S.S.1    Chambers, M.G.2    Van Den Berg, W.B.3    Little, C.B.4
  • 31
    • 84888986938 scopus 로고    scopus 로고
    • TGF-β activates cyclin D1 expression through a Smad3/β-catenin- dependent mechanism in chondrocytes
    • Li T, Chen M, Wu Q, Sheu T, Drissi H, Zuscik M, et al. TGF-β activates cyclin D1 expression through a Smad3/β-catenin-dependent mechanism in chondrocytes. J Bone Miner Res 2006; 21: S91.
    • (2006) J Bone Miner Res , vol.21
    • Li, T.1    Chen, M.2    Wu, Q.3    Sheu, T.4    Drissi, H.5    Zuscik, M.6
  • 32
    • 19944426775 scopus 로고    scopus 로고
    • Altered endochondral bone development in matrix metalloproteinase 13-deficient mice
    • Stickens D, Behonick DJ, Ortega N, Heyer B, Hartenstein B, Yu Y, et al. Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development 2004; 131: 5883-95.
    • (2004) Development , vol.131 , pp. 5883-5895
    • Stickens, D.1    Behonick, D.J.2    Ortega, N.3    Heyer, B.4    Hartenstein, B.5    Yu, Y.6
  • 33
    • 73149118687 scopus 로고    scopus 로고
    • Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: Initial evidence for MMP-13/MMP-9 activation cascade
    • Hernandez Rios M, Sorsa T, Obregon F, Tervahartiala T, Valenzuela MA, Pozo P, et al. Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade. J Clin Periodontol 2009; 36: 1011-7.
    • (2009) J Clin Periodontol , vol.36 , pp. 1011-1017
    • Hernandez Rios, M.1    Sorsa, T.2    Obregon, F.3    Tervahartiala, T.4    Valenzuela, M.A.5    Pozo, P.6
  • 34
    • 84869050198 scopus 로고    scopus 로고
    • Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis
    • Chen CG, Thuillier D, Chin EN, Alliston T,. Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis. Arthritis Rheum 2012; 64: 3278-89.
    • (2012) Arthritis Rheum , vol.64 , pp. 3278-3289
    • Chen, C.G.1    Thuillier, D.2    Chin, E.N.3    Alliston, T.4
  • 35
    • 73249137617 scopus 로고    scopus 로고
    • Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development
    • Little CB, Barai A, Burkhardt D, Smith SM, Fosang AJ, Werb Z, et al. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum 2009; 60: 3723-33.
    • (2009) Arthritis Rheum , vol.60 , pp. 3723-3733
    • Little, C.B.1    Barai, A.2    Burkhardt, D.3    Smith, S.M.4    Fosang, A.J.5    Werb, Z.6
  • 36
    • 33748659352 scopus 로고    scopus 로고
    • Expression of transforming growth factor-β (TGFβ) and the TGFβ signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: Role in cartilage degradation, chondrogenesis and osteophyte formation
    • Blaney Davidson EN, Vitters EL, van der Kraan PM, van den Berg WB,. Expression of transforming growth factor-β (TGFβ) and the TGFβ signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation. Ann Rheum Dis 2006; 65: 1414-21.
    • (2006) Ann Rheum Dis , vol.65 , pp. 1414-1421
    • Blaney Davidson, E.N.1    Vitters, E.L.2    Van Der Kraan, P.M.3    Van Den Berg, W.B.4
  • 37
    • 0034730629 scopus 로고    scopus 로고
    • Tumor necrosis factor-α inhibits transforming growth factor-β/Smad signaling in human dermal fibroblasts via AP-1 activation
    • Verrecchia F, Pessah M, Atfi A, Mauviel A,. Tumor necrosis factor-α inhibits transforming growth factor-β/Smad signaling in human dermal fibroblasts via AP-1 activation. J Biol Chem 2000; 275: 30226-31.
    • (2000) J Biol Chem , vol.275 , pp. 30226-30231
    • Verrecchia, F.1    Pessah, M.2    Atfi, A.3    Mauviel, A.4
  • 39
    • 34247209652 scopus 로고    scopus 로고
    • Smads keep TABs on inflammation
    • Seth RB, Chen ZJ,. Smads keep TABs on inflammation. Nat Immunol 2007; 8: 477-8.
    • (2007) Nat Immunol , vol.8 , pp. 477-478
    • Seth, R.B.1    Chen, Z.J.2
  • 40
    • 0027480320 scopus 로고
    • Transforming growth factor-β1 stimulates chondrogenesis and inhibits osteogenesis in high density culture of periosteum-derived cells
    • Iwasaki M, Nakata K, Nakahara H, Nakase T, Kimura T, Kimata K, et al. Transforming growth factor-β1 stimulates chondrogenesis and inhibits osteogenesis in high density culture of periosteum-derived cells. Endocrinology 1993; 132: 1603-8.
    • (1993) Endocrinology , vol.132 , pp. 1603-1608
    • Iwasaki, M.1    Nakata, K.2    Nakahara, H.3    Nakase, T.4    Kimura, T.5    Kimata, K.6
  • 41
    • 58149393749 scopus 로고    scopus 로고
    • Transforming growth factor-β1 stimulates chondrogenic differentiation of posterofrontal suture-derived mesenchymal cells in vitro
    • Xu Y, James AW, Longaker MT,. Transforming growth factor-β1 stimulates chondrogenic differentiation of posterofrontal suture-derived mesenchymal cells in vitro. Plast Reconstr Surg 2008; 122: 1649-59.
    • (2008) Plast Reconstr Surg , vol.122 , pp. 1649-1659
    • Xu, Y.1    James, A.W.2    Longaker, M.T.3
  • 42
    • 26444464413 scopus 로고    scopus 로고
    • Wnt-mediated regulation of chondrocyte maturation: Modulation by TGF-β
    • Dong Y, Drissi H, Chen M, Chen D, Zuscik MJ, Schwarz EM, et al. Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-β. J Cell Biochem 2005; 95: 1057-68.
    • (2005) J Cell Biochem , vol.95 , pp. 1057-1068
    • Dong, Y.1    Drissi, H.2    Chen, M.3    Chen, D.4    Zuscik, M.J.5    Schwarz, E.M.6
  • 43
    • 70449640613 scopus 로고    scopus 로고
    • TGF-β signaling in chondrocyte terminal differentiation and osteoarthritis: Modulation and integration of signaling pathways through receptor-Smads
    • Van der Kraan PM, Blaney Davidson EN, Blom A, van den Berg WB,. TGF-β signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads. Osteoarthritis Cartilage 2009; 17: 1539-45.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 1539-1545
    • Van Der Kraan, P.M.1    Blaney Davidson, E.N.2    Blom, A.3    Van Den Berg, W.B.4


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