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Volumn 6, Issue 1, 2013, Pages

Fact or fiction - Identifying the elusive multiple myeloma stem cell

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; CARFILZOMIB; CD19 ANTIGEN; CD27 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; CD45 ANTIGEN; CELL SURFACE MARKER; CYCLOPHOSPHAMIDE; DEXAMETHASONE; MELPHALAN; PREDNISONE; SYNDECAN 1;

EID: 84889051762     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/1756-8722-6-91     Document Type: Review
Times cited : (27)

References (116)
  • 1
    • 0014355169 scopus 로고
    • Growth characteristics of a mouse plasma cell tumor
    • Growth characteristics of a mouse plasma cell tumor. Bergsagel DE, Valeriote FA, Cancer Res 1968 28 11 2187 2196
    • (1968) Cancer Res , vol.28 , Issue.11 , pp. 2187-2196
    • Bergsagel, D.E.1    Valeriote, F.A.2
  • 2
    • 0015008867 scopus 로고
    • Mouse myeloma tumor stem cells: A primary cell culture assay
    • Mouse myeloma tumor stem cells: a primary cell culture assay. Park CH, Bergsagel DE, McCulloch EA, J Natl Cancer Inst 1971 46 2 411 422
    • (1971) J Natl Cancer Inst , vol.46 , Issue.2 , pp. 411-422
    • Park, C.H.1    Bergsagel, D.E.2    McCulloch, E.A.3
  • 3
    • 0017785769 scopus 로고
    • Primary bioassay of human tumor stem cells
    • Primary bioassay of human tumor stem cells. Hamburger AW, Salmon SE, Science 1977 197 4302 461 463
    • (1977) Science , vol.197 , Issue.4302 , pp. 461-463
    • Hamburger, A.W.1    Salmon, S.E.2
  • 5
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • DOI 10.1038/nm0797-730
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Bonnet D, Dick JE, Nat Med 1997 3 7 730 737 (Pubitemid 27298715)
    • (1997) Nature Medicine , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 8
    • 84870893647 scopus 로고    scopus 로고
    • Understanding the molecular biology of myeloma and its therapeutic implications
    • Understanding the molecular biology of myeloma and its therapeutic implications. Boyd KD, et al. Expert Rev Hematol 2012 5 6 603 617
    • (2012) Expert Rev Hematol , vol.5 , Issue.6 , pp. 603-617
    • Boyd, K.D.1
  • 9
    • 84857913363 scopus 로고    scopus 로고
    • Latest advances and current challenges in the treatment of multiple myeloma
    • Latest advances and current challenges in the treatment of multiple myeloma. Mahindra A, et al. Nat Rev Clin Oncol 2012 9 3 135 143
    • (2012) Nat Rev Clin Oncol , vol.9 , Issue.3 , pp. 135-143
    • Mahindra, A.1
  • 10
    • 0026786675 scopus 로고
    • Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation
    • Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation. Bakkus MH, et al. Blood 1992 80 9 2326 2335
    • (1992) Blood , vol.80 , Issue.9 , pp. 2326-2335
    • Bakkus, M.H.1
  • 11
    • 0028246112 scopus 로고
    • Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell
    • Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell. Bakkus MH, et al. Br J Haematol 1994 87 1 68 74 (Pubitemid 24207001)
    • (1994) British Journal of Haematology , vol.87 , Issue.1 , pp. 68-74
    • Bakkus, M.H.C.1    Van Riet, I.2    Van Camp, B.3    Thielemans, K.4
  • 12
    • 0028908877 scopus 로고
    • In multiple myeloma, clonotypic B lymphocytes are detectable among CD19+ peripheral blood cells expressing CD38, CD56, and monotypic Ig light chain
    • In multiple myeloma, clonotypic B lymphocytes are detectable among CD19+ peripheral blood cells expressing CD38, CD56, and monotypic Ig light chain. Bergsagel PL, et al. Blood 1995 85 2 436 447
    • (1995) Blood , vol.85 , Issue.2 , pp. 436-447
    • Bergsagel, P.L.1
  • 13
    • 0027257608 scopus 로고
    • The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell
    • The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell. Billadeau D, et al. J Exp Med 1993 178 3 1023 1031 (Pubitemid 23260440)
    • (1993) Journal of Experimental Medicine , vol.178 , Issue.3 , pp. 1023-1031
    • Billadeau, D.1    Ahmann, G.2    Greipp, P.3    Van Ness, B.4
  • 15
    • 0032531999 scopus 로고    scopus 로고
    • A high frequency of circulating B cells share clonotypic Ig heavy-chain VDJ rearrangements with autologous bone marrow plasma cells in multiple myeloma, as measured by single-cell and in situ reverse transcriptase- polymerase chain reaction
