Elevated non-esterified fatty acids and β-hydroxybutyrate and their association with transition dairy cow performance

Veterinary Journal

Volumn 198, Issue 3, 2013, Pages 560-570

  McArt, Jessica A A ^a   Nydam, Daryl V ^b   Oetzel, Garrett R ^c   Overton, Thomas R ^b   Ospina, Paula A ^b  

^a Veterinary Dentistry and Oral Surgery   (United States)

^b Cornell University ^*  (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Hydroxybutyrate; Dairy cow; Negative energy balance; Non esterified fatty acids; Subclinical ketosis

Indexed keywords

3 HYDROXYBUTYRIC ACID; DEXAMETHASONE; FATTY ACID; GLUCOCORTICOID; INSULIN; PROPYLENE GLYCOL; VITAMIN B GROUP;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ACCURACY; ADAPTATION; BIOACCUMULATION; BLOOD ANALYSIS; BLOOD LEVEL; DAIRY CATTLE; DRUG EFFECT; ECONOMIC EVALUATION; ENERGY BALANCE; FATTY ACID ANALYSIS; FATTY ACID METABOLISM; HYPERKETONEMIA; KETOACIDOSIS; MOLECULAR DYNAMICS; NONHUMAN; PUERPERIUM; REVIEW;

ANIMALIA;

DAIRY COW; NEGATIVE ENERGY BALANCE; NON-ESTERIFIED FATTY ACIDS; SUBCLINICAL KETOSIS; Β-HYDROXYBUTYRATE;

3-HYDROXYBUTYRIC ACID; ANIMALS; CATTLE; CATTLE DISEASES; DAIRYING; ENERGY METABOLISM; FATTY ACIDS, NONESTERIFIED; FEMALE; KETOSIS; LACTATION; POSTPARTUM PERIOD;

EID: 84888434387     PISSN: 10900233     EISSN: 15322971     Source Type: Journal    
DOI: 10.1016/j.tvjl.2013.08.011     Document Type: Review

References (89)

