Energetic and dynamic aspects of the affinity maturation process: Characterizing improved variants from the bevacizumab antibody with molecular simulations

Journal of Chemical Information and Modeling

Volumn 53, Issue 11, 2013, Pages 2937-2950

  Corrada, Dario ^a   Colombo, Giorgio ^a  

^a CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN-ANTIBODY REACTIONS; ANTIGENS; MOLECULAR BIOLOGY; MOLECULAR STRUCTURE; MOLECULES;

AFFINITY MATURATION; ATOMISTIC SIMULATIONS; INTERACTION ENERGIES; INTERNAL COORDINATION; MOLECULAR DETERMINANTS; MOLECULAR SIMULATIONS; PROTEIN MODIFICATIONS; STABILIZATION ENERGY;

ANTIBODIES;

ANTIGEN; BEVACIZUMAB; MONOCLONAL ANTIBODY; VASCULOTROPIN A;

ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ARTICLE; CHEMISTRY; CLUSTER ANALYSIS; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR DYNAMICS; MUTATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; THERMODYNAMICS;

ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIBODY AFFINITY; ANTIGENS; BINDING SITES, ANTIBODY; CLUSTER ANALYSIS; HUMANS; KINETICS; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; THERMODYNAMICS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84888589998     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci400416e     Document Type: Article

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