Inflammation unmasks gabapentin's effect on Aδ-fiber evoked excitatory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord

Chinese Medical Journal

Volumn 116, Issue 6, 2003, Pages 883-887

  Liu, Zhiliang ^a   Xu, Ruxiang ^a   Yang, Kun ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Carrageenan inflammation; Gabapentin; Spinal cord; Synaptic transmission; Whole cell voltage clamp recording

Indexed keywords

ANTICONVULSIVE AGENT; ANTINOCICEPTIVE AGENT; CARRAGEENAN; GABAPENTIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DELTA NERVE FIBER; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; EXCITATORY POSTSYNAPTIC POTENTIAL; NEURITIS; NONHUMAN; RAT; RECORDING; SENSORY NERVE; SLOW INWARD CURRENT; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; STUDENT T TEST; SUBSTANTIA GELATINOSA; TISSUE SLICE; VOLTAGE CLAMP;

ACETIC ACIDS; AMINES; ANIMALS; CYCLOHEXANECARBOXYLIC ACIDS; GAMMA-AMINOBUTYRIC ACID; NERVE FIBERS, MYELINATED; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SODIUM CHANNELS; SUBSTANTIA GELATINOSA; SYNAPTIC TRANSMISSION; TETRODOTOXIN;

EID: 0037898153     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Suman-Chauhan N, Webdale L, Hill DR, et al. Characterisaztion of [3H] gabapentin binding to a novel site in rat brain: homogenate binding studies. Eur J Pharmacol 1993;244:293-301.
2. Carlton SM, Zhou ST. Attenuation of formalin-induced nociceptive behavious following local peripheral injection of gabapentin. Pain 1997;76:201-207.
3. Champman V, Dickenson AH. Inflammation reveals inhibition of noxious responses of rat spinal neurons by carbamazepine. Neuro Report 1997;8:1399-1404.
4. Field MJ, Holloman EF, McCleary S, et al. Evaluation of gabapentin and S- (+)-3-isobutylgaba in a rat model of postoperative pain. J Pharmamal Exp Ther 1997;282:1242-1246.
5. Jones DL, Sorkin LS. Systemic gabapentin and S (+)-3-isobutyl-g-aminobutyric acid block secondary hyperalgesia. Brain Res 1998;810:93-99.
6. Partridge BJ, Chaplan SR, Sakamoto E, et al. Characterization of the effects of gabapentin and 3-isobutyl-g-aninobutyris acid on suybstance P-induced thermal hyperalgesia. Anesthesiology 1998;88:196-205.
7. Shimoyama N Shimoyama M, Davis AM, Inturrisi CE, et al. Spinal gabapentin is anti nociceptivbe in the rat formalin test. Neurosci Lett 1997;222:65-67.
8. Stanfa LC, Singh L, Willisams RG, et al. Gabapentin, ineffective in normal rats, markedly reduces C-fiber evoked responses after inflammation. NeuroReaport 1997; 8: 587-590.
9. Shimoyama M, Shimoyama N, Hori Y. Gabapentin affects synaptically-evoked NMDA current in rat dorsal horn neurons. Soc Neurosci Abstr 1998;24:639.
10. Dickenson AH. The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord. Gen Pharmacol 1997; 28:633-638.
11. Ren K, Dubner R. NMDA receptor antagonsits attenuate mechanical hyperalgesia in rats with unilateral inflammation of the hindpaw. Neurosci Lett 1993;163:22-26.
12. Gu Y, Huang LYM. Gabapentin potentiates NMDA response in dorsal horn neurons treated with protein kinase C. Soc Neurosci Abstr 1998;24:640.
13. Willis WD, Congeshall RE. Functional organization of dorsal horn interneurons, In: Sensory mechanisms of the spinal cord. New York: Penum Press; 1991:153-215.
14. Yang K, Kumamoto E, Furue H, et al. Action of capsaicin on dorsal root-evoked synaptic transmission to substantia gelatinosa neurons in adult rat spinal cord slices. Brain Research 1999;830:268-273.
15. Yang K, Kumamoto E, Furue H, et al. Capsaicin induces a slow inward current which is not mediated by substance P in substantia gelatinosa neurons of the rat spinal cord. Neuropharmacology 2000;39:2185-2194.
16. Jeftinija S, Urban L. Repetitive stimulation induced potentiation of excitatory transmission in the rat dorsal horn: an in vitro study. J Neurophysiol 1994;71:216-228.
17. Sandluhler J, Chen JG, Cheng G, et al. Low-frequency stimulation of afferent ad-fibers induced long-tern depression at primary afferent synapses with substantia gelatinosa neurons in the rat. J Neurosci 1997;17:6483-6491.
18. Champman V, Suzuki R, Chamarette HLC, et al. Effects of systemic carbamazepine and gabapentin in spinal neuronal responses in spinal nerve ligated rats. Pain 1998 ; 75: 261-272.
19. Stanfa LC, Dichenson AH. Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurones. Eur J Pharmacol 1998;347:165-172.
20. Rock DM, kelly KM, Macdonald RL. Gabapentin action on ligand- and volgate-gated responses in cultured rodent neurons. Epliepsy Res 1993;16:89-98.
21. Gee NS, Brown JP, Dissanayake VU, et al. The novel anticonvulsant drug, gabapentin (neurontin), binds to the a2d subunit of a calcium channel. J Biol Chem 1996;271: 5768-5776.