1. Allen M.S., Bradford B.J., Oba M. Board Invited Review: The hepatic oxidation theory of the control of feed intake and its application to ruminants. Journal of Animal Science 2009, 87:3317-3334.
2. Andersson L. Sub-clinical ketosis in dairy cows. Veterinary Clinics of North America-Food Animal Practice 1988, 4:233-251.
3. Baird G.D. Primary ketosis in the high-producing dairy cow: Clinical and sub-clinical disorders, treatment, prevention, and outlook. Journal of Dairy Science 1982, 65:1-10.
4. Bauman D.E., Currie W.B. Partitioning of nutrients during pregnancy and lactation: A review of mechanisms involving homeostasis and homeorhesis. Journal of Dairy Science 1980, 63:1514-1529.
5. Bell A.W. Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation. Journal of Animal Science 1995, 73:2804-2819.
6. Bertics S.J., Grummer R.R., Cadorniga-Valino C., Stoddard E.E. Effect of pre-partum dry matter intake on liver triglyceride concentration and early lactation. Journal of Dairy Science 1992, 75:1914-1922.
7. Bruss M.L. Lipids and ketones. Clinical Biochemistry of Domestic Animals 1997, 83-115. Academic Press, San Diego, California, USA. Fifth Ed.
8. Cameron R.E., Dyk P.B., Herdt T.H., Kaneene J.B., Miller R., Bucholtz H.F., Liesman J.S., Vandehaar M.J., Emery R.S. Dry cow diet, management, and energy balance as risk factors for displaced abomasum in high producing dairy herds. Journal of Dairy Science 1998, 81:132-139.
9. Carrier J., Stewart S., Godden S., Fetrow J., Rapnicki P. Evaluation and use of three cowside tests for detection of sub-clinical ketosis in early post-partum cows. Journal of Dairy Science 2004, 87:3725-3735.
10. Carrier, J., Godden, S., Fetrow, J., Rapnicki, P., 2011. Clinical trial of early ketosis detection and therapy in fresh cows. In: Proceedings of the Annual Conference of the American Association of Bovine Practitioners, Saint Louis, Missouri, USA, pp. 157.
11. Chapinal N., Carson M., Duffield T.F., Capel M., Godden S., Overton M., Santos J.E., LeBlanc S.J. The association of serum metabolites with clinical disease during the transition period. Journal of Dairy Science 2011, 94:4897-4903.
12. Chapinal N., Carson M.E., LeBlanc S.J., Leslie K.E., Godden S., Capel M., Santos J.E., Overton M.W., Duffield T.F. The association of serum metabolites in the transition period with milk production and early-lactation reproductive performance. Journal of Dairy Science 2012, 95:1301-1309.
13. Chapinal N., Leblanc S.J., Carson M.E., Leslie K.E., Godden S., Capel M., Santos J.E., Overton M.W., Duffield T.F. Herd-level association of serum metabolites in the transition period with disease, milk production, and early lactation reproductive performance. Journal of Dairy Science 2012, 95:5676-5682.
14. Contreras G.A., O'Boyle N.J., Herdt T.H., Sordillo L.M. Lipomobilization in periparturient dairy cows influences the composition of plasma nonesterified fatty acids and leukocyte phospholipid fatty acids. Journal of Dairy Science 2010, 93:2508-2516.
15. Dale H., Vik-Mo L., Fjellheim P. A field survey of fat mobilization and liver function of dairy cows during early lactation. Relationship to energy balance, appetite and ketosis. Nordisk Veterinaermedicin 1979, 31:97-105.
16. Dann H.M., Litherland N.B., Underwood J.P., Bionaz M., D'Angelo A., McFadden J.W., Drackley J.K. Diets during far-off and close-up dry periods affect periparturient metabolism and lactation in multiparous cows. Journal of Dairy Science 2006, 89:3563-3577.
17. Denis-Robichaud J., DesCÔteaux L., Dubuc J. Accuracy of a new milk strip cow-side test for diagnosis of hyperketonemia. Bovine Practitioner 2011, 45:97-100.
18. Dohoo I.R., Martin S.W. Sub-clinical ketosis: Prevalence and associations with production and disease. Canadian Journal of Comparative Medicine-Revue Canadienne de Medecine Comparee 1984, 48:1-5.
19. Drackley J.K., Overton T.R., Douglas N.G. Adaptations of glucose and long chain fatty acid metabolism in liver of dairy cows during the periparturient period. Journal of Dairy Science 2001, 84:E100-E112.
20. Drackley J.K. ADSA Foundation Scholar Award. Biology of dairy cows during the transition period: The final frontier?. Journal of Dairy Science 1999, 82:2259-2273.
21. Drackley J.K., Andersen J.B. Splanchnic metabolism of long-chain fatty acids in ruminants. Ruminant Physiology: Digestion, Metabolism and Impact of Nutrition on Gene Expression, Immunology and Stress 2006, 199-224. Academic Publishers, Wageningen, The Netherlands.
22. Duffield T.F., Sandals D., Leslie K.E., Lissemore K., McBride B.W., Lumsden J.H., Dick P., Bagg R. Efficacy of monensin for the prevention of sub-clinical ketosis in lactating dairy cows. Journal of Dairy Science 1998, 81:2866-2873.
