메뉴 건너뛰기




Volumn 87, Issue 12, 2009, Pages 1028-1036

Changes in PPAR gene expression and myocardial tolerance to ischaemia: Relevance to pleiotropic effects of statins

Author keywords

Myocardial ischaemia; PPAR; Rat heart; Statins

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SIMVASTATIN; TRIPHENYLTETRAZOLIUM;

EID: 76549098871     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y09-071     Document Type: Conference Paper
Times cited : (27)

References (47)
  • 1
    • 33749039679 scopus 로고    scopus 로고
    • Protective effect of sirnvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats
    • PMID:17020164
    • Adameová, A., Kuzelová, M., Faberová, V., and Svec, P. 2006. Protective effect of sirnvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats. Pharmazie, 61(9): 807-808. PMID:17020164.
    • (2006) Pharmazie , vol.61 , Issue.9 , pp. 807-808
    • Adameová, A.1    Kuzelová, M.2    Faberová, V.3    Svec, P.4
  • 2
    • 0034467428 scopus 로고    scopus 로고
    • PPAR signaling in the control of cardiac energy metabolism
    • PMID:11282301, doi: 10.1016/S1050-1738(00)00077-3
    • Barger, P.M., and Kelly, D.P. 2000. PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc. Med. 10(6): 238-245. doi: 10.1016/S1050-1738(00)00077-3. PMID:11282301.
    • (2000) Trends Cardiovasc. Med , vol.10 , Issue.6 , pp. 238-245
    • Barger, P.M.1    Kelly, D.P.2
  • 3
    • 0033933236 scopus 로고    scopus 로고
    • Deactivation of peroxisome proliferator-activated receptor-α during cardiac hypertrophic growth
    • PMID:10862787, doi:10.1172/JCI9056
    • Barger, P.M., Brandt, J.M., Leone, T.C., Weinheimer, C.J., and Kelly, D.P. 2000. Deactivation of peroxisome proliferator-activated receptor-α during cardiac hypertrophic growth. J. Clin. Invest. 105(12): 1723-1730. doi:10.1172/JCI9056. PMID:10862787.
    • (2000) J. Clin. Invest , vol.105 , Issue.12 , pp. 1723-1730
    • Barger, P.M.1    Brandt, J.M.2    Leone, T.C.3    Weinheimer, C.J.4    Kelly, D.P.5
  • 4
    • 0037419766 scopus 로고    scopus 로고
    • Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up-regulating a pro-survival pathway
    • PMID:12575984, doi:10.1016/S0735-1097(02)02816-4
    • Bell, R.M., and Yellon, D.M. 2003. Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up-regulating a pro-survival pathway. J. Am. Coll. Cardiol. 41(3): 508-515. doi:10.1016/S0735-1097(02)02816-4. PMID:12575984.
    • (2003) J. Am. Coll. Cardiol , vol.41 , Issue.3 , pp. 508-515
    • Bell, R.M.1    Yellon, D.M.2
  • 5
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
    • PMID:8536636, doi:10.1210/en.137.1.354
    • Braissant, O., Foufelle, F., Scotto, C., Dauça, M., and Wahli, W. 1996. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology, 137(1): 354-366. doi:10.1210/en.137.1.354. PMID:8536636.
    • (1996) Endocrinology , vol.137 , Issue.1 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauça, M.4    Wahli, W.5
  • 6
    • 0141920778 scopus 로고    scopus 로고
    • Pravastatin prevents arrhythmias induced by coronary artery ischemia/reperfusion in anesthetized normocholesterolemic rats
    • PMID:14501157, doi: 10.1254/jphs.93.87
    • Chen, J., Nagasawa, Y., Zhu, B.M., Ohmori, M., Harada, K., Fujimura, A., and Hashimoto, K. 2003. Pravastatin prevents arrhythmias induced by coronary artery ischemia/reperfusion in anesthetized normocholesterolemic rats. J. Pharmacol. Sci. 93(1): 87-94. doi: 10.1254/jphs.93.87. PMID:14501157.
