Correlation between mass transfer coefficient kLa and relevant operating parameters in cylindrical disposable shaken bioreactors on a bench-to-pilot scale

Journal of Biological Engineering

Volumn 7, Issue 1, 2013, Pages

  Klöckner, Wolf ^a   Gacem, Riad ^a   Anderlei, Tibor ^b   Raven, Nicole ^c   Schillberg, Stefan ^c   Lattermann, Clemens ^a   Büchs, Jochen ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b ADOLF KÜHNER AG   (Switzerland)

^c FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

Author keywords

Dimensional analysis; Maximum oxygen transfer capacity; Orbitally shaken; Plant cell suspension cultures; Single use; Volumetric mass transfer coefficient

Indexed keywords

OXYGEN;

ARTICLE; BIOREACTOR; BREATHING; CELL SUSPENSION; DISPOSABLE EQUIPMENT; GRAVITY; MASS; NONHUMAN; OXYGEN CONCENTRATION; OXYGEN CONSUMPTION; OXYGEN DIFFUSION; OXYGEN SUPPLY; PLANT CELL; PRIORITY JOURNAL; REACTOR; STIRRED REACTOR; SUSPENSION CELL CULTURE; TOBACCO; CONSTANTS AND COEFFICIENTS; CYLINDRICAL DISPOSABLE SHAKEN BIOREACTOR; DIFFUSION COEFFICIENT; GRAVITATIONAL STRESS; MASS TRANSFER COEFFICIENT; NICOTIANA TABACUM; PLANT CELL CULTURE; PLANT GROWTH;

MAMMALIA; NICOTIANA TABACUM;

EID: 84888597641     PISSN: None     EISSN: 17541611     Source Type: Journal    
DOI: 10.1186/1754-1611-7-28     Document Type: Article

References (53)

