Synthesis of novel 7-substituted pyrido[2′,3′:4,5]furo[3,2-d] pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6784-6788

  Deau, Emmanuel ^a   Loidreau, Yvonnick ^a   Marchand, Pascal ^b   Nourrisson, Marie Renée ^b   Loaëc, Nadège ^c,d   Meijer, Laurent ^d   Levacher, Vincent ^a   Besson, Thierry ^a  

^a NORMANDIE UNIVERSITÉ   (France)

^b UNIVERSITÉ DE NANTES   (France)

^c STATION BIOLOGIQUE   (France)

^d Centre de Perharidy   (France)

Author keywords

Dimroth rearrangement; Formamide degradation; Microwave assisted chemistry; Serine threonine kinases inhibitors; Suzuki Miyaura cross coupling

Indexed keywords

AMINE; CASEIN KINASE IDELTA; CASEIN KINASE IEPSILON; CYCLIN DEPENDENT KINASE 5; FORMAMIDE; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; HETEROCYCLIC COMPOUND; N,N DIMETHYLFORMAMIDE; PALLADIUM; PROTEIN P25; PROTEIN SERINE THREONINE KINASE; PYRIDO[2',3':4,5]FURO[3,2 D]PYRIMIDIN 4 AMINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; ATMOSPHERIC PRESSURE; CATALYSIS; CHEMICAL REACTION; CYCLIZATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; MICROWAVE IRRADIATION; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION;

DIMROTH REARRANGEMENT; FORMAMIDE DEGRADATION; MICROWAVE-ASSISTED CHEMISTRY; SERINE/THREONINE KINASES INHIBITORS; SUZUKI-MIYAURA CROSS-COUPLING;

AMINES; CATALYSIS; CYCLIZATION; ENZYME ACTIVATION; HETEROCYCLIC COMPOUNDS, 3-RING; MICROWAVES; PALLADIUM; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84888861819     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.10.019     Document Type: Article

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