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Volumn 97, Issue 1, 2013, Pages 33-43

Early ischaemic preconditioning requires Akt- and PKA-mediated activation of eNOS via serine1176 phosphorylation

Author keywords

Endothelial nitric oxide synthase structure; Protein phosphorylation; Reactive oxygen species; Signalling pathways

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; N(G) NITROARGININE METHYL ESTER; PROTEIN KINASE B; SERINE;

EID: 84871758700     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs287     Document Type: Article
Times cited : (57)

References (44)
  • 1
    • 35848968042 scopus 로고    scopus 로고
    • Signaling pathways in ischemic preconditioning
    • DOI 10.1007/s10741-007-9025-2, Special Issue on Cardioprotection; Guest Editors: Dennis V. Cokkinos and Gerd Heusch
    • Downey JM, Davis AM, Cohen MV. Signaling pathways in ischemic preconditioning. Heart Fail Rev 2007;12:181-188. (Pubitemid 350176691)
    • (2007) Heart Failure Reviews , vol.12 , Issue.3-4 , pp. 181-188
    • Downey, J.M.1    Davis, A.M.2    Cohen, M.V.3
  • 3
    • 33750714102 scopus 로고    scopus 로고
    • Nitric oxide triggers late preconditioning against myocardial infarction in conscious rabbits
    • Qiu Y, Rizvi A, Tang XL, Manchikalapudi S, Takano H, Jadoon AK et al. Nitric oxide triggers late preconditioning against myocardial infarction in conscious rabbits. Am J Physiol 1997;273:H2931-H2936.
    • (1997) Am J Physiol , vol.273
    • Qiu, Y.1    Rizvi, A.2    Tang, X.L.3    Manchikalapudi, S.4    Takano, H.5    Jadoon, A.K.6
  • 4
    • 0030777615 scopus 로고    scopus 로고
    • The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase: Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning
    • Bolli R, Manchikalapudi S, Tang XL, Takano H, Qiu Y, Guo Y et al. The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase. Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning. Circ Res 1997;81:1094-1107. (Pubitemid 27514960)
    • (1997) Circulation Research , vol.81 , Issue.6 , pp. 1094-1107
    • Bolli, R.1    Manchikalapudi, S.2    Tang, X.-L.3    Takano, H.4    Qiu, Y.5    Guo, Y.6    Zhang, Q.7    Jadoon, A.K.8
  • 5
    • 77955453735 scopus 로고    scopus 로고
    • ENOS is required for acute in vivo ischemic preconditioning of the heart: Effects of ischemic duration and sex
    • Talukder MA, Yang F, Shimokawa H, Zweier JL. eNOS is required for acute in vivo ischemic preconditioning of the heart: effects of ischemic duration and sex. Am J Physiol Heart Circ Physiol 2010;299:H437-H445.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299
    • Talukder, M.A.1    Yang, F.2    Shimokawa, H.3    Zweier, J.L.4
  • 6
    • 0345735391 scopus 로고    scopus 로고
    • Early preconditioning prevents the loss of endothelial nitric oxide synthase and enhances its activity in the ischemic/reperfused rat heart
    • DOI 10.1016/j.lfs.2003.10.001
    • Muscari C, Bonafe F, Gamberini C, Giordano E, Tantini B, Fattori M et al. Early preconditioning prevents the loss of endothelial nitric oxide synthase and enhances its activity in the ischemic/reperfused rat heart. Life Sci 2004;74:1127-1137. (Pubitemid 37542419)
    • (2004) Life Sciences , vol.74 , Issue.9 , pp. 1127-1137
    • Muscari, C.1    Bonafe, F.2    Gamberini, C.3    Giordano, E.4    Tantini, B.5    Fattori, M.6    Guarnieri, C.7    Caldarera, C.M.8
  • 7
    • 0034777430 scopus 로고    scopus 로고
    • The contribution of endothelial nitric oxide synthase to early ischaemic preconditioning: The lowering of the preconditioning threshold. An investigation in eNOS knockout mice
    • DOI 10.1016/S0008-6363(01)00394-7, PII S0008636301003947
    • Bell RM, Yellon DM. The contribution of endothelial nitric oxide synthase to early ischaemic preconditioning: the lowering of the preconditioning threshold. An investigation in eNOS knockout mice. Cardiovasc Res 2001;52:274-280. (Pubitemid 33000404)
    • (2001) Cardiovascular Research , vol.52 , Issue.2 , pp. 274-280
    • Bell, R.M.1    Yellon, D.M.2
  • 8
    • 0028798004 scopus 로고
    • Inhibition of nitric oxide synthesis does not affect ischemic preconditioning in isolated perfused rat hearts
    • Weselcouch EO, Baird AJ, Sleph P, Grover GJ. Inhibition of nitric oxide synthesis does not affect ischemic preconditioning in isolated perfused rat hearts. Am J Physiol 1995; 268:H242-H249.