    • (2003) J. Pharmacol. Sci , vol.93 , Issue.1 , pp. 87-94
    • Chen, J.1    Nagasawa, Y.2    Zhu, B.M.3    Ohmori, M.4    Harada, K.5    Fujimura, A.6    Hashimoto, K.7
  • 7
    • 0032127160 scopus 로고    scopus 로고
    • Characterisation, utilisation and clinical relevance of isolated perfused heart models of ischaemia-induced ventricular fibrillation
    • PMID:9764200, doi: 10.1016/S0008-6363(98)00083-2
    • Curtis, M.J. 1998. Characterisation, utilisation and clinical relevance of isolated perfused heart models of ischaemia-induced ventricular fibrillation. Cardiovasc. Res. 39(1): 194-215. doi: 10.1016/S0008-6363(98)00083-2. PMID:9764200.
    • (1998) Cardiovasc. Res , vol.39 , Issue.1 , pp. 194-215
    • Curtis, M.J.1
  • 8
    • 65549166707 scopus 로고    scopus 로고
    • Rosuvastatin given during reperfusion decreases infarct size and inhibits matrix metalloproteinase-2 activity in normocholesterolemic and hypercholesterolemic rabbits
    • PMID:19188835, doi: 10.1097/FJC.0b013e318197c5e9
    • D'Annunzio, V., Donato, M., Erni, L., Miksztowicz, V., Buchholz, B., Carrión, C.L., et al. 2009. Rosuvastatin given during reperfusion decreases infarct size and inhibits matrix metalloproteinase-2 activity in normocholesterolemic and hypercholesterolemic rabbits. J. Cardiovasc. Pharmacol. 53(2): 137-144. doi: 10.1097/FJC.0b013e318197c5e9. PMID:19188835.
    • (2009) J. Cardiovasc. Pharmacol , vol.53 , Issue.2 , pp. 137-144
    • D'Annunzio, V.1    Donato, M.2    Erni, L.3    Miksztowicz, V.4    Buchholz, B.5    Carrión, C.L.6
  • 9
    • 0034965596 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in inflammation control
    • PMID:11375115, doi:10.1677/joe.0.1690453
    • Delerive, P., Fruchart, J.C., and Staels, B. 2001. Peroxisome proliferator-activated receptors in inflammation control. J. Endocrinol. 169(3): 453-459. doi:10.1677/joe.0.1690453. PMID:11375115.
    • (2001) J. Endocrinol , vol.169 , Issue.3 , pp. 453-459
    • Delerive, P.1    Fruchart, J.C.2    Staels, B.3
  • 10
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • PMID:10529898, doi:10.1210/er.20.5.649
    • Desvergne, B., and Wahli, W. 1999. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev. 20(5): 649-688. doi:10.1210/er.20.5.649. PMID:10529898.
    • (1999) Endocr. Rev , vol.20 , Issue.5 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 11
    • 0034942037 scopus 로고    scopus 로고
    • Simvastatin reduces reperfusion injury by modulating nitric oxide synthase expression: An ex vivo study in isolated working rat hearts
    • PMID:11470468, doi: 10.1016/S0008-6363(01)00306-6
    • Di Napoli, P., Antonio Taccardi, A., Grilli, A., Spina, R., Felaco, M., Barsotti, A., and De Caterina, R. 2001. Simvastatin reduces reperfusion injury by modulating nitric oxide synthase expression: an ex vivo study in isolated working rat hearts. Cardiovasc. Res. 51(2): 283-293. doi: 10.1016/S0008-6363(01)00306-6. PMID:11470468.
    • (2001) Cardiovasc. Res , vol.51 , Issue.2 , pp. 283-293
    • Di Napoli, P.1    Antonio Taccardi, A.2    Grilli, A.3    Spina, R.4    Felaco, M.5    Barsotti, A.6    De Caterina, R.7
  • 12
    • 14744280775 scopus 로고    scopus 로고
    • Atorvastatin and myocardial reperfusion injury: New pleiotropic effect implicating multiple prosurvival signaling
    • PMID:15725950, doi: 10.1097/01.fjc.0000154376.82445.06
    • Efthymiou, C.A., Mocanu, M.M., and Yellon, D.M. 2005. Atorvastatin and myocardial reperfusion injury: new pleiotropic effect implicating multiple prosurvival signaling. J. Cardiovasc. Pharmacol. 45(3): 247-252. doi: 10.1097/01.fjc.0000154376.82445.06. PMID:15725950.
    • (2005) J. Cardiovasc. Pharmacol , vol.45 , Issue.3 , pp. 247-252
    • Efthymiou, C.A.1    Mocanu, M.M.2    Yellon, D.M.3
  • 13
    • 0034801882 scopus 로고    scopus 로고
    • Rat PPARs: Quantitative analysis in adult rat tissues and regulation in fasting and refeeding
    • PMID:11564675, doi: 10.1210/en.142.10.4195
    • Escher, P., Braissant, O., Basu-Modak, S., Michalik, L., Wahli, W., and Desvergne, B. 2001. Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology, 142(10): 4195-4202. doi: 10.1210/en.142.10.4195. PMID:11564675.
