-
1
-
-
84865396291
-
+ in rat
-
+ in rat. Toxicol Sci 128:471-481.
-
(2012)
Toxicol Sci
, vol.128
, pp. 471-481
-
-
Ahmadimoghaddam, D.1
Hofman, J.2
Zemankova, L.3
Nachtigal, P.4
Dolezelova, E.5
Cerveny, L.6
Ceckova, M.7
Micuda, S.8
Staud, F.9
-
2
-
-
67651235787
-
Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin
-
Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee SW, and Choi JH, et al. (2009) Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. Pharmacogenet Genomics 19:497-504.
-
(2009)
Pharmacogenet Genomics
, vol.19
, pp. 497-504
-
-
Chen, Y.1
Li, S.2
Brown, C.3
Cheatham, S.4
Castro, R.A.5
Leabman, M.K.6
Urban, T.J.7
Chen, L.8
Yee, S.W.9
Choi, J.H.10
-
3
-
-
78649598223
-
Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3
-
Duan H and Wang J (2010) Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3. J Pharmacol Exp Ther 335:743-753.
-
(2010)
J Pharmacol Exp Ther
, vol.335
, pp. 743-753
-
-
Duan, H.1
Wang, J.2
-
4
-
-
27544453846
-
Interaction of organic cations with a newly identified plasma membrane monoamine transporter
-
Engel K and Wang J (2005) Interaction of organic cations with a newly identified plasma membrane monoamine transporter. Mol Pharmacol 68:1397-1407.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 1397-1407
-
-
Engel, K.1
Wang, J.2
-
5
-
-
9644268195
-
Identification and characterization of a novel monoamine transporter in the human brain
-
Engel K, Zhou M, and Wang J (2004) Identification and characterization of a novel monoamine transporter in the human brain. J Biol Chem 279:50042-50049.
-
(2004)
J Biol Chem
, vol.279
, pp. 50042-50049
-
-
Engel, K.1
Zhou, M.2
Wang, J.3
-
6
-
-
77950950434
-
Pharmacokinetics of metformin during pregnancy
-
Eyal S, Easterling TR, Carr D, Umans JG, Miodovnik M, Hankins GD, Clark SM, Risler L, Wang J, and Kelly EJ, et al. (2010) Pharmacokinetics of metformin during pregnancy. Drug Metab Dispos 38:833-840.
-
(2010)
Drug Metab Dispos
, vol.38
, pp. 833-840
-
-
Eyal, S.1
Easterling, T.R.2
Carr, D.3
Umans, J.G.4
Miodovnik, M.5
Hankins, G.D.6
Clark, S.M.7
Risler, L.8
Wang, J.9
Kelly, E.J.10
-
7
-
-
77649216536
-
Membrane transporters in drug development
-
International Transporter Consortium
-
Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, and Hillgren KM, et al.; International Transporter Consortium (2010) Membrane transporters in drug development. Nat Rev Drug Discov 9:215-236.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 215-236
-
-
Giacomini, K.M.1
Huang, S.M.2
Tweedie, D.J.3
Benet, L.Z.4
Brouwer, K.L.5
Chu, X.6
Dahlin, A.7
Evers, R.8
Fischer, V.9
Hillgren, K.M.10
-
8
-
-
49149083537
-
Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: A University of Washington specialized center of research study
-
Hebert MF, Easterling TR, Kirby B, Carr DB, Buchanan ML, Rutherford T, Thummel KE, Fishbein DP, and Unadkat JD (2008) Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study. Clin Pharmacol Ther 84:248-253.
-
(2008)
Clin Pharmacol Ther
, vol.84
, pp. 248-253
-
-
Hebert, M.F.1
Easterling, T.R.2
Kirby, B.3
Carr, D.B.4
Buchanan, M.L.5
Rutherford, T.6
Thummel, K.E.7
Fishbein, D.P.8
Unadkat, J.D.9
-
9
-
-
85047683695
-
Alterations in drug disposition during pregnancy: Implications for drug therapy
-
Hodge LS and Tracy TS (2007) Alterations in drug disposition during pregnancy: implications for drug therapy. Expert Opin Drug Metab Toxicol 3:557-571.
-
(2007)
Expert Opin Drug Metab Toxicol
, vol.3
, pp. 557-571
-
-
Hodge, L.S.1
Tracy, T.S.2
-
10
-
-
84872714794
-
Drug metabolism and transport during pregnancy: How does drug disposition change during pregnancy and what are the mechanisms that cause such changes?
