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Volumn 14, Issue 12, 2013, Pages 1564-1572

Gabapentin alleviates facet-mediated pain in the rat through reduced neuronal hyperexcitability and astrocytic activation in the spinal cord

Author keywords

astrocyte; facet joint; gabapentin; Neuronal hyperexcitability; spinal cord

Indexed keywords

GABAPENTIN; GLIAL FIBRILLARY ACIDIC PROTEIN;

EID: 84888637722     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2013.07.016     Document Type: Article
Times cited : (15)

References (59)
  • 1
    • 0029655582 scopus 로고    scopus 로고
    • Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain
    • C. Abbadie, J.L. Brown, P.W. Manthh, and A.I. Basbaum Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain Neuroscience 70 1996 201 209 (Pubitemid 126755236)
    • (1996) Neuroscience , vol.70 , Issue.1 , pp. 201-209
    • Abbadie, C.1    Brown, J.L.2    Mantyh, P.W.3    Basbaum, A.I.4
  • 2
    • 0344936034 scopus 로고    scopus 로고
    • The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain
    • S. Abdi, D.H. Lee, and J.M. Chung The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain Anesth Analg 87 1998 1360 1366 (Pubitemid 28549506)
    • (1998) Anesthesia and Analgesia , vol.87 , Issue.6 , pp. 1360-1366
    • Abdi, S.1    Lee, D.H.2    Chung, J.M.3
  • 3
    • 0026776780 scopus 로고
    • The prevalence of cervical zygapophyseal joint pain. A first approximation
    • C. Aprill, and N. Bogduk The prevalence of cervical zygapophyseal joint pain. A first approximation Spine 17 1992 744 747
    • (1992) Spine , vol.17 , pp. 744-747
    • Aprill, C.1    Bogduk, N.2
  • 4
    • 0027934926 scopus 로고
    • Whiplash injury
    • DOI 10.1016/0304-3959(94)90123-6
    • L. Barnsley, S. Lord, and N. Bogduk Whiplash injury Pain 58 1994 283 307 (Pubitemid 24284071)
    • (1994) Pain , vol.58 , Issue.3 , pp. 283-307
    • Barnsley, L.1    Lord, S.2    Bogduk, N.3
  • 6
    • 65749106982 scopus 로고    scopus 로고
    • Pharmacological modulation of movement-evoked pain in a rat model of osteoarthritis
    • P. Chandran, M. Pai, E.A. Blomme, G.C. Hsieh, M.W. Decker, and P. Honore Pharmacological modulation of movement-evoked pain in a rat model of osteoarthritis Eur J Pharmacol 613 2009 39 45
    • (2009) Eur J Pharmacol , vol.613 , pp. 39-45
    • Chandran, P.1    Pai, M.2    Blomme, E.A.3    Hsieh, G.C.4    Decker, M.W.5    Honore, P.6
  • 7
    • 33746919061 scopus 로고    scopus 로고
    • Distribution of A-δ and C-fiber receptors in the cervical facet joint capsule and their response to stretch
    • DOI 10.2106/JBJS.E.00880
    • C. Chen, Y. Lu, S. Kallakuri, A. Patwardhan, and J.M. Cavanaugh Distribution of A-delta and C-fiber receptors in the cervical facet joint capsule and their response to stretch J Bone Joint Surg Am 88 2006 1807 1816 (Pubitemid 44200222)
    • (2006) Journal of Bone and Joint Surgery - Series A , vol.88 , Issue.8 , pp. 1807-1816
    • Chen, C.1    Lu, Y.2    Kallakuri, S.3    Patwardhan, A.4    Cavanaugh, J.M.5
  • 8
    • 33646415952 scopus 로고    scopus 로고
    • Cyclooxygenases, microsomal prostaglandin e synthast-1, and cardiovascular function
    • C. Cheng, M. Wang, Y. Yu, J. Lawson, C.D. Funk, and G.A. Fitzgerald Cyclooxygenases, microsomal prostaglandin E synthast-1, and cardiovascular function J Clin Invest 116 2006 1391 1399