    • (2001) Endocrinology , vol.142 , Issue.10 , pp. 4195-4202
    • Escher, P.1    Braissant, O.2    Basu-Modak, S.3    Michalik, L.4    Wahli, W.5    Desvergne, B.6
  • 14
    • 1542496389 scopus 로고    scopus 로고
    • Fragasso, G., Piatti Md, P.M., Monti, L., Palloshi, A., Setola, E., Puccetti. P., et al. 2003. Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy. Am. Heart J. 146(5): E18. doi: 10.1016/S0002-8703(03)00415-0. PMID:14597947.
    • Fragasso, G., Piatti Md, P.M., Monti, L., Palloshi, A., Setola, E., Puccetti. P., et al. 2003. Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy. Am. Heart J. 146(5): E18. doi: 10.1016/S0002-8703(03)00415-0. PMID:14597947.
  • 15
    • 0037459358 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) α and PPARβ/δ, but not PPARγ, modulate the expression of genes involved in cardiac lipid metabolism
    • PMID:12600885, doi: 10.1161/01.RES.0000060700.55247.7C
    • Gilde, A.J., van der Lee, K.A., Willemsen, P.H., Chinetti, G., van der Leij, F.R., van der Vusse, G.J., et al. 2003. Peroxisome proliferator-activated receptor (PPAR) α and PPARβ/δ, but not PPARγ, modulate the expression of genes involved in cardiac lipid metabolism. Circ. Res. 92(5): 518-524. doi: 10.1161/01.RES.0000060700.55247.7C. PMID:12600885.
    • (2003) Circ. Res , vol.92 , Issue.5 , pp. 518-524
    • Gilde, A.J.1    van der Lee, K.A.2    Willemsen, P.H.3    Chinetti, G.4    van der Leij, F.R.5    van der Vusse, G.J.6
  • 16
    • 33748557190 scopus 로고    scopus 로고
    • Regulating the regulator: NP-κB signaling in heart
    • PMID:16949095, doi:10.1016/j.yjmcc.2006.07.006
    • Hall, G., Hasday, J.D., and Rogers, T.B. 2006. Regulating the regulator: NP-κB signaling in heart. J. Mol. Cell. Cardiol. 41(4): 580-591. doi:10.1016/j.yjmcc.2006.07.006. PMID:16949095.
    • (2006) J. Mol. Cell. Cardiol , vol.41 , Issue.4 , pp. 580-591
    • Hall, G.1    Hasday, J.D.2    Rogers, T.B.3
  • 17
    • 4644231528 scopus 로고    scopus 로고
    • Nuclear receptor signaling and cardiac energetics
    • PMID:15375023, doi:10.1161/01.RES.0000141774. 29937.e3
    • Huss, J.M., and Kelly, D.P. 2004. Nuclear receptor signaling and cardiac energetics. Circ. Res. 95(6): 568-578. doi:10.1161/01.RES.0000141774. 29937.e3. PMID:15375023.
    • (2004) Circ. Res , vol.95 , Issue.6 , pp. 568-578
    • Huss, J.M.1    Kelly, D.P.2
  • 18
    • 0037381031 scopus 로고    scopus 로고
    • Rosuvastatin, a new HMG-CoA reductase inhibitor, protects ischemic reperfused myucardium in normochulesterolemic rats
    • PMID:12658068, doi: 10.1097/00005344-200304000-00019
    • Ikeda, Y., Young, L.H., and Lefer, A.M. 2003. Rosuvastatin, a new HMG-CoA reductase inhibitor, protects ischemic reperfused myucardium in normochulesterolemic rats. J. Cardiovasc. Pharmacol. 41(4): 649-656. doi: 10.1097/00005344-200304000-00019. PMID:12658068.
    • (2003) J. Cardiovasc. Pharmacol , vol.41 , Issue.4 , pp. 649-656
    • Ikeda, Y.1    Young, L.H.2    Lefer, A.M.3
  • 19
    • 0034678082 scopus 로고    scopus 로고
    • The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase
    • PMID:10720420
    • Kantor, P.F., Lucien, A., Kozak. R., and Lopaschuk, G.D. 2000. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ. Res. 86(5): 580-588. PMID:10720420.
