MiR-34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway

Biochemical and Biophysical Research Communications

Volumn 441, Issue 4, 2013, Pages 958-963

  Ma, Yanfei ^a   Qin, Huadong ^a   Cui, Yunfu ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

GAS1; MiR 34a; Papillary thyroid carcinoma; PI3K Akt Bad pathway

Indexed keywords

CASPASE 3; GROWTH ARREST SPECIFIC1 PROTEIN; MESSENGER RNA; MICRORNA 34A; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN KINASE B; PROTEIN RET; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THYROID CARCINOMA; UPREGULATION; WESTERN BLOTTING;

GAS1; GDNF; GLIAL CELL-DERIVED NEUROTROPHIC FACTOR; GLYCOSYLPHOSPHATIDYLINOSITOL; GPI; GROWTH ARREST SPECIFIC1; MICRORNA-34A; MIR-34A; PAPILLARY THYROID CARCINOMA; PI3K/AKT/BAD PATHWAY; PTC; UNTRANSLATED REGION; UTR;

APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CARCINOMA; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GPI-LINKED PROTEINS; HUMANS; MICRORNAS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; THYROID NEOPLASMS; UP-REGULATION;

EID: 84888822226     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.11.010     Document Type: Article

References (33)

1. Evdokiou A., Cowled P.A. Growth-regulatory activity of the growth arrest-specific gene, GAS1, in NIH3T3 fibroblasts. Exp. Cell Res. 1998, 240:359-367.
2. Dominguez-Monzon G., Benitez J.A., Vergara P., Lorenzana R., Segovia J. Gas1 inhibits cell proliferation and induces apoptosis of human primary gliomas in the absence of Shh. Int. J. Dev. Neurosci. 2009, 27:305-313.
3. Zarco N., Gonzalez-Ramirez R., Gonzalez R.O., Segovia J. GAS1 induces cell death through an intrinsic apoptotic pathway. Apoptosis 2012, 17:627-635.
4. Evdokiou A., Cowled P.A. Tumor-suppressive activity of the growth arrest-specific gene GAS1 in human tumor cell lines. Int. J. Cancer 1998, 75:568-577.
5. Zamorano A., Mellstrom B., Vergara P., Naranjo J.R., Segovia J. Glial-specific retrovirally mediated gas1 gene expression induces glioma cell apoptosis and inhibits tumor growth in vivo. Neurobiol. Dis. 2004, 15:483-491.
6. Wang H., Zhou X., Zhang Y., Zhu H., Zhao L., Fan L., Wang Y., Gang Y., Wu K., Liu Z., Fan D. Growth arrest-specific gene 1 is downregulated and inhibits tumor growth in gastric cancer. FEBS J. 2012, 279:3652-3664.
7. Rizzi F., Belloni L., Crafa P., Lazzaretti M., Remondini D., Ferretti S., Cortellini P., Corti A., Bettuzzi S. A novel gene signature for molecular diagnosis of human prostate cancer by RT-qPCR. PLoS ONE 2008, 3:e3617.
8. Gobeil S., Zhu X., Doillon C.J., Green M.R. A genome-wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene. Genes Dev. 2008, 22:2932-2940.
9. Jiang Z., Xu Y., Cai S. Down-regulated GAS1 expression correlates with recurrence in stage II and III colorectal cancer. Hum. Pathol. 2011, 42:361-368.
10. Huang Y., Prasad M., Lemon W.J., Hampel H., Wright F.A., Kornacker K., LiVolsi V., Frankel W., Kloos R.T., Eng C., Pellegata N.S., de la Chapelle A. Gene expression in papillary thyroid carcinoma reveals highly consistent profiles. Proc. Natl. Acad. Sci. USA 2001, 98:15044-15049.
11. Lapouge G., Millon R., Muller D., Abecassis J., Eber M., Bergerat J.P., Klein-Soyer C. Cisplatin-induced genes as potential markers for thyroid cancer. Cell. Mol. Life Sci. 2005, 62:53-64.
12. Ibanez C.F. Structure and physiology of the RET receptor tyrosine kinase. Cold Spring Harb Perspect. Biol. 5 2013.
13. Grieco M., Santoro M., Berlingieri M.T., Melillo R.M., Donghi R., Bongarzone I., Pierotti M.A., Della Porta G., Fusco A., Vecchio G. PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell 1990, 60:557-563.
14. Xing M. Genetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancer. Thyroid 2010, 20:697-706.
