Quorum sensing in Pseudomonas aeruginosa

Journal of Pure and Applied Microbiology

Volumn 7, Issue 3, 2013, Pages 2003-2015

  Xu, Yangyang ^a   Duan, Kangmin ^a,b   Shen, Lixin ^a  

^a NORTHWEST UNIVERSITY   (China)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Pseudomonas aeruginosa; Quorum sensing; Quorum sensing inhibitor

Indexed keywords

4 QUINOLONE DERIVATIVE; AJOENE; ANDROGRAPHOLIDE; AZITHROMYCIN; CAFFEINE; CEFTAZIDIME; CIPROFLOXACIN; EUGENOL; FURANONE DERIVATIVE; GARLIC EXTRACT; GINSENG EXTRACT; GOYAZENSOLIDE; HYDROLASE; ISOGOYAZENSOLIDE; LACTONE DERIVATIVE; N ACYLHOMOSERINE LACTONE; N BUTANOYLHOMOSERINE LACTONE; N OCTANOYLCYCLOPENTYLAMIDE; PHENAZINE; RHAMNOLIPID; SESQUITERPENE LACTONE DERIVATIVE; TOBRAMYCIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

DRUG MECHANISM; DRUG TARGETING; GENE EXPRESSION; NONHUMAN; PATHOGENICITY; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; REVIEW; SIGNAL TRANSDUCTION;

EID: 84888771367     PISSN: 09737510     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (121)

1. Marshall, B. C.; Carroll, K. C. In Interaction between Pseudomonas aeruginosa and host defenses in cystic fibrosis, 1991; 1991; pp 11.
2. Fuqua, C.; Parsek, M. R.; Greenberg, E. P., Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing. Annual review of genetics 2001; 35(1): 439-468.
3. de Kievit, T. R.; Iglewski, B. H., Bacterial quorum sensing in pathogenic relationships. Infection and immunity 2000; 68(9): 4839-49.
4. Juhas, M.; Eberl, L.; Tummler, B., Quorum sensing: the power of cooperation in the world of Pseudomonas. Environmental microbiology 2005; 7(4): 459-71.
5. Withers, H.; Swift, S.; Williams, P., Quorum sensing as an integral component of gene regulatory networks in Gram-negative bacteria. Current opinion in microbiology 2001; 4 (2).
6. Schuster, M.; Peter Greenberg, E., A network of networks: Quorum-sensing gene regulation in Pseudomonas aeruginosa. International journal of medical microbiology 2006; 296(2): 73-81.
7. Gambello, M. J.; Iglewski, B. H., Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. Journal of bacteriology 1991; 173(9): 3000-3009.
8. Passador, L.; Cook, J. M.; Gambello, M. J.; Rust, L.; Iglewski, B. H., Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication. Science 1993; 260(5111): 1127-30.
9. Pearson, J. P.; Gray, K. M.; Passador, L.; Tucker, K. D.; Eberhard, A.; Iglewski, B. H.; Greenberg, E. P., Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proceedings of the National Academy of Sciences of the United States of America 1994; 91(1): 197-201.
10. Sappington, K. J.; Dandekar, A. A.; Oinuma, K.; Greenberg, E. P., Reversible signal binding by the Pseudomonas aeruginosa quorum-sensing signal receptor LasR. mBio 2011; 2(1): e00011-11.
11. Schuster, M.; Urbanowski, M. L.; Greenberg, E. P., Promoter specificity in Pseudomonas aeruginosa quorum sensing revealed by DNA binding of purified LasR. Proceedings of the National Academy of Sciences of the United States of America 2004; 101(45): 15833-9.
12. Rayo, J.; Amara, N.; Krief, P.; Meijler, M. M., Live cell labeling of native intracellular bacterial receptors using aniline-catalyzed oxime ligation. Journal of the American Chemical Society 2011; 133(19): 7469-75.
13. Ochsner, U. A.; Koch, A. K.; Fiechter, A.; Reiser, J., Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. J Bacteriol 1994; 176(7): 2044-54.
14. Ochsner, U. A.; Reiser, J., Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America 1995; 92(14): 6424-8.
15. Pearson, J. P.; Passador, L.; Iglewski, B. H.; Greenberg, E. P., A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences 1995; 92(5): 1490-1494.
