Caspase-1 deficient mice are more susceptible to influenza A virus infectionwith PA variation

Journal of Infectious Diseases

Volumn 208, Issue 11, 2013, Pages 1898-1905

  Huang, Chih Heng ^a,c   Chen, Chi Jene ^d   Yen, Chia Tsui ^c   Yu, Cheng Ping ^c   Huang, Peng Nien ^a   Kuo, Rei Lin ^a,b   Lin, Sue Jane ^a,b   Chang, Cheng Kai ^a   Shih, Shin Ru ^a,b  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b Laboratory Science   (United States)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Acidic polymerase; Caspase 1; Influenza reassortant; Pathogenesis

Indexed keywords

INTERLEUKIN 1BETA CONVERTING ENZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CASPASE 1 GENE; CELL DIVISION; ENZYME DEFICIENCY; GENE; GENE ACTIVITY; GENE MUTATION; GENETIC REASSORTMENT; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; IL 1 BETA GENE; INFLUENZA; INFLUENZA VIRUS A; INFLUENZA VIRUS A H3N2; INFLUENZA VIRUS A H5N1; INNATE IMMUNITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PA GENE; PATHOGENESIS; PNEUMONIA; PRIORITY JOURNAL; VIRUS RECOMBINANT; VIRUS VIRULENCE;

ACIDIC POLYMERASE; CASPASE-1; INFLUENZA REASSORTANT; PATHOGENESIS;

ANIMALS; CASPASE 1; CELL LINE; DISEASE MODELS, ANIMAL; DOGS; GENETIC ENGINEERING; HUMANS; IMMUNITY, INNATE; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA, HUMAN; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORTHOMYXOVIRIDAE INFECTIONS; REASSORTANT VIRUSES; RNA REPLICASE; SPECIFIC PATHOGEN-FREE ORGANISMS; VIRAL PROTEINS; VIRULENCE; VIRUS REPLICATION;

EID: 84888583372     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit381     Document Type: Article

References (41)

