MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis

Haematologica

Volumn 94, Issue 4, 2009, Pages 479-486

  Felli, Nadia ^a   Pedini, Francesca ^a   Romania, Paolo ^a   Biffoni, Mauro ^a   Morsilli, Ornella ^a   Castelli, Germana ^a   Santoro, Simona ^a   Chicarella, Simona ^a   Sorrentino, Antonio ^a   Peschle, Cesare ^a,b   Marziali, Giovanna ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b IRCCS MULTIMEDICA   (Italy)

Author keywords

Erythroid differentiation; Hematopoietic progenitors cells; MicroRNA; Transcription factors

Indexed keywords

ERYTHROPOIETIN; LIM ONLY PROTEIN 2; LIM PROTEIN; MICRORNA; PROTEIN; RNA; UNCLASSIFIED DRUG;

ARTICLE; CD34 SELECTION; CELL CULTURE; CLONOGENIC ASSAY; CONTROLLED STUDY; CULTURE MEDIUM; ERYTHROBLAST; ERYTHROID CELL; ERYTHROPOIESIS; GENE EXPRESSION REGULATION; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RNA INTERFERENCE; UMBILICAL CORD BLOOD; UNTRANSLATED REGION;

CELL DIFFERENTIATION; DNA-BINDING PROTEINS; ERYTHROID CELLS; ERYTHROPOIESIS; FETAL BLOOD; GENE EXPRESSION REGULATION; HUMANS; METALLOPROTEINS; MICRORNAS;

EID: 66349138750     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2008.002345     Document Type: Article

References (40)