    • A high frequency of circulating B cells share clonotypic Ig heavy-chain VDJ rearrangements with autologous bone marrow plasma cells in multiple myeloma, as measured by single-cell and in situ reverse transcriptase-polymerase chain reaction. Szczepek AJ, et al. Blood 1998 92 8 2844 2855 (Pubitemid 28469098)
    • (1998) Blood , vol.92 , Issue.8 , pp. 2844-2855
    • Szczepek, A.J.1    Seeberger, K.2    Wizniak, J.3    Mant, M.J.4    Belch, A.R.5    Pilarski, L.M.6
  • 16
    • 0024365825 scopus 로고
    • Interleukin 3 and interleukin 6 synergistically promote the proliferation and differentiation of malignant plasma cell precursors in multiple myeloma
    • Interleukin 3 and interleukin 6 synergistically promote the proliferation and differentiation of malignant plasma cell precursors in multiple myeloma. Bergui L, et al. J Exp Med 1989 170 2 613 618 (Pubitemid 19204289)
    • (1989) Journal of Experimental Medicine , vol.170 , Issue.2 , pp. 613-618
    • Bergui, L.1    Schena, M.2    Gaidano, G.3    Riva, M.4    Caligaris-Cappio, F.5
  • 17
    • 0029077309 scopus 로고
    • Myeloma Ig heavy chain v region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity
    • Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity. Vescio RA, et al. J Immunol 1995 155 5 2487 2497
    • (1995) J Immunol , vol.155 , Issue.5 , pp. 2487-2497
    • Vescio, R.A.1
  • 18
    • 2542604492 scopus 로고    scopus 로고
    • + memory B cells recirculate trhough bone marrow, peripheral blood and lymph nodes
    • DOI 10.1080/10428190410001655157
    • In multiple myeloma clonotypic CD38- /CD19+ / CD27+ memory B cells recirculate through bone marrow, peripheral blood and lymph nodes. Rasmussen T, et al. Leuk Lymphoma 2004 45 7 1413 1417 (Pubitemid 38701919)
    • (2004) Leukemia and Lymphoma , vol.45 , Issue.7 , pp. 1413-1417
    • Rasmussen, T.1    Lodahl, M.2    Hancke, S.3    Johnsen, H.E.4
  • 19
    • 0032532608 scopus 로고    scopus 로고
    • Primary myeloma cells growing in SCID-hu mice: A model for studying the biology and treatment of myeloma and its manifestations
    • Primary myeloma cells growing in SCID-hu mice: a model for studying the biology and treatment of myeloma and its manifestations. Yaccoby S, Barlogie B, Epstein J, Blood 1998 92 8 2908 2913 (Pubitemid 28469106)
    • (1998) Blood , vol.92 , Issue.8 , pp. 2908-2913
    • Yaccoby, S.1    Barlogie, B.2    Epstein, J.3
  • 20
    • 0033570946 scopus 로고    scopus 로고
    • The proliferative potential of myeloma plasma cells manifest in the SCID-hu host
    • The proliferative potential of myeloma plasma cells manifest in the SCID-hu host. Yaccoby S, Epstein J, Blood 1999 94 10 3576 3582 (Pubitemid 29536154)
    • (1999) Blood , vol.94 , Issue.10 , pp. 3576-3582
    • Yaccoby, S.1    Epstein, J.2
  • 21
    • 84871238560 scopus 로고    scopus 로고
    • CD19-CD45 low/- CD38 high/CD138+ plasma cells enrich for human tumorigenic myeloma cells
    • CD19-CD45 low/- CD38 high/CD138+ plasma cells enrich for human tumorigenic myeloma cells. Kim D, et al. Leukemia 2012 26 12 2530 2537
    • (2012) Leukemia , vol.26 , Issue.12 , pp. 2530-2537
    • Kim, D.1
  • 22
    • 0034142369 scopus 로고    scopus 로고
    • Myeloma progenitors in the blood of patients with aggressive or minimal disease: Engraftment and self-renewal of primary human myeloma in the bone marrow of NOD SCD mice
    • Myeloma progenitors in the blood of patients with aggressive or minimal disease: engraftment and self-renewal of primary human myeloma in the bone marrow of NOD SCID mice. Pilarski LM, et al. Blood 2000 95 3 1056 1065 (Pubitemid 30062731)
    • (2000) Blood , vol.95 , Issue.3 , pp. 1056-1065
    • Pilarski, L.M.1    Hipperson, G.2    Seeberger, K.3    Pruski, E.4    Coupland, R.W.5    Belch, A.R.6
  • 26
    • 84884327949 scopus 로고    scopus 로고
    • Clonogenic multiple myeloma cells have shared stemness signature assocuated with patient survival
    • Clonogenic multiple myeloma cells have shared stemness signature assocuated with patient survival. Reghunathan R, et al. Oncotarget 2013 4 8 1230 1240
    • (2013) Oncotarget , vol.4 , Issue.8 , pp. 1230-1240
    • Reghunathan, R.1
  • 27
