Crocin improved locomotor function and mechanical behavior in the rat model of contused spinal cord injury through decreasing calcitonin gene related peptide (CGRP)

Phytomedicine

Volumn 21, Issue 1, 2013, Pages 62-67

  Karami, Masoume ^a   Bathaie, S Zahra ^a   Tiraihi, Taqi ^a,b   Habibi Rezaei, Mehran ^c   Arabkheradmand, Jalil ^b   Faghihzadeh, Soghrat ^a  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b Khatam Al Anbia Hospital   (Iran)

^c UNIVERSITY OF TEHRAN   (Iran)

Author keywords

Crocin; Locomotor recovery test; Mechanical behavioral test; Spinal cord injury; Thermal behavioral test

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CROCIN;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR CHANGE; BLOOD LEVEL; CHRONIC PAIN; CONTROLLED STUDY; FEMALE; INFLAMMATION; LOCOMOTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

CROCIN; LOCOMOTOR RECOVERY TEST; MECHANICAL BEHAVIORAL TEST; SPINAL CORD INJURY; THERMAL BEHAVIORAL TEST;

ANIMALS; BEHAVIOR, ANIMAL; CALCITONIN GENE-RELATED PEPTIDE; CAROTENOIDS; CHRONIC PAIN; CROCUS; FEMALE; HOT TEMPERATURE; LOCOMOTION; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR; SPINAL CORD INJURIES;

EID: 84888856813     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.07.013     Document Type: Article

References (56)

