Engineering the niche for stem cells

Growth Factors

Volumn 31, Issue 6, 2013, Pages 175-184

  Tan, Shawna ^a   Barker, Nicholas ^a,b,c  

^a INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Biomaterials; Lgr5; Microenvironment; Niche; Scaffold; Stem cells

Indexed keywords

AGAROSE; BIOMATERIAL; CHITOSAN; COLLAGEN; FIBRIN; FIBRINOGEN; FIBRONECTIN; HYALURONIC ACID; LAMININ; MACROGOL; MATRIGEL; NANOPARTICLE; STROMAL CELL DERIVED FACTOR 1;

ARTICLE; BIOENGINEERING; BIOMEDICINE; CELL DIFFERENTIATION; CELL ENGINEERING; CELL PROLIFERATION; CELL RENEWAL; EPIDERMIS; HEMATOPOIETIC STEM CELL; HUMAN; HYDROGEL; INTESTINAL STEM CELL; INTESTINE CRYPT; MICROENVIRONMENT; MULTIPOTENT STEM CELL; NONHUMAN; PANETH CELL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; SKIN STEM CELL; STEM CELL NICHE; ADULT STEM CELL; ANIMAL; CHEMISTRY; CYTOLOGY; EMBRYONIC STEM CELL; GASTROINTESTINAL TRACT; INTESTINE; STEM CELL;

ADULT STEM CELLS; ANIMALS; BIOENGINEERING; CELL DIFFERENTIATION; CELL PROLIFERATION; EMBRYONIC STEM CELLS; EPIDERMIS; GASTROINTESTINAL TRACT; HEMATOPOIETIC STEM CELLS; HUMANS; INTESTINES; MULTIPOTENT STEM CELLS; STEM CELL NICHE; STEM CELLS;

EID: 84888868864     PISSN: 08977194     EISSN: 10292292     Source Type: Journal    
DOI: 10.3109/08977194.2013.859683     Document Type: Article

References (92)

