IL-6 levels decrease with SSRI treatment in patients with major depression

Human Psychopharmacology

Volumn 20, Issue 7, 2005, Pages 473-476

  Basterzi, Ayse Devrim ^a   Aydemir, Çigdem ^b   Kisa, Cebrail ^b   Aksaray, Sabahat ^b   Tuzer, Verda ^b   Yazici, Kemal ^a   Göka, Erol ^b  

^a MERSIN UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b ANKARA TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Antidepressants; Cytokines; IL 6; Major depressive disorder

Indexed keywords

INTERLEUKIN 6; SEROTONIN UPTAKE INHIBITOR;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE SEVERITY; DRUG RESPONSE; ENZYME IMMUNOASSAY; FEMALE; HAMILTON SCALE; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCORING SYSTEM; STATISTICAL SIGNIFICANCE;

ADULT; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; INTERLEUKIN-6; MALE; PSYCHIATRIC STATUS RATING SCALES; SEROTONIN UPTAKE INHIBITORS;

EID: 27144496670     PISSN: 08856222     EISSN: None     Source Type: Journal    
DOI: 10.1002/hup.717     Document Type: Article

References (25)

1. Akdemir A, Örsel S, Dag I, Türkçapar H, Iscan N, Özbay H. 1996. The validity-reliability and clinical use of Hamilton Depression Rating Scale. 3P Journal (Turkish) 4: 251-259.
2. Berk M, Wade AA, Kuscke RH, O'Neill-Kerr A. 1997. Acute phase proteins in major depression. J Psychosom Med 43: 529-534.
3. Dantzer R, Bluthe RM, Ghensi G, et al. 1998. Molecular basis of sickness behaviour. Ann N Y Acad Sci 856: 132-138.
4. Epstein FH. 1993. Neuroendocrine-Immune Interactions. N Engl J Med 329: 1246-1253.
5. Frommberger UH, Bauer J, Haselbauer P, Fraulin A, Riemann D, Berger M. 1997. IL-6 plasma levels in depression and schizophrenia: comparison between the acute state and after remission. Eur Arch Psychiatry Clin Neurosci 247: 228-233.
6. Hickie I, Lloyd A. 1995. Are cytokines associated with neuropsychiatric syndromes in humans? Int J Immunopharmacol 17: 677-683.
7. Hirano T, Akira S, Taga T, Kishimoto T. 1990. Biological and clinical aspects of IL-6. Immun Today 11: 443-449.
8. Kagaya A, Kuyaga A, Takebayashi M, et al. 2001. Plasma concentrations of IL-1β, IL-6, soluble IL-2 receptor and TNF-α of depressed patients. Neuropsychobiology 43: 59-62.
9. Kelley KW, Bluthe RM, Dantzer R, et al. 2003. Cytokine-induced sickness behavior. Brain Behav Immun 17: 112-118.
10. Konsman JP, Parnet P, Dantzer R. 2002. Cytokine-induced sickness behavior: mechanism and implications. Trends Neurosci 25: 154-159.
11. Kubera M, Kenis G, Bosmans E, et al. 2000. Plasma levels of IL-6, IL-10, IL-1 receptor antagonist in depression: comparison between the acute state and after remission. Pol J Pharmacol 52: 237-241.
12. Lanquillon S, Krieg JC, Bening-Abu-Shach V, Vedder H. 2000. Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology 22: 370-379.
13. Leonard BE. 2001. The immune system, depression and the action of antidepressants. Prog Neuro Psychopharmacol Biol Psychiatry 25: 767-780.
14. Levine J, Barak Y, Chengappa KNR, Rapaport A, Rebey M, Barak V. 1999. Cerebrospinal cytokine levels in patient with acute depression. Neuropsychobiology 40: 171-176.
15. Maes M. 1995. Evidence for an immune response in major depression: a review and hypothesis. Prog Neuropsychopharmacol Biol Psychiatry 19: 11-38.
16. Maes M, Bosmans E, Meltzer HY, Scharpe S, Suy E. 1993a. Interleukin - 1β: a putative mediator of HPA axis hyperactivity in major depression. Am J Psychiatry 150: 1189-1193.
17. Maes M, Meltzer HY, Jacobs Y, et al. 1993b. Autoimmunity in depression: higher phospholipid autoantibody titers. Acta Psychiatr Scand 87: 160-166.
18. Maes M, Scharpe S, Meltzer HY, et al. 1993c. Relation between interleukin 6 activity, acute phase proteins and function of the hypothalamic-pituatary-adrenal axis in severe depression. Psychiatry Res 49: 11-27.
19. Maes M, Scharpe S, van Grootel L, et al. 1992. Higher alpha-1 antitrypsin, haptoglobin, ceruloplasmin and lower retinol binding protein plasma levels during depression: further evidence for the existence of an acute phase response. J Affect Disord 24: 183-192.
20. Maier SF, Watkins LR. 1998. Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood and cognition. Psychol Rev 105: 83-107.
21. Reichlin S. 1993. Neuroendocrine-immune interactions. N Engl J Med 329: 1246-1253.
22. Reichenberg A, Yirmiya R, Schuld A, Kraus T. 2001. Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry 58: 445-452.
23. Smith RS. 1991. The macrophage theory of depression. Med Hypoth 35: 298-306.
24. Xia Z, Depierre JW, Nassberger L. 1996. Tricyclic antidepressants inhibit IL-6, IL-1β, TNF-α release in human blood monocytes and IL-2 and IFN-δ in T cells. Immunopharmacology 34: 27-37.
25. Williams BW. 1978. A structured interview guide for Hamilton depression rating scale. Arch Gen Psychiatry 45: 742-747.