1. K. Abe, and H. Saito Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation Phytotherapy Research 14 2000 149 152
2. W. Abebe Herbal medication: potential for adverse interactions with analgesic drugs Journal of Clinical Pharmacy and Therapeutics 27 2002 391 401
3. D.M. Basso, M.F. Beattie, and J.C. Bresnahan Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection Experimental Neurology 139 1996 244 256
4. S.Z. Bathaie, A. Bolhasani, R. Hoshyar, B. Ranjbar, F. Sabouni, and A.A. Moosavi-Movahedi Interaction of saffron carotenoids as anticancer compounds with ctDNA, Oligo (dG.dC)15, and Oligo (dA.dT)15 DNA and Cell Biology 26 2007 533 540
5. S.Z. Bathaie, F. Moghadas Zadeh Kermani, and S. Shams Crocin bleaching assay using purified di-gentiobiosyl crocin (α-crocin) from iranian saffron Iranian Journal of Basic Medical Sciences 14 2011 399 406
6. S.Z. Bathaie, and S.Z. Mousavi New applications and mechanisms of action of saffron and its important ingredients Critical Reviews in Food Science and Nutrition 50 2010 761 786
7. A. Bolhasani, S.Z. Bathaie, I. Yavari, A.A. Moosavi-Movahedi, and M. Ghaffari Separation and purification of some components of iranian saffron Asian Journal of Chemistry 17 2005 725 729
8. M.F. Coronel, F. Labombarda, M.J. Villar, A.F. De Nicola, and S.L. Gonzalez Progesterone prevents allodynia after experimental spinal cord injury Journal of Pain 12 2011 71 83
9. J.-A. Fernández Biology, biotechnology and biomedicine of saffron Recent Research Developments in Plant Science 2 2004 127 159
10. K. Gale, H. Kerasidis, and W. Wrathall Spinal cord contusion in the rat: behavioral analysis of functional neurologic impairment Experimental Neurology 88 1985 123 134
11. V. Gonzalez-Nunez, and R.E. Rodriguez The zebrafish: a model to study the endogenous mechanisms of pain ILAR Journal 50 2009 373 386
12. B.J. Hall, J.E. Lally, E.V. Vukmanic, J.E. Armstrong, J.D. Fell, D.S. Gupta, and C.H. Hubscher Spinal cord injuries containing asymmetrical damage in the ventrolateral funiculus is associated with a higher incidence of at-level allodynia Journal of Pain 11 2010 864 875
13. A. Hama, and J. Sagen Antinociceptive effect of riluzole in rats with neuropathic spinal cord injury pain Journal of Neurotrauma 28 2011 127 134
14. R. Hoshyar, S.Z. Bathaie, and M. Ashrafi Interaction of safranal and picrocrocin with ctDNA and their preferential mechanisms of binding to GC- and AT-rich oligonucleotides DNA and Cell Biology 27 2008 665 673
15. H. Hosseinzadeh, and H.M. Younesi Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice BMC Pharmacology 2 2002 7
16. R. Houshyar, S.Z. Bathaie, and B. Etemadikia Quantitative and comparative analysis of major metabolites (crocin, picrocrocin and safranal) in different packages of Iranian saffron by HPLC Modares Journal of Medical Sciences: Pathobiology 13 2010 63 71
17. Jacques, E., Jun 21, 2011. Chronic nerve pain treatment common approaches to chronic nerve pain treatment. http://pain.about.com/bio/Erica-Jacques-55017. htm
18. Z. Jiang, W. Chen, S. Liu, and Q. Du Preparation of crocin from gardenia yellow pigment by slow rotary countercurrent chromatography Se Pu 29 2011 277 280
19. G. Kaka A Study on In Vitro Transdifferentiation of Bone Marrow Stromal Cells into Oligodendrocyte like Cells and Autologous Transplanting them into Contusion Spinal Cord Injury in Rat 2009 School of Medical Sciences, Tarbiat Modares University Tehran 202
20. N. Kalderon, M. Muruganandham, J.A. Koutcher, and M. Potuzak Therapeutic strategy for acute spinal cord contusion injury: cell elimination combined with microsurgical intervention PLoS ONE 2 2007 e565
21. A.R. Khalatbary, and T. Tiraihi Localization of bone marrow stromal cells in injured spinal cord treated by intravenous route depends on the hemorrhagic lesions in traumatized spinal tissues Neurological Research 29 2007 21 26
22. D.H. Kim, and T.A. Jahng Continuous brain-derived neurotrophic factor (BDNF) infusion after methylprednisolone treatment in severe spinal cord injury Journal of Korean Medical Science 19 2004 113 122
23. A. Kresse, D.M. Jacobowitz, and G. Skofitsch Detailed mapping of CGRP mRNA expression in the rat central nervous system: comparison with previous immunocytochemical findings Brain Research Bulletin 36 1995 261 274
24. S. Kunz, I. Tegeder, O. Coste, C. Marian, A. Pfenninger, C. Corvey, M. Karas, G. Geisslinger, and E. Niederberger Comparative proteomic analysis of the rat spinal cord in inflammatory and neuropathic pain models Neuroscience Letters 381 2005 289 293
25. I.A. Lee, J.H. Lee, N.I. Baek, and D.H. Kim Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia Jasminoides and its metabolite crocetin Biological and Pharmaceutical Bulletin 28 2005 2106 2110
26. X. Li, Y.B. Yang, Q. Yang, L.N. Sun, and W.S. Chen Anti-inflammatory and analgesic activities of Chaenomeles speciosa fractions in laboratory animals Journal of Medicinal Food 12 2009 1016 1022
27. C.Y. Lin, Y.S. Lee, V.W. Lin, and J. Silver Fibronectin inhibits chronic pain development after spinal cord injury Journal of Neurotrauma 29 2012 589 599
28. J.J. Lynch III, C.L. Wade, C.M. Zhong, J.P. Mikusa, and P. Honore Attenuation of mechanical allodynia by clinically utilized drugs in a rat chemotherapy-induced neuropathic pain model Pain 110 2004 56 63