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • DOI 10.1038/35077219
    • The Hedgehog and Wnt signalling pathways in cancer. Taipale J, Beachy PA, Nature 2001 411 6835 349 354 (Pubitemid 32467044)
    • (2001) Nature , vol.411 , Issue.6835 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 28
    • 0036559186 scopus 로고    scopus 로고
    • Gli and hedgehog in cancer: Tumours, embryos and stem cells
    • Gli and hedgehog in cancer: tumours, embryos and stem cells. Ruizi Altaba AP, Sanchez N, Dahmane, Nat Rev Cancer 2002 2 5 361 372 (Pubitemid 37328949)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.5 , pp. 361-372
    • RuizI Altaba, A.1    Sanchez, P.2    Dahmane, N.3
  • 29
    • 67349193226 scopus 로고    scopus 로고
    • Emerging role of Notch in stem cells and cancer
    • Emerging role of Notch in stem cells and cancer. Wang Z, et al. Cancer Lett 2009 279 1 8 12
    • (2009) Cancer Lett , vol.279 , Issue.1 , pp. 8-12
    • Wang, Z.1
  • 30
    • 79551600015 scopus 로고    scopus 로고
    • Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
    • Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Takebe N, et al. Nat Rev Clin Oncol 2011 8 2 97 106
    • (2011) Nat Rev Clin Oncol , vol.8 , Issue.2 , pp. 97-106
    • Takebe, N.1
  • 32
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • DOI 10.1101/gad.938601
    • Hedgehog signaling in animal development: paradigms and principles. Ingham PW, McMahon AP, Genes Dev 2001 15 23 3059 3087 (Pubitemid 33115673)
    • (2001) Genes and Development , vol.15 , Issue.23 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 34
    • 77949674648 scopus 로고    scopus 로고
    • Cytotoxic effects induced by docetaxel, gefitinib, and cyclopamine on side population and nonside population cell fractions from human invasive prostate cancer cells
    • Cytotoxic effects induced by docetaxel, gefitinib, and cyclopamine on side population and nonside population cell fractions from human invasive prostate cancer cells. Mimeault M, et al. Mol Cancer Ther 2010 9 3 617 630
    • (2010) Mol Cancer Ther , vol.9 , Issue.3 , pp. 617-630
    • Mimeault, M.1
  • 35
    • 70349238733 scopus 로고    scopus 로고
    • Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
    • Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. Von Hoff DD, et al. N Engl J Med 2009 361 12 1164 1172
    • (2009) N Engl J Med , vol.361 , Issue.12 , pp. 1164-1172
    • Von Hoff, D.D.1
  • 36
    • 70349244812 scopus 로고    scopus 로고
    • Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
    • Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. Rudin CM, et al. N Engl J Med 2009 361 12 1173 1178
    • (2009) N Engl J Med , vol.361 , Issue.12 , pp. 1173-1178
    • Rudin, C.M.1
  • 37
    • 67649470380 scopus 로고    scopus 로고
    • Proximal events in Wnt signal transduction
    • Proximal events in Wnt signal transduction. Angers S, Moon RT, Nat Rev Mol Cell Biol 2009 10 7 468 477
    • (2009) Nat Rev Mol Cell Biol , vol.10 , Issue.7 , pp. 468-477
    • Angers, S.1    Moon, R.T.2
  • 38
    • 51149118892 scopus 로고    scopus 로고
    • Deciphering the function of canonical Wnt signals in development and disease: Conditional loss- and gain-of-function mutations of beta-catenin in mice
    • Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Grigoryan T, et al. Genes Dev 2008 22 17 2308 2341
    • (2008) Genes Dev , vol.22 , Issue.17 , pp. 2308-2341
    • Grigoryan, T.1
  • 40
    • 34748846279 scopus 로고    scopus 로고
    • Bone marrow stromal cell-derived Wnt signals as a potential underlying mechanism for cyclin D1 deregulation in multiple myeloma lacking t(11;14)(q13;q32)
    • DOI 10.1016/j.bcmd.2007.06.001, PII S1079979607001143
    • Bone marrow stromal cell-derived Wnt signals as a potential underlying mechanism for cyclin D1 deregulation in multiple myeloma lacking t(11;14)(q13;q32). Bueno C, Lopes LF, Menendez P, Blood Cells Mol Dis 2007 39 3 366 368 (Pubitemid 47484466)
    • (2007) Blood Cells, Molecules, and Diseases , vol.39 , Issue.3 , pp. 366-368
    • Bueno, C.1    Menendez, P.2    Lopes, L.F.3
  • 41
    • 36349013133 scopus 로고    scopus 로고
    • Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma
    • DOI 10.1038/sj.leu.2404939, PII 2404939
    • Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma. Chim CS, et al. Leukemia 2007 21 12 2527 2536 (Pubitemid 350148897)
    • (2007) Leukemia , vol.21 , Issue.12 , pp. 2527-2536
    • Chim, C.S.1    Pang, R.2    Fung, T.K.3    Choi, C.L.4    Liang, R.5
  • 42
    • 70350492327 scopus 로고    scopus 로고
    • Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression
    • Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression. Dutta-Simmons J, et al. Blood 2009 114 13 2699 2708
    • (2009) Blood , vol.114 , Issue.13 , pp. 2699-2708
    • Dutta-Simmons, J.1
  • 43
    • 76449110274 scopus 로고    scopus 로고
    • Characterization of Wnt/beta-catenin signalling in osteoclasts in multiple myeloma
    • Characterization of Wnt/beta-catenin signalling in osteoclasts in multiple myeloma. Qiang YW, et al. Br J Haematol 2010 148 5 726 738
    • (2010) Br J Haematol , vol.148 , Issue.5 , pp. 726-738
    • Qiang, Y.W.1
  • 44
    • 84863921921 scopus 로고    scopus 로고
    • AV-65, a novel Wnt/beta-catenin signal inhibitor, successfully suppresses progression of multiple myeloma in a mouse model
    • AV-65, a novel Wnt/beta-catenin signal inhibitor, successfully suppresses progression of multiple myeloma in a mouse model. Yao H, et al. Blood Cancer J 2011 1 11 43
    • (2011) Blood Cancer J , vol.1 , Issue.11 , pp. 543
    • Yao, H.1
  • 45
    • 84872651192 scopus 로고    scopus 로고
    • Antagonistic effect of small-molecule inhibitors of Wnt/beta-catenin in multiple myeloma
    • Antagonistic effect of small-molecule inhibitors of Wnt/beta-catenin in multiple myeloma. Narayanan BA, et al. Anticancer Res 2012 32 11 4697 4707
    • (2012) Anticancer Res , vol.32 , Issue.11 , pp. 4697-4707
    • Narayanan, B.A.1
  • 46
    • 79951857650 scopus 로고    scopus 로고
    • Unfolded protein response in cancer: The Physician's perspective
    • Unfolded protein response in cancer: the Physician's perspective. Li X, Zhang K, Li Z, J Hematol Oncol 2011 4 1 8
    • (2011) J Hematol Oncol , vol.4 , Issue.1 , pp. 8
    • Li, X.1    Zhang, K.2    Li, Z.3
  • 47
    • 84876878450 scopus 로고    scopus 로고
    • Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway
    • Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway. Liu B, et al. Proc Natl Acad Sci U S A 2013 110 17 6877 6882
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.17 , pp. 6877-6882
    • Liu, B.1
  • 48
    • 84888104741 scopus 로고    scopus 로고
    • Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma
    • Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma. Hua Y, et al. Clin Cancer Res 2013 19 22 6242 6251
    • (2013) Clin Cancer Res , vol.19 , Issue.22 , pp. 6242-6251
    • Hua, Y.1
  • 49
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: Cell fate control and signal integration in development
    • DOI 10.1126/science.284.5415.770
    • Notch signaling: cell fate control and signal integration in development. Artavanis-Tsakonas S, Rand MD, Lake RJ, Science 1999 284 5415 770 776 (Pubitemid 29291335)
    • (1999) Science , vol.284 , Issue.5415 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 50
    • 84877093512 scopus 로고    scopus 로고
    • Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma
    • Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Hassan KA, et al. Clin Cancer Res 2013 19 8 1972 1980
    • (2013) Clin Cancer Res , vol.19 , Issue.8 , pp. 1972-1980
    • Hassan, K.A.1
  • 51
    • 84870346423 scopus 로고    scopus 로고
    • Loss of Mel-18 enhances breast cancer stem cell activity and tumorigenicity through activating Notch signaling mediated by the Wnt/TCF pathway
    • Loss of Mel-18 enhances breast cancer stem cell activity and tumorigenicity through activating Notch signaling mediated by the Wnt/TCF pathway. Won HY, et al. FASEB J 2012 26 12 5002 5013
    • (2012) FASEB J , vol.26 , Issue.12 , pp. 5002-5013
    • Won, H.Y.1
  • 52
    • 79957487931 scopus 로고    scopus 로고
    • Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
    • Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. Bao B, et al. Cancer Lett 2011 307 1 26 36
    • (2011) Cancer Lett , vol.307 , Issue.1 , pp. 26-36
    • Bao, B.1
  • 53
    • 79958011688 scopus 로고    scopus 로고
    • Stem cell and lung cancer development: Blaming the Wnt, Hh and Notch signalling pathway
