Mitochondrial KATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms

Canadian Journal of Physiology and Pharmacology

Volumn 87, Issue 12, 2009, Pages 1055-1062

  Matejíková, Jana ^a   Ravingerová, Táňa ^a   Pancza, Dezider ^a   Čarnická, Slávka ^a   Kolář, František ^b  

^a INSTITUTE OF CHEMISTRY   (Slovakia)

^b INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

Arrhythmias; mitoKATP opening; Myocardial ischaemia; PI3K AKT; Rat heart

Indexed keywords

ADENOSINE TRIPHOSPHATE; DIAZOXIDE; PROTEIN KINASE B; WORTMANNIN; ANDROSTANE DERIVATIVE; MITOCHONDRIAL K(ATP) CHANNEL; PHOSPHATIDYLINOSITOL 3 KINASE; POTASSIUM CHANNEL; PROTEIN KINASE INHIBITOR; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG INHIBITION; HEART ARRHYTHMIA; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE TACHYCARDIA; ISCHEMIC PRECONDITIONING; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; ANIMAL; ARTICLE; DRUG EFFECT; HEART MITOCHONDRION; PATHOPHYSIOLOGY; PHYSIOLOGY; WISTAR RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; ARRHYTHMIAS, CARDIAC; DIAZOXIDE; MITOCHONDRIA, HEART; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; POTASSIUM CHANNELS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; VASODILATOR AGENTS;

EID: 76549128178     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y09-100     Document Type: Conference Paper

References (50)

