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Volumn 117, Issue 7, 2011, Pages 2146-2156

Structure of the leukemia oncogene LMO2: Implications for the assembly of a hematopoietic transcription factor complex

Author keywords

[No Author keywords available]

Indexed keywords

LIM ONLY PROTEIN 2; NUCLEIC ACID BINDING PROTEIN; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR TAL1; UNCLASSIFIED DRUG;

EID: 79951831250     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-07-293357     Document Type: Article
Times cited : (59)

References (60)
  • 2
    • 0025933456 scopus 로고
    • TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11)
    • Royer-Pokora B, Loos U, Ludwig WD. TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). Oncogene. 1991;6(10):1887-1893. (Pubitemid 21924023)
    • (1991) Oncogene , vol.6 , Issue.10 , pp. 1887-1893
    • Royer-Pokora, B.1    Loos, U.2    Ludwig, W.-D.3
  • 3
    • 33751168051 scopus 로고    scopus 로고
    • The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia
    • Van Vlierberghe P, van Grotel M, Beverloo HB, et al. The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia. Blood. 2006;108(10):3520-3529.
    • (2006) Blood , vol.108 , Issue.10 , pp. 3520-3529
    • Van Vlierberghe, P.1    Van Grotel, M.2    Beverloo, H.B.3
  • 4
    • 76749097260 scopus 로고    scopus 로고
    • The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal
    • McCormack MP, Young LF, Vasudevan S, et al. The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal. Science. 2010;327(5967):879-883.
    • (2010) Science , vol.327 , Issue.5967 , pp. 879-883
    • McCormack, M.P.1    Young, L.F.2    Vasudevan, S.3
  • 6
    • 8444240109 scopus 로고    scopus 로고
    • The LIM domain: From the cytoskeleton to the nucleus
    • DOI 10.1038/nrm1499
    • Kadrmas JL, Beckerle MC. The LIM domain: from the cytoskeleton to the nucleus. Nat Rev Mol Cell Biol. 2004;5(11):920-931. (Pubitemid 39486543)
    • (2004) Nature Reviews Molecular Cell Biology , vol.5 , Issue.11 , pp. 920-931
    • Kadrmas, J.L.1    Beckerle, M.C.2
  • 7
    • 0033135847 scopus 로고    scopus 로고
    • The SCL gene: From case report to critical hematopoietic regulator
    • Begley CG, Green AR. The SCL gene: from case report to critical hematopoietic regulator. Blood. 1999;93(9):2760-2770. (Pubitemid 29200765)
    • (1999) Blood , vol.93 , Issue.9 , pp. 2760-2770
    • Begley, C.G.1    Green, A.R.2
  • 8
    • 0029981648 scopus 로고    scopus 로고
    • Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice
    • Larson RC, Lavenir I, Larson TA, et al. Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. EMBO J. 1996;15(5):1021-1027. (Pubitemid 26077830)
    • (1996) EMBO Journal , vol.15 , Issue.5 , pp. 1021-1027
    • Larson, R.C.1    Lavenir, I.2    Larson, T.A.3    Baer, R.4    Warren, A.J.5    Wadman, I.6    Nottage, K.7    Rabbitts, T.H.8
  • 9
    • 0027980311 scopus 로고
    • The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells
    • Valge-Archer VE, Osada H, Warren AJ, et al. The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. Proc Natl Acad Sci U S A. 1994;91(18):8617-8621.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.18 , pp. 8617-8621
    • Valge-Archer, V.E.1    Osada, H.2    Warren, A.J.3
  • 10
    • 0030581174 scopus 로고    scopus 로고
    • The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages
    • DOI 10.1016/S0092-8674(00)80076-8
    • Porcher C, Swat W, Rockwell K, Fujiwara Y, Alt FW, Orkin SH. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell. 1996;86(1):47-57. (Pubitemid 26256577)
    • (1996) Cell , vol.86 , Issue.1 , pp. 47-57
    • Porcher, C.1    Swat, W.2    Rockwell, K.3    Fujiwara, Y.4    Alt, F.W.5    Orkin, S.H.6
  • 11
    • 0028858855 scopus 로고
    • Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
    • Shivdasani RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995;373(6513):432- 434.