23. Duffield T. Sub-clinical ketosis in lactating dairy cattle. Veterinary Clinics of North America-Food Animal Practice 2000, 16:231-253.
24. Duffield T.F., Lissemore K.D., McBride B.W., Leslie K.E. Impact of hyperketonemia in early lactation dairy cows on health and production. Journal of Dairy Science 2009, 92:571-580.
25. Eicher R., Liesegang A., Bouchard E., Tremblay A. Effect of cow-specific factors and feeding frequency of concentrate on diurnal variations of blood metabolites in dairy cows. American Journal of Veterinary Research 1999, 60:1493-1499.
26. Emanuelson U., Oltenacu P.A., Grohn Y.T. Nonlinear mixed model analyses of five production disorders of dairy cattle. Journal of Dairy Science 1993, 76:2765-2772.
27. Emery R.S., Burg N., Brown L.D., Blank G.N. Detection, occurrence, and prophylactic treatment of borderline ketosis with propylene glycol feeding. Journal of Dairy Science 1964, 47:1074-1079.
28. Fetrow J.P., Pankowski J.W., Vicini J.L., Ames T.R. The Minnesota Dairy Practitioners Study Group. Use of bovine somatotropin at the time of surgery for left displacement of the abomasum in dairy cows. Journal of the American Veterinary Medical Association 1999, 214:529-531.
29. Foster L.A. Clinical ketosis. Veterinary Clinics of North America-Food Animal Practice 1988, 4:253-267.
30. Garverick H.A., Harris M.N., Vogel-Bluel R., Sampson J.D., Bader J., Lamberson W.R., Spain J.N., Lucy M.C., Youngquist R.S. Concentrations of nonesterified fatty acids and glucose of periparturient dairy cows are indicative of pregnancy success at first insemination. Journal of Dairy Science 2013, 96:181-188.
31. Geishauser T., Leslie K., Duffield T., Edge V. Evaluation of aspartate transaminase activity and beta-hydroxybutyrate concentration in blood as tests for prediction of left displaced abomasum in dairy cows. American Journal of Veterinary Research 1997, 58:1216-1220.
32. Geishauser T., Leslie K., Tenhag J., Bashiri A. Evaluation of eight cow-side ketone tests in milk for detection of sub-clinical ketosis in dairy cows. Journal of Dairy Science 2000, 83:296-299.
33. Geishauser T., Leslie K., Kelton D., Duffield T. Monitoring for sub-clinical ketosis in dairy herds. Compendium on Continuing Education for the Practicing Veterinarian 2001, 23:S65-S71.
34. Goff J.P., Horst R.L. Physiological changes at parturition and their relationship to metabolic disorders. Journal of Dairy Science 1997, 80:1260-1268.
35. Gordon J., LeBlanc S., Neuder L., Herdt T.H., Kelton D.F., Duffield T. Efficacy of a combination butaphosphan and cyanocobalamin product and insulin for ketosis treatment. Journal of Dairy Science 2012, 95:177.
36. Gordon J., LeBlanc S., Duffield T. Ketosis treatment in lactating dairy cattle. Veterinary Clinics of North America-Food Animal Practice 2013, 29:433-445.
37. Grohn Y.T., Erb H.N., McCulloch C.E., Saloniemi H.S. Epidemiology of metabolic disorders in dairy cattle: Association among host characteristics, disease, and production. Journal of Dairy Science 1989, 72:1876-1885.
38. Grummer R.R. Etiology of lipid-related metabolic disorders in periparturient dairy cows. Journal of Dairy Science 1993, 76:3882-3896.
39. Grummer R.R. Impact of changes in organic nutrient metabolism on feeding the transition dairy cow. Journal of Animal Science 1995, 73:2820-2833.
40. Guard, C.L., 2008. The costs of common diseases of dairy cattle. In: Abstract: Proceedings of the Central Veterinary Conference West, San Diego, California, USA, pp. 695-700.
41. Hammon D.S., Evjen I.M., Dhiman T.R., Goff J.P., Walters J.L. Neutrophil function and energy status in Holstein cows with uterine health disorders. Veterinary Immunology and Immunopathology 2006, 113:21-29.
42. Hayirli A., Grummer R.R., Nordheim E.V., Crump P.M. Animal and dietary factors affecting feed intake during the prefresh transition period in Holsteins. Journal of Dairy Science 2002, 85:3430-3443.
43. Herdt T.H. Ruminant adaptation to negative energy balance. Influences on the etiology of ketosis and fatty liver. Veterinary Clinics of North America-Food Animal Practice 2000, 16:215-230.
44. Holmes J.H., Lambourne L.J. The relation between plasma free fatty acid concentration and the digestible energy intake of cattle. Research in Veterinary Science 1970, 11:27-36.
45. Holtenius P. Hormonal regulation related to the development of fatty liver and ketosis. Acta Veterinaria Scandinavica 1993, 89:55-60.
46. Holtenius K., Agenas S., Delavaud C., Chilliard Y. Effects of feeding intensity during the dry period. 2. Metabolic and hormonal responses. Journal of Dairy Science 2003, 86:883-891.
