Heuristic modeling of macromolecule release from PLGA microspheres

International Journal of Nanomedicine

Volumn 8, Issue , 2013, Pages 4601-4611

  Szlek, Jakub ^a   Pacławski, Adam ^a   Llau, Raymond ^b   Jachowicz, Renata ^a   Mendyk, Aleksander ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

Artificial neural networks; Feature selection; Genetic programming; Molecular descriptors; Poly(lactic co glycolic acid) (PLGA) microparticles

Indexed keywords

ALPHA 1 ANTITRYPSIN; AMYLOID BETA PROTEIN; ASPARAGINASE; BOVINE INSULIN; BOVINE SERUM ALBUMIN; CHYMOTRYPSIN; HUMAN SERUM ALBUMIN; INSULIN; LYSOZYME; MICROSPHERE; OVALBUMIN; POLYGLACTIN; RECOMBINANT EPIDERMAL GROWTH FACTOR; RECOMBINANT ERYTHROPOIETIN; RECOMBINANT GROWTH HORMONE;

ARTICLE; ARTIFICIAL NEURAL NETWORK; COMPUTER ANALYSIS; COMPUTER PREDICTION; DRUG RELEASE; DRUG SOLUBILITY; FEATURE SELECTION; GENETIC PROGRAMMING; MATHEMATICAL MODEL; NONLINEAR REGRESSION ANALYSIS;

ARTIFICIAL NEURAL NETWORKS; FEATURE SELECTION; GENETIC PROGRAMMING; MOLECULAR DESCRIPTORS; POLY(LACTIC-CO-GLYCOLIC ACID) (PLGA) MICROPARTICLES;

ARTIFICIAL INTELLIGENCE; DRUG CARRIERS; LACTIC ACID; MICROSPHERES; MODELS, MOLECULAR; MODELS, STATISTICAL; NANOPARTICLES; POLYGLYCOLIC ACID; PROTEINS;

EID: 84888879464     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S53364     Document Type: Article

References (33)