    • Stem cell and lung cancer development: blaming the Wnt, Hh and Notch signalling pathway. Garcia Campelo MR, et al. Clin Transl Oncol 2011 13 2 77 83
    • (2011) Clin Transl Oncol , vol.13 , Issue.2 , pp. 77-83
    • Garcia Campelo, M.R.1
  • 54
    • 77956623598 scopus 로고    scopus 로고
    • Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate
    • Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate. Hovinga KE, et al. Stem Cells 2010 28 6 1019 1029
    • (2010) Stem Cells , vol.28 , Issue.6 , pp. 1019-1029
    • Hovinga, K.E.1
  • 55
    • 84858796264 scopus 로고    scopus 로고
    • Critical role of the NOTCH ligand JAG2 in self-renewal of myeloma cells
    • Critical role of the NOTCH ligand JAG2 in self-renewal of myeloma cells. Chiron D, et al. Blood Cells Mol Dis 2012 48 4 247 253
    • (2012) Blood Cells Mol Dis , vol.48 , Issue.4 , pp. 247-253
    • Chiron, D.1
  • 56
    • 84862022388 scopus 로고    scopus 로고
    • Dll1/Notch activation accelerates multiple myeloma disease development by promoting CD138+ MM-cell proliferation
    • Dll1/Notch activation accelerates multiple myeloma disease development by promoting CD138+ MM-cell proliferation. Xu D, et al. Leukemia 2012 26 6 1402 1405
    • (2012) Leukemia , vol.26 , Issue.6 , pp. 1402-1405
    • Xu, D.1
  • 58
    • 84869209212 scopus 로고    scopus 로고
    • Stemness of B-cell progenitors in multiple myeloma bone marrow
    • Stemness of B-cell progenitors in multiple myeloma bone marrow. Boucher K, et al. Clin Cancer Res 2012 18 22 6155 6168
    • (2012) Clin Cancer Res , vol.18 , Issue.22 , pp. 6155-6168
    • Boucher, K.1
  • 59
    • 41349095228 scopus 로고    scopus 로고
    • Inhibition of notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy
    • DOI 10.1182/blood-2007-07-102632
    • Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy. Nefedova Y, et al. Blood 2008 111 4 2220 2229 (Pubitemid 351451536)
    • (2008) Blood , vol.111 , Issue.4 , pp. 2220-2229
    • Nefedova, Y.1    Sullivan, D.M.2    Bolick, S.C.3    Dalton, W.S.4    Gabrilovich, D.I.5
  • 60
    • 57849158165 scopus 로고    scopus 로고
    • Notch inhibition blocks multiple myeloma cell-induced osteoclast activation
    • Notch inhibition blocks multiple myeloma cell-induced osteoclast activation. Schwarzer R, et al. Leukemia 2008 22 12 2273 2277
    • (2008) Leukemia , vol.22 , Issue.12 , pp. 2273-2277
    • Schwarzer, R.1
  • 61
    • 84880272654 scopus 로고    scopus 로고
    • Anti-Notch treatment prevents multiple myeloma cells localization to the bone marrow via the chemokine system CXCR4/SDF-1
    • Anti-Notch treatment prevents multiple myeloma cells localization to the bone marrow via the chemokine system CXCR4/SDF-1. Mirandola L, et al. Leukemia 2013 27 7 1558 1566
    • (2013) Leukemia , vol.27 , Issue.7 , pp. 1558-1566
    • Mirandola, L.1
  • 62
    • 76549257254 scopus 로고
    • Urethane in the treatment of multiple myeloma
    • Urethane in the treatment of multiple myeloma. Weder C, Can Med Assoc J 1950 62 6 589 590
    • (1950) Can Med Assoc J , vol.62 , Issue.6 , pp. 589-590
    • Weder, C.1
  • 63
    • 0014104626 scopus 로고
    • Melphalan in multiple myeloma
    • Melphalan in multiple myeloma. Hoogstraten B, et al. Blood 1967 30 1 74 83
    • (1967) Blood , vol.30 , Issue.1 , pp. 74-83
    • Hoogstraten, B.1
  • 64
    • 0001653947 scopus 로고
    • Multiple myeloma. Ii. Analysis of cyclophosphamide therapy in 165 patients
    • Multiple myeloma. Ii. Analysis of cyclophosphamide therapy in 165 patients. Korst DR, et al. JAMA 1964 189 758 762
    • (1964) JAMA , vol.189 , pp. 758-762
    • Korst, D.R.1
  • 65
    • 0014661330 scopus 로고
    • Treatment for multiple myeloma. Combination chemother with different melphalan dose regimens
    • Treatment for multiple myeloma. Combination chemother with different melphalan dose regimens. Alexanian R, et al. JAMA 1969 208 9 1680 1685
    • (1969) JAMA , vol.208 , Issue.9 , pp. 1680-1685
    • Alexanian, R.1
  • 66
    • 0022922684 scopus 로고
    • Single, sequential, and multiple alkylating agent therapy for multiple myeloma: A CALGB study
    • Single, sequential, and multiple alkylating agent therapy for multiple myeloma: a CALGB Study. Cooper MR, et al. J Clin Oncol 1986 4 9 1331 1339 (Pubitemid 16028027)
