Carrier-mediated transport of metformin across the human placenta determined by using the ex vivo perfusion of the placental cotyledon model

Prenatal Diagnosis

Volumn 28, Issue 6, 2008, Pages 544-548

  Kovo, Michal ^a,b   Kogman, Naomi ^c   Ovadia, Oded ^c   Nakash, Ishak ^a   Golan, Abraham ^a,b   Hoffman, Amnon ^c  

^a WOLFSON MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

in vitro perfusion; Metformin; Placenta; Pregnancy

Indexed keywords

DRUG CARRIER; METFORMIN; PHENAZONE; TESTOSTERONE;

ARTICLE; ASSAY; CONTROLLED STUDY; DRUG DIFFUSION; DRUG PENETRATION; DRUG TRANSPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; PARALLEL ARTIFICIAL MEMBRANE PERMEATION ASSAY; PLACENTA PERFUSION; PREGNANCY; PRIORITY JOURNAL;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIPYRINE; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; MATERNAL-FETAL EXCHANGE; METFORMIN; MODELS, BIOLOGICAL; PLACENTA; PLACENTAL CIRCULATION; PREGNANCY;

EID: 46749113148     PISSN: 01973851     EISSN: 10970223     Source Type: Journal    
DOI: 10.1002/pd.2026     Document Type: Article

References (27)

1. AbuRuz S, Millership J, McElnay J. 2003. Determination of metformin in plasma using a new ion pair solid phase extraction technique and ion pair liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci 798(2): 203-209.
2. Balimane PV, Han YH, Chong SH. 2006. Current industrial practices of assessing permeability and P-glycoprotein interaction. AAPS J 8(1): E1-13.
3. Bourdet DL, Pritchard JB, Thakker DR. 2005. Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3). J Pharmacol Exp Ther 315(3): 1288-1297.
4. Charles B, Norris R, Xiao X, Hague W. 2006. Population pharmacokinetics of metformin in late pregnancy. Ther Drug Monit 28(1): 67-72.
5. Feig DS, Briggs GG, Koren G. 2007. Oral antidiabetic agents in pregnancy and lactation: a paradigm shift? Ann Pharmacother 41(7): 1174-1180.
6. Ganapathy V, Prasad PD. 2005. Role of transporters in placental transfer of drugs. Toxicol Appl Pharmacol 207(Suppl. 2): 381-387.
7. Ganapathy V, Prasad PD, Ganapathy ME, Leibach FH. 2000. Placental transporters relevant to drug distribution across the maternal-fetal interface. J Pharmacol Exp Ther 294(2): 413-420.
8. Glueck CJ, Bornovali S, Pranikoff J, Goldenberg N, Dharashivkar S, Wang P. 2004a. Metformin, pre-eclampsia, and pregnancy outcomes in women with polycystic ovary syndrome. Diabet Med 21(8): 829-836.
9. Glueck CJ, Goldenberg N, Pranikoff J, Loftspring M, Sieve L, Wang P. 2004b. Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy. Hum Reprod 19(6): 1323-1330.
10. Glueck CJ, Pranikoff J, Aregawi D, Wang P. 2008. Prevention of gestational diabetes by metformin plus diet in patients with polycystic ovary syndrome. Fertil Steril 89(3): 625-634.
11. Glueck CJ, Wang P, Goldenberg N, Sieve-Smith L. 2002a. Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin. Hum Reprod 17(11): 2858-2864.
12. Glueck CJ, Wang P, Kobayashi S, Phillips H, Sieve-Smith L. 2002b. Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome. Fertil Steril 77(3): 520-525.
13. Gorboulev V, Ulzheimer JC, Akhoundova A, et al. 1997. Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol 16(7): 871-881.
14. Gutzin SJ, Kozer E, Magee LA, Feig DS, Koren G. 2003. The safety of oral hypoglycemic agents in the first trimester of pregnancy: a meta-analysis. Can J Clin Pharmacol 10(4): 179-183.
15. Kovo MS, Haroutiunian S, Feldman N, Hoffman A, Glezerman M. 2008. Determination of metformin transfer across the human placenta using a dually perfused ex vivo placental cotyledon model. Eur J Obstet Gynecol Reprod Biol 136(1): 29-33.
16. Kraemer J, Klein J, Lubetsky A, Koren G. 2006. Perfusion studies of glyburide transfer across the human placenta: implications for fetal safety. Am J Obstet Gynecol 195(1): 270-274.
17. Lord JM, Flight IH, Norman RJ. 2003. Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ 327(7421): 951-953.
18. Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K. 2004. Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol 503(1-3): 25-30.
19. Nanovskaya TN, Nekhayeva IA, Patrikeeva SL, Hankins GD, Ahmed MS. 2006. Transfer of metformin across the dually perfused human placental lobule. Am J Obstet Gynecol 195(4): 1081-1085.
20. Schneider H, Huch A. 1985. Dual in vitro perfusion of an isolated lobe of human placenta: method and instrumentation. Contrib Gynecol Obstet 13: 40-47.
21. Schneider H, Panigel M, Dancis J. 1972. Transfer across the perfused human placenta of antipyrine, sodium and leucine. Am J Obstet Gynecol 114(6): 822-828.
22. Sirtori CR, Pasik C. 1994. Re-evaluation of a biguanide, metformin: mechanism of action and tolerability. Pharmacol Res 30(3): 187-228.
23. St-Pierre MV, Ugele B, Gambling L, Shiverick KT. 2002. Mechanisms of drug transfer across the human placenta-a workshop report. Placenta 23(Suppl. A): S159-S164.
24. Vanky E, Salvesen KA, Heimstad R, Fougner KJ, Romundstad P, Carlsen SM. 2004. Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: results of a randomized study. Hum Reprod 19(8): 1734-1740.
25. Vanky E, Zahlsen K, Spigset O, Carlsen SM. 2005. Placental passage of metformin in women with polycystic ovary syndrome. Fertil Steril 83(5): 1575-1578.
26. Wohnsland F, Faller B. 2001. High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. J Med Chem 44(6): 923-930.
27. Wu X, Huang W, Ganapathy ME, et al. 2000. Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. Am J Physiol Renal Physiol 279(3): F449-F458.