    • (2000) Circ. Res , vol.86 , Issue.5 , pp. 580-588
    • Kantor, P.F.1    Lucien, A.2    Kozak, R.3    Lopaschuk, G.D.4
  • 20
    • 0035786906 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: From genes to physiology
    • PMID:11237216, doi:10.1210/rp.56.1.239
    • Kliewer, S.A., Xu, H.E., Lambert, M.H., and Willson, T.M. 2001. Peroxisome proliferator-activated receptors: from genes to physiology. Recent Prog. Horm. Res. 56(1): 239-263. doi:10.1210/rp.56.1.239. PMID:11237216.
    • (2001) Recent Prog. Horm. Res , vol.56 , Issue.1 , pp. 239-263
    • Kliewer, S.A.1    Xu, H.E.2    Lambert, M.H.3    Willson, T.M.4
  • 21
    • 0032988969 scopus 로고    scopus 로고
    • Early activation of transcription factor NP-κB during ischemia in perfused rat heart
    • PMID:9950856
    • Li, C., Browder, W., and Kao, R.L. 1999. Early activation of transcription factor NP-κB during ischemia in perfused rat heart. Am. J. Physiol. 276(2 Pt 2): H543-H552. PMID:9950856.
    • (1999) Am. J. Physiol , vol.276 , Issue.2 PART 2
    • Li, C.1    Browder, W.2    Kao, R.L.3
  • 22
    • 59349103110 scopus 로고    scopus 로고
    • Differential roles of MAPKs and MSK1 signalling pathways in the regulation of c-Jun during phenylephrine-induced cardiac myocyte hypertrophy
    • PMID:19002563, doi:10.1007/s11010-008-9945-8
    • Markou, T., Cieslak, D., Gaitanaki, C., and Lazou, A. 2009. Differential roles of MAPKs and MSK1 signalling pathways in the regulation of c-Jun during phenylephrine-induced cardiac myocyte hypertrophy. Mol. Cell. Biochem. 322(1-2): 103-112. doi:10.1007/s11010-008-9945-8. PMID:19002563.
    • (2009) Mol. Cell. Biochem , vol.322 , Issue.1-2 , pp. 103-112
    • Markou, T.1    Cieslak, D.2    Gaitanaki, C.3    Lazou, A.4
  • 23
    • 0034994075 scopus 로고    scopus 로고
    • Statin-induced inhibition of the Rho-signaling pathway activates PPARα and induces HDL apoA-I
    • PMID:11390424, doi:10.1172/JCI10852
    • Martin, G., Duez, H., Blanquart, Ch., Berezowski, V., Poulain, Ph., Fruchart. J.C., et al. 2001. Statin-induced inhibition of the Rho-signaling pathway activates PPARα and induces HDL apoA-I. J. Clin. Invest. 107(11): 1423-1432. doi:10.1172/JCI10852. PMID:11390424.
    • (2001) J. Clin. Invest , vol.107 , Issue.11 , pp. 1423-1432
    • Martin, G.1    Duez, H.2    Blanquart, C.3    Berezowski, V.4    Poulain, P.5    Fruchart, J.C.6
  • 24
    • 34548421559 scopus 로고    scopus 로고
    • The central role of adenosine in statin-induced ERK1/2, Akt, and eNOS phosphorylation
    • PMID:17616749, doi: 10.1152/ajpheart.00416.2007
    • Merla, R., Ye, Y., Lin, Y., Manickavasagam, S., Huang, M.H., Perez-Polo, R.J., et al. 2007. The central role of adenosine in statin-induced ERK1/2, Akt, and eNOS phosphorylation. Am. J. Physiol. Heart Circ. Physiol. 293(3): H1918-H1928. doi: 10.1152/ajpheart.00416.2007. PMID:17616749.
    • (2007) Am. J. Physiol. Heart Circ. Physiol , vol.293 , Issue.3
    • Merla, R.1    Ye, Y.2    Lin, Y.3    Manickavasagam, S.4    Huang, M.H.5    Perez-Polo, R.J.6
  • 25
    • 33644652740 scopus 로고    scopus 로고
    • Involvement of PPAR nuclear receptors in tissue injury and wound repair
    • PMID:16511592, doi:10.1172/JCI27958
    • Michalik, L., and Wahli, W. 2006. Involvement of PPAR nuclear receptors in tissue injury and wound repair. J. Clin. Invest. 116(3): 598-606. doi:10.1172/JCI27958. PMID:16511592.