16. Ventre, I.; Ledgham, F.; Prima, V.; Lazdunski, A.; Foglino, M.; Sturgis, J. N., Dimerization of the quorum sensing regulator RhlR: development of a method using EGFP fluorescence anisotropy. Molecular microbiology 2003; 48(1): 187-198.
17. Raychaudhuri, A.; Jerga, A.; Tipton, P. A., Chemical mechanism and substrate specificity of RhlI, an acylhomoserine lactone synthase from Pseudomonas aeruginosa. Biochemistry 2005, 44(8): 2974-81.
18. Dekimpe, V.; Deziel, E., Revisiting the quorum-sensing hierarchy in Pseudomonas aeruginosa: the transcriptional regulator RhlR regulates LasR-specific factors. Microbiology 2009; 155(Pt 3): 712-23.
19. Kim, M. H.; Choi, W. C.; Kang, H. O.; Lee, J. S.; Kang, B. S.; Kim, K. J.; Derewenda, Z. S.; Oh, T. K.; Lee, C. H.; Lee, J. K., The molecular structure and catalytic mechanism of a quorum-quenching N-acyl-L-homoserine lactone hydrolase. Proceedings of the National Academy of Sciences of the United States of America 2005; 102(49): 17606-11.
20. Williams, S. C.; Patterson, E. K.; Carty, N. L.; Griswold, J. A.; Hamood, A. N.; Rumbaugh, K. P., Pseudomonas aeruginosa autoinducer enters and functions in mammalian cells. Journal of bacteriology 2004; 186(8): 2281-7.
21. Yarwood, J. M.; Volper, E. M.; Greenberg, E. P., Delays in Pseudomonas aeruginosa quorum-controlled gene expression are conditional. Proceedings of the National Academy of Sciences of the United States of America 2005; 102(25): 9008-13.
22. Heeb, S.; Fletcher, M. P.; Chhabra, S. R.; Diggle, S. P.; Williams, P.; Camara, M., Quinolones: from antibiotics to autoinducers. FEMS microbiology reviews 2011; 35(2): 247-74.
23. Pesci, E. C.; Milbank, J. B.; Pearson, J. P.; McKnight, S.; Kende, A. S.; Greenberg, E. P.; Iglewski, B. H., Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America 1999; 96(20): 11229-34.
24. Jimenez, P. N.; Koch, G.; Thompson, J. A.; Xavier, K. B.; Cool, R. H.; Quax, W. J., The multiple signaling systems regulating virulence in Pseudomonas aeruginosa. Microbiology and molecular biology reviews : MMBR 2012; 76(1): 46-65.
25. Schertzer, J. W.; Brown, S. A.; Whiteley, M., Oxygen levels rapidly modulate Pseudomonas aeruginosa social behaviours via substrate limitation of PqsH. Molecular microbiology 2010; 77(6): 1527-38.
26. Xiao, G.; Deziel, E.; He, J.; Lepine, F.; Lesic, B.; Castonguay, M. H.; Milot, S.; Tampakaki, A. P.; Stachel, S. E.; Rahme, L. G., MvfR, a key Pseudomonas aeruginosa pathogenicity LTTR-class regulatory protein, has dual ligands. Molecular microbiology 2006; 62(6): 1689-99.
27. Wade, D. S.; Calfee, M. W.; Rocha, E. R.; Ling, E. A.; Engstrom, E.; Coleman, J. P.; Pesci, E. C., Regulation of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa. Journal of bacteriology 2005; 187(13): 4372-80.
28. Farrow, J. M., 3rd; Sund, Z. M.; Ellison, M. L.; Wade, D. S.; Coleman, J. P.; Pesci, E. C., PqsE functions independently of PqsR-Pseudomonas quinolone signal and enhances the rhl quorum-sensing system. Journal of bacteriology 2008; 190(21): 7043-51.
29. Mashburn, L. M.; Whiteley, M., Membrane vesicles traffic signals and facilitate group activities in a prokaryote. Nature 2005; 437(7057): 422-5.
30. Schuster, M.; Lostroh, C. P.; Ogi, T.; Greenberg, E. P., Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis. Journal of bacteriology 2003;185(7): 2066-79.
31. Karatuna, O.; Yagci, A., Analysis of quorum sensing-dependent virulence factor production and its relationship with antimicrobial susceptibility in Pseudomonas aeruginosa respiratory isolates. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2010; 16(12): 1770-5.
32. Toder, D. S.; Gambello, M. J.; Iglewski, B. H., Pseudomonas aeruginosa LasA: a second elastase under the transcriptional control of lasR. Mol Microbiol 1991; 5(8): 2003-10.