47. Huzzey J.M., Nydam D.V., Grant R.J., Overton T.R. Associations of pre-partum plasma cortisol, haptoglobin, fecal cortisol metabolites, and nonesterified fatty acids with post-partum health status in Holstein dairy cows. Journal of Dairy Science 2011, 94:5878-5889.
48. Ingvartsen K.L., Dewhurst R.J., Friggens N.C. On the relationship between lactational performance and health: Is it yield or metabolic imbalance that cause production diseases in dairy cattle? A position paper. Livestock Production Science 2003, 83:277-308.
49. Iwersen M., Falkenberg U., Voigtsberger R., Forderung D., Heuwieser W. Evaluation of an electronic cowside test to detect sub-clinical ketosis in dairy cows. Journal of Dairy Science 2009, 92:2618-2624.
50. Jorritsma R., Jorritsma H., Schukken Y.H., Bartlett P.C., Wensing T., Wentink G.H. Prevalence and indicators of post partum fatty infiltration of the liver in nine commercial dairy herds in the Netherlands. Livestock Production Science 2001, 68:53-60.
51. Kehrli M.E., Nonnecke B.J., Roth J.A. Alterations in bovine lymphocyte function during the periparturient period. American Journal of Veterinary Research 1989, 50:215-220.
52. Kessel S., Stroehl M., Meyer H.H., Hiss S., Sauerwein H., Schwarz F.J., Bruckmaier R.M. Individual variability in physiological adaptation to metabolic stress during early lactation in dairy cows kept under equal conditions. Journal of Animal Science 2008, 86:2903-2912.
53. Komatsu T., Itoh F., Kushibiki S., Hodate K. Changes in gene expression of glucose transporters in lactating and nonlactating cows. Journal of Animal Science 2005, 83:557-564.
54. Konkol, K.S., Godden, S., Rapnicki, P., Overton, M., 2009. Validation of a rapid cow-side test for the measurement of blood beta-hydroxybutyrate in fresh cows. In: Abstract: Proceedings of the Annual Conference of the American Association of Bovine Practitioners, Stillwater, Oklahoma, USA, pp. 290.
55. LeBlanc S.J., Leslie K.E., Duffield T.F. Metabolic predictors of displaced abomasum in dairy cattle. Journal of Dairy Science 2005, 88:159-170.
56. Leroy J.L., Bossaert P., Opsomer G., Bols P.E. The effect of animal handling procedures on the blood non-esterified fatty acid and glucose concentrations of lactating dairy cows. The Veterinary Journal 2011, 187:81-84.
57. Lohr B., Brunner B., Janowitz H., Hummel M., Seeger T., Weber I., Wittek T., Schmidt B., Hellmann K. Efficacy of Catosal for the treatment of ketosis in cows with left abomasal displacement. Tierarztliche Umschau 2006, 61:187-190.
58. Mallard B.A., Dekkers J.C., Ireland M.J., Leslie K.E., Sharif S., Vankampen C.L., Wagter L., Wilkie B.N. Alteration in immune responsiveness during the peripartum period and its ramification on dairy cow and calf health. Journal of Dairy Science 1998, 81:585-595.
59. McArt J.A., Nydam D.V., Ospina P.A., Oetzel G.R. A field trial on the effect of propylene glycol on milk yield and resolution of ketosis in fresh cows diagnosed with sub-clinical ketosis. Journal of Dairy Science 2011, 94:6011-6020.
60. McArt J.A., Nydam D.V., Oetzel G.R. Epidemiology of sub-clinical ketosis in early lactation dairy cattle. Journal of Dairy Science 2012, 95:5056-5066.
61. McArt J.A., Nydam D.V., Oetzel G.R. A field trial on the effect of propylene glycol on displaced abomasum, removal from herd, and reproduction in fresh cows diagnosed with sub-clinical ketosis. Journal of Dairy Science 2012, 95:2505-2512.
62. McArt J.A.A., Nydam D.V., Oetzel G.R. Dry and parturient predictors of early lactation hyperketonemia in dairy cattle. Journal of Dairy Science 2012, 96:198-209.
63. McLaren C.J., Lissemore K.D., Duffield T.F., Leslie K.E., Kelton D.F., Grexton B. The relationship between herd level disease incidence and a return over feed index in Ontario dairy herds. Canadian Veterinary Journal 2006, 47:767-773.
64. McNamara J.P. Regulation of adipose tissue metabolism in support of lactation. Journal of Dairy Science 1991, 74:706-719.
65. Mepham T.B. The development of ideas on the role of glucose in regulating milk secretion. Australian Journal of Agricultural Research 1993, 44:509-522.
66. Murondoti A., Jorritsma R., Beynen A.C., Wensing T., Geelen M.J. Activities of the enzymes of hepatic gluconeogenesis in periparturient dairy cows with induced fatty liver. Journal of Dairy Research 2004, 71:129-134.
67. Oetzel G.R. Monitoring and testing dairy herds for metabolic disease. Veterinary Clinics of North America-Food Animal Practice 2004, 20:651-674.