    • (1995) Nature , vol.373 , Issue.6513 , pp. 432-434
    • Shivdasani, R.A.1    Mayer, E.L.2    Orkin, S.H.3
  • 12
    • 33947223259 scopus 로고    scopus 로고
    • The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish
    • DOI 10.1182/blood-2006-02-003087
    • Patterson LJ, Gering M, Eckfeldt CE, et al. The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish. Blood. 2007;109(6):2389-2398. (Pubitemid 46425879)
    • (2007) Blood , vol.109 , Issue.6 , pp. 2389-2398
    • Patterson, L.J.1    Gering, M.2    Eckfeldt, C.E.3    Green, A.R.4    Verfaillie, C.M.5    Ekker, S.C.6    Patient, R.7
  • 13
    • 0030824801 scopus 로고    scopus 로고
    • LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1
    • Osada H, Grutz GG, Axelson H, Forster A, Rabbitts TH. LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1. Leukemia. 1997;11(suppl 3):307-312.
    • (1997) Leukemia , vol.11 , Issue.SUPPL. 3 , pp. 307-312
    • Osada, H.1    Grutz, G.G.2    Axelson, H.3    Forster, A.4    Rabbitts, T.H.5
  • 14
    • 0037134789 scopus 로고    scopus 로고
    • The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene
    • DOI 10.1016/S0014-5793(02)02814-4, PII S0014579302028144
    • Begay-Muller V, Ansieau S, Leutz A. The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene. FEBS Lett. 2002;521(1):36-38. (Pubitemid 34628453)
    • (2002) FEBS Letters , vol.521 , Issue.1-3 , pp. 36-38
    • Begay-Muller, V.1    Ansieau, S.2    Leutz, A.3
  • 16
    • 0029906061 scopus 로고    scopus 로고
    • Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins
    • DOI 10.1038/384270a0
    • Agulnick AD, Taira M, Breen JJ, Tanaka T, Dawid IB, Westphal H. Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature. 1996;384(6606):270-272. (Pubitemid 26396977)
    • (1996) Nature , vol.384 , Issue.6606 , pp. 270-272
    • Agulnick, A.D.1    Taira, M.2    Breen, J.J.3    Tanaka, T.4    Dawid, I.B.5    Westphal, H.6
  • 17
    • 0027973545 scopus 로고
    • Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia
    • Wadman I, Li J, Bash RO, et al. Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. EMBO J. 1994;13(20):4831-4839. (Pubitemid 24319365)
    • (1994) EMBO Journal , vol.13 , Issue.20 , pp. 4831-4839
    • Wadman, I.1    Li, J.2    Bash, R.O.3    Forster, A.4    Osada, H.5    Rabbitts, T.H.6    Baer, R.7
  • 18
    • 0030999645 scopus 로고    scopus 로고
    • The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins
    • DOI 10.1093/emboj/16.11.3145
    • Wadman IA, Osada H, Grutz GG, et al. The LIMonly protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J. 1997;16(11):3145-3157. (Pubitemid 27234954)
    • (1997) EMBO Journal , vol.16 , Issue.11 , pp. 3145-3157
    • Wadman, I.A.1    Osada, H.2    Grutz, G.G.3    Agulnick, A.D.4    Westphal, H.5    Forster, A.6    Rabbitts, T.H.7
  • 19
    • 0030756298 scopus 로고    scopus 로고
    • Functional analysis of the nuclear LIM domain interactor NLI
    • Jurata LW, Gill GN. Functional analysis of the nuclear LIM domain interactor NLI. Mol Cell Biol. 1997;17(10):5688-5698. (Pubitemid 27411076)
    • (1997) Molecular and Cellular Biology , vol.17 , Issue.10 , pp. 5688-5698
    • Jurata, L.W.1    Gill, G.N.2
  • 20
    • 0034004352 scopus 로고    scopus 로고
    • The LIM domain: Regulation by association
    • DOI 10.1016/S0925-4773(99)00314-7, PII S0925477399003147
    • Bach I. The LIM domain: regulation by association. Mech Dev. 2000;91(1):5-17. (Pubitemid 30125900)
    • (2000) Mechanisms of Development , vol.91 , Issue.1-2 , pp. 5-17
    • Bach, I.1
  • 21
    • 0032569833 scopus 로고    scopus 로고