    • (2006) J Clin Invest , vol.116 , pp. 1391-1399
    • Cheng, C.1    Wang, M.2    Yu, Y.3    Lawson, J.4    Funk, C.D.5    Fitzgerald, G.A.6
  • 9
    • 0030879294 scopus 로고    scopus 로고
    • Chronic central pain after spinal cord injury
    • M.D. Christensen, and C.E. Hulsebosch Chronic central pain after spinal cord injury J Neurotrauma 14 1997 517 537 (Pubitemid 27377660)
    • (1997) Journal of Neurotrauma , vol.14 , Issue.8 , pp. 517-537
    • Christensen, M.D.1    Hulsebosch, C.E.2
  • 10
    • 84876710850 scopus 로고    scopus 로고
    • Spinal neuronal plasticity is evident within 1 day after a painful cervical facet capsule injury
    • N.D. Crosby, C.L., Weisshaar, and B.A. Winkelstein Spinal neuronal plasticity is evident within 1 day after a painful cervical facet capsule injury Neurosci Lett 542 2013 102 106
    • (2013) Neurosci Lett , vol.542 , pp. 102-106
    • Crosby, N.D.1    Weisshaar, C.L.2    Winkelstein, B.A.3
  • 11
    • 4644259036 scopus 로고    scopus 로고
    • Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitro
    • DOI 10.1111/j.1460-9568.2004.03625.x
    • M.O. Cunningham, G.L. Woodhall, S.E. Thompson, D.J. Dooley, and R.S. Jones Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitro Eur J Neurosci 20 2004 1566 1576 (Pubitemid 39294695)
    • (2004) European Journal of Neuroscience , vol.20 , Issue.6 , pp. 1566-1576
    • Cunningham, M.O.1    Woodhall, G.L.2    Thompson, S.E.3    Dooley, D.J.4    Jones, R.S.G.5
  • 12
    • 33748938566 scopus 로고    scopus 로고
    • Diabetes-induced mechanical hyperalgesia involves spinal mitogen-activated protein kinase activation in neurons and microglia via N-methyl-D-aspartate- dependent mechanisms
    • DOI 10.1124/mol.106.025478
    • L. Daulhac, C. Mallet, C. Courteix, M. Etienne, E. Duroux, A.M. Privat, A. Eschalier, and J. Fialip Diabetes-induced mechanical hyperalgesia involves spinal mitogen-activated protein kinase activation in neurons and microglia via N-methyl-d-aspartate-dependent mechanisms Mol Pharmacol 70 2006 1246 1254 (Pubitemid 44435976)
    • (2006) Molecular Pharmacology , vol.70 , Issue.4 , pp. 1246-1254
    • Daulhac, L.1    Mallet, C.2    Courteix, C.3    Etienne, M.4    Duroux, E.5    Privat, A.-M.6    Eschalier, A.7    Fialip, J.8
  • 13
    • 33646043440 scopus 로고    scopus 로고
    • The tetrapartite synapse: Path to CNS sensitization and chronic pain
    • J.A. DeLeo, V.L. Tawfik, and M.L. LaCroix-Fralish The tetrapartite synapse: Path to CNS sensitization and chronic pain Pain 122 2006 17 21
    • (2006) Pain , vol.122 , pp. 17-21
    • Deleo, J.A.1    Tawfik, V.L.2    Lacroix-Fralish, M.L.3
  • 14
    • 0036725365 scopus 로고    scopus 로고
    • A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy
    • DOI 10.1097/00000542-200209000-00007
    • J. Dirks, B.B. Fredensborg, D. Christensen, J.S. Fomsgaard, H. Flyger, and J.B. Dahl A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy Anesthesiology 97 2002 560 564 (Pubitemid 34977313)
    • (2002) Anesthesiology , vol.97 , Issue.3 , pp. 560-564
    • Dirks, J.1    Fredensborg, B.B.2    Christensen, D.3    Fomsgaard, J.S.4    Flyger, H.5    Dahl, J.B.6
  • 15
    • 49749092657 scopus 로고    scopus 로고
    • Painful facet injury induces neuronal stress activation in the DRG: Implications for cellular mechanisms of pain
