Role of transcriptional corepressor ETO2 in erythroid cells

Experimental Hematology

Volumn 41, Issue 3, 2013, Pages 303-315.e1

  Fujiwara, Tohru ^a   Alqadi, Yarob Wael ^a   Okitsu, Yoko ^a   Fukuhara, Noriko ^a   Onishi, Yasushi ^a   Ishizawa, Kenichi ^a   Harigae, Hideo ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; ETO2 PROTEIN; RETROVIRUS VECTOR; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR PU 1; UNCLASSIFIED DRUG;

ALAS2 GENE; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN K 562; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; ERYTHROBLAST; ERYTHROID CELL; EX VIVO STUDY; GENE EXPRESSION PROFILING; GENE LOCUS; GENE REPRESSION; GLOBIN GENE; HBA GENE; HBB GENE; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; UPREGULATION;

EID: 84874995503     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2012.10.015     Document Type: Article

References (36)

1. Bresnick E.H., Lee H.Y., Fujiwara T., Johnson K.D., Keles S. GATA switches as developmental drivers. J Biol Chem 2010, 285:31087-31093.
2. Yamamoto M., Ko L.J., Leonard M.W., Beug H., Orkin S.H., Engel J.D. Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes Dev 1990, 4:1650-1662.
3. Lim K.C., Lakshmanan G., Crawford S.E., Gu Y., Grosveld F., Engel J.D. Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Nat Genet 2000, 25:209-212.
4. Tsai F.Y., Keller G., Kuo F.C., et al. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 1994, 371:221-226.
5. Evans T., Reitman M., Felsenfeld G. An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes. Proc Natl Acad Sci U S A 1988, 85:5976-5980.
6. Lahlil R., Lécuyer E., Herblot S., Hoang T. SCL assembles a multifactorial complex that determines glycophorin A expression. Mol Cell Biol 2004, 24:1439-1452.
7. Wadman I.A., Osada H., Grütz G.G., et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J 1997, 16:3145-3157.
8. Shivdasani R.A., Mayer E.L., Orkin S.H. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature 1995, 373:432-434.
9. Göttgens B., Nastos A., Kinston S., et al. Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors. EMBO J 2002, 21:3039-3050.
10. Fujiwara T., O'Geen H., Keles S., et al. Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell 2009, 36:667-681.
11. Fujiwara T., Lee H.Y., Sanalkumar R., Bresnick E.H. Building multifunctionality into a complex containing master regulators of hematopoiesis. Proc Natl Acad Sci U S A 2010, 107:20429-20434.
12. Amann J.M., Nip J., Strom D.K., et al. ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. Mol Cell Biol 2001, 21:6470-6483.
13. Schuh A.H., Tipping A.J., Clark A.J., et al. ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis. Mol Cell Biol 2005, 25:10235-10250.
14. Goardon N., Lambert J.A., Rodriguez P., et al. ETO2 coordinates cellular proliferation and differentiation during erythropoiesis. EMBO J 2006, 25:357-366.
15. Kiefer C.M., Lee J., Hou C., et al. Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells. Blood 2011, 118:6200-6208.
16. Meier N., Krpic S., Rodriguez P., et al. Novel binding partners of Ldb1 are required for haematopoietic development. Development 2006, 133:4913-4923.
17. Tripic T., Deng W., Cheng Y., et al. SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood 2009, 113:2191-2201.
18. Soler E., Andrieu-Soler C., de Boer E., et al. The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation. Genes Dev 2010, 24:277-289.
19. Chyla B.J., Moreno-Miralles I., Steapleton M.A., et al. Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation. Mol Cell Biol 2008, 28:6234-6247.
20. Fischer M.A., Moreno-Miralles I., Hunt A., Chyla B.J., Hiebert S.W. Myeloid translocation gene 16 is required for maintenance of haematopoietic stem cell quiescence. EMBO J 2012, 31:1494-1505.
21. Hamlett I., Draper J., Strouboulis J., Iborra F., Porcher C., Vyas P. Characterization of megakaryocyte GATA1-interacting proteins: the corepressor ETO2 and GATA1 interact to regulate terminal megakaryocyte maturation. Blood 2008, 112:2738-2749.
22. Guo Y.M., Ishii K., Hirokawa M., et al. CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells. Blood 2010, 115:4569-4579.
23. Fujiwara T., Harigae H., Takahashi S., et al. Differential gene expression profiling between wild-type and ALAS2-null erythroblasts: identification of novel heme-regulated genes. Biochem Biophys Res Commun 2006, 340:105-110.
24. Morgenstern J.P., Land H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res 1990, 18:3587-3596.
25. Benjamini Y., Yekutieli D. The control of the false discovery rate in multiple testing under dependency. Ann Stat 2001, 29:1165-1188.
26. Wontakal S.N., Guo X., Smith C., et al. A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation. Proc Natl Acad Sci U S A 2012, 109:3832-3837.
27. Rekhtman N., Radparvar F., Evans T., Skoultchi A.I. Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Genes Dev 1999, 13:1398-1411.
28. Wontakal S.N., Guo X., Will B., et al. A large gene network in immature erythroid cells is controlled by the myeloid and B cell transcriptional regulator PU.1. PLoS Genet 2011, 7:e1001392.
29. Kerenyi M.A., Orkin S.H. Networking erythropoiesis. J Exp Med 2010, 207:2537-2541.
30. Engel M.E., Nguyen H.N., Mariotti J., Hunt A., Hiebert S.W. Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specification. Mol Cell Biol 2010, 30:1852-1863.
31. Moore A.C., Amann J.M., Williams C.S., et al. Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription. Mol Cell Biol 2008, 28:977-987.
32. Wilson N.K., Foster S.D., Wang X., et al. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell 2010, 7:532-544.
33. Yoshida M., Nomura S., Beppu T. Effects of trichostatins on differentiation of murine erythroleukemia cells. Cancer Res 1987, 47:3688-3691.
34. Ando K., Yahata T., Sato T., et al. Direct evidence for ex vivo expansion of human hematopoietic stem cells. Blood 2006, 107. 3371-3317.
35. Lindberg S.R., Olsson A., Persson A.M., Olsson I. The Leukemia-associated ETO homologues are differently expressed during hematopoietic differentiation. Exp Hematol 2005, 33:189-198.
36. Welch J.J., Watts J.A., Vakoc C.R., et al. Global regulation of erythroid gene expression by transcription factor GATA-1. Blood 2004, 104:3136-3147.