    • (1986) Journal of Clinical Oncology , vol.4 , Issue.9 , pp. 1331-1339
    • Cooper, M.R.1    McIntyre, O.R.2    Propert, K.J.3
  • 68
    • 0032748385 scopus 로고    scopus 로고
    • Antitumor activity of thalidomide in refractory multiple myeloma
    • Antitumor activity of thalidomide in refractory multiple myeloma. Singhal S, et al. N Engl J Med 1999 341 21 1565 1571
    • (1999) N Engl J Med , vol.341 , Issue.21 , pp. 1565-1571
    • Singhal, S.1
  • 70
    • 77958124439 scopus 로고    scopus 로고
    • The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1
    • The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1. Usmani SZ, et al. J Hematol Oncol 2010 3 1 40
    • (2010) J Hematol Oncol , vol.3 , Issue.1 , pp. 40
    • Usmani, S.Z.1
  • 71
    • 84883160397 scopus 로고    scopus 로고
    • Ibrutinib and novel BTK inhibitors in clinical development
    • Ibrutinib and novel BTK inhibitors in clinical development. Akinleye A, et al. J Hematol Oncol 2013 6 59
    • (2013) J Hematol Oncol , vol.6 , pp. 59
    • Akinleye, A.1
  • 72
    • 84872186323 scopus 로고    scopus 로고
    • Novel immunomodulatory compounds in multiple myeloma
    • Novel immunomodulatory compounds in multiple myeloma. Saini N, Mahindra A, Expert Opin Investig Drugs 2013 22 2 207 215
    • (2013) Expert Opin Investig Drugs , vol.22 , Issue.2 , pp. 207-215
    • Saini, N.1    Mahindra, A.2
  • 73
    • 84885992798 scopus 로고    scopus 로고
    • Thalidomide and its analogues in the treatment of multiple myeloma
    • Thalidomide and its analogues in the treatment of multiple myeloma. Latif T, et al. Exp Hematol Oncol 2012 1 1 27
    • (2012) Exp Hematol Oncol , vol.1 , Issue.1 , pp. 27
    • Latif, T.1
  • 74
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: Premises, promises and challenges
    • The cancer stem cell: premises, promises and challenges. Clevers H, Nat Med 2011 17 3 313 319
    • (2011) Nat Med , vol.17 , Issue.3 , pp. 313-319
    • Clevers, H.1
  • 75
    • 33646146498 scopus 로고    scopus 로고
    • Stromal niches, plasma cell differentiation and survival
    • Stromal niches, plasma cell differentiation and survival. Moser K, et al. Curr Opin Immunol 2006 18 3 265 270
    • (2006) Curr Opin Immunol , vol.18 , Issue.3 , pp. 265-270
    • Moser, K.1
  • 76
    • 77649190767 scopus 로고    scopus 로고
    • Organization of immunological memory by bone marrow stroma
    • Organization of immunological memory by bone marrow stroma. Tokoyoda K, et al. Nat Rev Immunol 2010 10 3 193 200
    • (2010) Nat Rev Immunol , vol.10 , Issue.3 , pp. 193-200
    • Tokoyoda, K.1
  • 77
    • 34848857602 scopus 로고    scopus 로고
    • Flexible and dynamic organization of bone marrow stromal compartment
    • DOI 10.1111/j.1365-2141.2007.06827.x
    • Flexible and dynamic organization of bone marrow stromal compartment. Anjos-Afonso F, Bonnet D, Br J Haematol 2007 139 3 373 384 (Pubitemid 47512189)
    • (2007) British Journal of Haematology , vol.139 , Issue.3 , pp. 373-384
    • Anjos-Afonso, F.1    Bonnet, D.2
  • 79
    • 0032939906 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 acts as a chemoattractant factor for 5T2 multiple myeloma cells
    • Insulin-like growth factor-1 acts as a chemoattractant factor for 5 T2 multiple myeloma cells. Vanderkerken K, et al. Blood 1999 93 1 235 241 (Pubitemid 29019408)
    • (1999) Blood , vol.93 , Issue.1 , pp. 235-241
    • Vanderkerken, K.1    Asosingh, K.2    Braet, F.3    Van Riet, I.4    Van Camp, B.5
  • 80
    • 0035880256 scopus 로고    scopus 로고
    • Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration
    • Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration. Podar K, et al. Blood 2001 98 2 428 435
    • (2001) Blood , vol.98 , Issue.2 , pp. 428-435
    • Podar, K.1
  • 85
    • 0035958517 scopus 로고    scopus 로고
    • The role of tumor necrosis factor α in the pathophysiology of human multiple myeloma: Therapeutic applications
    • DOI 10.1038/sj.onc.1204623
    • The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications. Hideshima T, et al. Oncogene 2001 20 33 4519 4527 (Pubitemid 32772434)
    • (2001) Oncogene , vol.20 , Issue.33 , pp. 4519-4527