    • L. Dong, A.O. Odeleye, K.L. Jordan-Sciutto, and B.A. Winkelsten Painful facet injury induces neuronal stress activation in the DRG: Implications for cellular mechanisms of pain Neurosci Lett 443 2008 90 94
    • (2008) Neurosci Lett , vol.443 , pp. 90-94
    • Dong, L.1    Odeleye, A.O.2    Jordan-Sciutto, K.L.3    Winkelsten, B.A.4
  • 16
    • 76349088999 scopus 로고    scopus 로고
    • Simulated whiplash modulates expression of the glutamatergic system in the spinal cord suggesting spinal plasticity is associated with painful dynamic cervical facet loading
    • L. Dong, and B.A. Winkelstein Simulated whiplash modulates expression of the glutamatergic system in the spinal cord suggesting spinal plasticity is associated with painful dynamic cervical facet loading J Neurotrauma 27 2010 163 174
    • (2010) J Neurotrauma , vol.27 , pp. 163-174
    • Dong, L.1    Winkelstein, B.A.2
  • 17
    • 0036785749 scopus 로고    scopus 로고
    • The analgesic effect of gabapentin and mexiletine after breast surgery for cancer
    • A. Fassoulaki, K. Patris, C. Sarantopoulos, and Q. Hogan The analgesic effect of gabapentin and mexiletine after breast surgery for cancer Anesth Analg 95 2002 985 991
    • (2002) Anesth Analg , vol.95 , pp. 985-991
    • Fassoulaki, A.1    Patris, K.2    Sarantopoulos, C.3    Hogan, Q.4
  • 19
    • 0141529982 scopus 로고    scopus 로고
    • v1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury
    • B.C. Hains, J.P. Klein, C.Y. Saab, M.J. Craner, J.A. Black, and S.G. Waxman Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury J Neurosci 23 2003 8881 8892 (Pubitemid 37210901)
    • (2003) Journal of Neuroscience , vol.23 , Issue.26 , pp. 8881-8892
    • Hains, B.C.1    Klein, J.P.2    Saab, C.Y.3    Craner, M.J.4    Black, J.A.5    Waxman, S.G.6
  • 20
    • 24744470059 scopus 로고    scopus 로고
    • Transient cervical nerve root compression in the rat induces bilateral forepaw allodynia and spinal glial activation: Mechanical factors in painful neck injuries
    • DOI 10.1097/01.brs.0000176239.72928.00
    • R.D. Hubbard, and B.A. Winkelstein Transient cervical nerve root compression in the rat induces bilateral forepaw allodynia and spinal glial activation: Mechanical factors in painful neck injuries Spine 301 2005 1924 1932 (Pubitemid 41292215)
    • (2005) Spine , vol.30 , Issue.17 , pp. 1924-1932
    • Hubbard, R.D.1    Winkelstein, B.A.2
  • 21
    • 42149083825 scopus 로고    scopus 로고
    • Tensile stretching of cervical facet joint capsule and related axonal changes
    • S. Kallakuri, A. Singh, Y. Lu, C. Chen, A. Patwardhan, and J.M. Cavanaugh Tensile stretching of cervical facet joint capsule and related axonal changes Eur Spine J 17 2008 556 563
    • (2008) Eur Spine J , vol.17 , pp. 556-563
    • Kallakuri, S.1    Singh, A.2    Lu, Y.3    Chen, C.4    Patwardhan, A.5    Cavanaugh, J.M.6
  • 22
    • 38649109757 scopus 로고    scopus 로고
    • In vivo cervical facet capsule distraction: Mechanical implications for whiplash and neck pain
    • K.E. Lee, M.B. Davis, R.M. Mejilla, and B.A. Winkelstein In vivo cervical facet capsule distraction: Mechanical implications for whiplash and neck pain Stapp Car Crash J 48 2004 373 396
    • (2004) Stapp Car Crash J , vol.48 , pp. 373-396
    • Lee, K.E.1    Davis, M.B.2    Mejilla, R.M.3    Winkelstein, B.A.4