    • (1995) Am J Physiol , vol.268
    • Weselcouch, E.O.1    Baird, A.J.2    Sleph, P.3    Grover, G.J.4
  • 9
    • 0033839876 scopus 로고    scopus 로고
    • Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning
    • Nakano A, Liu GS, Heusch G, Downey JM, Cohen MV. Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning. J Mol Cell Cardiol 2000;32:1159-1167.
    • (2000) J Mol Cell Cardiol , vol.32 , pp. 1159-1167
    • Nakano, A.1    Liu, G.S.2    Heusch, G.3    Downey, J.M.4    Cohen, M.V.5
  • 12
    • 77950354449 scopus 로고    scopus 로고
    • Cardioselec-tive nitric oxide synthase 3 gene transfer protects against myocardial reperfusion injury
    • Szelid Z, Pokreisz P, Liu X, Vermeersch P, Marsboom G, Gillijns H et al. Cardioselec-tive nitric oxide synthase 3 gene transfer protects against myocardial reperfusion injury. Basic Res Cardiol 2010;105:169-179.
    • (2010) Basic Res Cardiol , vol.105 , pp. 169-179
    • Szelid, Z.1    Pokreisz, P.2    Liu, X.3    Vermeersch, P.4    Marsboom, G.5    Gillijns, H.6
  • 13
  • 14
    • 4444303977 scopus 로고    scopus 로고
    • Ischemic preconditioning attenuates calpain-mediated degradation of structural proteins through a protein kinase A-dependent mechanism
    • DOI 10.1016/j.cardiores.2004.06.001, PII S0008636304002408
    • Inserte J, Garcia-Dorado D, Ruiz-Meana M, Agullo L, Pina P, Soler-Soler J. Ischemic preconditioning attenuates calpain-mediated degradation of structural proteins through a protein kinase A-dependent mechanism. Cardiovasc Res 2004;64:105-114. (Pubitemid 39208927)
    • (2004) Cardiovascular Research , vol.64 , Issue.1 , pp. 105-114
    • Inserte, J.1    Garcia-Dorado, D.2    Ruiz-Meana, M.3    Agullo, L.4    Pina, P.5    Soler-Soler, J.6
  • 15
    • 41149094470 scopus 로고    scopus 로고
    • Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide
    • DOI 10.1093/cvr/cvn017
    • Gonon AT, Widegren U, Bulhak A, Salehzadeh F, Persson J, Sjoquist PO et al. Adipo-nectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide. Cardiovasc Res 2008;78:116-122. (Pubitemid 351430967)
    • (2008) Cardiovascular Research , vol.78 , Issue.1 , pp. 116-122
    • Gonon, A.T.1    Widegren, U.2    Bulhak, A.3    Salehzadeh, F.4    Persson, J.5    Sjoquist, P.-O.6    Pernow, J.7
  • 17
    • 0032782417 scopus 로고    scopus 로고
    • Role of neuronal and endothelial nitric oxide synthase in nitric oxide generation in the brain following cerebral ischemia
    • DOI 10.1016/S0925-4439(99)00051-4, PII S0925443999000514
    • Wei G, Dawson VL, Zweier JL. Role of neuronal and endothelial nitric oxide synthase in nitric oxide generation in the brain following cerebral ischemia. Biochim Biophys Acta 1999;1455:23-34. (Pubitemid 29397486)
    • (1999) Biochimica et Biophysica Acta - Molecular Basis of Disease , vol.1455 , Issue.1 , pp. 23-34
    • Wei, G.1    Dawson, V.L.2    Zweier, J.L.3
  • 18
    • 0042357128 scopus 로고    scopus 로고
    • Nitric-oxide synthase (NOS) reductase domain models suggest a new control element in endothelial NOS that attenuates calmodulin-dependent activity
    • DOI 10.1074/jbc.M303267200
