Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreERT2 transgenic mice

Osteoarthritis and Cartilage

Volumn 16, Issue 1, 2008, Pages 129-130

  Zhu, M ^a   Chen, M ^a   Lichtler, A C ^b   O'Keefe, R J ^a   Chen, D ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Articular chondrocyte; Cre recombination; Tamoxifen

Indexed keywords

CRE RECOMBINASE; NEUTRAL RED; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL COUNT; CONTROLLED STUDY; FROZEN SECTION; GENE DELETION; GENE TARGETING; GENETIC RECOMBINATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STAINING; TRANSGENIC MOUSE;

ANIMALS; BONE DENSITY CONSERVATION AGENTS; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; INTEGRASES; MICE; MICE, TRANSGENIC; POLYMERASE CHAIN REACTION; TAMOXIFEN;

EID: 38349143951     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2007.08.001     Document Type: Article

References (9)

1. Zemmyo M., Meharra E.J., Kuhn K., Creighton-Achermann L., and Lotz M. Accelerated, aging-dependent development of osteoarthritis in alpha1 integrin-deficient mice. Arthritis Rheum 48 (2003) 2873-2880
2. Clements K.M., Price J.S., Chambers M.G., Visco D.M., Poole A.R., and Mason R.M. Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy. Arthritis Rheum 48 (2003) 3452-3463
3. Glasson S.S., Askew R., Sheppard B., Carito B.A., Blanchet T., Ma H.L., et al. Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. Arthritis Rheum 50 (2004) 2547-2558
4. Kerin A., Patwari P., Kuettner K., Cole A., and Grodzinsky A. Molecular basis of osteoarthritis: biomechanical aspects. Cell Mol Life Sci 59 (2002) 27-35 Review
5. Chen M., Lichtler A.C., Sheu T., Xie C., Zhang X., O'Keefe R.J., et al. Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis 45 (2007) 44-50
6. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21 (1999) 70-71
7. Mao X., Fujiwara Y., and Orkin S.H. Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc Natl Acad Sci U S A 96 (1999) 5037-5042
8. Ovchinnikov D.A., Deng J.M., Ogunrinu G., and Behringer R.R. Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice. Genesis 26 (2000) 145-146
9. Nakamura E., Nguyen M.T., and Mackem S. Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeleton. Dev Dyn 235 (2006) 2603-2612