-
Isoherranen N and Thummel KE (2013) Drug metabolism and transport during pregnancy: how does drug disposition change during pregnancy and what are the mechanisms that cause such changes? Drug Metab Dispos 41:256-262.
-
(2013)
Drug Metab Dispos
, vol.41
, pp. 256-262
-
-
Isoherranen, N.1
Thummel, K.E.2
-
11
-
-
43049114146
-
Quantitative atlas of membrane transporter proteins: Development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria
-
Kamiie J, Ohtsuki S, Iwase R, Ohmine K, Katsukura Y, Yanai K, Sekine Y, Uchida Y, Ito S, and Terasaki T (2008) Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. Pharm Res 25:1469-1483.
-
(2008)
Pharm Res
, vol.25
, pp. 1469-1483
-
-
Kamiie, J.1
Ohtsuki, S.2
Iwase, R.3
Ohmine, K.4
Katsukura, Y.5
Yanai, K.6
Sekine, Y.7
Uchida, Y.8
Ito, S.9
Terasaki, T.10
-
12
-
-
0032569029
-
Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta
-
Kekuda R, Prasad PD, Wu X, Wang H, Fei YJ, Leibach FH, and Ganapathy V (1998) Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem 273:15971-15979.
-
(1998)
J Biol Chem
, vol.273
, pp. 15971-15979
-
-
Kekuda, R.1
Prasad, P.D.2
Wu, X.3
Wang, H.4
Fei, Y.J.5
Leibach, F.H.6
Ganapathy, V.7
-
13
-
-
33644664085
-
Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1
-
Kimura N, Masuda S, Tanihara Y, Ueo H, Okuda M, Katsura T, and Inui K (2005) Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet 20:379-386.
-
(2005)
Drug Metab Pharmacokinet
, vol.20
, pp. 379-386
-
-
Kimura, N.1
Masuda, S.2
Tanihara, Y.3
Ueo, H.4
Okuda, M.5
Katsura, T.6
Inui, K.7
-
14
-
-
34249943356
-
Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharmaceutical implications
-
Koepsell H, Lips K, and Volk C (2007) Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res 24:1227-1251.
-
(2007)
Pharm Res
, vol.24
, pp. 1227-1251
-
-
Koepsell, H.1
Lips, K.2
Volk, C.3
-
15
-
-
46749113148
-
Carrier-mediated transport of metformin across the human placenta determined by using the ex vivo perfusion of the placental cotyledon model
-
Kovo M, Kogman N, Ovadia O, Nakash I, Golan A, and Hoffman A (2008) Carrier-mediated transport of metformin across the human placenta determined by using the ex vivo perfusion of the placental cotyledon model. Prenat Diagn 28:544-548.
-
(2008)
Prenat Diagn
, vol.28
, pp. 544-548
-
-
Kovo, M.1
Kogman, N.2
Ovadia, O.3
Nakash, I.4
Golan, A.5
Hoffman, A.6
-
16
-
-
45249105082
-
Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice
-
Lickteig AJ, Cheng X, Augustine LM, Klaassen CD, and Cherrington NJ (2008) Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice. Life Sci 83:59-64.
-
(2008)
Life Sci
, vol.83
, pp. 59-64
-
-
Lickteig, A.J.1
Cheng, X.2
Augustine, L.M.3
Klaassen, C.D.4
Cherrington, N.J.5
-
17
-
-
25844485913
-
P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages
-
Mathias AA, Hitti J, and Unadkat JD (2005) P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages. Am J Physiol Regul Integr Comp Physiol 289:R963-R969.
-
(2005)
Am J Physiol Regul Integr Comp Physiol
, vol.289
-
-
Mathias, A.A.1
Hitti, J.2
Unadkat, J.D.3
-
18
-
-
70350075408
-
Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver
-
Nies AT, Koepsell H, Winter S, Burk O, Klein K, Kerb R, Zanger UM, Keppler D, Schwab M, and Schaeffeler E (2009) Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. Hepatology 50:1227-1240.
-
(2009)
Hepatology
, vol.50
, pp. 1227-1240
-
-
Nies, A.T.1
Koepsell, H.2
Winter, S.3
Burk, O.4
Klein, K.5
Kerb, R.6
Zanger, U.M.7
Keppler, D.8
Schwab, M.9
Schaeffeler, E.10
-
19
-
-
84455194082
-
Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: Comparison with mRNA levels and activities
-
Ohtsuki S, Schaefer O, Kawakami H, Inoue T, Liehner S, Saito A, Ishiguro N, Kishimoto W, Ludwig-Schwellinger E, and Ebner T, et al. (2012) Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities. Drug Metab Dispos 40:83-92.