    • Knudsen GM, Nishida CR, Mooney SD, Ortiz de Montellano PR. Nitric-oxide syn-thase (NOS) reductase domain models suggest a new control element in endothelial NOS that attenuates calmodulin-dependent activity. J Biol Chem 2003;278:31814-31824. (Pubitemid 37048363)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.34 , pp. 31814-31824
    • Knudsen, G.M.1    Nishida, C.R.2    Mooney, S.D.3    Ortiz De Montellano, P.R.4
  • 19
    • 0034054493 scopus 로고    scopus 로고
    • Enhanced electron flux and reduced calmodulin dissociation may explain 'calcium-independent' eNOS activation by phosphorylation
    • DOI 10.1074/jbc.275.9.6123
    • McCabe TJ, Fulton D, Roman LJ, Sessa WC. Enhanced electron flux and reduced cal-modulin dissociation may explain "calcium-independent" eNOS activation by phos-phorylation. J Biol Chem 2000;275:6123-6128. (Pubitemid 30129896)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.9 , pp. 6123-6128
    • McCabe, T.J.1    Fulton, D.2    Roman, L.J.3    Sessa, W.C.4
  • 20
    • 34548445394 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase is essential for actute ischemic preconditioning
    • Wei G, Zweier JL. Endothelial nitric oxide synthase is essential for actute ischemic preconditioning. FASEB J 2001;15:A465.
    • (2001) FASEB J , vol.15
    • Wei, G.1    Zweier, J.L.2
  • 21
    • 84871762063 scopus 로고    scopus 로고
    • Novel rapid-multiple-short-cycle preconditioning stimuli induces robust cardioprotective signaling mechanisms and protects the heart against in vivo ischemia reperfusion injury: An effective approach with clinical justification
    • Zweier JL, Yang F, Nishijima Y, Chen CA, Yang C, Varadharaj S et al. Novel rapid-multiple-short-cycle preconditioning stimuli induces robust cardioprotective signaling mechanisms and protects the heart against in vivo ischemia reperfusion injury: an effective approach with clinical justification. FASEB J 2012;26:1136.
    • (2012) FASEB J , vol.26 , pp. 1136
    • Zweier, J.L.1    Yang, F.2    Nishijima, Y.3    Chen, C.A.4    Yang, C.5    Varadharaj, S.6
  • 23
    • 0029114339 scopus 로고
    • Enzyme-independent formation of nitric oxide in biological tissues
    • Zweier JL, Wang P, Samouilov A, Kuppusamy P. Enzyme-independent formation of nitric oxide in biological tissues. Nat Med 1995;1:804-809.
    • (1995) Nat Med , vol.1 , pp. 804-809
    • Zweier, J.L.1    Wang, P.2    Samouilov, A.3    Kuppusamy, P.4
  • 24
    • 0028985256 scopus 로고
    • Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy
    • Zweier JL, Wang P, Kuppusamy P. Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy. J Biol Chem 1995;270:304-307.
    • (1995) J Biol Chem , vol.270 , pp. 304-307
    • Zweier, J.L.1    Wang, P.2    Kuppusamy, P.3
  • 25
    • 0344146411 scopus 로고    scopus 로고
    • Classic preconditioning decreases the harmful accumulation of nitric oxide during ischemia and reperfusion in rat hearts
    • Csonka C, Szilvassy Z, Fulop F, Pali T, Blasig IE, Tosaki A et al. Classic preconditioning decreases the harmful accumulation of nitric oxide during ischemia and reperfusion in rat hearts. Circulation 1999;100:2260-2266.