  • 23
    • 57349170153 scopus 로고    scopus 로고
    • Capsular ligament involvement in the development of mechanical hyperalgesia after facet joint loading: Behavioral and inflammatory outcomes in a rodent model of pain
    • K.E. Lee, M.B. Davis, and B.A. Winkelstein Capsular ligament involvement in the development of mechanical hyperalgesia after facet joint loading: Behavioral and inflammatory outcomes in a rodent model of pain J Neurotrauma 25 2008 1383 1393
    • (2008) J Neurotrauma , vol.25 , pp. 1383-1393
    • Lee, K.E.1    Davis, M.B.2    Winkelstein, B.A.3
  • 24
    • 62649133815 scopus 로고    scopus 로고
    • Joint distraction magnitude is associated with different behavioral outcomes and substance P levels for cervical facet joint loading in the rat
    • K.E. Lee, and B.A. Winkelstein Joint distraction magnitude is associated with different behavioral outcomes and substance P levels for cervical facet joint loading in the rat J Pain 10 2009 436 445
    • (2009) J Pain , vol.10 , pp. 436-445
    • Lee, K.E.1    Winkelstein, B.A.2
  • 25
    • 10444245040 scopus 로고    scopus 로고
    • Pregabalin relieves symptoms of painful diabetic neuropathy: A randomized controlled trial
    • H. Lesser, U. Sharma, L. LaMoreaux, and R.M. Poole Pregabalin relieves symptoms of painful diabetic neuropathy: A randomized controlled trial Neurology 63 2004 2104 2110 (Pubitemid 39636259)
    • (2004) Neurology , vol.63 , Issue.11 , pp. 2104-2110
    • Lesser, H.1    Sharma, U.2    LaMoreaux, L.3    Poole, R.M.4
  • 26
    • 0037898153 scopus 로고    scopus 로고
    • Inflammation unmasks gabapentin's effect on Aδ-fiber evoked excitatory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord
    • Z. Liu, R. Xu, and K. Yang Inflammation unmasks gabapentin's effect on A delta-fiber evoked excitatory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord Chin Med J (Eng) 116 2003 883 887 (Pubitemid 36834051)
    • (2003) Chinese Medical Journal , vol.116 , Issue.6 , pp. 883-887
    • Liu, Z.1    Xu, R.2    Yang, K.3
  • 27
    • 21844459470 scopus 로고    scopus 로고
    • Neurophysiological and biomechanical characterization of goat cervical facet joint capsules
    • DOI 10.1016/j.orthres.2005.01.002, PII S0736026605000094
    • Y. Lu, C. Chen, S. Kallakuri, A. Patwardhan, and J.M. Cavanaugh Neurophysiological and biomechanical characterization of goat cervical facet joint capsules J Orthop Res 23 2005 779 787 (Pubitemid 40960028)
    • (2005) Journal of Orthopaedic Research , vol.23 , Issue.4 , pp. 779-787
    • Lu, Y.1    Chen, C.2    Kallakuri, S.3    Patwardhan, A.4    Cavanaugh, J.M.5
  • 28
    • 0032967201 scopus 로고    scopus 로고
    • Gabapentin attenuates nociceptive behaviors in an acute arthritis model in rats
    • Y. Lu, and K.N. Westlund Gabapentin attenuates nociceptive behaviors in an acute arthritis model in rats J Pharmacol Exp Ther 290 1999 214 219 (Pubitemid 29302322)
    • (1999) Journal of Pharmacology and Experimental Therapeutics , vol.290 , Issue.1 , pp. 214-219
    • Lu, Y.1    Westlund, K.N.2
  • 29
    • 0036059512 scopus 로고    scopus 로고
    • Prevalence of cervical facet joint pain in chronic neck pain
    • L. Manchikanti, V. Singh, J. Rivera, and V. Pampati Prevalence of cervical facet joint pain in chronic neck pain Pain Physician 5 2002 243 249