29. S. Ma, S. Zhou, B. Shu, and J. Zhou Pharmacological studies on Crocus glycosides I. Effects on antiinflammatory and immune function Zhongcaoyao 29 1998 536 539
30. S. Marchand The physiology of pain mechanisms: from the periphery to the brain Rheumatic Disease Clinics of North America 34 2008 285 309
31. T. Massey, S. Derry, R.A. Moore, and H.J. McQuay Topical NSAIDs for acute pain in adults Cochrane Database System Review 2010 CD007402
32. S.Z. Mousavi, and S.Z. Bathaie Historical uses of saffron: identifying potential new avenues for modern research Avicenna Journal of Phytomedicine 1 2011 57 66
33. D. Nascimento, D.H. Pozza, J.M. Castro-Lopes, and F.L. Neto Neuronal injury marker ATF-3 is induced in primary afferent neurons of monoarthritic rats Neurosignals 19 2011 210 221
34. T. Ochiai, S. Soeda, S. Ohno, H. Tanaka, Y. Shoyama, and H. Shimeno Crocin prevents the death of PC-12 cells through sphingomyelinase-ceramide signaling by increasing glutathione synthesis Neurochemistry International 44 2004 321 330
35. M. Ohta, Y. Suzuki, T. Noda, Y. Ejiri, M. Dezawa, K. Kataoka, H. Chou, N. Ishikawa, N. Matsumoto, Y. Iwashita, E. Mizuta, S. Kuno, and C. Ide Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation Experimental Neurology 187 2004 266 278
36. S.M. Onifer, A.G. Rabchevsky, and S.W. Scheff Rat models of traumatic spinal cord injury to assess motor recovery ILAR Journal 48 2007 385 395
37. N. Pitsikas, S. Zisopoulou, P.A. Tarantilis, C.D. Kanakis, M.G. Polissiou, and N. Sakellaridis Effects of the active constituents of Crocus sativus L., crocins on recognition and spatial rats' memory Behavioural Brain Research 183 2007 141 146
38. Rashbaum, R.F., 2012. Treatment options for neuropathic pain. http://www.spine-health.com/treatment/pain-management/treatment-options- neuropathic-pain
39. J. Rémillard Implication of the Calcitonin Gene-Related Peptide and its Receptor Binding Sites in Animal Models of Chronic Pain 1999 Department of Pharmacology and Therapeutics, McGill University Montreal Canada
40. J.L. Rios, M.C. Recio, R.M. Giner, and S. Manez An update review of saffron and its active constituents Phytotherapy Research 10 1996 189 193
41. J.L. Ríos, M.C. Recio, R.M. Giner, and S. Máñez An update review of saffron and its active constituents Phytotherapy Research 10 1996 189 193
42. G. Saldanha, J. Hongo, G. Plant, J. Acheson, I. Levy, and P. Anand Decreased CGRP, but preserved Trk A immunoreactivity in nerve fibres in inflamed human superficial temporal arteries Journal of Neurology, Neurosurgery and Psychiatry 66 1999 390 392
43. P. Sarzi-Puttini, F. Atzeni, L. Lanata, M. Bagnasco, M. Colombo, F. Fischer, and M. D'Imporzano Pain and ketoprofen: what is its role in clinical practice? Reumatismo 62 2010 172 188
44. L.R. Saville, C.H. Pospisil, L.A. Mawhinney, F. Bao, F.C. Simedrea, A.A. Peters, P.J. O'Connell, L.C. Weaver, and G.A. Dekaban A monoclonal antibody to CD11d reduces the inflammatory infiltrate into the injured spinal cord: a potential neuroprotective treatment Journal of Neuroimmunology 156 2004 42 57
45. A. Sekiguchi, H. Kanno, H. Ozawa, S. Yamaya, and E. Itoi Rapamycin promotes autophagy and reduces neural tissue damage and locomotor impairment after spinal cord injury in mice Journal of Neurotrauma 29 2012 946 956
46. J.P. Silva, R.S. Rodarte, A.S. Calheiros, C.Z. Souza, F.C. Amendoeira, M.A. Martins, P.M. Silva, V.S. Frutuoso, and E. Barreto Antinociceptive activity of aqueous extract of Bowdichia virgilioides in mice Journal of Medicinal Food 13 2010 348 351
47. S. Soeda, T. Ochiai, L. Paopong, H. Tanaka, Y. Shoyama, and H. Shimeno Crocin suppresses tumor necrosis factor-alpha-induced cell death of neuronally differentiated PC-12 cells Life Sciences 69 2001 2887 2898
48. E. Tamaddonfard, and N. Hamzeh-Gooshchi Effect of crocin on the morphine-induced antinociception in the formalin test in rats Phytotherapy Research 24 2010 410 413
49. M. Tanabe, K. Ono, M. Honda, and H. Ono Gabapentin and pregabalin ameliorate mechanical hypersensitivity after spinal cord injury in mice European Journal of Pharmacology 609 2009 65 68
50. J.A. Vallin, and W.S. Kingery Adjacent neuropathic hyperalgesia in rats: a model for sympathetic independent pain Neuroscience Letters 133 1991 241 244
51. D. van Rossum, U.K. Hanisch, and R. Quirion Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors Neuroscience and Biobehavioral Reviews 21 1997 649 678
52. L.X. Wang, and Z.J. Wang Animal and cellular models of chronic pain Advanced Drug Delivery Reviews 55 2003 949 965
53. A. Pajoohesh-Ganji, K.R. Byrnes, G. Fatemi, and A.I. Faden A combined scoring method to assess behavioral recovery after mouse spinal cord injury Neuroscience Research 67 2010 117 125 (Epub 2010 Feb 2025)
54. P. Winterhalter, and M. Straubinger Saffron-renewed interest in an ancient spice Food Reviews International 16 2000 39 59
55. W.-P. Wu, J.-X. Hao, X.-J. Xu, Z. Wiesenfeld-Hallin, W. Koek, and F.C. Colpaert The very-high-efficacy 5-HT1A receptor agonist, F 13640, preempts the development of allodynia-like behaviors in rats with spinal cord injury European Journal of Pharmacology 478 2003 131 137
56. L. Xi, Z. Qian, P. Du, and J. Fu Pharmacokinetic properties of crocin (crocetin digentiobiose ester) following oral administration in rats Phytomedicine 14 2007 633 636