    • Hideshima, T.1    Chauhan, D.2    Schlossman, R.3    Richardson, P.4    Anderson, K.C.5
  • 87
    • 0026530892 scopus 로고
    • Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone
    • Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone. Roodman GD, et al. J Clin Invest 1992 89 1 46 52
    • (1992) J Clin Invest , vol.89 , Issue.1 , pp. 46-52
    • Roodman, G.D.1
  • 88
    • 0028810948 scopus 로고
    • Myeloma cells upregulate interleukin-6 secretion in osteoblastic cells through cell-to-cell contact but downregulate osteocalcin
    • Myeloma cells upregulate interleukin-6 secretion in osteoblastic cells through cell-to-cell contact but downregulate osteocalcin. Barille S, et al. Blood 1995 86 8 3151 3159
    • (1995) Blood , vol.86 , Issue.8 , pp. 3151-3159
    • Barille, S.1
  • 89
    • 0037374460 scopus 로고    scopus 로고
    • Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells
    • Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells. Shipman CM, Croucher PI, Cancer Res 2003 63 5 912 916 (Pubitemid 36278418)
    • (2003) Cancer Research , vol.63 , Issue.5 , pp. 912-916
    • Shipman, C.M.1    Croucher, P.I.2
  • 91
    • 62549117773 scopus 로고    scopus 로고
    • Pathogenesis of myeloma bone disease
    • Pathogenesis of myeloma bone disease. Roodman GD, Leukemia 2009 23 3 435 441
    • (2009) Leukemia , vol.23 , Issue.3 , pp. 435-441
    • Roodman, G.D.1
  • 92
    • 28544437394 scopus 로고    scopus 로고
    • The role of immune cells and inflammatory cytokines in Paget's disease and multiple myeloma
    • The role of immune cells and inflammatory cytokines in Paget's disease and multiple myeloma. Ehrlich LA, Roodman GD, Immunol Rev 2005 208 252 266 (Pubitemid 41746397)
    • (2005) Immunological Reviews , vol.208 , pp. 252-266
    • Ehrlich, L.A.1    Roodman, G.D.2
  • 93
    • 72949119124 scopus 로고    scopus 로고
    • Integrins in cancer: Biological implications and therapeutic opportunities
    • Integrins in cancer: biological implications and therapeutic opportunities. Desgrosellier JS, Cheresh DA, Nat Rev Cancer 2010 10 1 9 22
    • (2010) Nat Rev Cancer , vol.10 , Issue.1 , pp. 9-22
    • Desgrosellier, J.S.1    Cheresh, D.A.2
  • 94
    • 0029118548 scopus 로고
    • Adhesion molecules on human myeloma cells: Significant changes in expression related to malignancy, tumor spreading, and immortalization
    • Adhesion molecules on human myeloma cells: significant changes in expression related to malignancy, tumor spreading, and immortalization. Pellat-Deceunynck C, et al. Cancer Res 1995 55 16 3647 3653
    • (1995) Cancer Res , vol.55 , Issue.16 , pp. 3647-3653
    • Pellat-Deceunynck, C.1
  • 95
    • 0033105537 scopus 로고    scopus 로고
    • Cell adhesion mediated drug resistance (CAM-DR): Role of integrins and resistance to apoptosis in human myeloma cell lines
    • Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. Damiano JS, et al. Blood 1999 93 5 1658 1667 (Pubitemid 29102494)
    • (1999) Blood , vol.93 , Issue.5 , pp. 1658-1667
    • Damiano, J.S.1    Cress, A.E.2    Hazlehurst, L.A.3    Shtil, A.A.4    Dalton, W.S.5
  • 96
    • 51349083548 scopus 로고    scopus 로고
    • Identification of a novel switch in the dominant forms of cell adhesion-mediated drug resistance in glioblastoma cells
    • Identification of a novel switch in the dominant forms of cell adhesion-mediated drug resistance in glioblastoma cells. Westhoff MA, et al. Oncogene 2008 27 39 5169 5181
    • (2008) Oncogene , vol.27 , Issue.39 , pp. 5169-5181
    • Westhoff, M.A.1
  • 97
    • 39149106436 scopus 로고    scopus 로고
    • Combination therapy of an anticancer drug with the FNIII14 peptide of fibronectin effectively overcomes cell adhesion-mediated drug resistance of acute myelogenous leukemia
    • DOI 10.1038/sj.leu.2405017, PII 2405017
    • Combination therapy of an anticancer drug with the FNIII14 peptide of fibronectin effectively overcomes cell adhesion-mediated drug resistance of acute myelogenous leukemia. Matsunaga T, et al. Leukemia 2008 22 2 353 360 (Pubitemid 351250540)
    • (2008) Leukemia , vol.22 , Issue.2 , pp. 353-360
    • Matsunaga, T.1    Fukai, F.2    Miura, S.3    Nakane, Y.4    Owaki, T.5    Kodama, H.6    Tanaka, M.7    Nagaya, T.8    Takimoto, R.9    Takayama, T.10    Niitsu, Y.11