    • (2006) J. Clin. Invest , vol.116 , Issue.3 , pp. 598-606
    • Michalik, L.1    Wahli, W.2
  • 26
    • 19344362320 scopus 로고    scopus 로고
    • PPAR-α activation required for decreased glucose uptake and increased susceptibility to injury during ischemia
    • PMID:15665064, doi: 10.1152/ajpheart.00200.2004
    • Panagia, M., Gibbons, G.F., Radda, G.K., and Clarke, K. 2005. PPAR-α activation required for decreased glucose uptake and increased susceptibility to injury during ischemia. Am. J. Physiol. Heart Circ. Physiol. 288(6): H2677-H2683. doi: 10.1152/ajpheart.00200.2004. PMID:15665064.
    • (2005) Am. J. Physiol. Heart Circ. Physiol , vol.288 , Issue.6
    • Panagia, M.1    Gibbons, G.F.2    Radda, G.K.3    Clarke, K.4
  • 27
    • 43049118952 scopus 로고    scopus 로고
    • Cross-talk between statins and PPARCα in cardiovascular diseases: Clinical evidence and basic mechanisms
    • PMID:18436144, doi:10.1016/j.tcm.2008.01.001
    • Paumelle, R., and Staels, B. 2008. Cross-talk between statins and PPARCα in cardiovascular diseases: clinical evidence and basic mechanisms. Trends Cardiovasc. Med. 18(3): 73-78. doi:10.1016/j.tcm.2008.01.001. PMID:18436144.
    • (2008) Trends Cardiovasc. Med , vol.18 , Issue.3 , pp. 73-78
    • Paumelle, R.1    Staels, B.2
  • 28
    • 33646817773 scopus 로고    scopus 로고
    • Acute antiinflammatory properties of statins involve peroxisome proliferator-activated receptor-α via inhibition of the protein kinase C signaling pathway
    • PMID:16397146, doi:10.1161/01.RES. 0000202706.70992.95
    • Paumelle, R., Blanquart, C., Briand, O., Barbier, O., Duhem, C., Woerly, O., et al. 2006. Acute antiinflammatory properties of statins involve peroxisome proliferator-activated receptor-α via inhibition of the protein kinase C signaling pathway. Circ. Res. 98(3): 361-369. doi:10.1161/01.RES. 0000202706.70992.95. PMID:16397146.
    • (2006) Circ. Res , vol.98 , Issue.3 , pp. 361-369
    • Paumelle, R.1    Blanquart, C.2    Briand, O.3    Barbier, O.4    Duhem, C.5    Woerly, O.6
  • 29
    • 13644255995 scopus 로고    scopus 로고
    • Atorvastatin improves peroxisome proliferator-activated receptor signaling in cardiac hypertrophy by preventing nuclear factor-κB activation
    • PMID:15708355
    • Planavila, A., Laguna, J.C., and Vázquez-Carrera, M. 2005. Atorvastatin improves peroxisome proliferator-activated receptor signaling in cardiac hypertrophy by preventing nuclear factor-κB activation. Biochim. Biophys. Acta, 1687(1-3): 76-83. PMID:15708355.
    • (2005) Biochim. Biophys. Acta , vol.1687 , Issue.1-3 , pp. 76-83
    • Planavila, A.1    Laguna, J.C.2    Vázquez-Carrera, M.3
  • 30
    • 33947371601 scopus 로고    scopus 로고
    • Differential role of PI3K/Akt pathway in the infarct size limitation and antiarrhythmic protection in the rat heart
    • PMID:17016676, doi:10.1007/s11010-006-9335-z
    • Ravingerová, T., Matejíková, J., Neckář, J., Andelová, E., and Kolář, F. 2007. Differential role of PI3K/Akt pathway in the infarct size limitation and antiarrhythmic protection in the rat heart. Mol. Cell. Biochem. 297(1-2): 111-120. doi:10.1007/s11010-006-9335-z. PMID:17016676.