    • (2002) Pain Physician , vol.5 , pp. 243-249
    • Manchikanti, L.1    Singh, V.2    Rivera, J.3    Pampati, V.4
  • 30
    • 0035032465 scopus 로고    scopus 로고
    • 2δ subunits - Structure and gabapentin binding
    • E. Marais, N. Klugbauer, and F. Hofmann Calcium channel alpha(2)delta subunits-structure and gabapentin binding Mol Pharmacol 59 2001 1243 1248 (Pubitemid 32381604)
    • (2001) Molecular Pharmacology , vol.59 , Issue.5 , pp. 1243-1248
    • Marais, E.1    Klugbauer, N.2    Hofmann, F.3
  • 32
    • 33745005034 scopus 로고    scopus 로고
    • The lumbar spinal cord glial cells actively modulate subcutaneous formalin induced hyperalgesia in the rat
    • DOI 10.1016/j.neures.2006.04.017, PII S0168010206001131
    • M. Qin, J.J. Wang, R. Cao, H. Zhang, L. Duan, B. Gao, Y.F. Xiong, L.W. Chen, and Z.R. Rao The lumbar spinal cord glial cells actively modulate subcutaneous formalin induced hyperalgesia in the rat Neurosci Res 55 2006 442 450 (Pubitemid 43866257)
    • (2006) Neuroscience Research , vol.55 , Issue.4 , pp. 442-450
    • Qin, M.1    Wang, J.-J.2    Cao, R.3    Zhang, H.4    Duan, L.5    Gao, B.6    Xiong, Y.-F.7    Chen, L.-W.8    Rao, Z.-R.9
  • 33
    • 77957918666 scopus 로고    scopus 로고
    • Neuronal hyperexcitability in the dorsal horn after painful facet joint injury
    • K.P. Quinn, L. Dong, F.J. Golder, and B.A. Winkelstein Neuronal hyperexcitability in the dorsal horn after painful facet joint injury Pain 151 2010 414 421
    • (2010) Pain , vol.151 , pp. 414-421
    • Quinn, K.P.1    Dong, L.2    Golder, F.J.3    Winkelstein, B.A.4
  • 34
    • 40649123567 scopus 로고    scopus 로고
    • Structural changes in the cervical facet capsular ligament: Potential contributions to pain following subfailure loading
    • K.P. Quinn, K.E. Lee, C.C. Ahaghotu, and B.A. Winkelstein Structural changes in the cervical facet capsular ligament: Potential contributions to pain following subfailure loading Stapp Car Crash J 51 2007 169 187
    • (2007) Stapp Car Crash J , vol.51 , pp. 169-187
    • Quinn, K.P.1    Lee, K.E.2    Ahaghotu, C.C.3    Winkelstein, B.A.4
  • 35
    • 3242758909 scopus 로고    scopus 로고
    • Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS
    • DOI 10.1111/j.1460-9568.2004.03514.x
    • V. Raghavendra, F.Y. Tanga, and J.A. DeLeo Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS Eur J Neurosci 20 2004 467 473 (Pubitemid 38969631)
    • (2004) European Journal of Neuroscience , vol.20 , Issue.2 , pp. 467-473
    • Raghavendra, V.1    Tanga, F.Y.2    DeLeo, J.A.3
  • 36
    • 0027527142 scopus 로고
    • Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons
    • DOI 10.1016/0920-1211(93)90023-Z
    • D.M. Rock, K.M. Kelly, and R.L. Macdonald Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons Epilepsy Res 16 1993 89 98 (Pubitemid 23340046)
    • (1993) Epilepsy Research , vol.16 , Issue.2 , pp. 89-98
    • Rock, D.M.1    Kelly, K.M.2    Macdonald, R.L.3
  • 37
    • 60649118102 scopus 로고    scopus 로고
    • Effects of gabapentin on calcium transients in neurons of the rat dorsal root ganglia
    • S.V. Romanenko, P.G. Kostyuk, and E.P. Kostyuk Effects of gabapentin on calcium transients in neurons of the rat dorsal root ganglia Neurophysiol 40 2008 231 237
    • (2008) Neurophysiol , vol.40 , pp. 231-237