  • 99
    • 0034932187 scopus 로고    scopus 로고
    • Mechanism of human stem cell migration and repopulation of NOD/SCID and B2mnull NOD/SCID mice: The role of SDF-1/CXCR4 interactions
    • Mechanism of human stem cell migration and repopulation of NOD/SCID and B2mnull NOD/SCID mice. The role of SDF-1/CXCR4 interactions. Lapidot T, Ann N Y Acad Sci 2001 938 83 95 (Pubitemid 32620021)
    • (2001) Annals of the New York Academy of Sciences , vol.938 , pp. 83-95
    • Lapidot, T.1
  • 102
    • 65949096301 scopus 로고    scopus 로고
    • The CML stem cell: Evolution of the progenitor
    • The CML stem cell: evolution of the progenitor. Stuart SA, Minami Y, Wang JY, Cell Cycle 2009 8 9 1338 1343
    • (2009) Cell Cycle , vol.8 , Issue.9 , pp. 1338-1343
    • Stuart, S.A.1    Minami, Y.2    Wang, J.Y.3
  • 104
    • 0033890773 scopus 로고    scopus 로고
    • Gene transfer of GM-CSF, CD80 and CD154 cDNA enhances survival in a murine model of acute leukemia with persistence of aminimal residual disease
    • Gene transfer of GM-CSF, CD80 and CD154 cDNA enhances survival in a murine model of acute leukemia with persistence of a minimal residual disease. Vereecque R, et al. Gene Ther 2000 7 15 1312 1316 (Pubitemid 30623778)
    • (2000) Gene Therapy , vol.7 , Issue.15 , pp. 1312-1316
    • Vereecque, R.1    Buffenoir, G.2    Preudhomme, C.3    Hetuin, D.4    Bauters, F.5    Fenaux, P.6    Quesnel, B.7
  • 105
    • 4644256639 scopus 로고    scopus 로고
    • In a model of tumor dormancy, long-term persistent leukemic cells have increased B7-H1 and B7.1 expression and resist CTL-mediated lysis
    • DOI 10.1182/blood-2004-01-0064
    • In a model of tumor dormancy, long-term persistent leukemic cells have increased B7-H1 and B7.1 expression and resist CTL-mediated lysis. Saudemont A, Quesnel B, Blood 2004 104 7 2124 2133 (Pubitemid 39297867)
    • (2004) Blood , vol.104 , Issue.7 , pp. 2124-2133
    • Saudemont, A.1    Quesnel, B.2
  • 106
    • 84255197842 scopus 로고    scopus 로고
    • Cancer immunotherapy comes of age
    • Cancer immunotherapy comes of age. Mellman I, Coukos G, Dranoff G, Nature 2011 480 7378 480 489
    • (2011) Nature , vol.480 , Issue.7378 , pp. 480-489
    • Mellman, I.1    Coukos, G.2    Dranoff, G.3
  • 107
    • 33644520242 scopus 로고    scopus 로고
    • Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma
    • Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma. Tirapu I, et al. Cancer Res 2006 66 4 2442 2450
    • (2006) Cancer Res , vol.66 , Issue.4 , pp. 2442-2450
    • Tirapu, I.1
  • 108
    • 34547677725 scopus 로고    scopus 로고
    • Immunodeficiency and immunotherapy in multiple myeloma
    • DOI 10.1111/j.1365-2141.2007.06705.x
    • Immunodeficiency and immunotherapy in multiple myeloma. Pratt G, Goodyear O, Moss P, Br J Haematol 2007 138 5 563 579 (Pubitemid 47208476)
    • (2007) British Journal of Haematology , vol.138 , Issue.5 , pp. 563-579
    • Pratt, G.1    Goodyear, O.2    Moss, P.3
  • 111
    • 84867372743 scopus 로고    scopus 로고
    • Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma
    • Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma. Muthu Raja KR, et al. PLoS One 2012 7 10 47077
    • (2012) PLoS One , vol.7 , Issue.10 , pp. 547077
    • Muthu Raja, K.R.1
  • 112
    • 53449089919 scopus 로고    scopus 로고
    • Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma
    • Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma. Dhodapkar KM, et al. Blood 2008 112 7 2878 2885
    • (2008) Blood , vol.112 , Issue.7 , pp. 2878-2885
    • Dhodapkar, K.M.1
  • 113
    • 77955862810 scopus 로고    scopus 로고
    • Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma
    • Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma. Prabhala RH, et al. Blood 2010 115 26 5385 5392
    • (2010) Blood , vol.115 , Issue.26 , pp. 5385-5392
    • Prabhala, R.H.1
  • 114
    • 84879452593 scopus 로고    scopus 로고
    • Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans
    • Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans. Gorgun GT, et al. Blood 2013 121 15 2975 2987
    • (2013) Blood , vol.121 , Issue.15 , pp. 2975-2987
    • Gorgun, G.T.1


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