33. Conibear, T. C.; Willcox, M. D.; Flanagan, J. L.; Zhu, H., Characterization of protease IV expression in Pseudomonas aeruginosa clinical isolates. Journal of medical microbiology 2012; 61(Pt 2): 180-90.
34. Brint, J. M.; Ohman, D. E., Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family. Journal of Bacteriology 1995; 177(24): 7155-7163 %@ 0021-9193.
35. Limmer, S.; Haller, S.; Drenkard, E.; Lee, J.; Yu, S.; Kocks, C.; Ausubel, F. M.; Ferrandon, D., Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model. Proceedings of the National Academy of Sciences of the United States of America 2011; 108(42): 17378-83.
36. Sana, T. G.; Hachani, A.; Bucior, I.; Soscia, C.; Garvis, S.; Termine, E.; Engel, J.; Filloux, A.; Bleves, S., The second type VI secretion system of Pseudomonas aeruginosa strain PAO1 is regulated by quorum sensing and Fur and modulates internalization in epithelial cells. The Journal of biological chemistry 2012; 287(32): 27095-105.
37. Sakuragi, Y.; Kolter, R., Quorum-sensing regulation of the biofilm matrix genes (pel) of Pseudomonas aeruginosa. Journal of bacteriology 2007; 189(14): 5383-6.
38. Lazenby, J. J.; Griffin, P. E.; Kyd, J.; Whitchurch, C. B.; Cooley, M. A., A Quadruple Knockout of lasIR and rhlIR of Pseudomonas aeruginosa PAO1 That Retains Wild-Type Twitching Motility Has Equivalent Infectivity and Persistence to PAO1 in a Mouse Model of Lung Infection. PloS one 2013; 8(4): e60973.
39. Reis, R. S.; Pereira, A. G.; Neves, B. C.; Freire, D. M., Gene regulation of rhamnolipid production in Pseudomonas aeruginosa - a review. Bioresource technology 2011; 102(11): 6377-84.
40. Van Gennip, M.; Christensen, L. D.; Alhede, M.; Phipps, R.; Jensen, P. O.; Christophersen, L.; Pamp, S. J.; Moser, C.; Mikkelsen, P. J.; Koh, A. Y.; Tolker-Nielsen, T.; Pier, G. B.; Hoiby, N.; Givskov, M.; Bjarnsholt, T., Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2009; 117(7): 537-46.
41. Alhede, M.; Bjarnsholt, T.; Jensen, P. O.; Phipps, R. K.; Moser, C.; Christophersen, L.; Christensen, L. D.; van Gennip, M.; Parsek, M.; Hoiby, N.; Rasmussen, T. B.; Givskov, M., Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes. Microbiology 2009; 155(Pt 11): 3500-8.
42. Déziel, E.; Lépine, F.; Milot, S.; Villemur, R., rhlA is required for the production of a novel biosurfactant promoting swarming motility in Pseudomonas aeruginosa: 3-(3-hydroxyalkanoyloxy) alkanoic acids (HAAs), the precursors of rhamnolipids. Microbiology 2003; 149(8): 2005-2013 %@ 1350-0872.
43. Medina, G.; Juárez, K.; Valderrama, B.; Soberón- Chávez, G., Mechanism of Pseudomonas aeruginosa RhlR transcriptional regulation of the rhlAB promoter. Journal of bacteriology 2003; 185(20): 5976-5983 %@ 0021-9193.
44. Delaney, S. M.; Mavrodi, D. V.; Bonsall, R. F.; Thomashow, L. S., phzO, a gene for biosynthesis of 2-hydroxylated phenazine compounds in Pseudomonas aureofaciens 30-84. J Bacteriol 2001; 183(1): 318-27.
45. Mavrodi, D. V.; Bonsall, R. F.; Delaney, S. M.; Soule, M. J.; Phillips, G.; Thomashow, L. S., Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1. J Bacteriol 2001; 183(21): 6454-65.
46. Byng, G. S.; Eustice, D. C.; Jensen, R. A., Biosynthesis of phenazine pigments in mutant and wild-type cultures of Pseudomonas aeruginosa. J Bacteriol 1979; 138(3): 846-52.
47. Lau, G. W.; Hassett, D. J.; Ran, H.; Kong, F., The role of pyocyanin in Pseudomonas aeruginosa infection. Trends in molecular medicine 2004; 10(12): 599-606.