1. ATP channel. J. Mol. Cell. Cardiol. 31(10): 1821-1831. doi:10.1006/jmcc.1999.1013. PMID:10525420.
2. Barančík, M., Ivanová, M., Matejíková, J., Špánilcová, A., and Ravingerová, T. 2008. Mechanisms involved in wortmannin-induced modulation of ischemic tolerance in rat hearts. Physiol. Res. 57: 9P. PMID:18798350.
3. + channels? Circ. Res. 77(2): 361-369. PMID:7614722.
4. ATP channels. Circ. Res. 89(3): 273-278. doi:10.1161/hh1501. 094266. PMID:11485978.
5. Curtis, M.J., and Hearse, D.J. 1989. Reperfusion-induced arrhythmias are critically dependent upon occluded zone size: relevance to the mechanism of arrhythmogenesis. J. Mol. Cell. Cardiol. 21(6): 625-637. doi:10.1016/0022-2828(89)90828-6. PMID:2778810.
6. ATP channel activation important in the antiarrhythmic and cardioprotective effects during acute ischemia/reperfusion in the intact anesthetized rabbit model? Life Sci. 77(11): 1226-1248. doi:10.1016/j.lfs.2004.12.042. PMID:15964023.
7. Davies, S.P., Reddy, H., Caivano, M., and Cohen, P. 2000. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351(Pt 1): 95-105. doi:10.1042/0264-6021:3510095. PMID:10998351.
8. v currents via a direct mechanism. FASEB J. 17(6): 720-722. PMID:12586735.
9. Forbes, R.A., Steenbergen, C.H., and Murphy, E. 2001. Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism. Circ. Res. 88(8): 802-809. doi:10.1161/hh0801.089342. PMID:11325872.
10. + channels via PI3-kinase, PDK1 and SGK1. Pflugers Arch. 443(4): 625-634. doi:10.1007/s00424-001-0741-5.
11. + channel in cardiac function and cardioprotection. Biochim. Biophys. Acta, 1606(1-3): 1-21. doi:10.1016/S0005-2728(03)00109- 9. PMID:14507424.
12. Halestrap, A.P., Clarke, S.J., and Khaliulin, I. 2007. The role of mitochondria in protection of the heart by preconditioning. Biochim. Biophys. Acta, 1767(8): 1007-1031. doi:10.10t6/j.bbabio.2007.05.008. PMID:17631856.
13. ATP channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart. J. Physiol. 542(Pt 3): 735-741. doi:10.1113/jphysiol.2002.023960. PMID:12154175.
14. Hausenloy, D.J., and Yellon, D.M. 2006. Survival kinases in ischemic preconditioning and postconditioning. Cardiovasc. Res. 70(2): 240-253. doi:10.1016/j.cardiores.2006.01.017. PMID:16545352.
15. Hirata, A., Minamino, T., Asanuma, H., Sanada, S., Fujita, M., Tsukamoto, O., et al. 2005. Erythropoietin just before reperfusion reduces both lethal arrhythmias and infarct size via the phosphatidylinositol-3 kinase-dependent pathway in canine hearts. Cardiovasc. Drugs Ther. 19(1): 33-40. doi:10.1007/s10557-005-6895-1. PMID:15883754.
16. Krenz, M., Oldenburg, O., Wimpee, H., Cohen, M.V., Garlid, K.D., Critz, S.D., et al. 2002. Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells. Basic Res. Cardiol. 97(5): 365-373. doi:10.1007/s003950200045. PMID:12200636.
17. Krieg, T., Qin, Q., Philipp, S., Alexeyev, M.F., Cohen, M.V., and Downey, J.M. 2004. Acetylcholin and bradykinin trigger preconditioning in the heart through a pathway that includes Akt and NOS. Am. J. Physiol. 287: H2606-H2611.
18. Lebuffe, G., Schumacker, P.T., Shao, Z.H., Anderson, T., Iwase, H., and Vanden Hoek, T.L. 2003. ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel. Am. J. Physiol. Heart Circ. Physiol. 284W: H299-H308. PMID:12388274.
19. Liu, L., Zhang, X.J., Jiang, S.R., Ding, Z.N., Ding, G.X., Huang, J., and Cheng, Y.L. 2007. Heat shock protein 27 regulates oxidative stress-induced apoptosis in cardiomyocytes: mechanisms via reactive oxygen species generation and Akt activation. Chin. Med. J. (Engl.), 120(24): 2271-2277. PMID:18167217.
20. + channels in pancreatic beta cells: role, regulation and potential as therapeutic targets. Diabetologia, 46(8): 1046-1062. doi:10.1007/s00125-003-l 159-8. PMID:12830383.
21. Matejíková, J., Neckář, J., Kolář, F., and Ravingerová, T. 2008. Suppression of ischemic arrhythmias in the diabetic heart does not require PI3K/Akt and ROS: Relevance to ischemic preconditioning. J. Mol. Cell. Cardiol. 44(4): 761-762. doi:10.1016/j.yjmcc.2008.02.121.
22. ATP channels and reactive oxygen species. Physiol. Res. 58(1): 9-19. PMID:18198991.
23. Matsui, T., and Rosenzweig, A. 2005. Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt. J. Mol. Cell. Cardiol. 38(1): 63-71. doi:10.1016/j.yjmcc.2004.11.005. PMID:15623422.
24. Mocanu, MM., Bell, R.M., and Yellon, D.M. 2002. PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning. J. Mol. Cell. Cardiol. 34(6): 661-668. doi:10.1006/jmcc.2002.2006. PMID:12054853.
25. Mockridge, J.W., Marber, MS., and Heads, R.J. 2000. Activation of Akt during simulated ischemia/reperfusion in cardiac myocytes. Biochem. Biophys. Res. Commun. 270(3): 947-952. doi:10.1006/bbrc.2000.2522. PMID:10772931.
