Distinct Self-Renewal and Differentiation Phases in the Niche of Infrequently Dividing Hair Follicle Stem Cells

Cell Stem Cell

Volumn 5, Issue 3, 2009, Pages 267-278

  Zhang, Ying V ^a   Cheong, Janice ^a   Ciapurin, Nichita ^a   McDermitt, David J ^a   Tumbar, Tudorita ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

STEMCELL

Indexed keywords

CRE RECOMBINASE; GREEN FLUORESCENT PROTEIN; HISTONE H2B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL DIVISION; CELL FUNCTION; CELL LINEAGE; CELL POPULATION; CELL RENEWAL; CONTROLLED STUDY; HAIR FOLLICLE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; TISSUE DISTRIBUTION;

ANIMALS; ANTIGENS, CD34; CELL DIFFERENTIATION; CELL DIVISION; CELL LINEAGE; CELL PROLIFERATION; GENE EXPRESSION PROFILING; HAIR FOLLICLE; HOMEOSTASIS; INTEGRIN ALPHA6; MICE; MODELS, BIOLOGICAL; STEM CELL NICHE; STEM CELLS; TIME FACTORS;

INVERTEBRATA; MAMMALIA; MUS; VERTEBRATA;

EID: 69249202346     PISSN: 19345909     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stem.2009.06.004     Document Type: Article

References (25)

1. Barker N., van Es J.H., Kuipers J., Kujala P., van den Born M., Cozijnsen M., Haegebarth A., Korving J., Begthel H., Peters P.J., and Clevers H. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449 (2007) 1003-1007
2. Clayton E., Doupe D.P., Klein A.M., Winton D.J., Simons B.D., and Jones P.H. A single type of progenitor cell maintains normal epidermis. Nature 446 (2007) 185-189
3. Cotsarelis G. Epithelial stem cells: a folliculocentric view. J. Invest. Dermatol. 126 (2006) 1459-1468
4. Fuchs E. The tortoise and the hair: Slow-cycling cells in the stem cell race. Cell 137 (2009) 811-819
5. Greco V., Chen T., Rendl M., Schober M., Pasolli H.A., Stokes N., Dela Cruz-Racelis J., and Fuchs E. A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell 4 (2009) 155-169
6. Horsley V., O'Carroll D., Tooze R., Ohinata Y., Saitou M., Obukhanych T., Nussenzweig M., Tarakhovsky A., and Fuchs E. Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell 126 (2006) 597-609
7. Jaks V., Barker N., Kasper M., van Es J.H., Snippert H.J., Clevers H., and Toftgard R. Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat. Genet. 40 (2008) 1291-1299
8. Jones C.L., and Reiners Jr. J.J. Differentiation status of cultured murine keratinocytes modulates induction of genes responsive to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch. Biochem. Biophys. 347 (1997) 163-173
9. Lansdorp P.M. Immortal strands? Give me a break. Cell 129 (2007) 1244-1247
10. Legue E., and Nicolas J.F. Hair follicle renewal: organization of stem cells in the matrix and the role of stereotyped lineages and behaviors. Development 132 (2005) 4143-4154
11. Luong M.X., van der Meijden C.M., Xing D., Hesselton R., Monuki E.S., Jones S.N., Lian J.B., Stein J.L., Stein G.S., Neufeld E.J., and van Wijnen A.J. Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility. Mol. Cell. Biol. 22 (2002) 1424-1437
12. Morrison S.J., and Kimble J. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 441 (2006) 1068-1074
13. Oshima H., Rochat A., Kedzia C., Kobayashi K., and Barrandon Y. Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell 104 (2001) 233-245
14. Osorio K.M., Lee S.E., McDermitt D.J., Waghmare S.K., Zhang Y.V., Woo H.N., and Tumbar T. Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation. Development 135 (2008) 1059-1068
15. Plikus M.V., Mayer J.A., de la Cruz D., Baker R.E., Maini P.K., Maxson R., and Chuong C.M. Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature 451 (2008) 340-344
16. Rendl M., Lewis L., and Fuchs E. Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol. 3 (2005) e331 10.1371/journal.pbio.0030331
17. Rieger E., Bijl J.J., van Oostveen J.W., Soyer H.P., Oudejans C.B., Jiwa N.M., Walboomers J.M., and Meijer C.J. Expression of the homeobox gene HOXC4 in keratinocytes of normal skin and epithelial skin tumors is correlated with differentiation. J. Invest. Dermatol. 103 (1994) 341-346
18. Sangiorgi E., and Capecchi M.R. Bmi1 is expressed in vivo in intestinal stem cells. Nat. Genet. 40 (2008) 915-920
19. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21 (1999) 70-71
20. Sur I., Rozell B., Jaks V., Bergstrom A., and Toftgard R. Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis. J. Cell Sci. 119 (2006) 3593-3601
21. Tanahashi H., and Tabira T. Alkaline treatment after X-Gal staining reaction for Escherichia coli beta-galactosidase enhances sensitivity. Anal. Biochem. 279 (2000) 122-123
22. Tumbar T. Epithelial skin stem cells. Methods Enzymol. 419 (2006) 73-99
23. Tumbar T., Guasch G., Greco V., Blanpain C., Lowry W.E., Rendl M., and Fuchs E. Defining the epithelial stem cell niche in skin. Science 303 (2004) 359-363
24. Vasioukhin V., Degenstein L., Wise B., and Fuchs E. The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc. Natl. Acad. Sci. USA 96 (1999) 8551-8556
25. Waghmare S.K., Bansal R., Lee J., Zhang Y.V., McDermitt D.J., and Tumbar T. Quantitative proliferation dynamics and random chromosome segregation of hair follicle stem cells. EMBO J. 27 (2008) 1309-1320