    • Romanenko, S.V.1    Kostyuk, P.G.2    Kostyuk, E.P.3
  • 38
    • 45849091466 scopus 로고    scopus 로고
    • A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain
    • A. Romero-Sandoval, N. Chai, N. Nutile-McMenemy, and J. Deleo A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain Brain Res 1219 2008 116 126
    • (2008) Brain Res , vol.1219 , pp. 116-126
    • Romero-Sandoval, A.1    Chai, N.2    Nutile-Mcmenemy, N.3    Deleo, J.4
  • 39
    • 0036252330 scopus 로고    scopus 로고
    • Gabapentin: Pharmacology and its use in pain management
    • DOI 10.1046/j.0003-2409.2001.02399.x
    • M.A. Rose, and P.C. Kam Gabapentin: Pharmacology and its use in pain management Anaesthesia 57 2002 451 462 (Pubitemid 34477042)
    • (2002) Anaesthesia , vol.57 , Issue.5 , pp. 451-462
    • Rose, M.A.1    Kam, P.C.A.2
  • 40
    • 3843088696 scopus 로고    scopus 로고
    • Pregabalin for the treatment of painful diabetic peripheral neuropathy: A double-blind, placebo-controlled trial
    • DOI 10.1016/j.pain.2004.05.001, PII S0304395904002465
    • J. Rosenstock, M. Tuchman, L. LaMoreaux, and U. Sharma Pregabalin for the treatment of painful diabetic peripheral neuropathy: A double-blind, placebo-controlled trial Pain 110 2004 628 638 (Pubitemid 39036794)
    • (2004) Pain , vol.110 , Issue.3 , pp. 628-638
    • Rosenstock, J.1    Tuchman, M.2    Lamoreaux, L.3    Sharma, U.4
  • 41
    • 0029993650 scopus 로고    scopus 로고
    • Gabapentin adjunctive therapy in neuropathic pain states
    • DOI 10.1097/00002508-199603000-00010
    • H. Rosner, L. Rubin, and A. Kestenbaum Gabapentin adjunctive therapy in neuropathic pain states Clin J Pain 12 1996 56 58 (Pubitemid 26128587)
    • (1996) Clinical Journal of Pain , vol.12 , Issue.1 , pp. 56-58
    • Rosner, H.1    Rubin, L.2    Kestenbaum, A.3
  • 42
    • 35548937457 scopus 로고    scopus 로고
    • The neuropathic pain triad: Neurons, immune cells and glia
    • DOI 10.1038/nn1992, PII NN1992
    • J. Scholz, and C.J. Woolf The neuropathic pain triad: Neurons, immune cells and glia Nat Neurosci 10 2007 1361 1368 (Pubitemid 350014681)
    • (2007) Nature Neuroscience , vol.10 , Issue.11 , pp. 1361-1368
    • Scholz, J.1    Woolf, C.J.2
  • 43
    • 0029981273 scopus 로고    scopus 로고
    • Gabapentin as a novel treatment for postherpetic neuralgia
    • A.Z. Segal, and G. Rordorf Gabapentin as a novel treatment for postherpetic neuralgia Neurology 46 1996 1175 1176 (Pubitemid 26134680)
    • (1996) Neurology , vol.46 , Issue.4 , pp. 1175-1176
    • Segal, A.Z.1    Rordorf, G.2
  • 44
    • 0030936903 scopus 로고    scopus 로고
    • Gabapentin, ineffective in normal rats, markedly reduces C-fibre evoked responses after inflammation
    • L. Stanfa, L. Singh, R. Williams, and A. Dickenson Gabapentin, ineffective in normal rats, markedly reduces C-fibre evoked responses after inflammation Neuroreport 8 1997 587 590 (Pubitemid 27128198)
    • (1997) NeuroReport , vol.8 , Issue.3 , pp. 587-590
    • Stanfa, L.C.1    Singh, L.2    Williams, R.G.3    Dickenson, A.H.4
  • 45
    • 0035282239 scopus 로고    scopus 로고
    • The effects of gabapentin on different ligand- and voltage-gated currents in isolated cortical neurons
    • DOI 10.1016/S0920-1211(00)00201-1, PII S0920121100002011