48. Dietrich, L. E.; Price-Whelan, A.; Petersen, A.; Whiteley, M.; Newman, D. K., The phenazine pyocyanin is a terminal signalling factor in the quorum sensing network of Pseudomonas aeruginosa. Molecular microbiology 2006; 61(5): 1308-21.
49. Whiteley, M.; Lee, K. M.; Greenberg, E. P., Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America 1999; 96(24): 13904-9.
50. Reimmann, C.; Beyeler, M.; Latifi, A.; Winteler, H.; Foglino, M.; Lazdunski, A.; Haas, D., The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase. Mol Microbiol 1997; 24(2): 309-19.
51. Cao, H.; Krishnan, G.; Goumnerov, B.; Tsongalis, J.; Tompkins, R.; Rahme, L. G., A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism. Proceedings of the National Academy of Sciences of the United States of America 2001; 98(25): 14613-8.
52. Kong, W.; Liang, H.; Shen, L.; Duan, K., [Regulation of type III secretion system by Rhl and PQS quorum sensing systems in Pseudomonas aeruginosa]. Wei sheng wu xue bao = Acta microbiologica Sinica 2009; 49(9): 1158-64.
53. Rampioni, G.; Pustelny, C.; Fletcher, M. P.; Wright, V. J.; Bruce, M.; Rumbaugh, K. P.; Heeb, S.; Camara, M.; Williams, P., Transcriptomic analysis reveals a global alkyl-quinolone-independent regulatory role for PqsE in facilitating the environmental adaptation of Pseudomonas aeruginosa to plant and animal hosts. Environmental microbiology 2010; 12 (6): 1659-73.
54. Kesarwani, M.; Hazan, R.; He, J.; Que, Y. A.; Apidianakis, Y.; Lesic, B.; Xiao, G.; Dekimpe, V.; Milot, S.; Deziel, E.; Lepine, F.; Rahme, L. G., A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes. PLoS pathogens 2011; 7(8): e1002192.
55. Tateda, K.; Ishii, Y.; Horikawa, M.; Matsumoto, T.; Miyairi, S.; Pechere, J. C.; Standiford, T. J.; Ishiguro, M.; Yamaguchi, K., The Pseudomonas aeruginosa autoinducer N-3-oxododecanoyl homoserine lactone accelerates apoptosis in macrophages and neutrophils. Infection and immunity 2003; 71(10): 5785-93.
56. Mayer, M. L.; Sheridan, J. A.; Blohmke, C. J.; Turvey, S. E.; Hancock, R. E., The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells. PloS one 2011; 6(1): e16246.
57. Karlsson, T.; Turkina, M. V.; Yakymenko, O.; Magnusson, K. E.; Vikstrom, E., The Pseudomonas aeruginosa N-acylhomoserine lactone quorum sensing molecules target IQGAP1 and modulate epithelial cell migration. PLoS pathogens 2012; 8(10): e1002953.
58. Lu, Q.; Lin, Y.; Yang, X.; Liu, W.; Zhang, X.; Huang, D.; Zhong, H., Regulation on expression of toll-like receptors on monocytes after stimulation with the 3-o-C12-HSL molecule from Pseudomonas aeruginosa. Current microbiology 2012; 65(4): 384-9.
59. Nakagami, G.; Minematsu, T.; Asada, M.; Nagase, T.; Akase, T.; Huang, L.; Morohoshi, T.; Ikeda, T.; Ohta, Y.; Sanada, H., The Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl) homoserine lactone can accelerate cutaneous wound healing through myofibroblast differentiation in rats. FEMS immunology and medical microbiology 2011; 62(2): 157-63.
60. Flickinger, S. T.; Copeland, M. F.; Downes, E. M.; Braasch, A. T.; Tuson, H. H.; Eun, Y. J.; Weibel, D. B., Quorum sensing between Pseudomonas aeruginosa biofilms accelerates cell growth. Journal of the American Chemical Society 2011; 133(15): 5966-75.
61. Gaisford, W.; Pritchard, D. I.; Cooke, A., OdDHL inhibits T cell subset differentiation and delays diabetes onset in NOD mice. Clinical and vaccine immunology : CVI 2011; 18(8): 1213-20.