15. Cabrera J.R., Sanchez-Pulido L., Rojas A.M., Valencia A., Manes S., Naranjo J.R., Mellstrom B. Gas1 is related to the glial cell-derived neurotrophic factor family receptors alpha and regulates Ret signaling. J. Biol. Chem. 2006, 281:14330-14339.
16. Lewis B.P., Burge C.B., Bartel D.P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005, 120:15-20.
17. Jansson M.D., Lund A.H. MicroRNA and cancer. Mol. Oncol. 2012, 6:590-610.
18. He L., He X., Lim L.P., de Stanchina E., Xuan Z., Liang Y., Xue W., Zender L., Magnus J., Ridzon D., Jackson A.L., Linsley P.S., Chen C., Lowe S.W., Cleary M.A., Hannon G.J. A microRNA component of the p53 tumour suppressor network. Nature 2007, 447:1130-1134.
19. Bommer G.T., Gerin I., Feng Y., Kaczorowski A.J., Kuick R., Love R.E., Zhai Y., Giordano T.J., Qin Z.S., Moore B.B., MacDougald O.A., Cho K.R., Fearon E.R. P53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr. Biol. 2007, 17:1298-1307.
20. Mackiewicz M., Huppi K., Pitt J.J., Dorsey T.H., Ambs S., Caplen N.J. Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA. Breast Cancer Res. Treat. 2011, 130:663-679.
21. Liu C., Kelnar K., Liu B., Chen X., Calhoun-Davis T., Li H., Patrawala L., Yan H., Jeter C., Honorio S., Wiggins J.F., Bader A.G., Fagin R., Brown D., Tang D.G. The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat. Med. 2011, 17:211-215.
22. Garofalo M., Jeon Y.J., Nuovo G.J., Middleton J., Secchiero P., Joshi P., Alder H., Nazaryan N., Di Leva G., Romano G., Crawford M., Nana-Sinkam P., Croce C.M. MiR-34a/c-dependent PDGFR-alpha/beta downregulation inhibits tumorigenesis and enhances TRAIL-Induced apoptosis in lung cancer. PLoS ONE 2013, 8:e67581.
23. Wang W., Li T., Han G., Li Y., Shi L.H., Li H. Expression and role of miR-34a in bladder cancer. Indian J. Biochem. Biophys. 2013, 50:87-92.
24. Dang Y., Luo D., Rong M., Chen G. Underexpression of miR-34a in hepatocellular carcinoma and its contribution towards enhancement of proliferating inhibitory effects of agents targeting c-MET. PLoS ONE 2013, 8:e61054.
25. Zhao H., Ma B., Wang Y., Han T., Zheng L., Sun C., Liu T., Zhang Y., Qiu X., Fan Q. MiR-34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44. Oncol. Rep. 2013, 29:1027-1036.
26. Di Martino M.T., Leone E., Amodio N., Foresta U., Lionetti M., Pitari M.R., Cantafio M.E., Gulla A., Conforti F., Morelli E., Tomaino V., Rossi M., Negrini M., Ferrarini M., Caraglia M., Shammas M.A., Munshi N.C., Anderson K.C., Neri A., Tagliaferri P., Tassone P. Synthetic miR-34a mimics as a novel therapeutic agent for multiple myeloma: in vitro and in vivo evidence. Clin. Cancer Res. 2012, 18:6260-6270.
27. Li L., Yuan L., Luo J., Gao J., Guo J., Xie X. MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1. Clin. Exp. Med. 2013, 13:109-117.
28. Cahill S., Smyth P., Finn S.P., Denning K., Flavin R., O'Regan E.M., Li J., Potratz A., Guenther S.M., Henfrey R., O'Leary J.J., Sheils O. Effect of ret/PTC 1 rearrangement on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model. Mol. Cancer 2006, 5:70.
29. Sheu S.Y., Grabellus F., Schwertheim S., Worm K., Broecker-Preuss M., Schmid K.W. Differential miRNA expression profiles in variants of papillary thyroid carcinoma and encapsulated follicular thyroid tumours. Br. J. Cancer 2010, 102:376-382.
30. Franke T.F., Hornik C.P., Segev L., Shostak G.A., Sugimoto C. PI3K/Akt and apoptosis: size matters. Oncogene 2003, 22:8983-8998.
31. Hu M.I., Vassilopoulou-Sellin R., Lustig R., Lamont J.P. Thyroid and Parathyroid Cancers, Cancer Management: A Multidisciplinary Approach 2009, 11 ed.
32. Marini F., Luzi E., Brandi M.L. MicroRNA role in thyroid cancer development. J. Thyroid Res. 2011, 2011:407123.
33. Lal A., Thomas M.P., Altschuler G., Navarro F., O'Day E., Li X.L., Concepcion C., Han Y.C., Thiery J., Rajani D.K., Deutsch A., Hofmann O., Ventura A., Hide W., Lieberman J. Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet. 2011, 7:e1002363.