Tumor-suppressive activity of the growth arrest-specific gene GAS1 in human tumor cell lines

International Journal of Cancer

Volumn 75, Issue 4, 1998, Pages 568-577

  Evdokiou, Andreas ^a   Cowled, Prudence A ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GENE PRODUCT; MEMBRANE PROTEIN; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CARCINOGENICITY; CONTROLLED STUDY; FIBROSARCOMA; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; MALE; NONHUMAN; NUDE MOUSE; PLASMID; PRIORITY JOURNAL; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL CYCLE; CELL CYCLE PROTEINS; DEXAMETHASONE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; GENES, TUMOR SUPPRESSOR; GLUCOCORTICOIDS; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; NUCLEAR PROTEINS; POINT MUTATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RNA, MESSENGER; RNA, NEOPLASM; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 0032498549     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19980209)75:4<568::AID-IJC13>3.0.CO;2-5     Document Type: Article

References (23)

1. ANDERSON, M.J., CASEY, G., FASCHING, C.L. and STANBRIDGE, E.J., Evidence that wild-type TP53, and not genes on either chromosome 1 or 11, controls the tumorigenic phenotype of the human fibrosarcoma HT1080. Genes, Chromosomes Cancer, 9, 266-281 (1994).
2. CAIRNS, P., SHAW, M.E. and KNOWLES, M.A., Initiation of bladder cancer may involve deletion of a tumour-suppressor gene on chromosome 9. Oncogene, 8, 1083-108 (1993).
3. CHEN, J., LIN, J. and LEVINE, A.J., Regulation of transcription functions of the p53 tumor suppressor by the mdm2 oncogene. Mol. Med., 1, 142-152 (1995).
4. 1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol. cell. Biol., 16, 2445-2452 (1996).
5. CORDON-CARDO, C., LATRES, E., DROBNJAK, M., OLIVA, M.R., POLLACK, D., WOODRUFF, J.M., MARECHAL, V., CHEN, J., BRENNAN, M.F. and LEVINE, A.J., Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res., 54, 794-799 (1994).
6. DE MARTIN, R., COWLED, P.A., SMITH, S.E., PAPAVASSILIOU, A.G., SORRENTINO, V., PHILIPSON, L. and BOHMANN, D., Structure and regulation of the growth arrest-specific (gas-1) promoter. J. biol. Chem., 268, 22788-22793 (1993).
7. DEL SAL, G., COLLAVIN, L., RUARO, M.E., EDOMI, P., SACCONE, S., DELLA VALLE, G. and SCHNEIDER, C., Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gasl gene. Proc. nat. Acad. Sci. (Wash.), 91, 1848-1852 (1994).
8. DEL SAL, G., RUARO, M.E., PHILIPSON, L. and SCHNEIDER, C. The growth arrest-specific gene, gas1, is involved in growth suppression. Cell, 70, 595-607 (1992).
9. DEL SAL, G., RUARO, E.M., UTRERA, R., COLE, C.N., LEVINE, A.J. and SCHNEIDER, C., Gas1-induced growth suppression requires a transactivationinciependent p53 function. Mol. cell. Biol., 15, 7152-7160 (1995).
10. DUBS-POTERSZMAN, M.-C., TOCQUE, B. and WASYLYK, B., MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest. Oncogene, 11, 2445-2449 (1995).
11. EVDOKIOU, A., WEBB, G.C., PETERS, G.B., DOBROVIC, A., O'KEEFE, D.S., FORBES, I.J. and COWLED, P.A.. Localization of the human growth arrestspecific gene (GAS1) to chromosome bands 9q21.3-q22, a region frequently deleted in myeloid malignancies. Genomics, 18, 731-733 (1993).
12. HAUPT, Y., MAYA, R., KAZAZ, A. and OREN, M., Mdm2 promotes the rapid degradation of p53. Nature (Lond.), 387, 296-299 (1997).
13. KONSTANTINOVA, L.N., FLEISCHMAN, E.W., KNISCH, V.l., PEREVOZCHIKOV, A.G. and KOPNIN, B.P., Karyotype peculiarities of human colorectal adenocarcinomas. Hum. Genet., 86, 491-496 (1991).
14. LEACH, F.S., TOKINO, T., MELTZER, P., BURRELL, M., OLINER, J.D., SMITH, S., HILL, D.E., SIDRANSKY, D., KINZLER, K.W. and VOGELSTEIN, B., p53 mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res., 53, 2231-2234 (1993).
15. MARTIN, K., TROUCHE, D., HAGEMEIER, C., SORENSEN, T.S., LA-THANGUE, N.B. and KOUZARIDES, T., Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature (Lond.), 375, 691-694 (1995).
16. MOMAND, J., ZAMBETTI, O.P., OLSON, D.C., GEORGE, D. and LEVINE, A.J., The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell, 69, 1237-1245 (1992).
17. OLINER, J.D., KINZLER, K.W., MELTZER, P.S., GEORGE, D.L. and VOGELSTEIN, B., Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature (Lond.). 358, 80-83 (1992).
18. REIFENBERGER, G., Liu, L., ICHIMURA, K., SCHMIDT, E.E. and COLLINS, V.P., Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res., 53, 2736-2739 (1993).
19. RUARO, E.M., COLLAVIN, L., DEL SAL, G., HAFFNER, R., OREN, M., LEVINE. A.J. and SCHNEIDER, C., A proline-rich motif in p53 is required for transactivation-independent growth arrest as induced by Gas1. Proc. nat. Acad. Sci. (Wash.), 94, 4675-4680 (1997).
20. SHARMA, S., SCHWARTE-WALDHOFF, I., OBERHUBER, H. and SCHAEFER, R., Functional interaction of wild-type and mutant p53 transfected into human tumor cell lines carrying activated RAS genes. Cell. Growth Differentiation, 4, 861-869 (1993).
21. SIMONEAU, A.R., SPRUCK, C.H., GONZALEZ-ZULUETA, M., GONZALGO, M.L., CHAN, M.F., TSAI, Y.C., DEAN, M., STEVEN, K., HORN, T. and JONES, P.A., Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations. Cancer Res., 56, 5039-5043 (1996).
22. SREEKANTAIAH, C., BAER, M.R., PREISLER, H.D. and SANDBERG, A.A., Involvement of bands 9q21-q22 in five cases of acute nonlymphocytic leukemia. Cancer Genet. Cytogenet., 39, 55-64 (1989).
23. WHITAKER, N.J., BRYAN, T.M., BONNEFIN, P., CHANG, A.C.-M., MUSGROVE, E.A., BRAITHWAITE, A.W. and REDDEL, R.R., Involvement of RB-1, p53. p16INK4 and telomerase in immortalisation of human cells. Oncogene, 11, 971-976 (1995).