1. Cantor AB, Orkin SH. Transcript- ional regulation of erythropoiesis: an affair involving multiple partners. Oncogene 2002;21: 3368-76.
2. Kim SI, Bresnick EH. Transcriptional control of erythropoiesis: emerging mechanisms and principles. Oncogene 2007;26:6777-94.
3. Nam CH, Rabbitts TH. The role of LMO2 in development and in T cell leukemia after chromosomal trans- location or retroviral insertion. Mol Ther 2006;13:15-25.
4. Warren AJ, Colledge WH, Carlton MB, Evans MJ, Smith AJ, Rabbitts TH. The oncogenic cysteine-rich LIM domain protein rbtn2 is essen- tial for erythroid development. Cell 1994;78:45-57.
5. Wadman IA, Osada H, Grütz GG, Agulnick AD, Westphal H, Forster A, et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J 1997;16:3145-57.
6. Terano T, Zhong Y, Toyokuni S, Hiai H, Yamada Y. Transcriptional con- trol of fetal liver hematopoiesis: dominant negative effect of the overexpression of the LIM domain mutants of LMO2. Exp Hematol 2005;33:641-51.
7. Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, et al. The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. Blood 2002;100:2430-40.
8. Lahlil R, Lécuyer E, Herblot S, Hoang T. SCL assembles a multifac- torial complex that determines gly- cophorin A expression. Mol Cell Biol 2004;24:1439-52.
9. Anguita E, Hughes J, Heyworth C, Blobel GA, Wood WG, Higgs DR. Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2. EMBO J 2004;23:2841-52.
10. Hansson A, Zetterblad J, van Duren C, Axelson H, Jönsson JI. The Lim- only protein LMO2 acts as a positive regulator of erythroid differentia- tion. Biochem Biophys Res Com- mun 2007;364:675-81.
11. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and func- tion. Cell 2004;116:281-97.
12. Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 2006;20:515-24.
13. Shivdasani RA. MicroRNAs: regula- tors of gene expression and cell dif- ferentiation. Blood 2006;108:3646-53.
14. Lawrie CH. MicroRNAs and haema- tology: small molecules, big func- tion. Br J Haematol 2007;137:503-12.
15. Garzon R, Croce CM. MicroRNAs in normal and malignant hemato- poiesis. Curr Opin Hematol 2008; 15:352-8.
16. Bruchova H, Yoon D, Agarwal AM, Mendell J, Prchal JT. Regulated expression of microRNAs in normal and polycythemia vera erythro- poiesis. Exp Hematol 2007;35:1657-67.
17. Masaki S, Ohtsuka R, Abe Y, Muta K, Umemura T. Expression patterns of microRNAs 155 and 451 during normal human erythropoiesis. Biochem Biophys Res Commun 2007;364:509-14.
18. Choong ML, Yang HH, McNiece I. MicroRNA expression profiling dur- ing human cord blood-derived CD34 cell erythropoiesis. Exp Hematol 2007;35:551-64.
19. Kosaka N, Sugiura K, Yamamoto Y, Yoshioka Y, Miyazaki H, Komatsu N, et al. Identification of erythropoi- etin-induced microRNAs in haematopoietic cells during ery- throid differentiation. Br J Haematol 2008;142:293-300.
20. Chen SY, Wang Y, Telen MJ, Chi JT. The genomic analysis of erythrocyte microRNA expression in sickle cell diseases. PLoS ONE 2008;3:e2360.
21. Fazi F, Rosa A, Fatica A, Gelmetti V, De Marchis ML, Nervi C, et al. Minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regu- lates human granulopoiesis. Cell 2005;123:819-31.
22. Fukao T, Fukuda Y, Kiga K, Sharif J, Hino K, Enomoto Y, et al. An evolu- tionarily conserved mechanism for microRNA-223 expression revealed by microRNA gene profiling. Cell 2007;129:617-31.
23. Johnnidis JB, Harris MH, Wheeler RT, Stehling-Sun S, Lam MH, Kirak O, et al. Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 2008;451:1125-9.
24. Monticelli S, Ansel KM, Xiao C, Socci ND, Krichevsky AM, Thai TH, et al. MicroRNA profiling of the murine hematopoietic system. Genome Biol 2005;6:R71.
25. Gabbianelli M, Testa U, Massa A, Pelosi E, Sposi NM, Riccioni R, et al. Hemoglobin switching in unicellular erythroid culture of sibling erythroid burst-forming units: kit ligand induces a dose-dependent fetal hemoglobin reactivation potentiat- ed by sodium butyrate. Blood 2000; 95:3555-61.
26. Kuhn DE, Martin MM, Feldman DS, Terry AV Jr, Nuovo GJ, Elton TS. Experimental validation of miRNA targets. Methods 2008;44:47-54.
27. Kertesz M, Iovino N, Unnerstall U, Gaul U, Segal E. The role of site accessibility in microRNA target recognition. Nat Genet 2007;39: 1278-84.
28. Felli N, Fontana L, Pelosi E, Botta R, Bonci D, Facchiano F, et al. MicroRNAs 221 and 222 inhibit nor- mal erythropoiesis and erythro- leukemic cell growth via kit receptor down-modulation. Proc Natl Acad Sci USA 2005;102:18081-6.
29. Bahnson AB, Dunigan JT, Baysal BE, Mohney T, Atchison RW, Nimga- onkar MT, et al. Centrifugal en- hancement of retroviral mediated gene transfer. J Virol Methods 1995; 54:131-43.
30. Labbaye C, Spinello I, Quaranta MT, Pelosi E, Pasquini L, Petrucci E, et al. A pathway comprising PLZF, miR-146a and its target CXCR4 con- trols megakaryopoiesis. Nat Cell Biol 2008;10:788-801.
31. Fontana L, Pelosi E, Greco P, Racanicchi S, Testa U, Liuzzi F, et al. MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation. Nat Cell Biol 2007;9: 775-93.
32. Eulalio A, Huntzinger E, Izaurralde E. Getting to the root of miRNA- mediated gene silencing. Cell 2008; 132:9-14.
33. Meister G, Landthaler M, Dorsett Y, Tuschl T. Sequence-specific inhibi- tion of microRNA- and siRNA- induced RNA silencing. RNA 2004; 10:544-50.
34. Bakker WJ, van Dijk TB, Parren-van Amelsvoort M, Kolbus A, Yama- moto K, Steinlein P, et al. Differ- ential regulation of Foxo3a target genes in erythropoiesis. Mol Cell Biol 2007;27:3839-54.
35. Bakker WJ, Blázquez-Domingo M, Kolbus A, Besooyen J, Steinlein P, Beug H, et al. FoxO3a regulates ery- throid differentiation and induces BTG1, an activator of protein argi- nine methyl transferase 1. J Cell Biol 2004;164:175-84.
36. Van Loo PF, Bouwman P, Ling KW, Middendorp S, Suske G, Grosveld F, et al. Impaired hematopoiesis in mice lacking the transcription factor Sp3. Blood 2003;102:858-66.
37. Vitelli L, Condorelli G, Lulli V, Hoang T, Luchetti L, Croce CM, Peschle C. A pentamer transcrip- tional complex including tal-1 and retinoblastoma protein downmodu- lates c-kit expression in normal ery- throblasts. Mol Cell Biol 2000;20: 5330-42.
38. Goh SH, Josleyn M, Lee YT, Danner RL, Gherman RB, Cam MC, Miller JL. The human reticulocyte tran- scriptome. Physiol Genomics 2007; 30:172-8.
39. Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD, et al. MicroRNA miR- 24 inhibits erythropoiesis by target- ing activin type I receptor ALK4. Blood 2008;111:588-95.
40. Zhao H, Kalota A, Jin S, Gewirtz AM. The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells. Blood 2009;113:505-16.