    • Identification of the LMO4 gene encoding an interaction partner of the LIM-binding protein LDB1/NLI1: A candidate for displacement by LMO proteins in T cell acute leukaemia
    • Grutz G, Forster A, Rabbitts TH. Identification of the LMO4 gene encoding an interaction partner of the LIM-binding protein LDB1/NLI1: a candidate for displacement by LMO proteins in T cell acute leukaemia. Oncogene. 1998;17(21):2799-2803. (Pubitemid 28554239)
    • (1998) Oncogene , vol.17 , Issue.21 , pp. 2799-2803
    • Grutz, G.1    Forster, A.2    Rabbitts, T.H.3
  • 22
    • 0028278325 scopus 로고
    • The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development
    • DOI 10.1016/0092-8674(94)90571-1
    • Warren AJ, Colledge WH, Carlton MB, Evans MJ, Smith AJ, Rabbitts TH. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell. 1994;78(1):45-57. (Pubitemid 24228299)
    • (1994) Cell , vol.78 , Issue.1 , pp. 45-57
    • Warren, A.J.1    Colledge, W.H.2    Carlton, M.B.L.3    Evans, M.J.4    Smith, A.J.H.5    Rabbitts, T.H.6
  • 24
    • 0032789064 scopus 로고    scopus 로고
    • Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene
    • Vyas P, McDevitt MA, Cantor AB, Katz SG, Fujiwara Y, Orkin SH. Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene. Development. 1999;126(12):2799-2811. (Pubitemid 29338639)
    • (1999) Development , vol.126 , Issue.12 , pp. 2799-2811
    • Vyas, P.1    McDevitt, M.A.2    Cantor, A.B.3    Katz, S.G.4    Fujiwara, Y.5    Orkin, S.H.6
  • 25
    • 0033944604 scopus 로고    scopus 로고
    • A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts
    • DOI 10.1128/MCB.20.14.5330-5342.2000
    • Vitelli L, Condorelli G, Lulli V, et al. A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts. Mol Cell Biol. 2000;20(14):5330-5342. (Pubitemid 30431586)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.14 , pp. 5330-5342
    • Vitelli, L.1    Condorelli, G.2    Lulli, V.3    Hoang, T.4    Luchetti, L.5    Croce, C.M.6    Peschle, C.7
  • 26
    • 0032486401 scopus 로고    scopus 로고
    • Multiple proteins binding to a GATA-E box-GATA motif regulate the erythroid Kruppel-like factor (EKLF) gene
    • DOI 10.1074/jbc.273.23.14347
    • Anderson KP, Crable SC, Lingrel JB. Multiple proteins binding to a GATA-E box-GATA motif regulate the erythroid Kruppel-like factor (EKLF) gene. J Biol Chem. 1998;273(23):14347-14354. (Pubitemid 28319151)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.23 , pp. 14347-14354
    • Anderson, K.P.1    Crable, S.C.2    Lingrel, J.B.3
  • 27
    • 0032541488 scopus 로고    scopus 로고
    • The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells
    • DOI 10.1093/emboj/17.16.4594
    • Grutz GG, Bucher K, Lavenir I, Larson T, Larson R, Rabbitts TH. The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells. EMBO J. 1998;17(16):4594-4605. (Pubitemid 28377160)
    • (1998) EMBO Journal , vol.17 , Issue.16 , pp. 4594-4605
    • Grutz, G.G.1    Bucher, K.2    Lavenir, I.3    Larson, T.4    Larson, R.5    Rabbitts, T.H.6
  • 29
    • 0037148909 scopus 로고    scopus 로고
    • The LIM-domain protein Lmo2 is a key regulator of tumour angiogenesis: A new anti-angiogenesis drug target
    • DOI 10.1038/sj/onc/1205285
    • Yamada Y, Pannell R, Forster A, Rabbitts TH. The LIM-domain protein Lmo2 is a key regulator of tumour angiogenesis: a new anti-angiogenesis drug target. Oncogene. 2002;21(9):1309-1315. (Pubitemid 34214496)
    • (2002) Oncogene , vol.21 , Issue.9 , pp. 1309-1315
    • Yamada, Y.1    Pannell, R.2    Forster, A.3    Rabbitts, T.H.4
  • 31
    • 0037543995 scopus 로고    scopus 로고