-
(2012)
Drug Metab Dispos
, vol.40
, pp. 83-92
-
-
Ohtsuki, S.1
Schaefer, O.2
Kawakami, H.3
Inoue, T.4
Liehner, S.5
Saito, A.6
Ishiguro, N.7
Kishimoto, W.8
Ludwig-Schwellinger, E.9
Ebner, T.10
-
20
-
-
29144523534
-
A human transporter protein that mediates the final excretion step for toxic organic cations
-
Otsuka M, Matsumoto T, Morimoto R, Arioka S, Omote H, and Moriyama Y (2005) A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci USA 102:17923-17928.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17923-17928
-
-
Otsuka, M.1
Matsumoto, T.2
Morimoto, R.3
Arioka, S.4
Omote, H.5
Moriyama, Y.6
-
21
-
-
84878129920
-
Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): Effect of age, sex, and genotype
-
Prasad B, Lai Y, Lin Y, and Unadkat JD (2013) Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex, and genotype. J Pharm Sci 102:787-793.
-
(2013)
J Pharm Sci
, vol.102
, pp. 787-793
-
-
Prasad, B.1
Lai, Y.2
Lin, Y.3
Unadkat, J.D.4
-
22
-
-
27144499255
-
Functional analysis of organic cation transporter 3 expressed in human placenta
-
Sata R, Ohtani H, Tsujimoto M, Murakami H, Koyabu N, Nakamura T, Uchiumi T, Kuwano M, Nagata H, and Tsukimori K, et al. (2005) Functional analysis of organic cation transporter 3 expressed in human placenta. J Pharmacol Exp Ther 315:888-895.
-
(2005)
J Pharmacol Exp Ther
, vol.315
, pp. 888-895
-
-
Sata, R.1
Ohtani, H.2
Tsujimoto, M.3
Murakami, H.4
Koyabu, N.5
Nakamura, T.6
Uchiumi, T.7
Kuwano, M.8
Nagata, H.9
Tsukimori, K.10
-
23
-
-
34248156160
-
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
-
Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, Ianculescu AG, Yue L, Lo JC, and Burchard EG, et al. (2007) Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest 117:1422-1431.
-
(2007)
J Clin Invest
, vol.117
, pp. 1422-1431
-
-
Shu, Y.1
Sheardown, S.A.2
Brown, C.3
Owen, R.P.4
Zhang, S.5
Castro, R.A.6
Ianculescu, A.G.7
Yue, L.8
Lo, J.C.9
Burchard, E.G.10
-
24
-
-
84872705756
-
Gestational age-dependent changes in gene expression of metabolic enzymes and transporters in pregnant mice
-
Shuster DL, Bammler TK, Beyer RP, Macdonald JW, Tsai JM, Farin FM, Hebert MF, Thummel KE, and Mao Q (2013) Gestational age-dependent changes in gene expression of metabolic enzymes and transporters in pregnant mice. Drug Metab Dispos 41:332-342.
-
(2013)
Drug Metab Dispos
, vol.41
, pp. 332-342
-
-
Shuster, D.L.1
Bammler, T.K.2
Beyer, R.P.3
Macdonald, J.W.4
Tsai, J.M.5
Farin, F.M.6
Hebert, M.F.7
Thummel, K.E.8
Mao, Q.9
-
26
-
-
33746508758
-
Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1
-
Terada T, Masuda S, Asaka J, Tsuda M, Katsura T, and Inui K (2006) Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1. Pharm Res 23:1696-1701.
-
(2006)
Pharm Res
, vol.23
, pp. 1696-1701
-
-
Terada, T.1
Masuda, S.2
Asaka, J.3
Tsuda, M.4
Katsura, T.5
Inui, K.6
-
27
-
-
66849142125
-
Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin
-
Tsuda M, Terada T, Mizuno T, Katsura T, Shimakura J, and Inui K (2009) Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin. Mol Pharmacol 75:1280-1286.
-
(2009)
Mol Pharmacol
, vol.75
, pp. 1280-1286
-
-
Tsuda, M.1
Terada, T.2
Mizuno, T.3
Katsura, T.4
Shimakura, J.5
Inui, K.6
-
28
-
-
79953686193
-
Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors
-
Uchida Y, Ohtsuki S, Katsukura Y, Ikeda C, Suzuki T, Kamiie J, and Terasaki T (2011) Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors. J Neurochem 117:333-345.