62. Kim, K.; Kim, Y. U.; Koh, B. H.; Hwang, S. S.; Kim, S. H.; Lepine, F.; Cho, Y. H.; Lee, G. R., HHQ and PQS, two Pseudomonas aeruginosa quorum-sensing molecules, down-regulate the innate immune responses through the nuclear factor-kappaB pathway. Immunology 2010; 129(4): 578-88.
63. Lamarche, M. G.; Deziel, E., MexEF-OprN efflux pump exports the Pseudomonas quinolone signal (PQS) precursor HHQ (4-hydroxy-2-heptylquinoline). PloS one 2011; 6(9): e24310.
64. Lee, K. M.; Yoon, M. Y.; Park, Y.; Lee, J. H.; Yoon, S. S., Anaerobiosis-induced loss of cytotoxicity is due to inactivation of quorum sensing in Pseudomonas aeruginosa. Infection and immunity 2011; 79(7): 2792-800.
65. Latifi, A.; Foglino, M.; Tanaka, K.; Williams, P.; Lazdunski, A., A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhIR (VsmR) to expression of the stationary-phase sigma factor RpoS. Molecular microbiology 1996; 21(6): 1137-46.
66. Miller, M. B.; Bassler, B. L., Quorum sensing in bacteria. Annual review of microbiology 2001; 55: 165-99.
67. Ledgham, F.; Ventre, I.; Soscia, C.; Foglino, M.; Sturgis, J. N.; Lazdunski, A., Interactions of the quorum sensing regulator QscR: interaction with itself and the other regulators of Pseudomonas aeruginosa LasR and RhlR. Molecular microbiology 2003; 48(1): 199-210.
68. Lee, J. H.; Lequette, Y.; Greenberg, E. P., Activity of purified QscR, a Pseudomonas aeruginosa orphan quorum-sensing transcription factor. Molecular microbiology 2006; 59 (2): 602-9.
69. Lequette, Y.; Lee, J. H.; Ledgham, F.; Lazdunski, A.; Greenberg, E. P., A distinct QscR regulon in the Pseudomonas aeruginosa quorum-sensing circuit. In Journal of bacteriology, 2006; 188: pp 3365-70.
70. Oinuma, K.; Greenberg, E. P., Acyl-homoserine lactone binding to and stability of the orphan Pseudomonas aeruginosa quorum-sensing signal receptor QscR. Journal of bacteriology 2011: 193(2): 421-8.
71. Ha, C.; Park, S. J.; Im, S. J.; Park, S. J.; Lee, J. H., Interspecies signaling through QscR, a quorum receptor of Pseudomonas aeruginosa. Molecules and cells 2012; 33(1): 53-9.
72. Kanack, K. J.; Runyen-Janecky, L. J.; Ferrell, E. P.; Suh, S. J.; West, S. E., Characterization of DNA-binding specificity and analysis of binding sites of the Pseudomonas aeruginosa global regulator, Vfr, a homologue of the Escherichia coli cAMP receptor protein. Microbiology 2006; 152(Pt 12): 3485-96.
73. Albus, A. M.; Pesci, E. C.; Runyen-Janecky, L. J.; West, S. E.; Iglewski, B. H., Vfr controls quorum sensing in Pseudomonas aeruginosa. Journal of bacteriology 1997; 179(12): 3928-35.
74. Croda-Garcia, G.; Grosso-Becerra, V.; Gonzalez-Valdez, A.; Servin-Gonzalez, L.; Soberon-Chavez, G., Transcriptional regulation of Pseudomonas aeruginosa rhlR: role of the CRP orthologue Vfr (virulence factor regulator) and quorum-sensing regulators LasR and RhlR. Microbiology 2011; 157(Pt 9): 2545-55.
75. Rampioni, G.; Schuster, M.; Greenberg, E. P.; Bertani, I.; Grasso, M.; Venturi, V.; Zennaro, E.; Leoni, L., RsaL provides quorum sensing homeostasis and functions as a global regulator of gene expression in Pseudomonas aeruginosa. Molecular microbiology 2007; 66(6): 1557-65.
76. Rampioni, G.; Schuster, M.; Greenberg, E. P.; Zennaro, E.; Leoni, L., Contribution of the RsaL global regulator to Pseudomonas aeruginosa virulence and biofilm formation. FEMS microbiology letters 2009; 301(2): 210-7.
77. Siehnel, R.; Traxler, B.; An, D. D.; Parsek, M. R.; Schaefer, A. L.; Singh, P. K., A unique regulator controls the activation threshold of quorum-regulated genes in Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America 2010; 107(17): 7916-21.