    • (2007) Mol. Cell. Biochem , vol.297 , Issue.1-2 , pp. 111-120
    • Ravingerová, T.1    Matejíková, J.2    Neckář, J.3    Andelová, E.4    Kolář, F.5
  • 31
    • 0035860177 scopus 로고    scopus 로고
    • Hypoxia in vivo decreases peroxisome proliferator-activated receptor α-regulated gene expression in rat heart
    • PMID:11549245, doi:10.1006/bbrc.2001.5541
    • Razeghi, P., Young, M.E., Abbasi, S., and Taegtmeyer, H. 2001. Hypoxia in vivo decreases peroxisome proliferator-activated receptor α-regulated gene expression in rat heart. Biochem. Biophys. Res. Commun. 287(1): 5-10. doi:10.1006/bbrc.2001.5541. PMID:11549245.
    • (2001) Biochem. Biophys. Res. Commun , vol.287 , Issue.1 , pp. 5-10
    • Razeghi, P.1    Young, M.E.2    Abbasi, S.3    Taegtmeyer, H.4
  • 32
    • 33644662725 scopus 로고    scopus 로고
    • Chronic activation of PPARα is detrimental to cardiac recovery after ischemia
    • PMID:16155108, doi:10.1152/ajpheart.00285.2005
    • Sambandam, N., Morabito, D., Wagg, C., Finck, B.N., Kelly, D.P., and Lopaschuk, G.D. 2006. Chronic activation of PPARα is detrimental to cardiac recovery after ischemia. Am. J. Physiol. Heart Circ. Physiol. 290(1): H87-H95. doi:10.1152/ajpheart.00285.2005. PMID:16155108.
    • (2006) Am. J. Physiol. Heart Circ. Physiol , vol.290 , Issue.1
    • Sambandam, N.1    Morabito, D.2    Wagg, C.3    Finck, B.N.4    Kelly, D.P.5    Lopaschuk, G.D.6
  • 33
    • 18244362843 scopus 로고    scopus 로고
    • Rosuvastatin reduces platelet activation in heart failure: Role of NO bioavailability
    • PMID:15761193, doi:10.1161/01.ATV.0000161926.43967.df
    • Schäfer, A., Fraccarollo, D., Eigenthaler, M., Tas, P., Firnschild, A., Frantz, S., et al. 2005. Rosuvastatin reduces platelet activation in heart failure: role of NO bioavailability. Arterioscler. Thromb. Vasc. Biol. 25(5): 1071-1077. doi:10.1161/01.ATV.0000161926.43967.df. PMID:15761193.
    • (2005) Arterioscler. Thromb. Vasc. Biol , vol.25 , Issue.5 , pp. 1071-1077
    • Schäfer, A.1    Fraccarollo, D.2    Eigenthaler, M.3    Tas, P.4    Firnschild, A.5    Frantz, S.6
  • 34
    • 0242349750 scopus 로고    scopus 로고
    • Direct anti-inflammatory mechanisms contribute to attenuation of experimental allograft arteriosclerosis by statins
    • PMID:14517172, doi:10.1161/01.CIR.0000092949.67153.74
    • Shimizu, K., Aikawa, M., Takayama, K., Libby, P., and Mitchell. R.N. 2003. Direct anti-inflammatory mechanisms contribute to attenuation of experimental allograft arteriosclerosis by statins. Circulation, 108(17): 2113-2120. doi:10.1161/01.CIR.0000092949.67153.74. PMID:14517172.
    • (2003) Circulation , vol.108 , Issue.17 , pp. 2113-2120
    • Shimizu, K.1    Aikawa, M.2    Takayama, K.3    Libby, P.4    Mitchell, R.N.5
  • 35
    • 35248852831 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and inflammation: Take it to heart
    • PMID:17935522
    • Smeets, P.J.H., Planavila, A., van der Vusse, G.J., and van Bilsen, M. 2007. Peroxisome proliferator-activated receptors and inflammation: take it to heart. Acta Physiol. (Oxf.), 191(3): 171-188. PMID:17935522.
    • (2007) Acta Physiol. (Oxf.) , vol.191 , Issue.3 , pp. 171-188
    • Smeets, P.J.H.1    Planavila, A.2    van der Vusse, G.J.3    van Bilsen, M.4
  • 36
    • 55449107744 scopus 로고    scopus 로고
    • Effect of acute and chronic simvastatin treatment on post-ischemic contractile dysfunction in isolated rat heart
    • PMID:18973424
    • Szárszoi, O., Malý, J., Ošťádal, P., Netuka, I., Besík, J., Kolář, F., and Ošť ádal, B. 2008. Effect of acute and chronic simvastatin treatment on post-ischemic contractile dysfunction in isolated rat heart. Physiol. Res. 57(5): 793-796. PMID:18973424.