1. Oosterhuis NMG, Van den Berg HJ. How multipurpose is a disposable bioreactor?. Biopharm International 2011, 24:51-56.
2. Eibl R, Kaiser S, Lombriser R, Eibl D. Disposable bioreactors: the current state-of-the-art and recommended applications in biotechnology. Appl Microbiol Biotechnol 2010, 86:41-49. 10.1007/s00253-009-2422-9, 20094714.
3. Eibl R, Löffelholz C, Eibl D. Single-use bioreactors-an overview. Single-Use Technology in Biopharmaceutical Manufacture 2010, 33-51. Hoboken, New Jersey: John Wiley & Sons, Inc, Eibl R, Eibl D.
4. Kybal J, Vlcek V. Simple device for stationary cultivation of microorganisms. Biotechnol Bioeng 1976, 18:1713-1718. 10.1002/bit.260181206, 990436.
5. Kybal J, Sikyta B. A device for cultivation of plant and animal cells. Biotechnol Lett 1985, 7:467-470.
6. Brod H, Vester A, Kauling J. Opportunities and limitations of disposable technologies in biopharmaceutical processes. Chem Ing Tech 2012, 84:633-645.
7. Eibl R, Eibl D. Disposable bioreactors in cell culture-based upstream processing. Bioprocess Int 2009, 7:18-23.
8. Rao G, Moreira A, Brorson K. Disposable bioprocessing: the future has arrived. Biotechnol Bioeng 2009, 102:348-356. 10.1002/bit.22192, 19090536.
9. Kato I, Tanaka H. Development of a novel box-shaped shake flask with efficient gas exchange capacity. J Ferment Bioeng 1998, 85:404-409.
10. Klöckner W, Tissot S, Wurm F, Büchs J. Power input correlation to characterize the hydrodynamics of cylindrical orbitally shaken bioreactors. Biochem Eng J 2012, 65:63-69.
11. Kato Y, Peter CP, Akgün A, Büchs J. Power consumption and heat transfer resistance in large rotary shaking vessels. Biochem Eng J 2004, 21:83-91.
12. De Jesus MJ, Girard P, Bourgeois M, Baumgartner G, Jacko B, Amstutz H, Wurm FM. TubeSpin satellites: a fast track approach for process development with animal cells using shaking technology. Biochem Eng J 2004, 17:217-223.
13. Zhang X, Stettler M, De Sanctis D, Perrone M, Parolini N, Discacciati M, De Jesus M, Hacker D, Quarteroni A, Wurm F. Use of orbital shaken disposable bioreactors for mammalian cell cultures from the milliliter-scale to the 1,000-liter scale. Adv Biochem Eng/Biotechnol 2010, 115:33-53.
14. Raval K, Kato Y, Büchs J. Comparison of torque method and temperature method for determination of power consumption in disposable shaken bioreactors. Biochem Eng J 2007, 34:224-227.
15. Raval KN, Liu C, Büchs J. Large-scale disposable shaking bioreactors: a promising choice. Bioprocess Int 2006, 4:46. 48,50.
16. Tissot S, Farhat M, Hacker DL, Anderlei T, Kühner M, Comninellis C, Wurm F. Determination of a scale-up factor from mixing time studies in orbitally shaken bioreactors. Biochem Eng J 2010, 52:181-186.
17. Liu CM, Hong LN. Development of a shaking bioreactor system for animal cell cultures. Biochem Eng J 2001, 7:121-125. 10.1016/S1369-703X(00)00111-X, 11173300.
18. Zhang X, Bürki C-A, Stettler M, De Sanctis D, Perrone M, Discacciati M, Parolini N, DeJesus M, Hacker DL, Quarteroni A, Wurm FM. Efficient oxygen transfer by surface aeration in shaken cylindrical containers for mammalian cell cultivation at volumetric scales up to 1000 L. Biochem Eng J 2009, 45:41-47.
19. Werner S, Eibl R, Lettenbauer C, Roll M, Eibl D, De Jesus M, Zhang X, Stettler M, Tissot S, Bürki C, et al. Innovative, non-stirred bioreactors in scales from milliliters up to 1000 Liters for suspension cultures of cells using disposable bags and containers - a swiss contribution. Chimia 2010, 64:819-823. 10.2533/chimia.2010.819, 21197848.
20. Stettler M, Zhang X, Hacker DL, De Jesus M, Wurm FM. Novel orbital shake bioreactors for transient production of CHO derived IgGs. Biotechnol Progr 2007, 23:1340-1346.
21. Tissot S, Michel PO, Hacker DL, Baldi L, De Jesus M, Wurm FM. k(L)a as a predictor for successful probe-independent mammalian cell bioprocesses in orbitally shaken bioreactors. New Biotechnol 2012, 29:387-394.
22. Tissot S, Oberbek A, Reclari M, Dreyer M, Hacker DL, Baldi L, Farhat M, Wurm FM. Efficient and reproducible mammalian cell bioprocesses without probes and controllers?. New Biotechnol 2011, 28:382-390.
23. Zhang X, Stettler M, Reif O, Kocourek A, DeJesus M, Hacker DL, Wurm FM. Shaken helical track bioreactors: Providing oxygen to high-density cultures of mammalian cells at volumes up to 1000 L by surface aeration with air. New Biotechnol 2008, 25:68-75.
24. Grimvall G. Characteristic quantities and dimensional analysis. Sci Model Simul 2008, 15:21-39.
25. Buckingham E. On physically similar systems; illustrations of the use of dimensional equations. Phys Rev 1914, 4:345-376.
26. Henzler HJ, Schedel M. Suitability of the shaking flask for oxygen supply to microbial cultures. Bioprocess Eng 1991, 7:123-131.
27. Doig SD, Pickering SCR, Lye GJ, Baganz F. Modelling surface aeration rates in shaken microtitre plates using dimensionless groups. Chem Eng Sci 2005, 60:2741-2750.