68. Ospina P.A., Nydam D.V., Stokol T., Overton T.R. Association between the proportion of sampled transition cows with increased nonesterified fatty acids and beta-hydroxybutyrate and disease incidence, pregnancy rate, and milk production at the herd level. Journal of Dairy Science 2010, 93:3595-3601.
69. Ospina P.A., Nydam D.V., Stokol T., Overton T.R. Associations of elevated nonesterified fatty acids and beta-hydroxybutyrate concentrations with early lactation reproductive performance and milk production in transition dairy cattle in the northeastern United States. Journal of Dairy Science 2010, 93:1596-1603.
70. Ospina P.A., Nydam D.V., Stokol T., Overton T.R. Evaluation of nonesterified fatty acids and beta-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases. Journal of Dairy Science 2010, 93:546-554.
71. Palmquist D.L., Davis C.L., Brown R.E., Sachan D.S. Availability and metabolism of various substrates in ruminants. V. Entry rate into the body incorporation into milk fat of d(-) β-hydroxybutyrate. Journal of Dairy Science 1969, 52:633-638.
72. Quiroz-Rocha G.F., LeBlanc S.J., Duffield T.F., Jefferson B., Wood D., Leslie K.E., Jacobs R.M. Short communication: Effect of sampling time relative to the first daily feeding on interpretation of serum fatty acid and beta-hydroxybutyrate concentrations in dairy cattle. Journal of Dairy Science 2010, 93:2030-2033.
73. Reynolds C.K., Huntington G.B., Tyrrell H.F., Reynolds P.J. Net portal-drained visceral and hepatic metabolism of glucose, l-lactate, and nitrogenous compounds in lactating Holstein cows. Journal of Dairy Science 1988, 71:1803-1812.
74. Roberts T., Chapinal N., Leblanc S.J., Kelton D.F., Dubuc J., Duffield T.F. Metabolic parameters in transition cows as indicators for early-lactation culling risk. Journal of Dairy Science 2012, 95:3057-3063.
75. Robertson J. The evaluation of results from a therapeutic trial on bovine ketosis. Journal of the American Veterinary Medical Association 1966, 149:1620-1623.
76. Roche J.R., Friggens N.C., Kay J.K., Fisher M.W., Stafford K.J., Berry D.P. Invited review: Body condition score and its association with dairy cow productivity, health, and welfare. Journal of Dairy Science 2009, 92:5769-5801.
77. Ruegsegger G.J., Schultz L.H. Use of a combination of propylene glycol and niacin for sub-clinical ketosis. Journal of Dairy Science 1986, 69:1411-1415.
78. Rukkwamsuk T., Wensing T., Geelen M.J. Effect of fatty liver on hepatic gluconeogenesis in periparturient dairy cows. Journal of Dairy Science 1999, 82:500-505.
79. Sakai T., Hayakawa T., Hamakawa M., Ogura K., Kubo S. Therapeutic effects of simultaneous use of glucose and insulin in ketotic dairy cows. Journal of Dairy Science 1993, 76:109-114.
80. Seifi H.A., Leblanc S.J., Leslie K.E., Duffield T.F. Metabolic predictors of post-partum disease and culling risk in dairy cattle. The Veterinary Journal 2011, 188:216-220.
81. Seifi H.A., LeBlanc S.J., Vernooy E., Leslie K.E., Duffield T.F. Effect of isoflupredone acetate with or without insulin on energy metabolism, reproduction, milk production, and health in dairy cows in early lactation. Journal of Dairy Science 2007, 90:4181-4191.
82. Simensen E., Halse K., Gillund P. Ketosis treatment and milk yield in dairy cows related to milk acetoacetate levels. Acta Veterinaria Scandinavica 1990, 31. 443-440.
83. Ster C., Loiselle M.C., Lacasse P. Effect of postcalving serum nonesterified fatty acids concentration on the functionality of bovine immune cells. Journal of Dairy Science 2012, 95:708-717.
84. Stokol T., Nydam D.V. Effect of anticoagulant and storage conditions on bovine nonesterified fatty acid and beta-hydroxybutyrate concentrations in blood. Journal of Dairy Science 2005, 88:3139-3144.
85. Stokol T., Nydam D.V. Effect of hemolysis on nonesterified fatty acid and beta-hydroxybutyrate concentrations in bovine blood. Journal of Veterinary Diagnostic Investigation 2006, 18:466-469.
86. Suthar V.S., Canelas-Raposo J., Deniz A., Heuwieser W. Prevalence of sub-clinical ketosis and relationships with post-partum diseases in European dairy cows. Journal of Dairy Science 2013, 96:2925-2938.
87. Tyopponen J., Kauppinen K. The stability and automatic determination of ketone bodies in blood samples taken in field conditions. Acta Veterinaria Scandinavica 1980, 21:55-61.
88. Voyvoda H., Erdogan H. Use of a hand-held meter for detecting sub-clinical ketosis in dairy cows. Research in Veterinary Science 2010, 89:344-351.
89. Walsh R.B., Walton J.S., Kelton D.F., LeBlanc S.J., Leslie K.E., Duffield T.F. The effect of sub-clinical ketosis in early lactation on reproductive performance of post-partum dairy cows. Journal of Dairy Science 2007, 90:2788-2796.