78. Seet, Q.; Zhang, L. H., Anti-activator QslA defines the quorum sensing threshold and response in Pseudomonas aeruginosa. Molecular microbiology 2011; 80(4): 951-65.
79. Liang, H.; Li, L.; Kong, W.; Shen, L.; Duan, K., Identification of a novel regulator of the quorum-sensing systems in Pseudomonas aeruginosa. FEMS microbiology letters 2009; 293(2): 196-204.
80. Jorgensen, F.; Bally, M.; Chapon-Herve, V.; Michel, G.; Lazdunski, A.; Williams, P.; Stewart, G. S., RpoS-dependent stress tolerance in Pseudomonas aeruginosa. Microbiology 1999; 145(Pt 4): 835-44.
81. Whiteley, M.; Parsek, M. R.; Greenberg, E. P., Regulation of quorum sensing by RpoS in Pseudomonas aeruginosa. Journal of bacteriology 2000; 182(15): 4356-60.
82. Schuster, M.; Hawkins, A. C.; Harwood, C. S.; Greenberg, E. P., The Pseudomonas aeruginosa RpoS regulon and its relationship to quorum sensing. Molecular microbiology 2004; 51(4): 973-85.
83. Venturi, V., Regulation of quorum sensing in Pseudomonas. FEMS microbiology reviews 2006; 30(2): 274-91.
84. Hendrickson, E. L.; Plotnikova, J.; Mahajan-Miklos, S.; Rahme, L. G.; Ausubel, F. M., Differential roles of the Pseudomonas aeruginosa PA14 rpoN gene in pathogenicity in plants, nematodes, insects, and mice. J Bacteriol 2001; 183(24): 7126-34.
85. Heurlier, K.; Denervaud, V.; Pessi, G.; Reimmann, C.; Haas, D., Negative control of quorum sensing by RpoN (sigma54) in Pseudomonas aeruginosa PAO1. Journal of bacteriology 2003; 185(7): 2227-35.
86. Thompson, L. S.; Webb, J. S.; Rice, S. A.; Kjelleberg, S., The alternative sigma factor RpoN regulates the quorum sensing gene rhlI in Pseudomonas aeruginosa. FEMS microbiology letters 2003; 220(2): 187-95.
87. Juhas, M.; Wiehlmann, L.; Huber, B.; Jordan, D.; Lauber, J.; Salunkhe, P.; Limpert, A. S.; von Gotz, F.; Steinmetz, I.; Eberl, L.; Tummler, B., Global regulation of quorum sensing and virulence by VqsR in Pseudomonas aeruginosa. Microbiology 2004; 150(Pt 4): 831-41.
88. Li, L. L.; Malone, J. E.; Iglewski, B. H., Regulation of the Pseudomonas aeruginosa quorum-sensing regulator VqsR. Journal of bacteriology 2007; 189(12): 4367-74.
89. Liang, H.; Deng, X.; Ji, Q.; Sun, F.; Shen, T.; He, C., The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression. Journal of bacteriology 2012; 194(12): 3098-108.
90. Dong, Y. H.; Zhang, X. F.; Xu, J. L.; Tan, A. T.; Zhang, L. H., VqsM, a novel AraC-type global regulator of quorum-sensing signalling and virulence in Pseudomonas aeruginosa. Molecular microbiology 2005; 58(2): 552-64.
91. Heeb, S.; Haas, D., Regulatory roles of the GacS/GacA two-component system in plant-associated and other gram-negative bacteria. Molecular plant-microbe interactions : MPMI 2001; 14(12): 1351-63.
92. Pessi, G.; Williams, F.; Hindle, Z.; Heurlier, K.; Holden, M. T.; Camara, M.; Haas, D.; Williams, P., The global posttranscriptional regulator RsmA modulates production of virulence determinants and N-acylhomoserine lactones in Pseudomonas aeruginosa. Journal of bacteriology 2001; 183(22): 6676-83.
93. Dong, Y. H.; Zhang, X. F.; Soo, H. M.; Greenberg, E. P.; Zhang, L. H., The two-component response regulator PprB modulates quorum-sensing signal production and global gene expression in Pseudomonas aeruginosa. Molecular microbiology 2005; 56(5): 1287-301.
94. Dong, Y. H.; Zhang, X. F.; An, S. W.; Xu, J. L.; Zhang, L. H., A novel two-component system BqsS-BqsR modulates quorum sensing-dependent biofilm decay in Pseudomonas aeruginosa. Communicative & integrative biology 2008; 1(1): 88-96.