1. Aljitawi O. 2010a. Expansion of umbilical cord blood using a unique bio-system. In: ClinicalTrials.gov (Internet). Bethesda (MD): National Library of Medicine (US) 2010. Available from: Http:// clinicaltrials.gov/ct2/show/ NCT01061879?termstemcellniche& rank2. NLM Identifier: NCT01061879 [last accessed 28 April 2012
2. Aljitawi O. 2010b. Research study looking at specific tissue of the umbilical cord. In: ClinicalTrials.gov (Internet). Bethesda (MD): National Library of Medicine (US) 2010. Available from: Http:// clinicaltrials.gov/ct2/ show/study/NCT01166776 [last accessed 28 April 2012
3. Bancroft GN, Sikavitsas VI, van den Dolder J, Sheffield TL, Ambrose CG, Jansen JA, Mikos AG. 2002. Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner. Proc Natl Acad Sci USA 99:12600-12605
4. Barker N, Bartfeld S, Clevers H. 2010. Tissue-resident adult stem cell populations of rapidly self-renewing organs. Cell Stem Cell 7: 656-670
5. Blanpain C, Lowry WE, Geoghegan A, Polak L, Fuchs E. 2004. Selfrenewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell 118:635-648
6. Bruzewicz DA, McGuigan AP, Whitesides GM. 2008. Fabrication of a modular tissue construct in a microfluidic chip. Lab Chip 8:663-671
7. Buske P, Galle J, Barker N, Aust G, Clevers H, Loeffler M. 2011
8. A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt. PLoS Comput Biol 7:e1001045
9. Casali A, Batlle E. 2009. Intestinal stem cells in mammals and drosophila. Cell Stem Cell 4:124-127
10. Choi JS, Harley BA. 2012. The combined influence of substrate elasticity and ligand density on the viability and biophysical properties of hematopoietic stem and progenitor cells. Biomaterials 33: 4460-4468
11. Cioffi M, Küffer J, Ströbel S, Dubini G, Martin I, Wendt D. 2008. Computational evaluation of oxygen and shear stress distributions in 3D perfusion culture systems: Macro-scale and micro-structured models. J Biomech 41:2918-2925
12. Clevers HC, Bevins CL. 2013. Paneth cells: Maestros of the small intestinal crypts. Annu Rev Physiol 75:289-311
13. Dahlberg A, Delaney C, Bernstein ID. 2011. Ex vivo expansion of human hematopoietic stem and progenitor cells. Blood 117: 6083-6090
14. Datta N, Holtorf HL, Sikavitsas VI, Jansen JA, Mikos AG. 2005. Effect of bone extracellular matrix synthesized in vitro on the osteoblastic differentiation of marrow stromal cells. Biomaterials 26: 971-977
15. de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, et al. 2011. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signaling. Nature 476:293-297
16. Di Maggio N, Piccinini E, Jaworski M, Trumpp A, Wendt DJ, Martin I. 2011. Toward modeling the bone marrow niche using scaffold-based 3D culture systems. Biomaterials 32:321-329
17. Discher DE, Mooney DJ, Zandstra PW. 2009. Growth factors, matrices, and forces combine and control stem cells. Science 324:1673-1677
18. Evans ND, Gentleman E, Chen X, Roberts CJ, Polak JM, Stevens MM. 2010. Extracellular matrix-mediated osteogenic differentiation of murine embryonic stem cells. Biomaterials 31:3244-3252
19. Flynn L, Prestwich GD, Semple JL, Woodhouse KA. 2007. Adipose tissue engineering with naturally derived scaffolds and adiposederived stem cells. Biomaterials 28:3834-3842
20. Flynn LE. 2010. The use of decellularized adipose tissue to provide an inductive microenvironment for the adipogenic differentiation of human adipose-derived stem cells. Biomaterials 31:4715-4724
21. Gilbert PM, Havenstrite KL, Magnusson KE, Sacco A, Leonardi NA, Kraft P, Nguyen NK, et al. 2010. Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture. Science 329: 1078-1081
22. Goldstein J, Horsley V. 2012. Home sweet home: Skin stem cell niches. Cell Mol Life Sci 69:2573-2582
23. Greco V, Guo S. 2010. Compartmentalized organization: A common and required feature of stem cell niches? Development 137:1586-1594
24. Hansen KC, Kiemele L, Maller O, O'Brien J, Shankar A, Fornetti J, Schedin P. 2009. An in-solution ultrasonication-assisted digestion method for improved extracellular matrix proteome coverage. Mol Cell Proteomics 8:1648-1657
25. He XC, Zhang J, Li L. 2005. Cellular and molecular regulation of hematopoietic and intestinal stem cell behavior. Ann N Y Acad Sci 1049:28-38
26. Hodgkinson T, Bayat A. 2011. Dermal substitute-assisted healing: Enhancing stem cell therapy with novel biomaterial design. Arch Dermatol Res 303:301-315
27. Holst J, Watson S, Lord MS, Eamegdool SS, Bax DV, Nivison-Smith LB, Kondyurin A, et al. 2010. Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells. Nat Biotechnol 28:1123-1128
28. Horsley V, Aliprantis AO, Polak L, Glimcher LH, Fuchs E. 2008. NFATc1 balances quiescence and proliferation of skin stem cells. Cell 132:299-310
29. Horst M, Madduri S, Gobet R, Sulser T, Hall H, Eberli D. 2010. Scaffold characteristics for functional hollow organ regeneration. Materials 3: 241-263
30. Huang S, Lu G, Wu Y, Jirigala E, Xu Y, Ma K, Fu X, 2012
31. Huang S, Lu G, Wu Y, Jirigala E, Xu Y, Ma K, Fu X. 2012. Mesenchymal stem cells delivered in a microsphere-based engineered skin contribute to cutaneous wound healing and sweat gland repair. J Dermatol Sci 66:29-36
