Stabilization and encapsulation of recombinant human erythropoietin into PLGA microspheres using human serum albumin as a stabilizer

International Journal of Pharmaceutics

Volumn 416, Issue 1, 2011, Pages 69-76

  He, Jintian ^a   Feng, Meiyan ^a   Zhou, Xianglian ^a   Ma, Shufen ^a,b   Jiang, Yang ^b   Wang, Ying ^b   Zhang, Hongxia ^b  

^a HEBEI NORMAL UNIVERSITY   (China)

^b NCPC GeneTech Biotechnology Development Co Ltd   (China)

Author keywords

Human serum albumin; Microspheres; Protein stabilization; Recombinant human erythropoietin; Solid in oil in water (s o w) emulsion method

Indexed keywords

HEMOGLOBIN; HUMAN SERUM ALBUMIN; MICROSPHERE; POLYGLACTIN; RECOMBINANT ERYTHROPOIETIN; SODIUM CHLORIDE; STABILIZING AGENT;

ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG STABILITY; EMULSION; ENCAPSULATION; ERYTHROCYTE COUNT; FREEZING; GEL PERMEATION CHROMATOGRAPHY; HEMOGLOBIN BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NANOFABRICATION; NONHUMAN; PHASE SEPARATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RAT; WESTERN BLOTTING;

ANIMALS; DRUG COMPOUNDING; DRUG STABILITY; EMULSIONS; ERYTHROCYTE COUNT; ERYTHROPOIETIN; EXCIPIENTS; HEMOGLOBINS; HUMANS; LACTIC ACID; MALE; MICE; MICE, INBRED BALB C; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN;

EID: 80051784753     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.06.008     Document Type: Article

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