26. Murphy, E. 2004. Primary and secondary signaling pathways in early preconditioning that converge on the mitochondria to produce cardioprotection. Circ. Res. 94(1): 7-16. doi:10.1161/01.RES.0000108082.76667.F4. PMID:14715531.
27. Murphy, E., and Steenhergen, C. 2007. Preconditioning: the mitochondrial connection. Annu. Rev. Physiol. 69(1): 51-67. doi:10.1146/annurev. physiol.69.031905.163645. PMID:17007587.
28. Neckář, J., Papoušek, F., Nováková, O., Ošťádal, B., and Kolář, F. 2002a. Cardioprotective effects of chronic hypoxia and ischaemic preconditioning are not additive. Basic Res. Cardiol. 97(2): 161-167. doi:10.1007/ s003950200007. PMID:12002264.
29. ATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats. Cardiovasc. Res. 55(3): 567-575. doi:10.1016/S0008-6363(02)00456-X. PMID:12160954.
30. ATP channel opening and leads to cardioprotection. Am. J. Physiol. Heart Circ. Physiol. 286(1): H468-H476. doi:10.t152/ajpheart. 00360.2003. PMID: 12958031.
31. Oudit, G.Y., Sun, H., Kerfant, B-S., Crackower, M.A., Penninger, J.M., and Backx, P.H. 2004. The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J. Mol. Cell. Cardiol. 37(2): 449-471. doi:10.1016/j.yjmcc.2004.05.015. PMID:15276015.
32. ATP channels triggers the preconditioned state by generating free radicals. Circ. Res. 87(6): 460-466. PMID:10988237.
33. ATP channels or reactive oxygen species? Cardiovasc. Res. 51(4): 633-636. doi:10.1016/S0008-6363(01)00396-0. PMID:11530096.
34. Qin, S., and Chock, P.B. 2003. Implication of phosphatidylinositol 3-kinase membrane recruitment in hydrogen peroxide-induced activation of P13K and Akt. Biochemistry, 42(10): 2995-3003. doi:10.1021/bi0205911. PMID:12627965.
35. ATP channels. Physiol. Res. 51(2): 109-119. PMID:12108920.
36. Ravingerová, T., Matejíková, J., Neckář, J., Andelová, E., and Kolář, F. 2007. Differential role of PI3K/Alt pathway in the infarct size limitation and antiarrhythmic protection in the rat heart. Mol. Cell. Biochem. 297(1-2): 111-120. doi:10.1007/s11010-006-9335-z. PMID:17016676.
37. Ravingerová, T., Matejíková, J., Pancza, D., and Kolář, F. 2009. Reduced susceptibility to ischemia-induced arrhythmias in the preconditioned rat heart is independent of P13-kinase/Akt. Physiol. Res. 58(3): 443-447. PMID:19627174.
38. + channels by protein kinase C. Circ. Res. 83(1): 110-114. PMID:9670924.
39. Simončíková. P., Ravingerová. T., Andelová, E., Tribulová, N., and Barančík, M. 2007. Changes in rat myocardium associated with modulation of ischemic tolerance by diazoxide. Gen. Physiol. Biophys. 26(2): 75-85. PMID:17660580.
40. Steinberg, S.F. 2001. PI3King the L-type calcium channel activation mechanism. Circ. Res. 89(8): 641-644. PMID:11597984.
41. Sugden, P.H., and Clerk, A. 2006. Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes. Antioxid. Redox Signal. 8(11-12): 2111-2124. doi:10.1089/ars.2006.8.2111. PMID:17034354.
42. k,slow currents. Cardiovasc. Res. 62(3): 509-520. doi:10.1016/j.cardiores.2004.01.029. PMID:15158143.
43. Tong, H., Chen, W., Steenbergen. C., and Murphy, E. 2000. Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C. Circ. Res. 87(4): 309-3 15. PMID:10948065.
44. Uchiyama, T., Engelman, R.M., Maulik, N., and Das, D.K. 2004. Role of Akt signaling in mitochondrial pathway triggered by hypoxic preconditioning. Circulation, 109(24): 3042-3049. doi:10.1161/01.CIR.0000130647.29030.90.
45. ATP channels in antiarrhythmic effects of ischaemic preconditioning in dogs. Br. J. Pharmacol. 137(7): 1107-1115. doi:10.1038/sj.bjp.0704966. PMID:12429584.
46. Walker, M.J., Curtis, M.J., Hearse, D.J., Campbell, R.W., Janse, M.J., Yellon, D.M., et al. 1988. The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion. Cardiovasc. Res. 22(7): 447-455. doi:10.1093/cvr/22.7.447. PMID:3252968.
47. Walker. E.H., Pacold, M.E., Perisic. O., Stephens, L., Hawkins, P.T., Wymann, M.P., and Williams, R.L. 2000. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol. Cell. 6(4): 909-919. doi:10.1016/S1097-2765(05)00089-4. PMID:11090628.
48. Yano, H., Nakanishi, S., Kimura, K., Hanai, N., Saitob, Y., Fukui, Y., et al. 1993. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL2H3 cells. J. Biol. Chem. 268(34): 25846-25856. PMID:7503989.
49. ATP channels, free radicals and p38 MAPK in preconditioning' s protective pathway in rat heart. Cardiovasc. Res. 55(3): 681-689. doi:10.1016/S0008-6363(02)00452-2. PMID:12160965.
50. Zhang, D.X., Chen, Y.F., Campbell, W.B., Zou, A.P., Gross, G.J., and Li, P.L. 2001. Characteristics and superoxide-induced activation of reconstituted myocardial mitochondrial ATP-sensitive potassium channels. Circ. Res. 89(12): 1177-1183. doi:10.1161/hh2401.101752. PMID:11739283.