32. Huang YC, Liu TJ. 2012. Mobilization of mesenchymal stem cells by stromal cell-derived factor-1 released from chitosan/tripolyphosphate/ fucoidan nanoparticles. Acta Biomater 8:1048-1056
33. Ji SZ, Xiao SC, Luo PF, Huang GF, Wang GY, Zhu SH, Wu MJ, Xia ZF. 2011. An epidermal stem cells niche microenvironment created by engineered human amniotic membrane. Biomaterials 32:7801-7811
34. Jin G, Prabhakaran MP, Ramakrishna S. 2011. Stem cell differentiation to epidermal lineages on electrospun nanofibrous substrates for skin tissue engineering. Acta Biomater 7:3113-3122
35. Jung P, Sato T, Merlos-Suárez A, Barriga FM, Iglesias M, Rossell D, Auer H, et al. 2003. Isolation and in vitro expansion of human colonic stem cells. Nat Med 2011;17:1225-1227
36. Kapur S, Baylink DJ, Lau KH. 2003. Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways. Bone 32: 241-251
37. Karpowicz P, Perrimon N. 2010. All for one, and one for all: The clonality of the intestinal stem cell niche. F1000 Biol Rep 2:73
38. Kim TH, Escudero S, Shivdasani RA. 2012. Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells. Proc Natl Acad Sci USA 109:3932-3937
39. Klees RF, Salasznyk RM, Kingsley K, Williams WA, Boskey A, Plopper GE. 2005. Laminin-5 induces osteogenic gene expression in human mesenchymal stem cells through an ERK-dependent pathway. Mol Biol Cell 16:881-890
40. Kobel S, Lutolf MP. 2011. Biomaterials meet microfluidics: Building the next generation of artificial niches. Curr Opin Biotechnol 22:690-697
41. Kobielak K, Stokes N, de la Cruz J, Polak L, Fuchs E. 2007. Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Proc Natl Acad Sci USA 104: 10063-10068
42. Krieg M, Arboleda-Estudillo Y, Puech PH, Käfer J, Graner F, Müller DJ, Heisenberg CP. 2008. Tensile forces govern germ-layer organization in zebrafish. Nat Cell Biol 10:429-436
43. Kshitiz, Kim DH, Beebe DJ, Levchenko A. 2011. Micro- and nanoengineering for stem cell biology: The promise with a caution. Trends Biotechnol 29:399-408
44. Kyba M, Perlingeiro R, Daley G. 2002. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell 109:29-37
45. Lampe KJ, Heilshorn SC. 2012. Building stem cell niches from the molecule up through engineered peptide materials. Neurosci Lett 519:138-146
46. Leisten I, Kramann R, Ventura Ferreira MS, Bovi M, Neuss S, Ziegler P, Wagner W, et al. 2012. 3D co-culture of hematopoietic stem and progenitor cells and mesenchymal stem cells in collagen scaffolds as a model of the hematopoietic niche. Biomaterials 33:1736-1747
47. Li L, Clever H. 2010. Coexistence of quiescent and active adult stem cells in mammals. Science 327:542-545
48. Lopez-Garcia C, Klein AM, Simons BD, Winton DJ. 2010. Intestinal stem cell replacement follows a pattern of neutral drift. Science 330: 822-825
49. Lowry WE, Blanpain C, Nowak JA, Guasch G, Lewis L, Fuchs E. 2005. Defining the impact of b-catenin/Tcf transactivation on epithelial stem cells. Genes Dev 19:1596-1611
50. Lutolf MP, Doyonnas R, Havenstrite K, Koleckar K, Blau HM. 2009. Perturbation of single hematopoietic stem cell fates in artificial niches. Integr Biol (Camb) 1:59-69
51. Martinez-Agosto JA, Mikkola HK, Hartenstein V, Banerjee U. 2007. The hematopoietic stem cell and its niche: A comparative view. Genes Dev 21:3044-3060
52. McAdams TA, Miller WM, Papoutsakis ET. 1997. Variations in culture pH affect the cloning efficiency and differentiation of progenitor cells in ex vivo haemopoiesis. Br J Haematol 97:889-895
53. Mohyeldin A, Garzón-Muvdi T, Quiñones-Hinojosa A. 2010. Oxygen in stem cell biology: A critical component of the stem cell niche. Cell Stem Cell 7:150-161
54. Morrison SJ, Spradling AC. 2008. Stem cells and niches: Mechanisms that promote stem cell maintenance throughout life. Cell 132: 598-611
55. Mortera-Blanco T, Mantalaris A, Bismarck A, Aqel N, Panoskaltsis N. 2011. Long-term cytokine-free expansion of cord blood mononuclear cells in three-dimensional scaffolds. Biomaterials 32:9263-9270
56. Nervi B, Ramirez P, Rettig MP, Uy GL, Holt MS, Ritchey JK, Prior JL, et al. 2009. Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100. Blood 113:6206-6214
57. Nilsson SK, Johnston HM, Whitty GA, et al. 2005. Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood 106:1232-1239
58. Ott HC, Matthiesen TS, Goh SK, Black LD, Kren SM, Netoff TI, Taylor DA. 2008. Perfusion-decellularized matrix: Using nature's platform to engineer a bioartificial heart. Nat Med 14:213-221
59. Peerani R, Zandstra PW. 2010. Enabling stem cell therapies through synthetic stem cell-niche engineering. J Clin Invest 120:60-70
60. Peyton SR, Kim PD, Ghajar CM, Seliktar D, Putnam AJ. 2008. The effects of matrix stiffness and RhoA on the phenotypic plasticity of smooth muscle cells in a 3-D biosynthetic hydrogel system. Biomaterials 29:2597-2607
61. Rocha FG, Sundback CA, Krebs NJ, Leach JK, Mooney DJ, Ashley SW, Vacanti JP, Whang EE. 2008. The effect of sustained delivery of vascular endothelial growth factor on angiogenesis in tissue-engineered intestine. Biomaterials 29:2884-2890
