Treatment of rats with hypolipidemic compound pirinixic acid protects their hearts against ischemic injury: Are mitochondrial KATP channels and reactive oxygen species involved?

Physiological Research

Volumn 62, Issue 5, 2013, Pages 577-584

  Nemcekova M ^a   Carnicka S ^a   Ferko, M ^a   Murarikova M ^a   Ledvenyiova V ^a   Ravingerova T ^a  

^a Institute for Heart Research   (Slovakia)

Author keywords

Cardioprotection; Endothelial NO synthase; Mitochondrial KATP channels; Myocardial ischemia reperfusion injury; PPAR activation; Reactive oxygen species

Indexed keywords

ANTILIPEMIC AGENT; CARDIOTONIC AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MITOCHONDRIAL K(ATP) CHANNEL; NOS3 PROTEIN, RAT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PIRINIXIC ACID; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PYRIMIDINE DERIVATIVE; REACTIVE OXYGEN METABOLITE;

ANIMAL; ARTICLE; CELL PROTECTION; DISEASE MODEL; DRUG EFFECT; DRUG POTENTIATION; HEART CONTRACTION; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; LIPID PEROXIDATION; MALE; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY; PERFUSION; RAT; REPERFUSION INJURY; TIME; WISTAR RAT;

ANIMALS; CARDIOTONIC AGENTS; CYTOPROTECTION; DISEASE MODELS, ANIMAL; HYPOLIPIDEMIC AGENTS; LIPID PEROXIDATION; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PERFUSION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; PPAR ALPHA; PYRIMIDINES; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

EID: 84888805143     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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