    • (1999) Circulation , vol.100 , pp. 2260-2266
    • Csonka, C.1    Szilvassy, Z.2    Fulop, F.3    Pali, T.4    Blasig, I.E.5    Tosaki, A.6
  • 26
    • 53749100860 scopus 로고    scopus 로고
    • Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: Role of its anti-adrenergic actions
    • Genade S, Genis A, Ytrehus K, Huisamen B, Lochner A. Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: role of its anti-adrenergic actions. J Pineal Res 2008;45:449-458.
    • (2008) J Pineal Res , vol.45 , pp. 449-458
    • Genade, S.1    Genis, A.2    Ytrehus, K.3    Huisamen, B.4    Lochner, A.5
  • 28
    • 1142309743 scopus 로고    scopus 로고
    • New directions for protecting the heart against ischaemia-reperfusion injury: Targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway
    • DOI 10.1016/j.cardiores.2003.09.024
    • Hausenloy DJ, Yellon DM. New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovasc Res 2004;61:448-460. (Pubitemid 38210151)
    • (2004) Cardiovascular Research , vol.61 , Issue.3 , pp. 448-460
    • Hausenloy, D.J.1    Yellon, D.M.2
  • 29
    • 23644446462 scopus 로고    scopus 로고
    • Akt1 in the cardiovascular system: Friend or foe?
    • DOI 10.1172/JCI25900
    • O'Neill BT, Abel ED. Akt1 in the cardiovascular system: friend or foe? J Clin Invest 2005;115:2059-2064. (Pubitemid 41134142)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.8 , pp. 2059-2064
    • O'Neill, B.T.1    Abel, E.D.2
  • 31
    • 70649095109 scopus 로고    scopus 로고
    • Signaling pathways of cardioprotective ischemic preconditioning
    • Sadat U. Signaling pathways of cardioprotective ischemic preconditioning. Int J Surg 2009;7:490-498.
    • (2009) Int J Surg , vol.7 , pp. 490-498
    • Sadat, U.1
  • 32
    • 77958033698 scopus 로고    scopus 로고
    • Tongxinluo reduces myocardial no-reflow and ischemia-reperfusion injury by stimulating the phosphorylation of eNOS via the PKA pathway
    • Li XD, Yang YJ, Geng YJ, Jin C, Hu FH, Zhao JL et al. Tongxinluo reduces myocardial no-reflow and ischemia-reperfusion injury by stimulating the phosphorylation of eNOS via the PKA pathway. Am J Physiol Heart Circ Physiol 2010;299:H1255-H1261.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299
    • Li, X.D.1    Yang, Y.J.2    Geng, Y.J.3    Jin, C.4    Hu, F.H.5    Zhao, J.L.6
  • 33
    • 19444385802 scopus 로고    scopus 로고
    • PI 3-kinase, protein kinase C, and protein kinase a are involved in the trigger phase of β1-adrenergic preconditioning
    • DOI 10.1016/j.cardiores.2005.02.010, PII S0008636305000878
    • Robinet A, Hoizey G, Millart H. PI 3-kinase, protein kinase C, and protein kinase A are involved in the trigger phase of beta1-adrenergic preconditioning. Cardiovasc Res 2005; 66:530-542. (Pubitemid 40725765)
    • (2005) Cardiovascular Research , vol.66 , Issue.3 , pp. 530-542
    • Robinet, A.1    Hoizey, G.2    Millart, H.3
  • 34
    • 0029841018 scopus 로고    scopus 로고
    • Measurement of nitric oxide and peroxynitrite generation in the postischemic heart: Evidence for peroxynitrite-mediated reperfusion injury
    • DOI 10.1074/jbc.271.46.29223
    • Wang P, Zweier JL. Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury. J Biol Chem 1996;271:29223-29230. (Pubitemid 26382634)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.46 , pp. 29223-29230
    • Wang, P.1    Zweier, J.L.2
  • 36
    • 0000104045 scopus 로고
    • Measurement of endothelial cell free radical generation: Evidence for a central mechanism of free radical injury in postischemic tissues
    • Zweier JL, Kuppusamy P, Lutty GA. Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues. Proc Natl Acad Sci USA 1988;85:4046-4050.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 4046-4050
    • Zweier, J.L.1    Kuppusamy, P.2    Lutty, G.A.3
  • 37
    • 0032475865 scopus 로고    scopus 로고
    • Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process
    • Xia Y, Tsai AL, Berka V, Zweier JL. Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process. J Biol Chem 1998;273:25804-25808.