    • (2008) Physiol. Res , vol.57 , Issue.5 , pp. 793-796
    • Szárszoi, O.1    Malý, J.2    Ošťádal, P.3    Netuka, I.4    Besík, J.5    Kolář, F.6    Ošť ádal, B.7
  • 37
    • 2642581745 scopus 로고    scopus 로고
    • Activation of the peroxisome proliferator-activated receptor α protects against myocardial ischaemic injury and improves endotheial vasodilatation
    • PMID:11940253, doi:10.1186/1471- 2210-2-10
    • Tabernero, A., Schoonjans, K., Jesel, L., Carpusca, I., Auwerx, J., and Andriantsitohaina, R. 2002. Activation of the peroxisome proliferator-activated receptor α protects against myocardial ischaemic injury and improves endotheial vasodilatation. BMC Pharmacol. 2(1): 10. doi:10.1186/1471- 2210-2-10. PMID:11940253.
    • (2002) BMC Pharmacol , vol.2 , Issue.1 , pp. 10
    • Tabernero, A.1    Schoonjans, K.2    Jesel, L.3    Carpusca, I.4    Auwerx, J.5    Andriantsitohaina, R.6
  • 38
    • 0035572718 scopus 로고    scopus 로고
    • Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
    • PMID:11701455, doi:10.1161/hq1101.098486
    • Takemoto, M., and Liao, J.K. 2001. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Arterioscler. Thromb. Vasc. Biol. 21(11): 1712-1719. doi:10.1161/hq1101.098486. PMID:11701455.
    • (2001) Arterioscler. Thromb. Vasc. Biol , vol.21 , Issue.11 , pp. 1712-1719
    • Takemoto, M.1    Liao, J.K.2
  • 39
    • 33645396685 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α agonist, clofibrate, has profound influence on myocardial fatty acid composition
    • PMID:16540100, doi:10.1016/j.cbi.2006.02.003
    • Tian, Q., Grzemski, F.A., Panagiotopoulos, S., and Ahokas, J.T. 2006. Peroxisome proliferator-activated receptor α agonist, clofibrate, has profound influence on myocardial fatty acid composition. Chem. Biol. Interact. 160(3): 241-251. doi:10.1016/j.cbi.2006.02.003. PMID:16540100.
    • (2006) Chem. Biol. Interact , vol.160 , Issue.3 , pp. 241-251
    • Tian, Q.1    Grzemski, F.A.2    Panagiotopoulos, S.3    Ahokas, J.T.4
  • 40
    • 34547688762 scopus 로고    scopus 로고
    • Anti-inflammatory effects of atorvastatin improve left ventricular function in experimental diabetic cardiomyopathy
    • PMID:17589825, doi:10.1007/s00125-007-0719-8
    • Van Linthout. S., Riad, A., Dhayat, N., Spillmann, F., Du. J., Dhayat, S., et al. 2007. Anti-inflammatory effects of atorvastatin improve left ventricular function in experimental diabetic cardiomyopathy. Diabetologia, 50(9): 1977-1986. doi:10.1007/s00125-007-0719-8. PMID:17589825.
    • (2007) Diabetologia , vol.50 , Issue.9 , pp. 1977-1986
    • Van Linthout, S.1    Riad, A.2    Dhayat, N.3    Spillmann, F.4    Du, J.5    Dhayat, S.6
  • 41
    • 0036314839 scopus 로고    scopus 로고
    • Ligands of the peroxisome proliferator-activated receptors (PPAR-γ and PPAR-α) reduce myocardial infarct size
    • PMID:12087064, doi:10.1096/fj.01-0793com
    • Wayman, N.S., Hattori, Y., McDonald, M.C., Mota-Filipe, H., Cuzzocrea, S., Pisano, B., et al. 2002. Ligands of the peroxisome proliferator-activated receptors (PPAR-γ and PPAR-α) reduce myocardial infarct size. FASEB J. 16(9): 1027-1040. doi:10.1096/fj.01-0793com. PMID:12087064.
    • (2002) FASEB J , vol.16 , Issue.9 , pp. 1027-1040
    • Wayman, N.S.1    Hattori, Y.2    McDonald, M.C.3    Mota-Filipe, H.4    Cuzzocrea, S.5    Pisano, B.6
  • 42
    • 0038171189 scopus 로고    scopus 로고
    • Simvastatin reduces infarct size in a model of acute myocardial ischemia and reperfusion in the rat
    • PMID:12761443
    • Wayman, N.S., Ellis, B.L., and Thiemermann, C. 2003. Simvastatin reduces infarct size in a model of acute myocardial ischemia and reperfusion in the rat. Med. Sci. Monit. 9(5): BR155-BR159. PMID:12761443.