    • Structural basis for the recognition of Idb1 by the N-terminal LIM domains of LMO2 and LMO4
    • DOI 10.1093/emboj/cdg196
    • Deane JE, Mackay JP, Kwan AH, Sum EY, Visvader JE, Matthews JM. Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4. EMBO J. 2003;22(9):2224-2233. (Pubitemid 36565545)
    • (2003) EMBO Journal , vol.22 , Issue.9 , pp. 2224-2233
    • Deane, J.E.1    Mackay, J.P.2    Kwan, A.H.Y.3    Sum, E.Y.M.4    Visvader, J.E.5    Matthews, J.M.6
  • 32
    • 19444371488 scopus 로고    scopus 로고
    • Transcriptional control of fetal liver hematopoiesis: Dominant negative effect of the overexpression of the LIM domain mutants of LMO2
    • DOI 10.1016/j.exphem.2005.01.018, PII S0301472X05001736
    • Terano T, Zhong Y, Toyokuni S, Hiai H, Yamada Y. Transcriptional control of fetal liver hematopoiesis: dominant negative effect of the overexpression of the LIM domain mutants of LMO2. Exp Hematol. 2005;33(6):641-651. (Pubitemid 40725830)
    • (2005) Experimental Hematology , vol.33 , Issue.6 , pp. 641-651
    • Terano, T.1    Zhong, Y.2    Toyokuni, S.3    Hiai, H.4    Yamada, Y.5
  • 33
    • 0034855611 scopus 로고    scopus 로고
    • Design, production and characterization of FLIN2 and FLIN4: The engineering of intramolecular ldb1:LMO complexes
    • Deane JE, Sum E, Mackay JP, Lindeman GJ, Visvader JE, Matthews JM. Design, production and characterization of FLIN2 and FLIN4: the engineering of intramolecular ldb1:LMO complexes. Protein Eng. 2001;14(7):493-499. (Pubitemid 32846935)
    • (2001) Protein Engineering , vol.14 , Issue.7 , pp. 493-499
    • Deane, J.E.1    Sum, E.2    Mackay, J.P.3    Lindeman, G.J.4    Visvader, J.E.5    Matthews, J.M.6
  • 34
    • 33646174873 scopus 로고    scopus 로고
    • Identification of the key LMO2-binding determinants on Ldb1
    • Ryan DP, Sunde M, Kwan AH, et al. Identification of the key LMO2-binding determinants on Ldb1. J Mol Biol. 2006;359(1):66-75.
    • (2006) J Mol Biol , vol.359 , Issue.1 , pp. 66-75
    • Ryan, D.P.1    Sunde, M.2    Kwan, A.H.3
  • 35
    • 78149343513 scopus 로고    scopus 로고
    • Purification, crystallization and preliminary X-ray analysis of a fusion of the LIM domains of LMO2 and the LID domain of Ldb1
    • El Omari K, Porcher C, Mancini EJ. Purification, crystallization and preliminary X-ray analysis of a fusion of the LIM domains of LMO2 and the LID domain of Ldb1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66(11):1466-1469.
    • (2010) Acta Crystallogr Sect F Struct Biol Cryst Commun , vol.66 , Issue.11 , pp. 1466-1469
    • El Omari, K.1    Porcher, C.2    Mancini, E.J.3
  • 36
    • 0031059866 scopus 로고    scopus 로고
    • Processing of X-ray diffraction data collected in oscillation mode
    • Otwinowski Z, Minor W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 1996;276:307-326.
    • (1996) Methods Enzymol , vol.276 , pp. 307-326
    • Otwinowski, Z.1    Minor, W.2
  • 38
    • 0000560808 scopus 로고    scopus 로고
    • MOLREP: An Automated Program for Molecular Replacement
    • Vagin A, Teplyakov A. MOLREP: an automated program for molecular replacement. J Appl Cryst. 1997;(30):1022-1025. (Pubitemid 127485985)
    • (1997) Journal of Applied Crystallography , vol.30 , Issue.6 , pp. 1022-1025
    • Vagin, A.1    Teplyakov, A.2
  • 41
    • 34547592557 scopus 로고    scopus 로고
    • MolProbity: All-atom contacts and structure validation for proteins and nucleic acids
    • Web Server issue
    • Davis IW, Leaver-Fay A, Chen VB, et al. MolProbity: all-atom contacts and structure validation for proteins and nucleic acids. Nucleic Acids Res. 2007;35(Web Server issue):W375-W383.
