Elucidation of the role of LMO2 in human erythroid cells

Experimental Hematology

Volumn 41, Issue 12, 2013, Pages 1062-1076.e1

  Inoue, Ai ^a   Fujiwara, Tohru ^a   Okitsu, Yoko ^a   Katsuoka, Yuna ^a   Fukuhara, Noriko ^a   Onishi, Yasushi ^a   Ishizawa, Kenichi ^a,b   Harigae, Hideo ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CD34 ANTIGEN; HEMOGLOBIN BETA CHAIN; LIM ONLY PROTEIN 2; LIM PROTEIN; PROTEIN LDB1; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR TAL1; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CHROMATIN; CONTROLLED STUDY; DOWN REGULATION; ERYTHROBLAST; ERYTHROID CELL; EX VIVO STUDY; GENE; HBB GENE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SLC4A1 GENE; UPREGULATION;

EID: 84888865384     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2013.09.003     Document Type: Article

References (39)

1. Bresnick E.H., Lee H.Y., Fujiwara T., Johnson K.D., Keles S. GATA switches as developmental drivers. J Biol Chem 2010, 285:31087-31093.
2. Yamamoto M., Ko L.J., Leonard M.W., Beug H., Orkin S.H., Engel J.D. Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes Dev 1990, 4:1650-1662.
3. Lim K.C., Lakshmanan G., Crawford S.E., Gu Y., Grosveld F., Engel J.D. Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Nat Genet 2000, 25:209-212.
4. Tsai F.Y., Keller G., Kuo F.C., et al. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 1994, 371:221-226.
5. Evans T., Reitman M., Felsenfeld G. An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes. Proc Natl Acad Sci U S A 1988, 85:5976-5980.
6. Lahlil R., Lécuyer E., Herblot S., Hoang T. SCL assembles a multifactorial complex that determines glycophorin A expression. Mol Cell Biol 2004, 24:1439-1452.
7. Wadman I.A., Osada H., Grütz G.G., et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J 1997, 16:3145-3157.
8. Shivdasani R.A., Mayer E.L., Orkin S.H. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature 1995, 373:432-434.
9. Göttgens B., Nastos A., Kinston S., et al. Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors. EMBO J 2002, 21:3039-3050.
10. Fujiwara T., O'Geen H., Keles S., et al. Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell 2009, 36:667-681.
11. Fujiwara T., Lee H.Y., Sanalkumar R., Bresnick E.H. Building multifunctionality into a complex containing master regulators of hematopoiesis. Proc Natl Acad Sci U S A 2010, 107:20429-20434.
12. Schuh A.H., Tipping A.J., Clark A.J., et al. ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis. Mol Cell Biol 2005, 25:10235-10250.
13. Goardon N., Lambert J.A., Rodriguez P., et al. ETO2 coordinates cellular proliferation and differentiation during erythropoiesis. EMBO J 2006, 25:357-366.
14. Meier N., Krpic S., Rodriguez P., et al. Novel binding partners of Ldb1 are required for haematopoietic development. Development 2006, 133:4913-4923.
15. Boehm T., Foroni L., Kaneko Y., Perutz M.F., Rabbitts T.H. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc Natl Acad Sci U S A 1991, 88:4367-4371.
16. Royer-Pokora B., Loos U., Ludwig W.D. TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). Oncogene 1991, 6:1887-1893.
17. Yamada Y., Pannell R., Forster A., Rabbitts T.H. The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice. Proc Natl Acad Sci U S A 2000, 97:320-324.
18. Yamada Y., Warren A.J., Dobson C., Forster A., Pannell R., Rabbitts T.H. The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Proc Natl Acad Sci U S A 1998, 95:3890-3895.
19. Li L., Jothi R., Cui K., et al. Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells. Nat Immunol 2011, 12:129-136.
20. Warren A.J., Colledge W.H., Carlton M.B., Evans M.J., Smith A.J., Rabbitts T.H. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell 1994, 78:45-57.
21. Tripic T., Deng W., Cheng Y., et al. SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood 2009, 113:2191-2201.
22. Kurita R., Suda N., Sudo K., et al. Establishment of immortalized human erythroid progenitor cell lines able to produce enucleated red blood cells. PLoS ONE 2013, 8:e59890.
23. Fujiwara T., Alqadi Y.W., Okitsu Y., et al. Role of transcriptional corepressor ETO2 in erythroid cells. Exp Hematol 2013, 41:303-315.
24. Sankaran V.G., Menne T.F., Xu J., et al. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science 2008, 322:1839-1842.
25. Cooper M.C., Levy J., Cantor L.N., Marks P.A., Rifkind R.A. The effect of erythropoietin on colonial growth of erythroid precursor cells invitro. Proc Natl Acad Sci U S A 1974, 71:1677-1680.
26. Morgenstern J.P., Land H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res 1990, 18:3587-3596.
27. Lam L.T., Ronchini C., Norton J., Capobianco A.J., Bresnick E.H. Suppression of erythroid but not megakaryocytic differentiation of human K562 erythroleukemic cells by notch-1. J Biol Chem 2000, 275:19676-19684.
28. Wilkinson-White L., Gamsjaeger R., Dastmalchi S., et al. Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1. Proc Natl Acad Sci U S A 2011, 108:14443-14448.
29. Campbell A.E., Wilkinson-White L., Mackay J.P., Matthews J.M., Blobel G.A. Analysis of disease-causing GATA1 mutations in murine gene complementation systems. Blood 2013, 121:5218-5227.
30. Lozzio C.B., Lozzio B.B., Machado E.A., Fuhr J.E., Lair S.V., Bamberger E.G. Effects of sodium butyrate on human chronic myelogenous leukaemia cell line K562. Nature 1979, 281:709-710.
31. Visvader J.E., Mao X., Fujiwara Y., Hahm K., Orkin S.H. The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc Natl Acad Sci U S A 1997, 94:13707-13712.
32. Kerenyi M.A., Orkin S.H. Networking erythropoiesis. J Exp Med 2010, 207:2537-2541.
33. Felli N., Pedini F., Romania P., et al. MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis. Haematologica 2009, 94:479-486.
34. El Omari K., Hoosdally S.J., Tuladhar K., et al. Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex. Blood 2011, 117:2146-2156.
35. Terano T., Zhong Y., Toyokuni S., Hiai H., Yamada Y. Transcriptional control of fetal liver hematopoiesis: dominant negative effect of the overexpression of the LIM domain mutants of LMO2. Exp Hematol 2005, 33:641-651.
36. Yu M., Riva L., Xie H., et al. Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell 2009, 36:682-695.
37. Bresnick E.H., Katsumura K.R., Lee H.Y., Johnson K.D., Perkins A.S. Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies. Nucleic Acids Res 2012, 40:5819-5831.
38. Pal S., Cantor A.B., Johnson K.D., et al. Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Proc Natl Acad Sci U S A 2004, 101:980-985.
39. Letting D.L., Chen Y.Y., Rakowski C., Reedy S., Blobel G.A. Context-dependent regulation of GATA-1 by friend of GATA-1. Proc Natl Acad Sci U S A 2004, 101:476-481.