28. Hermann R, Lehmann M, Büchs J. Characterization of gas-liquid mass transfer phenomena in microtiter plates. Biotechnol Bioeng 2003, 81:178-186. 10.1002/bit.10456, 12451554.
29. Kato Y, Hiraoka S, Tada Y, Koh ST, Lee YS. Mixing time and power consumption for a liquid in a vertical cylindrical vessel, shaken in a horizontal circle. Chem Eng Res Des 1996, 74:451-455.
30. Lotter S, Büchs J. Utilization of specific power input measurements for optimization of culture conditions in shaking flasks. Biochem Eng J 2004, 17:195-203.
31. Peter CP, Lotter S, Maier U, Büchs J. Impact of out-of-phase conditions on screening results in shaking flask experiments. Biochem Eng J 2004, 17:205-215.
32. Büchs J, Lotter S, Milbradt C. Out-of-phase operating conditions, a hitherto unknown phenomenon in shaking bioreactors. Biochem Eng J 2001, 7:135-141. 10.1016/S1369-703X(00)00113-3, 11173302.
33. Büchs J, Maier U, Milbradt C, Zoels B. Power consumption in shaking flasks on rotary shaking machines: II. Nondimensional description of specific power consumption and flow regimes in unbaffled flasks at elevated liquid viscosity. Biotechnol Bioeng 2000, 68:594-601. 10.1002/(SICI)1097-0290(20000620)68:6<594::AID-BIT2>3.0.CO;2-U, 10799984.
34. Klöckner W, Büchs J. Advances in shaking technologies. Trends Biotechnol 2012, 30:307-314. 10.1016/j.tibtech.2012.03.001, 22520242.
35. Ullisch DA, Müller CA, Maibaum S, Kirchhoff J, Schiermeyer A, Schillberg S, Roberts JL, Treffenfeldt W, Büchs J. Comprehensive characterization of two different Nicotiana tabacum cell lines leads to doubled GFP and HA protein production by media optimization. J Biosci Bioeng 2012, 113:242-248. 10.1016/j.jbiosc.2011.09.022, 22055919.
36. Curtis WR. Application of bioreactor design principles to plant micropropagation. Plant Cell Tiss Org 2005, 81:255-264.
37. Jamnongwong M, Loubiere K, Dietrich N, Hébrard G. Experimental study of oxygen diffusion coefficients in clean water containing salt, glucose or surfactant: Consequences on the liquid-side mass transfer coefficients. Chem Eng J 2010, 165:758-768.
38. Anderlei T, Büchs J. Device for sterile online measurement of the oxygen transfer rate in shaking flasks. Biochem Eng J 2001, 7:157-162. 10.1016/S1369-703X(00)00116-9, 11173305.
39. Weisenberger S, Schumpe A. Estimation of gas solubilities in salt solutions at temperatures from 273 K to 363 K. AlChE J 1996, 42:298-300.
40. Rischbieter E, Schumpe A, Wunder V. Gas solubilities in aqueous solutions of organic substances. J Chem Eng Data 1996, 41:809-812.
41. Maier U, Losen M, Büchs J. Advances in understanding and modeling the gas-liquid mass transfer in shake flasks. Biochem Eng J 2004, 17:155-167.
42. Maier B, Dietrich C, Büchs J. Correct application of the sulphite oxidation methodology of measuring the volumetric mass transfer coefficient k(L)a under non-pressurized and pressurized conditions. Food Bioprod Process 2001, 79:107-113.
43. Funke M, Diederichs S, Kensy F, Mueller C, Büchs J. The baffled microtiter plate: increased oxygen transfer and improved online monitoring in small scale fermentations. Biotechnol Bioeng 2009, 103:1118-1128. 10.1002/bit.22341, 19449392.
44. Linek V, Vacek V. Chemical engineering use of catalyzed sulfite oxidation kinetics for the determination of mass transfer characteristics of gas-liquid contactors. Chem Eng Sci 1981, 36:1747-1768.
45. Akita K. Diffusivities of gases in aqueous electrolyte solutions. Ind Eng Chem Fund 1981, 20:89-94.
46. Linek V, Vacek V. Comments on validity of measuring oxygen diffusion coefficients with polarographic oxygen electrodes. Biotechnol Bioeng 1988, 31:1010-1011. 10.1002/bit.260310914, 18584709.
47. Anderlei T, Zang W, Papaspyrou M, Büchs J. Online respiration activity measurement (OTR, CTR, RQ) in shake flasks. Biochem Eng J 2004, 17:187-194.
48. Anderlei T, Mrotzek C, Bartsch S, Amoabediny G, Peter CP, Büchs J. New method to determine the mass transfer resistance of sterile closures for shaken Bioreactors. Biotechnol Bioeng 2007, 98:999-1007. 10.1002/bit.21490, 17497734.
49. Bandyopadhyay B, Humphrey AE, Taguchi H. Dynamic measurement of volumetric oxygen transfer coefficient in fermentation systems. Biotechnol Bioeng 1967, 9:533-544.
50. Van Suijdam JC, Kossen NWF, Joha AC. Model for oxygen transfer in a shake flask. Biotechnol Bioeng 1978, 20:1695-1709.
51. Suresh S, Srivastava VC, Mishra IM. Techniques for oxygen transfer measurement in bioreactors: a review. J Chem Technol Biotechnol 2009, 84:1091-1103.
52. Raven N, Schillberg S, Kirchhoff J, Brändli J, Imseng N, Eibl R. Growth of BY-2 suspension cells and plantibody production in single-use bioreactors. Single-Use Technology in Biopharmaceutical Manufacture 2010, 251-261. Hoboken, NJ, USA: John Wiley & Sons, Eibl R, Eibl D.
53. Murashige T, Skoog F. A revised medium for rapid growth and bio assays with tobacco tissue cultures. Physiol Plantarum 1962, 15:473-497.