1. van den Brand JM, Stittelaar KJ, van Amerongen G, et al. Comparison of temporal and spatial dynamics of seasonal H3N2, pandemic H1N1 and highly pathogenic avian influenza H5N1 virus infections in ferrets. PLoS One 2012; 7:e42343.
2. Estimates of deaths associated with seasonal influenza- United States, 1976-2007. MMWR Morb Mortal Wkly Rep 2010; 59:1057-62.
3. World Health Organization (WHO). Cumulative number of confirmed human cases for avian influenza A (H5N1) reported to WHO 2012. http://www.who.int/ influenza/human-animal-interface/EN-GIP-20121217CumulativeNumberH5N1cases.pdf. Accessed 17 December 2012.
4. Hudjetz B, Gabriel G. Human-like PB2 627 K influenza virus polymerase activity is regulated by importin-alpha1 and -alpha7. PLoS Pathog 2012; 8:e1002488.
5. Hatta M, Gao P, Halfmann P, Kawaoka Y. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science 2001; 293:1840-2.
6. Shinya K, Hamm S, Hatta M, Ito H, Ito T, Kawaoka Y. PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice. Virology 2004; 320:258-66.
7. Labadie K, Dos-Santos Afonso E, Rameix-Welti MA, vander Werf S, Naffakh N. Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells. Virology 2007; 362:271-82.
8. Munster VJ, de Wit E, vanRiel D, et al. The molecular basis of the pathogenicity of the Dutch highly pathogenic human influenza A H7N7 viruses. J Infect Dis 2007; 196:258-65.
9. Salomon R, Franks J, Govorkova EA, et al. The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04. J Exp Med 2006; 203:689-97.
10. Steel J, Lowen AC, Mubareka S, Palese P. Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627 K or 627E/701N. PLoS Pathog 2009; 5:e1000252.
11. Song MS, Pascua PN, Lee JH, et al. The polymerase acidic protein gene of influenza a virus contributes to pathogenicity in a mouse model. J Virol 2009; 83:12325-35.
12. Song J, Feng H, Xu J, et al. The PA protein directly contributes to the virulence of H5N1 avian influenza viruses in domestic ducks. J Virol 2011; 85:2180-8.
13. Zhu W, Zhu Y, Qin K, et al. Mutations in polymerase genes enhanced the virulence of 2009 pandemic H1N1 influenza virus in mice. PLoS One 2012; 7:e33383.
14. Mehle A, Dugan VG, Taubenberger JK, Doudna JA. Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers. J Virol 2012; 86:1750-7.
15. Zhang Z, Hu S, Li Z, et al. Multiple amino acid substitutions involved in enhanced pathogenicity of LPAI H9N2 in mice. Infect Genet Evol 2011; 11:1790-7.
16. Jagger BW, Wise HM, Kash JC, et al. An overlapping protein-coding region in influenza A virus segment 3 modulates the host response. Science 2012; 337:199-204.
17. Hsieh EF, Lin SJ, Mok CK, et al. Altered pathogenicity for seasonal influenza virus by single reassortment of the RNP genes derived from the 2009 pandemic influenza virus. J Infect Dis 2011; 204:864-72.
18. Gao R, Cao B, Hu Y, et al. Human Infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med 2013; 368:1888-1897.
19. Chen Y, Liang W, Yang S, et al. Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome. Lancet 2013; 381:1916-1925.
20. Wu S, Metcalf JP, Wu W. Innate immune response to influenza virus. Curr Opin Infect Dis 2011; 24:235-40.
21. Schmitz N, Kurrer M, Bachmann MF, Kopf M. Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection. J Virol 2005; 79:6441-8.
22. Hoffmann E, Neumann G, Kawaoka Y, Hobom G, Webster RG. A DNA transfection system for generation of influenza A virus from eight plasmids. Proc Natl Acad Sci U S A 2000; 97:6108-13.
23. van den Brand JM, Stittelaar KJ, van Amerongen G, et al. Severity of pneumonia due to new H1N1 influenza virus in ferrets is intermediate between that due to seasonal H1N1 virus and highly pathogenic avian influenza H5N1 virus. J Infect Dis 2010; 201:993-9.
24. van den Brand JM, Kreijtz JH, Bodewes R, et al. Efficacy of vaccination with different combinations of MF59-adjuvanted and nonadjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 (2009) influenza virus infection in ferrets. J Virol 2011; 85:2851-8.
25. Boon AC, de Beauchamp J, Hollmann A, et al. Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza Avirus in mice. J Virol 2009; 83:10417-26.
26. Pica N, Iyer A, Ramos I, et al. The DBA.2 mouse is susceptible to disease following infection with a broad, but limited, range of influenza A and B viruses. J Virol 2011; 85:12825-9.
27. Boon AC, de Beauchamp J, Krauss S, et al. Cross-reactive neutralizing antibodies directed against pandemic H1N1 2009 virus are protective in a highly sensitive DBA/2 mouse influenza model. J Virol 2010; 84:7662-7.
28. Srivastava B, Blazejewska P, Hessmann M, et al. Host genetic background strongly influences the response to influenza A virus infections. PLoS One 2009; 4:e4857.
29. Medina RA, Garcia-Sastre A. Influenza A viruses: new research developments. Nature Reviews Microbiology 2011; 9:590-603.
30. Wang Q, Zhang S, Jiang H, et al. PA from an H5N1 highly pathogenic avian influenza virus activates viral transcription and replication and induces apoptosis and interferon expression at an early stage of infection. Virol J 2012; 9:106.
31. Sakabe S, Takano R, Nagamura-Inoue T, et al. Differences in cytokine production in human macrophages and in virulence in mice are attributable to the acidic polymerase protein of highly pathogenic influenza Avirus subtype H5N1. J Infect Dis 2013; 207:262-71.
32. Sun Y, Qin K, Wang J, et al. High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1/2009 influenza viruses. Proc Natl Acad Sci U S A 2011; 108: 4164-9.
33. Zhang Y, Zhang Q, Kong H, et al. H5N1 hybrid viruses bearing 2009/H1N1 virus genes transmit in guinea pigs by respiratory droplet. Science 2013; 340:1459-1463.
34. Chen LM, Davis CT, Zhou H, Cox NJ, Donis RO. Genetic compatibility and virulence of reassortants derived from contemporary avian H5N1 and human H3N2 influenza A viruses. PLoS Pathog 2008; 4: e1000072.
35. Li C, Hatta M, Nidom CA, et al. Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence. Proc Natl Acad Sci U S A 2010; 107:4687-92.
36. Thomas PG, Dash P, Aldridge JR Jr., et al. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 2009; 30:566-75.
37. Allen IC, Scull MA, Moore CB, et al. The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity 2009; 30:556-65.
38. Ichinohe T, Lee HK, Ogura Y, Flavell R, Iwasaki A. Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med 2009; 206:79-87.
39. Bauer RN, Brighton LE, Mueller L, et al. Influenza enhances caspase-1 in bronchial epithelial cells from asthmatic volunteers and is associated with pathogenesis. J Allergy Clin Immunol 2012; 130:958-67.
40. Szretter KJ, Gangappa S, Lu X, et al. Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice. J Virol 2007; 81:2736-44.
41. Pearce MB, Jayaraman A, Pappas C, et al. Pathogenesis and transmission of swine origin A(H3N2)V influenza viruses in ferrets. Proc Natl Acad Sci U S A 2012; 109:3944-9.