    • (1998) J Biol Chem , vol.273 , pp. 25804-25808
    • Xia, Y.1    Tsai, A.L.2    Berka, V.3    Zweier, J.L.4
  • 38
    • 55249112287 scopus 로고    scopus 로고
    • Phosphorylation of endothe-lial nitric-oxide synthase regulates superoxide generation from the enzyme
    • Chen CA, Druhan LJ, Varadharaj S, Chen YR, Zweier JL. Phosphorylation of endothe-lial nitric-oxide synthase regulates superoxide generation from the enzyme. J Biol Chem 2008;283:27038-27047.
    • (2008) J Biol Chem , vol.283 , pp. 27038-27047
    • Chen, C.A.1    Druhan, L.J.2    Varadharaj, S.3    Chen, Y.R.4    Zweier, J.L.5
  • 39
    • 33846392950 scopus 로고    scopus 로고
    • Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation
    • DOI 10.1016/j.yjmcc.2006.05.023, PII S0022282806005888
    • Mount PF, Kemp BE, Power DA. Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J Mol Cell Cardiol 2007;42:271-279. (Pubitemid 46135596)
    • (2007) Journal of Molecular and Cellular Cardiology , vol.42 , Issue.2 , pp. 271-279
    • Mount, P.F.1    Kemp, B.E.2    Power, D.A.3
  • 40
    • 0037207099 scopus 로고    scopus 로고
    • Site-specific dephosphorylation of endothelial nitric oxide synthase by protein phosphatase 2A: Evidence for crosstalk between phosphorylation sites
    • DOI 10.1021/bi026732g
    • Greif DM, Kou R, Michel T. Site-specific dephosphorylation of endothelial nitric oxide synthase by protein phosphatase 2A: evidence for crosstalk between phosphorylation sites. Biochemistry 2002;41:15845-15853. (Pubitemid 36062490)
    • (2002) Biochemistry , vol.41 , Issue.52 , pp. 15845-15853
    • Greif, D.M.1    Kou, R.2    Michel, T.3
  • 41
    • 0035947574 scopus 로고    scopus 로고
    • Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase
    • Michell BJ, Chen Z, Tiganis T, Stapleton D, Katsis F, Power DA et al. Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J Biol Chem 2001;276:17625-17628.
    • (2001) J Biol Chem , vol.276 , pp. 17625-17628
    • Michell, B.J.1    Chen, Z.2    Tiganis, T.3    Stapleton, D.4    Katsis, F.5    Power, D.A.6
  • 42
    • 0036479305 scopus 로고    scopus 로고
    • 1179 by Akt-independent mechanisms. Role of protein kinase A
    • DOI 10.1074/jbc.M108789200
    • Boo YC, Sorescu G, Boyd N, Shiojima I, Walsh K, Du J et al. Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A. J Biol Chem 2002;277:3388-3396. (Pubitemid 34953207)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.5 , pp. 3388-3396
    • Boo, Y.C.1    Sorescu, G.2    Boyd, N.3    Shiojima, I.4    Walsh, K.5    Du, J.6    Jo, H.7
  • 43
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999;399:601-605.
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 44
    • 33846349963 scopus 로고    scopus 로고
    • ENOS phosphorylation: A pivotal molecular switch in vasodilation and cardioprotection?
    • DOI 10.1016/j.yjmcc.2006.10.011, PII S0022282806009758
    • Kukreja RC, Xi L. eNOS phosphorylation: a pivotal molecular switch in vasodilation and cardioprotection?. J Mol Cell Cardiol 2007;42:280-282. (Pubitemid 46135602)
    • (2007) Journal of Molecular and Cellular Cardiology , vol.42 , Issue.2 , pp. 280-282
    • Kukreja, R.C.1    Xi, L.2


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