Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system

Nature Genetics

Volumn 25, Issue 2, 2000, Pages 209-212

  Lim, Kim Chew ^a   Lakshmanan, Ganesh ^a   Crawford, Susan E ^b   Gu, Yi ^a   Grosveld, Frank ^b,c   Engel, James Douglas ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

NORADRENALIN; TRANSCRIPTION FACTOR GATA 3;

ADRENERGIC SYSTEM; ARTICLE; CELL LINEAGE; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; GENE EXPRESSION; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL CREST CELL; NEUROENDOCRINE DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; TRANSGENIC MOUSE;

ANIMALS; CROSSES, GENETIC; DIHYDROXYPHENYLALANINE; DNA-BINDING PROTEINS; DOPAMINE BETA-HYDROXYLASE; DROXIDOPA; EMBRYO; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; GATA3 TRANSCRIPTION FACTOR; GENE DELETION; GENES, LETHAL; GENOTYPE; KIDNEY; MALE; MICE; MICE, KNOCKOUT; NEURAL CREST; NOREPINEPHRINE; PHENOTYPE; PREGNANCY; RNA, MESSENGER; SYMPATHETIC NERVOUS SYSTEM; TRANS-ACTIVATORS; TYROSINE 3-MONOOXYGENASE;

EID: 0034096902     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/76080     Document Type: Article

References (27)

1. Pandolfi, P.P. et al. Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis. Nature Genet. 11, 40-44 (1995).
2. Lakshmanan, G. et al. Localization of distant urogenital system-, central nervous system-, and endocardium-specific transcriptional regulatory elements in the GATA-3 locus. Mol. Cell. Biol. 19, 1558-1568 (1999).
3. Lakshmanan, G., Lieuw, K.H., Grosveld, F. & Engel, J.D. Partial rescue of Gata3 by yeast artificial chromosome transgenes. Dev. Biol. 204, 451-463 (1998).
4. Kitsukawa, T. et al. Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. Neuron 19, 995-1005 (1997).
5. Britsch, S. et al. The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev. 12, 1825-1836 (1998).
6. Groves, A.K. et al. Differential regulation of transcription factor gene expression and phenotypic markers in developing sympathetic neurons. Development 121, 887-901 (1995).
7. Rahman, M.K., Nagatsu, T. & Kato, T. Aromatic L-amino acid decarboxylase activity in central and peripheral tissues and serum of rats with L-DOPA and L-5-hydroxytryptophan as substrates. Biochem. Pharmacol. 30, 645-649 (1981).
8. Thomas, S.A., Matsumoto, A.M. & Palmiter, R.D. Noradrenaline is essential for mouse fetal development. Nature 374, 643-546 (1995).
9. Zhou, Q.Y., Quaife, C.J. & Palmiter, R.D. Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature 374, 640-643 (1995).
10. Kobayashi, K. et al. Targeted disruption of the tyrosine hydroxylase locus results in severe catecholamine depletion and perinatal lethality in mice. J. Biol. Chem. 270, 27235-27243 (1995).
11. Tiveron, M.C., Hirsch, M.R. & Brunet, J.F. The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system. J. Neurosci. 16, 7649-7660 (1996).
12. Hirsch, M.R., Tiveron, M.C., Guillemot, F., Brunet, J.F. & Goridis, C. Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system. Development 125, 599-608 (1998).
13. Pattyn, A., Morin, X., Cremer, H., Goridis, C. & Brunet, J.F. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature 399, 366-370 (1999).
14. Morin, X. et al. Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a. Neuron 18, 411-423 (1997).
15. Oosterwegel, M., Timmerman, J., Leiden, J. & Clevers, H. Expression of GATA-3 during lymphocyte differentiation and mouse embryogenesis. Dev. Immunol. 3, 1-11 (1992).
16. Nardelli, J., Thiesson, D., Fujiwara, Y., Tsai, F.Y. & Orkin, S.H. Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system. Dev. Biol. 210, 305-321 (1999).
17. George, K.M. et al. Embryonic expression and cloning of the murine GATA-3 gene. Development 120, 2673-2686 (1994).
18. Lieuw, K.H., Li, G., Zhou, Y., Grosveld, F. & Engel, J.D. Temporal and spatial control of murine GATA-3 transcription by promoter-proximal regulatory elements. Dev. Biol. 188, 1-16 (1997).
19. Vainio, S. & Muller, U. Inductive tissue interactions, cell signaling, and the control of kidney organogenesis. Cell 90, 975-978 (1997).
20. Esler, M., Kaye, D., Lambert, G., Esler, D. & Jennings, G. Adrenergic nervous system in heart failure. Am. J. Cardiol. 80, 7L-14L (1997).
21. Yang, C., Kim, H.S., Seo, H. & Kim, K.S. Identification and characterization of potential cis-regulatory elements governing transcriptional activation of the rat tyrosine hydroxylase gene. J. Neurochem. 71, 1358-1368 (1998).
22. Joh, T.H. et al. Unique and cell-type-specific tyrosine hydroxylase gene expression. Adv. Pharmacol. 42, 33-36 (1998).
23. Hoyle, G.W., Mercer, E.H., Palmiter, R.D. & Brinster, R.L. Cell-specific expression from the human dopamine β-hydroxylase promoter in transgenic mice is controlled via a combination of positive and negative regulatory elements. J. Neurosci. 14, 2455-2463 (1994).
24. Dressler, G.R. & Douglass, E.C. Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor. Proc. Natl Acad. Sci. USA 89, 1179-1183 (1992).
25. ten Berge, D., Brouwer, A., Korving, J., Martin, J.F. & Meijlink, F. Prx1 and Prx2 in skeletogenesis: Roles in the craniofacial region, inner ear and limbs. Development 125, 3831-3842 (1998).
26. Leonard, M.W., Lim, K.C. & Engel, J.D. Expression of the chicken GATA factor family during early erythroid development and differentiation. Development 119, 519-531 (1993).
27. Onodera, K., Shavit, J.A., Motohashi, H., Yamamoto, M. & Engel, J.D. Perinatal synthetic lethality and hematopoietic defects in compound mafG:mafK mutant mice. EMBO J. 19, 1335-1345 (2000).