Mutations in polymerase genes enhanced the virulence of 2009 pandemic H1N1 influenza virus in mice

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Zhu, Wenfei ^a   Zhu, Yun ^a   Qin, Kun ^a   Yu, Zaijiang ^a   Gao, Rongbao ^a   Yu, Huiyan ^a   Zhou, Jianfang ^a   Shu, Yuelong ^a  

^a National Institute for Viral Disease Control and Prevention   (China)

Author keywords

[No Author keywords available]

Indexed keywords

RNA POLYMERASE; PA PROTEIN, INFLUENZA VIRUSES; PB2 PROTEIN, INFLUENZAVIRUS A; RNA DIRECTED RNA POLYMERASE; VIRUS PROTEIN;

2009 H1N1 INFLUENZA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SPECIFICITY; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA VIRUS A H1N1; MAMMAL CELL; MOLECULAR EPIDEMIOLOGY; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM; STRUCTURAL GENE; VIROGENESIS; VIRUS CELL INTERACTION; VIRUS LOAD; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; DOG; ENZYMOLOGY; GENETIC RECOMBINATION; GENETICS; HISTORY; INFLUENZA; METABOLISM; MUTATION; ORTHOMYXOVIRUS INFECTION; PANDEMIC; PATHOGENICITY; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS; SWINE; VIROLOGY; VIRULENCE; VIRUS GENE;

ANIMALIA; AVES; INFLUENZA A VIRUS; MAMMALIA; MURINAE; MUS; ORTHOMYXOVIRIDAE; SUS;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; DOGS; FEMALE; GENES, VIRAL; HISTORY, 21ST CENTURY; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MICE; MICE, INBRED BALB C; MUTAGENESIS, SITE-DIRECTED; MUTATION; ORTHOMYXOVIRIDAE INFECTIONS; PANDEMICS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECOMBINATION, GENETIC; RNA REPLICASE; SWINE; VIRAL PROTEINS; VIRULENCE; VIRUS REPLICATION;

EID: 84863233974     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033383     Document Type: Article

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