    • A. Stefani, F. Spadoni, P. Giacomini, F. Lavaroni, and G. Bernardi The effect of gabapentin on different ligand- and voltage-gated currents in isolated cortical neurons Epilepsy Res 43 2001 239 248 (Pubitemid 32204449)
    • (2001) Epilepsy Research , vol.43 , Issue.3 , pp. 239-248
    • Stefani, A.1    Spadoni, F.2    Giacomini, P.3    Lavaroni, F.4    Bernardi, G.5
  • 46
    • 38949212281 scopus 로고    scopus 로고
    • Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling
    • DOI 10.1002/glia.20623
    • M. Tsuda, H. Ueno, A. Kataoka, H. Tozaki-Saitoh, and K. Inoue Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling Glia 56 2008 378 386 (Pubitemid 351212947)
    • (2008) GLIA , vol.56 , Issue.4 , pp. 378-386
    • Tsuda, M.1    Ueno, H.2    Kataoka, A.3    Tozaki-Saitoh, H.4    Inoue, K.5
  • 48
    • 0042591219 scopus 로고    scopus 로고
    • In vivo single unit extracellular recordings from spinal cord neurones of rats
    • DOI 10.1016/S1385-299X(03)00068-0
    • C.E. Urch, and A.H. Dickenson In vivo single unit extracellular recordings from spinal cord neurones of rats Brain Res Brain Res Protoc 12 2003 26 34 (Pubitemid 36962991)
    • (2003) Brain Research Protocols , vol.12 , Issue.1 , pp. 26-34
    • Urch, C.E.1    Dickenson, A.H.2
  • 49
    • 67949106325 scopus 로고    scopus 로고
    • Differential analgesic effects of morphine and gabapentin on behavioural measures of pain and disability in a model of osteoarthritis pain in rats
    • J.L. Vonsy, J. Ghandehari, and A.H. Dickenson Differential analgesic effects of morphine and gabapentin on behavioural measures of pain and disability in a model of osteoarthritis pain in rats Eur J Pain 13 2009 786 793
    • (2009) Eur J Pain , vol.13 , pp. 786-793
    • Vonsy, J.L.1    Ghandehari, J.2    Dickenson, A.H.3
  • 50
    • 0347169249 scopus 로고    scopus 로고
    • Glia: A novel drug discovery target for clinical pain
    • L.R. Watkins, and S.F. Maier Glia: A novel drug discovery target for clinical pain Nat Rev Drug Discov 2 2003 973 985 (Pubitemid 37540579)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.12 , pp. 973-985
    • Watkins, L.R.1    Maier, S.F.2
  • 51
    • 0035426434 scopus 로고    scopus 로고
    • Glial activation: A driving force for pathological pain
    • DOI 10.1016/S0166-2236(00)01854-3, PII S0166223600018543
    • L.R. Watkins, E.D. Milligan, and S.F. Maier Glial activation: A driving force for pathological pain Trends Neurosci 24 2001 450 455 (Pubitemid 32695356)
    • (2001) Trends in Neurosciences , vol.24 , Issue.8 , pp. 450-455
    • Watkins, L.R.1    Milligan, E.D.2    Maier, S.F.3
  • 52
    • 78650080975 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor-5 and protein kinase C-epsilon increase in dorsal root ganglion neurons and spinal glial activation in an adolescent rat model of painful neck injury
    • C.L. Weisshaar, L. Dong, A.S. Bowman, F.M. Perez, B.B. Guarino, S.M. Sweitzer, and B.A. Winkelstein Metabotropic glutamate receptor-5 and protein kinase C-epsilon increase in dorsal root ganglion neurons and spinal glial activation in an adolescent rat model of painful neck injury J Neurotrauma 27 2010 2261 2271
    • (2010) J Neurotrauma , vol.27 , pp. 2261-2271
    • Weisshaar, C.L.1    Dong, L.2    Bowman, A.S.3    Perez, F.M.4    Guarino, B.B.5    Sweitzer, S.M.6    Winkelstein, B.A.7
  • 53
    • 0028094950 scopus 로고