95. Dieppois, G.; Ducret, V.; Caille, O.; Perron, K., The transcriptional regulator CzcR modulates antibiotic resistance and quorum sensing in Pseudomonas aeruginosa. PloS one 2012; 7(5): e38148.
96. Diggle, S. P.; Winzer, K.; Lazdunski, A.; Williams, P.; Camara, M., Advancing the quorum in Pseudomonas aeruginosa: MvaT and the regulation of N-acylhomoserine lactone production and virulence gene expression. Journal of bacteriology 2002; 184(10): 2576-86.
97. Carty, N. L.; Layland, N.; Colmer-Hamood, J. A.; Calfee, M. W.; Pesci, E. C.; Hamood, A. N., PtxR modulates the expression of QS-controlled virulence factors in the Pseudomonas aeruginosa strain PAO1. Molecular microbiology 2006; 61(3): 782-94.
98. Sio, C. F.; Otten, L. G.; Cool, R. H.; Diggle, S. P.; Braun, P. G.; Bos, R.; Daykin, M.; Camara, M.; Williams, P.; Quax, W. J., Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1. Infection and immunity 2006; 74(3): 1673-82.
99. Abbas, A.; Adams, C.; Scully, N.; Glennon, J.; O'Gara, F., A role for TonB1 in biofilm formation and quorum sensing in Pseudomonas aeruginosa. FEMS microbiology letters 2007; 274(2): 269-78.
100. Takaya, A.; Tabuchi, F.; Tsuchiya, H.; Isogai, E.; Yamamoto, T., Negative regulation of quorum-sensing systems in Pseudomonas aeruginosa by ATP-dependent Lon protease. Journal of bacteriology 2008; 190(12): 4181-8.
101. Fito-Boncompte, L.; Chapalain, A.; Bouffartigues, E.; Chaker, H.; Lesouhaitier, O.; Gicquel, G.; Bazire, A.; Madi, A.; Connil, N.; Veron, W.; Taupin, L.; Toussaint, B.; Cornelis, P.; Wei, Q.; Shioya, K.; Deziel, E.; Feuilloley, M. G.; Orange, N.; Dufour, A.; Chevalier, S., Full virulence of Pseudomonas aeruginosa requires OprF. Infection and immunity 2011; 79(3): 1176-86.
102. Nadal Jimenez, P.; Koch, G.; Papaioannou, E.; Wahjudi, M.; Krzeslak, J.; Coenye, T.; Cool, R. H.; Quax, W. J., Role of PvdQ in Pseudomonas aeruginosa virulence under iron-limiting conditions. Microbiology 2010; 156(Pt 1): 49-59.
103. Garske, L. A.; Beatson, S.A.; Leech, A. J.; Walsh, S. L.; Bell, S. C., Sub-inhibitory concentrations of ceftazidime and tobramycin reduce the quorum sensing signals of Pseudomonas aeruginosa. Pathology 2004; 36(6): 571-5.
104. Skindersoe, M. E.; Alhede, M.; Phipps, R.; Yang, L.; Jensen, P. O.; Rasmussen, T. B.; Bjarnsholt, T.; Tolker-Nielsen, T.; Hoiby, N.; Givskov, M., Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy 2008; 52(10): 3648-63.
105. Kai, T.; Tateda, K.; Kimura, S.; Ishii, Y.; Ito, H.; Yoshida, H.; Kimura, T.; Yamaguchi, K., A low concentration of azithromycin inhibits the mRNA expression of N-acyl homoserine lactone synthesis enzymes, upstream of lasI or rhlI, in Pseudomonas aeruginosa. Pulmonary pharmacology & therapeutics 2009; 22(6): 483-6.
106. Bala, A.; Kumar, R.; Harjai, K., Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections. Journal of medical microbiology 2011; 60(Pt 3): 300-6.
107. Wu, H.; Song, Z.; Hentzer, M.; Andersen, J. B.; Molin, S.; Givskov, M.; Hoiby, N., Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice. The Journal of antimicrobial chemotherapy 2004; 53(6): 1054-61.
108. Bijtenhoorn, P.; Schipper, C.; Hornung, C.; Quitschau, M.; Grond, S.; Weiland, N.; Streit, W. R., BpiB05, a novel metagenome-derived hydrolase acting on N-acylhomoserine lactones. Journal of biotechnology 2011; 155(1): 86-94.