-
(2011)
J Neurochem
, vol.117
, pp. 333-345
-
-
Uchida, Y.1
Ohtsuki, S.2
Katsukura, Y.3
Ikeda, C.4
Suzuki, T.5
Kamiie, J.6
Terasaki, T.7
-
29
-
-
33845383376
-
Expression of the breast cancer resistance protein (Bcrp1/Abcg2) in tissues from pregnant mice: Effects of pregnancy and correlations with nuclear receptors
-
Wang H, Wu X, Hudkins K, Mikheev A, Zhang H, Gupta A, Unadkat JD, and Mao Q (2006) Expression of the breast cancer resistance protein (Bcrp1/Abcg2) in tissues from pregnant mice: effects of pregnancy and correlations with nuclear receptors. Am J Physiol Endocrinol Metab 291:E1295-E1304.
-
(2006)
Am J Physiol Endocrinol Metab
, vol.291
-
-
Wang, H.1
Wu, X.2
Hudkins, K.3
Mikheev, A.4
Zhang, H.5
Gupta, A.6
Unadkat, J.D.7
Mao, Q.8
-
30
-
-
65749099959
-
Role of metformin in the treatment of gestational diabetes
-
Wensel TM (2009) Role of metformin in the treatment of gestational diabetes. Ann Pharmacother 43:939-943.
-
(2009)
Ann Pharmacother
, vol.43
, pp. 939-943
-
-
Wensel, T.M.1
-
31
-
-
3042542425
-
Molecular and cellular physiology of renal organic cation and anion transport
-
Wright SH and Dantzler WH (2004) Molecular and cellular physiology of renal organic cation and anion transport. Physiol Rev 84:987-1049.
-
(2004)
Physiol Rev
, vol.84
, pp. 987-1049
-
-
Wright, S.H.1
Dantzler, W.H.2
-
32
-
-
84872689414
-
Down-regulation of brush border efflux transporter expression in the kidneys of pregnant mice
-
Yacovino LL, Gibson CJ, and Aleksunes LM (2013) Down-regulation of brush border efflux transporter expression in the kidneys of pregnant mice. Drug Metab Dispos 41:320-325.
-
(2013)
Drug Metab Dispos
, vol.41
, pp. 320-325
-
-
Yacovino, L.L.1
Gibson, C.J.2
Aleksunes, L.M.3
-
33
-
-
50449088026
-
Effect of pregnancy on cytochrome P450 3a and P-glycoprotein expression and activity in the mouse: Mechanisms, tissue specificity, and time course
-
Zhang H, Wu X, Wang H, Mikheev AM, Mao Q, and Unadkat JD (2008) Effect of pregnancy on cytochrome P450 3a and P-glycoprotein expression and activity in the mouse: mechanisms, tissue specificity, and time course. Mol Pharmacol 74:714-723.
-
(2008)
Mol Pharmacol
, vol.74
, pp. 714-723
-
-
Zhang, H.1
Wu, X.2
Wang, H.3
Mikheev, A.M.4
Mao, Q.5
Unadkat, J.D.6
-
34
-
-
40849097788
-
The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: An Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study
-
Zhou L, Naraharisetti SB, Wang H, Unadkat JD, Hebert MF, and Mao Q (2008) The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: an Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study. Mol Pharmacol 73:949-959.
-
(2008)
Mol Pharmacol
, vol.73
, pp. 949-959
-
-
Zhou, L.1
Naraharisetti, S.B.2
Wang, H.3
Unadkat, J.D.4
Hebert, M.F.5
Mao, Q.6
-
35
-
-
34748922537
-
Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine
-
Zhou M, Xia L, and Wang J (2007) Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine. Drug Metab Dispos 35:1956-1962.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1956-1962
-
-
Zhou, M.1
Xia, L.2
Wang, J.3
-
36
-
-
0034975789
-
Impaired activity of the extraneuronal monoamine transporter system known as uptake-2 in Orct3/Slc22a3-deficient mice
-
Zwart R, Verhaagh S, Buitelaar M, Popp-Snijders C, and Barlow DP (2001) Impaired activity of the extraneuronal monoamine transporter system known as uptake-2 in Orct3/Slc22a3-deficient mice. Mol Cell Biol 21:4188-4196.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 4188-4196
-
-
Zwart, R.1
Verhaagh, S.2
Buitelaar, M.3
Popp-Snijders, C.4
Barlow, D.P.5
|