LC3B-II deacetylation by histone deacetylase 6 is involved in serum-starvation-induced autophagic degradation

Biochemical and Biophysical Research Communications

Volumn 441, Issue 4, 2013, Pages 970-975

  Liu, Kun Peng ^a   Zhou, Dan ^a   Ouyang, Dong Yun ^a   Xu, Li Hui ^a   Wang, Yao ^a   Wang, Li Xian ^b   Pan, Hao ^a   He, Xian Hui ^a  

^a JINAN UNIVERSITY   (China)

^b Guangdong Provincial Institute of Sports Science   (China)

Author keywords

Autophagic degradation; Deacetylation; Histone deacetylase 6; Microtubule associated protein 1 light chain 3

Indexed keywords

CHLOROQUINE; HISTONE DEACETYLASE 6; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3B II; PHOSPHATIDYLETHANOLAMINE; TUBACIN; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVITY; FEMALE; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROCEDURES CONCERNING CELLS; PROTEIN DEGRADATION; SERUM STARVATION;

EUKARYOTA;

AUTOPHAGIC DEGRADATION; DEACETYLATION; HISTONE DEACETYLASE 6; MICROTUBULE-ASSOCIATED PROTEIN 1 LIGHT CHAIN 3;

ACETYLATION; ANILIDES; AUTOPHAGY; CULTURE MEDIA, SERUM-FREE; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; LYSOSOMES; MEMBRANE FUSION; MICROTUBULE-ASSOCIATED PROTEINS; PROTEOLYSIS;

EID: 84888841680     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.11.007     Document Type: Article

References (26)

1. Oh M., Choi I.K., Kwon H.J. Inhibition of histone deacetylase1 induces autophagy. Biochem. Biophys. Res. Commun. 2008, 369:1179-1183.
2. Levine B., Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008, 132:27-42.
3. Jin S., White E. Role of autophagy in cancer: management of metabolic stress. Autophagy 2007, 3:28-31.
4. Jeong H., Then F., Melia T.J., Mazzulli J.R., Cui L., Savas J.N., Voisine C., Paganetti P., Tanese N., Hart A.C., Yamamoto A., Krainc D. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell 2009, 137:60-72.
5. Lin S.Y., Li T.Y., Liu Q., Zhang C., Li X., Chen Y., Zhang S.M., Lian G., Ruan K., Wang Z., Zhang C.S., Chien K.Y., Wu J., Li Q., Han J., Lin S.C. GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science 2012, 336:477-481.
6. Yi C., Ma M., Ran L., Zheng J., Tong J., Zhu J., Ma C., Sun Y., Zhang S., Feng W., Zhu L., Le Y., Gong X., Yan X., Hong B., Jiang F.J., Xie Z., Miao D., Deng H., Yu L. Function and molecular mechanism of acetylation in autophagy regulation. Science 2012, 336:474-477.
7. Lee I.H., Finkel T. Regulation of autophagy by the p300 acetyltransferase. J. Biol. Chem. 2009, 284:6322-6328.
8. Lee I.H., Cao L., Mostoslavsky R., Lombard D.B., Liu J., Bruns N.E., Tsokos M., Alt F.W., Finkel T. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc. Natl. Acad. Sci. USA 2008, 105:3374-3379.
9. Kirisako T., Ichimura Y., Okada H., Kabeya Y., Mizushima N., Yoshimori T., Ohsumi M., Takao T., Noda T., Ohsumi Y. The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J. Cell Biol. 2000, 151:263-276.
10. Kabeya Y., Mizushima N., Yamamoto A., Oshitani-Okamoto S., Ohsumi Y., Yoshimori T. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J. Cell Sci. 2004, 117:2805-2812.
11. Klionsky D.J. The molecular machinery of autophagy: unanswered questions. J. Cell Sci. 2005, 118:7-18.
12. Yang X.J., Seto E. The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat. Rev. Mol. Cell Biol. 2008, 9:206-218.
13. Iwata A., Riley B.E., Johnston J.A., Kopito R.R. HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J. Biol. Chem. 2005, 280:40282-40292.
14. Lee J.Y., Nagano Y., Taylor J.P., Lim K.L., Yao T.P. Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J. Cell Biol. 2010, 189:671-679.
15. Lee J.Y., Koga H., Kawaguchi Y., Tang W., Wong E., Gao Y.S., Pandey U.B., Kaushik S., Tresse E., Lu J., Taylor J.P., Cuervo A.M., Yao T.P. HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J. 2010, 29:969-980.
16. Ren S., Ouyang D.Y., Saltis M., Xu L.H., Zha Q.B., Cai J.Y., He X.H. Anti-proliferative effect of 23,24-dihydrocucurbitacin F on human prostate cancer cells through induction of actin aggregation and cofilin-actin rod formation. Cancer Chemother. Pharmacol. 2012, 70:415-424.
17. Wang R.C., Wei Y., An Z., Zou Z., Xiao G., Bhagat G., White M., Reichelt J., Levine B. Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science 2012, 338:956-959.
18. Johansen T., Lamark T. Selective autophagy mediated by autophagic adapter proteins. Autophagy 2011, 7:279-296.
19. Haggarty S.J., Koeller K.M., Wong J.C., Grozinger C.M., Schreiber S.L. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc. Natl. Acad. Sci. USA 2003, 100:4389-4394.
20. Zhang Y., Li N., Caron C., Matthias G., Hess D., Khochbin S., Matthias P. HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J. 2003, 22:1168-1179.
21. Bjorkoy G., Lamark T., Brech A., Outzen H., Perander M., Overvatn A., Stenmark H., Johansen T. P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 2005, 171:603-614.
22. Kovacs J.J., Murphy P.J., Gaillard S., Zhao X., Wu J.T., Nicchitta C.V., Yoshida M., Toft D.O., Pratt W.B., Yao T.P. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol. Cell 2005, 18:601-607.
23. Riedel M., Goldbaum O., Schwarz L., Schmitt S., Richter-Landsberg C. 17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy. PLoS One 2010, 5:e8753.
24. Salminen A., Ojala J., Kaarniranta K., Hiltunen M., Soininen H. Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease. Prog. Neurobiol. 2011, 93:99-110.
25. Kawaguchi Y., Kovacs J.J., McLaurin A., Vance J.M., Ito A., Yao T.P. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 2003, 115:727-738.
26. Pandey U.B., Nie Z., Batlevi Y., McCray B.A., Ritson G.P., Nedelsky N.B., Schwartz S.L., DiProspero N.A., Knight M.A., Schuldiner O., Padmanabhan R., Hild M., Berry D.L., Garza D., Hubbert C.C., Yao T.P., Baehrecke E.H., Taylor J.P. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 2007, 447:859-863.