    • (2003) Med. Sci. Monit , vol.9 , Issue.5
    • Wayman, N.S.1    Ellis, B.L.2    Thiemermann, C.3
  • 43
    • 0037369529 scopus 로고    scopus 로고
    • Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme A reductase inhibitor is mediated by endothelial nitric oxide synthase
    • PMID:12605027, doi:10.1097/00005344-200303000-00017
    • Wolfrum, S., Grimm, M., Heidbreder. M., Dendorfer, A., Katus. H.A., Liao, J.K., and Richardt, G. 2003. Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme A reductase inhibitor is mediated by endothelial nitric oxide synthase. J. Cardiovasc. Pharmacol. 41(3): 474-480. doi:10.1097/00005344-200303000-00017. PMID:12605027.
    • (2003) J. Cardiovasc. Pharmacol , vol.41 , Issue.3 , pp. 474-480
    • Wolfrum, S.1    Grimm, M.2    Heidbreder, M.3    Dendorfer, A.4    Katus, H.A.5    Liao, J.K.6    Richardt, G.7
  • 44
    • 34249723258 scopus 로고    scopus 로고
    • Statins activate peroxisome proliferator-activated receptor γ through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages
    • PMID:17463321, doi:10.1161/01.RES. 0000268411.49545.9c
    • Yano, M., Matsumura, T., Senokuchi, T., Ishii, N., Murata, Y., Taketa, K., et al. 2007. Statins activate peroxisome proliferator-activated receptor γ through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages. Circ. Res. 100(10): 1442-1451. doi:10.1161/01.RES. 0000268411.49545.9c. PMID:17463321.
    • (2007) Circ. Res , vol.100 , Issue.10 , pp. 1442-1451
    • Yano, M.1    Matsumura, T.2    Senokuchi, T.3    Ishii, N.4    Murata, Y.5    Taketa, K.6
  • 45
    • 33747337433 scopus 로고    scopus 로고
    • Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor α but not gamma activators
    • PMID:16912651, doi:10.1097/01.shk.0000225863. 56714.96
    • Yeh, C.H., Chen, T.P., Lee, C.H., Wu, Y.C., Lin, Y.M., and Lin, P.J. 2006. Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor α but not gamma activators. Shock, 26(3): 262-270. doi:10.1097/01.shk.0000225863. 56714.96. PMID:16912651.
    • (2006) Shock , vol.26 , Issue.3 , pp. 262-270
    • Yeh, C.H.1    Chen, T.P.2    Lee, C.H.3    Wu, Y.C.4    Lin, Y.M.5    Lin, P.J.6
  • 46
    • 0242525729 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-α protects the heart from ischemia/reperfusion injury
    • PMID:14557369, doi:10.1161/01.CIR.0000093187.42015.6C
    • Yue, T.L., Bao, W., Jucker, B.M., Gu, J.L., Romanic, A.M., Brown, P.J., et al. 2003. Activation of peroxisome proliferator-activated receptor-α protects the heart from ischemia/reperfusion injury. Circulation, 108(19): 2393-2399. doi:10.1161/01.CIR.0000093187.42015.6C. PMID:14557369.
    • (2003) Circulation , vol.108 , Issue.19 , pp. 2393-2399
    • Yue, T.L.1    Bao, W.2    Jucker, B.M.3    Gu, J.L.4    Romanic, A.M.5    Brown, P.J.6
  • 47
    • 43549097537 scopus 로고    scopus 로고
    • Cardioprotective effect of fluvastatin on isoproterenol-induced myocardial infarction in rat
    • PMID:18384769, doi:10.1016/j.ejphar.2008.02.057
    • Zhou, R., Xu, Q., Zheng, P., Yan, L., Zheng, J., and Dai, G. 2008. Cardioprotective effect of fluvastatin on isoproterenol-induced myocardial infarction in rat. Eur. J. Pharmacol. 586(1-3): 244-250. doi:10.1016/j.ejphar.2008.02.057. PMID:18384769.
    • (2008) Eur. J. Pharmacol , vol.586 , Issue.1-3 , pp. 244-250
    • Zhou, R.1    Xu, Q.2    Zheng, P.3    Yan, L.4    Zheng, J.5    Dai, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.