    • Methylenedioxymethamphetamine depresses glutamate-evoked neuronal firing and increases extracellular levels of dopamine and serotonin in the nucleus accumbens in vivo
    • DOI 10.1016/0306-4522(94)90313-1
    • S.R. White, P. Duffy, and P.W. Kalivas Methylenedioxymethamphetamine depresses glutamate-evoked neuronal firing and increases extracellular levels of dopamine and serotonin in the nucleus accumbens in vivo Neuroscience 62 1994 41 50 (Pubitemid 24287344)
    • (1994) Neuroscience , vol.62 , Issue.1 , pp. 41-50
    • White, S.R.1
  • 54
    • 42149133141 scopus 로고    scopus 로고
    • An intact facet capsular ligament modulates behavioral sensitivity and spinal glial activation produced by cervical facet joint tension
    • DOI 10.1097/BRS.0b013e31816b4710, PII 0000763220080415000006
    • B.A. Winkelstein, and D.G. Santos An intact facet capsular ligament modulates behavioral sensitivity and spinal glial activation produced by cervical facet joint tension Spine 33 2008 856 862 (Pubitemid 351533853)
    • (2008) Spine , vol.33 , Issue.8 , pp. 856-862
    • Winkelstein, B.A.1    Santos, D.G.2
  • 55
    • 67949110917 scopus 로고    scopus 로고
    • Gabapentin reverses microglial activation in the spinal cord of streptozotocin-induced diabetic rats
    • R. Wodarski, A.K. Clark, J. Grist, F. Marchand, and M. Malcangio Gabapentin reverses microglial activation in the spinal cord of streptozotocin-induced diabetic rats Eur J Pain 13 2009 807 811
    • (2009) Eur J Pain , vol.13 , pp. 807-811
    • Wodarski, R.1    Clark, A.K.2    Grist, J.3    Marchand, F.4    Malcangio, M.5
  • 56
    • 0034625770 scopus 로고    scopus 로고
    • Neuronal plasticity: Increasing the gain in pain
    • C.J. Woolf, and M.W. Salter Neuronal plasticity: Increasing the gain in pain Science 288 2000 1765 1769
    • (2000) Science , vol.288 , pp. 1765-1769
    • Woolf, C.J.1    Salter, M.W.2
  • 57
    • 0026555273 scopus 로고
    • Peripheral nerve injury triggers central sprouting of myelinated afferents
    • C.J. Woolf, P. Shortland, and R.E. Coggeshall Peripheral nerve injury triggers central sprouting of myelinated afferents Nature 355 1992 75 78
    • (1992) Nature , vol.355 , pp. 75-78
    • Woolf, C.J.1    Shortland, P.2    Coggeshall, R.E.3
  • 58
    • 40049098691 scopus 로고    scopus 로고
    • Effect of etanercept, a tumor necrosis factor-alpha inhibitor, on neuropathic pain in the rat chronic constriction injury model
    • DOI 10.1097/BRS.0b013e318162340a, PII 0000763220080201000002
    • J.M. Zanella, E.N. Burright, K. Hildebrand, C. Hobot, M. Cox, L. Christoferson, and W.F. McKay Effect of etanercept, a tumor necrosis factor-alpha inhibitor, on neuropathic pain in the rat chronic constriction injury model Spine 33 2008 227 234 (Pubitemid 351322926)
    • (2008) Spine , vol.33 , Issue.3 , pp. 227-234
    • Zanella, J.M.1    Burright, E.N.2    Hildebrand, K.3    Hobot, C.4    Cox, M.5    Christoferson, L.6    McKay, W.F.7
  • 59
    • 0020525719 scopus 로고
    • Ethical guidelines for investigations of experimental pain in conscious animals
    • DOI 10.1016/0304-3959(83)90201-4
    • M. Zimmermann Ethical guidelines for investigations of experimental pain in conscious animals Pain 16 1983 109 110 (Pubitemid 13058546)
    • (1983) Pain , vol.16 , Issue.2 , pp. 109-110
    • Zimmermann, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.