    • (2007) Nucleic Acids Res , vol.35
    • Davis, I.W.1    Leaver-Fay, A.2    Chen, V.B.3
  • 42
    • 33646044395 scopus 로고    scopus 로고
    • WHISCY: What information does surface conservation yield? Application to data-driven docking
    • de Vries SJ, van Dijk AD, Bonvin AM. WHISCY: what information does surface conservation yield? Application to data-driven docking. Proteins. 2006;63(3):479-489.
    • (2006) Proteins , vol.63 , Issue.3 , pp. 479-489
    • De Vries, S.J.1    Van Dijk, A.D.2    Bonvin, A.M.3
  • 44
    • 34548232365 scopus 로고    scopus 로고
    • Inference of Macromolecular Assemblies from Crystalline State
    • DOI 10.1016/j.jmb.2007.05.022, PII S0022283607006420
    • Krissinel E, Henrick K. Inference of macromolecular assemblies from crystalline state. J Mol Biol. 2007;372(3):774-797. (Pubitemid 47321791)
    • (2007) Journal of Molecular Biology , vol.372 , Issue.3 , pp. 774-797
    • Krissinel, E.1    Henrick, K.2
  • 46
    • 0032722671 scopus 로고    scopus 로고
    • Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding
    • Porcher C, Liao EC, Fujiwara Y, Zon LI, Orkin SH. Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development. 1999;126(20):4603-4615.
    • (1999) Development , vol.126 , Issue.20 , pp. 4603-4615
    • Porcher, C.1    Liao, E.C.2    Fujiwara, Y.3    Zon, L.I.4    Orkin, S.H.5
  • 49
    • 0346888544 scopus 로고    scopus 로고
    • Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1
    • DOI 10.1242/dev.00875
    • Gering M, Yamada Y, Rabbitts TH, Patient RK. Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1. Development. 2003;130(25):6187-6199. (Pubitemid 38008818)
    • (2003) Development , vol.130 , Issue.25 , pp. 6187-6199
    • Gering, M.1    Yamada, Y.2    Rabbitts, T.H.3    Patient, R.K.4
  • 50
    • 0029812422 scopus 로고    scopus 로고
    • Double fluorescent in situ hybridization to zebrafish embryos
    • DOI 10.1016/S0168-9525(96)90091-8
    • Jowett T, Yan YL. Double fluorescent in situ hybridization to zebrafish embryos. Trends Genet. 1996;12(10):387-389. (Pubitemid 26336473)
    • (1996) Trends in Genetics , vol.12 , Issue.10 , pp. 387-389
    • Jowett, T.1    Yan, Y.-L.2
  • 51
    • 47949099570 scopus 로고    scopus 로고
    • Implementing the LIM code: The structural basis for cell type-specific assembly of LIM-homeodomain complexes
    • Bhati M, Lee C, Nancarrow AL, et al. Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes. EMBO J. 2008;27(14):2018-2029.
    • (2008) EMBO J , vol.27 , Issue.14 , pp. 2018-2029
    • Bhati, M.1    Lee, C.2    Nancarrow, A.L.3
  • 57
    • 0028799441 scopus 로고
    • Association of erythroid transcription factors: Complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1
    • Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH. Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. Proc Natl Acad Sci U S A. 1995;92(21):9585-9589.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , Issue.21 , pp. 9585-9589
    • Osada, H.1    Grutz, G.2    Axelson, H.3    Forster, A.4    Rabbitts, T.H.5
  • 59
    • 66349096574 scopus 로고    scopus 로고
    • Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia
    • Appert A, Nam CH, Lobato N, et al. Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia. Cancer Res. 2009;69(11):4784-4790.
    • (2009) Cancer Res , vol.69 , Issue.11 , pp. 4784-4790
    • Appert, A.1    Nam, C.H.2    Lobato, N.3
  • 60
    • 59149084489 scopus 로고    scopus 로고
    • Competition between LIM-binding domains
    • Matthews JM, Bhati M, Craig VJ, et al. Competition between LIM-binding domains. Biochem Soc Trans. 2008;36(6):1393-1397.
    • (2008) Biochem Soc Trans , vol.36 , Issue.6 , pp. 1393-1397
    • Matthews, J.M.1    Bhati, M.2    Craig, V.J.3


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