109. Ishida, T.; Ikeda, T.; Takiguchi, N.; Kuroda, A.; Ohtake, H.; Kato, J., Inhibition of quorum sensing in Pseudomonas aeruginosa by N-acyl cyclopentylamides. Applied and environmental microbiology 2007; 73(10): 3183-8.
110. Kim, C.; Kim, J.; Park, H. Y.; Lee, J. H.; Park, H. J.; Kim, C. K.; Yoon, J., Structural understanding of quorum-sensing inhibitors by molecular modeling study in Pseudomonas aeruginosa. Applied microbiology and biotechnology 2009; 83(6): 1095-103.
111. Ganin, H.; Tang, X.; Meijler, M. M., Inhibition of Pseudomonas aeruginosa quorum sensing by AI-2 analogs. Bioorganic & medicinal chemistry letters 2009; 19(14): 3941-4.
112. Lesic, B.; Lepine, F.; Deziel, E.; Zhang, J.; Zhang, Q.; Padfield, K.; Castonguay, M. H.; Milot, S.; Stachel, S.; Tzika, A. A.; Tompkins, R. G.; Rahme, L. G., Inhibitors of pathogen intercellular signals as selective anti-infective compounds. PLoS pathogens 2007; 3(9): 1229-39.
113. Rasmussen, T. B.; Bjarnsholt, T.; Skindersoe, M. E.; Hentzer, M.; Kristoffersen, P.; Kote, M.; Nielsen, J.; Eberl, L.; Givskov, M., Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector. Journal of bacteriology 2005; 187(5): 1799-814.
114. Harjai, K.; Kumar, R.; Singh, S., Garlic blocks quorum sensing and attenuates the virulence of Pseudomonas aeruginosa. FEMS immunology and medical microbiology 2010; 58(2): 161-8.
115. Jakobsen, T. H.; van Gennip, M.; Phipps, R. K.; Shanmugham, M. S.; Christensen, L. D.; Alhede, M.; Skindersoe, M. E.; Rasmussen, T. B.; Friedrich, K.; Uthe, F.; Jensen, P. O.; Moser, C.; Nielsen, K. F.; Eberl, L.; Larsen, T. O.; Tanner, D.; Hoiby, N.; Bjarnsholt, T.; Givskov, M., Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing. Antimicrobial agents and chemotherapy 2012; 56(5): 2314-25.
116. Song, Z.; Kong, K. F.; Wu, H.; Maricic, N.; Ramalingam, B.; Priestap, H.; Schneper, L.; Quirke, J. M.; Hoiby, N.; Mathee, K., Panax ginseng has anti-infective activity against opportunistic pathogen Pseudomonas aeruginosa by inhibiting quorum sensing, a bacterial communication process critical for establishing infection. Phytomedicine : international journal of phytotherapy and phytopharmacology 2010; 17(13): 1040-6.
117. Amaya, S.; Pereira, J. A.; Borkosky, S. A.; Valdez, J. C.; Bardon, A.; Arena, M. E., Inhibition of quorum sensing in Pseudomonas aeruginosa by sesquiterpene lactones. Phytomedicine : international journal of phytotherapy and phytopharmacology 2012; 19(13): 1173-7.
118. Ma, L.; Liu, X.; Liang, H.; Che, Y.; Chen, C.; Dai, H.; Yu, K.; Liu, M.; Ma, L.; Yang, C. H.; Song, F.; Wang, Y.; Zhang, L., Effects of 14-alpha-lipoyl andrographolide on quorum sensing in Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy 2012; 56(12): 6088-94.
119. Dagorn, A.; Hillion, M.; Chapalain, A.; Lesouhaitier, O.; Duclairoir Poc, C.; Vieillard, J.; Chevalier, S.; Taupin, L.; Le Derf, F.; Feuilloley, M. G., Gamma-aminobutyric acid acts as a specific virulence regulator in Pseudomonas aeruginosa. Microbiology 2013; 159(Pt 2): 339-51.
120. Norizan, S. N.; Yin, W. F.; Chan, K. G., Caffeine as a potential quorum sensing inhibitor. Sensors 2013; 13(4): 5117-29.
121. Zhou, L.; Zheng, H.; Tang, Y.; Yu, W.; Gong, Q., Eugenol inhibits quorum sensing at sub-inhibitory concentrations. Biotechnology letters 2013; 35(4): 631-7.