62. Roth S, Franken P, Sacchetti A, Kremer A, Anderson K, et al. 2012. Paneth cells in intestinal homeostasis and tissue injury. PLoS ONE 7: E38965
63. Rothenberg ME, Nusse Y, Kalisky T, Lee JJ, Dalerba P, Scheeren F, Lobo N, et al. 2012. Identification of a cKit colonic crypt base secretory cell that supports Lgr5 stem cells in mice. Gastroenterology 142:1195-1205.e6
64. Rustad KC, Wong VW, Sorkin M, Glotzbach JP, Major MR, Rajadas J, Longaker MT, Gurtner GC. 2012. Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold. Biomaterials 33:80-90
65. Sala FG, Matthews JA, Speer AL, Torashima Y, Barthel ER, Grikscheit TC. 2011. A multicellular approach forms a significant amount of tissue-engineered small intestine in the mouse. Tissue Eng Part A 17: 1841-1850
66. Sato T, Clevers H. 2013. Growing self-organizing mini-guts from a single intestinal stem cell: Mechanism and applications. Science 340: 1190-1194
67. Sato T, Stange DE, Ferrante M, Vries RG, Van Es JH, Van den Brink S, Van Houdt WJ, et al. 2011a. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology 141:1762-1772
68. Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, et al. 2011b. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469:415-418
69. SatoT, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, et al. 2009. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459:262-265
70. Scadden DT. 2006. The stem-cell niche as an entity of action. Nature 441:1075-1079
71. Schenke-Layland K, Riemann I, Opitz F, König K, Halbhuber KJ, Stock UA. 2004. Comparative study of cellular and extracellular matrix composition of native and tissue engineered heart valves. Matrix Biol 23:113-125
72. Schofield R. 1978. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 4:7-25
73. Slaughter BV, Khurshid SS, Fisher OZ, Khademhosseini A, Peppas NA. 2009. Hydrogels in regenerative medicine. Adv Mater 21:3307-3329
74. Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, et al. 2010. Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science 327:1385-1389
75. Stolberg S, McCloskey KE. 2009. Can shear stress direct stem cell fate? Biotechnol Prog 25:10-19
76. Suzuki T, Yokoyama Y, Kumano K, Takanashi M, Kozuma S, Takato T, Nakahata T, et al. 2006. Highly efficient ex vivo expansion of human hematopoietic stem cells using Delta1-Fc chimeric protein. Stem Cells 24:2456-2465
77. Tan J, Liu T, Hou L, Meng W, Wang Y, Zhi W, Deng L. 2010. Maintenance and expansion of hematopoietic stem/progenitor cells in biomimetic osteoblast niche. Cytotechnology 62:439-448
78. Tarasova A, Haylock D, Winkler D. 2011. Principal signalling complexes in haematopoiesis: Structural aspects and mimetic discovery. Cytokine Growth Factor Rev 22:231-253
79. Thibault RA, Scott Baggett L, Mikos AG, Kasper FK. 2010. Osteogenic differentiation of mesenchymal stem cells on pregenerated extracellular matrix scaffolds in the absence of osteogenic cell culture supplements. Tissue Eng Part A 16:431-440
80. Tian H, Biehs B, Warming S, Leong KG, Rangell L, Klein OD, de Sauvage FJ. 2011. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 478:255-259
81. Tiwari A, Tursky ML, Mushahary D, Wasnik S, Collier FM, Suma K, Kirkland MA, Pande G. 2012. Ex vivo expansion of haematopoietic stem/progenitor cells from human umbilical cord blood on acellular scaffolds prepared from MS-5 stromal cell line. J Tissue Eng Regen Med 7:871-883
82. Ventura Ferreira MS, Jahnen-Dechent W, Labude N, Bovi M, Hieronymus T, Zenke M, Schneider RK, Neurs S. 2012. Cord blood-hematopoietic stem cell expansion in 3D fibrin scaffolds with stromal support. Biomaterials 33:6987-6997
83. Voog J, Jones DL. 2010. Stem cells and the niche: A dynamic duo. Cell Stem Cell 6:103-115
84. Vunjak-Novakovic G, Scadden DT. 2011. Biomimetic platforms for human stem cell research. Cell Stem Cell 8:252-261
85. Walker MR, Patel KK, Stappenbeck TS. 2009. The stem cell niche. J Pathol 217:169-180
86. Watanabe K, Ueno M, Kamiya D, Nishiyama A, Matsumura M, Wataya T, Takahashi JB, et al. 2007. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol 25:681-686
87. Xie T, Spradling AC. 2000. A niche maintaining germ line stem cells in the Drosophila ovary. Science 290:328-230
88. Yang X, Shah JD, Wang H. 2009. Nanofiber enabled layer-by-layer approach toward three-dimensional tissue formation. Tissue Eng Part A 15:945-956
89. Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, et al. 2012. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5 stem cell. Nat Med 18:618-623
90. Zamir EA, Srinivasan V, Perucchio R, Taber LA. 2003. Mechanical asymmetry in the embryonic chick heart during looping. Ann Biomed Eng 31:1327-1336
91. Zhang YV, Cheong J, Ciapurin N, McDermitt DJ, Tumbar T. 2009. Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells. Cell Stem Cell 5: 267-278
92. Zhu X, Cui W, Li X, Jin Y. 2008. Electrospun fibrous mats with high porosity as potential scaffolds for skin tissue engineering. Biomacromolecules 9:1795-1801