Structural understanding of quorum-sensing inhibitors by molecular modeling study in Pseudomonas aeruginosa

Applied Microbiology and Biotechnology

Volumn 83, Issue 6, 2009, Pages 1095-1103

  Kim, Cheoljin ^a   Kim, Jaeeun ^b   Park, Hyung Yeon ^c   Lee, Joon Hee ^d   Park, Hee Jin ^e   Kim, Chan Kyung ^c   Yoon, Jeyong ^e  

^a PRINCETON UNIVERSITY   (United States)

^b SAMSUNG Electronics   (South Korea)

^c Inha University   (South Korea)

^d Pusan National University   (South Korea)

^e Seoul National University   (South Korea)

Author keywords

Autoinducer; Docking scores; FlexX docking; In silico modeling; Pseudomonas aeruginosa; Quorum sensing; Quorum sensing inhibitor

Indexed keywords

AUTOINDUCER; DOCKING SCORES; FLEXX DOCKING; IN SILICO MODELING; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; QUORUM-SENSING INHIBITOR;

BINDING ENERGY; BIOASSAY; CONFORMATIONS; SYNTHESIS (CHEMICAL);

DOCKING;

AROMATIC COMPOUND; HOMOSERINE; LACTONE DERIVATIVE; N (PHENYL) 3 OXODODECANAMIDE; N 3 OXODODECANOYL HOMOSERINE LACTONE; PROTEIN LASR; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

BACTERIUM; BIOASSAY; INHIBITOR; KETONE; MODELING; MOLECULAR ANALYSIS;

ARTICLE; BIOASSAY; CHEMICAL MODIFICATION; COMPLEX FORMATION; CONFORMATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENERGY; IN VIVO STUDY; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; SIGNAL TRANSDUCTION; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

4-BUTYROLACTONE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; COMPUTER SIMULATION; HOMOSERINE; MOLECULAR STRUCTURE; PROTEIN BINDING; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; TRANS-ACTIVATORS;

PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 67650744612     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-009-1954-3     Document Type: Article

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