Can immunoglobulin C(H)1 constant region domain modulate antigen binding affinity of antibodies?

Journal of Clinical Investigation

Volumn 98, Issue 10, 1996, Pages 2235-2243

  Pritsch, Otto ^a   Hudry Clergeon, Gilbert ^b   Buckle, Malcolm ^a   Pétillot, Yves ^b   Bouvet, Jean P ^a   Gagnon, Jean ^b   Dighiero, Guillaume ^a  

^a INSTITUT PASTEUR   (France)

^b CEA GRENOBLE   (France)

Author keywords

affinity; C(H)1; immunoglobulins; isotype; switching

Indexed keywords

ANTIGEN; MONOCLONAL ANTIBODY;

ANTIBODY AFFINITY; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; HUMAN; IMMUNOGLOBULIN CONSTANT REGION; MOLECULAR INTERACTION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 0029826981     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119033     Document Type: Article

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