1. Makadia HK, Siegel SJ. Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers (Basel). 2011;3: 1377-1397.
2. Danhier F, Ansorena E, Silva JM, Coco R, Le Breton A, Préat V. PLGA-based nanoparticles: an overview of biomedical applications. J Control Release. 2012;161(2): 505-522.
3. Houchin ML, Topp EM. Physical properties of PLGA films during polymer degradation. J Appl Polym Sci. 2009;114: 2848-2854.
4. Wang J, Ng CW, Win KY, et al. Release of paclitaxel from polylactide-co-glycolide (PLGA) microparticles and discs under irradiation. J Microencapsul. 2003;20(3): 317-327.
5. Hamishehkar H, Emami J, Najafabadi AR, et al. Pharmacokinetics and pharmacodynamics of controlled release insulin loaded PLGA microcapsules using dry powder inhaler in diabetic rats. Biopharm Drug Dispos. 2010;31(2-3): 189-201.
6. De S, Robinson DH. Particle size and temperature effect on the physical stability of PLGA nanospheres and microspheres containing Bodipy. AAPS PharmSciTech. 2004;5(4): e53.
7. Fredenberg S, Wahlgren M, Reslow M, Axelsson A. The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems-a review. Int J Pharm. 2011;415: 34-52.
8. D'Souza SS, DeLuca PP. Development of a dialysis in vitro release method for biodegradable microspheres. AAPS PharmSciTech. 2005;6(2): E323-E328.
9. Mollo R, Corrigan OI. An investigation of the mechanism of release of the amphoteric drug amoxycillin from poly(D, L-lactide-co-glycolide) matrices. Pharm Dev Technol. 2002;7: 333-343.
10. Kang J, Schwendeman SP. Pore closing and opening in biodegradable polymers and their effect on the controlled release of proteins. Mol Pharm. 2007;4(1): 104-18.
11. Blanco MD, Alonso MJ. Development and characterization of protein-loaded poly(lactide-co-glycolide) nanospheres. Eur J Pharm Biopharm. 1997;43(3): 287-294.
12. Kang J, Lambert O, Ausborn M, Schwendeman SP. Stability of proteins encapsulated in injectable and biodegradable poly(lactide-co-glycolide)-glucose millicylinders. Int J Pharm. 2008;357(1-2): 235-243.
13. Mainardes RM, Evangelista RC. PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution. Int J Pharm. 2005;290(1-2): 137-144.
14. Zygourakis K, Markenscoff PA. Computer-aided design of bioerodible devices with optimal release characteristics: a cellular automata approach. Biomaterials. 1996;17(2): 125-135.
15. Göpferich A. Mechanisms of polymer degradation and erosion. Biomaterials. 1996;17(2): 103-114.
16. Siepmann J, Faisant N, Benoit JP. A new mathematical model quantifying drug release from bioerodible microparticles using Monte Carlo simulations. Pharm Res. 2002;19: 1885-1893.
17. Barat A, Crane M, Ruskin HJ. Quantitative multi-agent models for simulating protein release from PLGA bioerodible nano-and microspheres. J Pharm Biomed Anal. 2008;48(2): 361-368.
18. Marvin ChemAxon (http: //www.chemaxon.com). Accessed 10, Jan 2013.
19. Żurada JM, Malinowski A, Usuib S. Perturbation method for deleting redundant inputs of perceptron networks. Neurocomputing. 1997;14: 177-193.
20. Mendyk A, Jachowicz R. Unified methodology of neural analysis in decision support systems built for pharmaceutical technology. Expert Syst Appl. 2007;32: 1124-1131.
21. Szle{ogonek}k J. The fscaret. Automated feature selection using variety of models provided by caret package. Available from: http: //cran.r-project.org/web/packages/fscaret/index.html. Accessed Jun 2013.
22. R Core Team. R: a language and environment for statistical computing. Vienna: The R Foundation for Statistical Computing. Available from: http: //www.R-project.org/. Accessed 1, Jun 2013.
23. Mendyk A, Tuszyński PK, Polak S, Jachowicz R. Generalized in vitro-in vivo relationship (IVIVR) model based on artificial neural networks. Drug Des Devel Ther. 2013;7: 223-232.
24. Cannon AJ. monmlp: Monotone multi-layer perceptron neural network [webpage on the Internet]. Available from: http: //cran.r-project.org/web/packages/monmlp/index.html. Accessed Jun 2012.
25. Yager RR, Filev DP. Essentials of Fuzzy Modeling and Control. NY: John Wiley & Sons; 1994.
26. Flasch O, Mersmann O, Bartz-Beielstein T, Stork J, Zaefferer M. rgp: R genetic programming framework [webpage on the Internet]. Available from: http: //CRAN.R-project.org/package=rgp. Accessed 1, Jun 2013.
27. Nash JC, Varadhan R. Unifying optimization algorithms to aid software system users: optimx for R. J Stat Softw. 2011;43(9): 1-14.
28. Sandor M, Enscore D, Weston P, Mathiowitz E. Effect of protein molecular weight on release from micron-sized PLGA microspheres. J Control Release. 2001;76(3): 297-311.
29. He J, Feng M, Zhou X, et al. Stabilization and encapsulation of recombinant human erythropoietin into PLGA microspheres using human serum albumin as a stabilizer. Int J Pharm. 2011;416(1): 69-76.
30. Kang F, Singh J. Effect of additives on the release of a model protein from PLGA microspheres. AAPS PharmSciTech. 2001;2(4): 30.
31. Blanco D, Alonso MJ. Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: effect of the protein and polymer properties and of the co-encapsulation of surfactants. Eur J Pharm Biopharm. 1998;45(3): 285-294.
32. Buske J, König C, Bassarab S, Lamprecht A, Mühlau S, Wagner KG. Influence of PEG in PEG-PLGA microspheres on particle properties and protein release. Eur J Pharm Biopharm. 2012;81(1): 57-63.
33. Jiang HL, Jin JF, Hu YQ, Zhu KJ. Improvement of protein loading and modulation of protein release from poly(lactide-co-glycolide) microspheres by complexation of proteins with polyanions. J Microencapsul. 2004;21(6): 615-624