Splanchnic metabolism of long-chain fatty acids in ruminants

Ruminant Physiology: Digestion, Metabolism and Impact of Nutrition on Gene Expression, Immunology and Stress

Volumn , Issue , 2006, Pages 199-224

  Drackley, J K ^a   Andersen, J B ^b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b DANISH INSTITUTE OF AGRICULTURAL SCIENCES   (Denmark)

Author keywords

Fatty acids; Ketone bodies; Liver; Metabolism; Portal drained viscera

Indexed keywords

EID: 35748963389     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.3920/978-90-8686-566-6     Document Type: Chapter

References (122)

1. Aiello, R.J., T.M. Kenna & J.H. Herbein (1984). Hepatic gluconeogenesis and ketogenic interrelationships in the lactating cow. Journal of Dairy Science, 67, 1707-1715.
2. Andersen, J.B., N.C. Friggens, K. Sejrsen, M.T. Sorensen, L. Munksgaard & K.L. Ingvartsen (2003). The effects of low vs. high concentrate level in the diet on performance in cows milked two or three times daily in early lactation. Livestock Production Science, 81, 119-128.
3. Andersen, J.B., T. Larsen & K.L. Ingvartsen (2001). Evaluation of tissue preparation for in vitro study of hepatic long-chain fatty acid metabolism. Acta Agriculture Scandinavia, Section A, Animal Science, 51, 47-52.
4. Andersen, J.B., T. Larsen, M.O. Nielsen & K.L. Ingvartsen (2002a). Effect of energy density in the diet and milking frequency on hepatic long chain fatty acid oxidation in early lactating dairy cows. Journal of Veterinary Medicine A, 49, 177-183.
5. Andersen, J.B., D.G. Mashek, T. Larsen, M.O. Nielsen & K.L. Ingvartsen (2002b). Effects of hyperinsulinaemia under euglycemic conditions on liver fat metabolism in dairy cows in early and mid-lactation. Journal of Veterinary Medicine A, 49, 65-71.
6. Armentano, L.E., R.R. Grummer, S.J. Bertics, T.C. Skaar & S.S. Donkin (1991). Effects of energy balance on hepatic capacity for oleate and propionate metabolism and triglyceride secretion. Journal of Dairy Science, 74, 132-139.
7. Atkins, K.B., R.A. Erdman & J.H. Vandersall (1988). Dietary choline effects on milk yield and duodenal choline flow in dairy cattle. Journal of Dairy Science, 71, 109-116.
8. Baffy, G., C.Y. Zhang, J.N. Glickman & B.B. Lowell (2002). Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2. Hepatology, 35, 753-761.
9. Bauchart, D. (1993). Lipid absorption and transport in ruminants. Journal of Dairy Science, 76, 3864-3881.
10. Bell, A.W. (1980). Lipid metabolism in liver and selected tissues and in the whole body of ruminant animals. Progress in Lipid Research, 18, 117-164.
11. Bernabucci, U., B. Ronchi, L. Basirico, D. Pirazzi, F. Rueca, N. Lacetera & A. Nardone (2004). Abundance of mRNA of apolipoprotein B100, apolipoprotein E, and microsomal triglyceride transfer protein in liver from periparturient dairy cows. Journal of Dairy Science, 87, 2881-2888.
12. Berry, M.N., D.G. Vlark, A.R. Grivell & P.G. Wallace (1983). The calorigenic nature of hepatic ketogenesis:an explanation for the stimulation of respiration induced by fatty acid substrates. European Journal of Biochemistry, 131, 205-214.
13. Bobe, G., B.N. Ametaj, J.W. Young & D.C. Beitz (2003). Potential treatment of fatty liver with 14-day subcutaneous injections of glucagon. Journal of Dairy Science, 86, 3138-3147.
14. Bobe, G., J.W. Young & D.C. Beitz (2004). Pathology, etiology, prevention, and treatment of fatty liver in dairy cows. Journal of Dairy Science, 87, 3105-3124.
15. Bremmer, D.R., S.J. Bertics, S.A. Besong & R.R. Grummer (2000). Changes in hepatic microsomal triglyceride transfer protein and triglyceride in periparturient dairy cattle. Journal of Dairy Science, 83, 2252-2260.
16. Bremmer, D.R., S.J. Bertics & R.R. Grummer (1999). Differences in activity of hepatic microsomal triglyceride transfer protein among species. Comparative Biochemistry and Physiology A, 124, 123-131.
17. Brindle, N.P.J., V.A. Zammit & C.I. Pogson (1985). Regulation of carnitine palmitoyltransferase activity by malonyl-CoA in mitochondria from sheep liver, a tissue with low capacity for fatty acid synthesis. Biochemical Journal, 232, 177-182.
18. Brown, G.C. (1992). Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochemical Journal, 284, 1-13.
19. Cadórniga-Valiño, C., R.R. Grummer, L.E. Armentano, S.S. Donkin & S.J. Bertics (1997). Effects of fatty acids and hormones on fatty acid metabolism and gluconeogenesis in bovine hepatocytes. Journal of Dairy Science, 80, 646-656.
20. Cappon, G.D., R.C.M. Liu, S.R. Frame & M.E. Hurtt (2002). Effects of the rat hepatic peroxisome proliferator, Wyeth 14,643, on the lactating goat. Drug and Chemical Toxicology, 25, 255-266.
21. Carlson, D.B., H.M. Dann, N.B. Litherland, J.C. Woodworth & J.K. Drackley (2004). Abomasal infusion of L-carnitine alters hepatic fatty acid metabolism and decreases liver lipid in lactating Holstein cows. Journal of Dairy Science, 87 (Supplement 1), 309. (Abstract)
22. Costa, N.D., G.H. McIntosh & A.M. Snoswell (1976). Production of endogenous acetate by the liver in lactating ewes. Australian Journal of Biological Sciences, 29, 33-42.
23. Dann, H.M. (2004). Dietary energy restriction during late gestation in multiparous Holstein cows. Ph.D. dissertation, University of Illinois, Urbana.
24. Debeer, L.J., A.C. Beynen, G.P. Mannaerts & M.J. Geelen (1982). Lipolysis of hepatic triacylglycerol stores. FEBS Letters, 140, 159-164.
25. Dolinsky, V.W., D.N. Douglas, R. Lehner & D.E.Vance (2004). Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone. Biochemical Journal, 378, 967-974.
26. Doreau, M. & Y. Chilliard (1997). Digestion and metabolism of dietary fat in farm animals. British Journal of Nutrition, 78 (Supplement 1), S15-S35.
27. Drackley, J.K. (1999). Biology of dairy cows during the transition period: the final frontier?. Journal of Dairy Science, 82, 2259-2273.
28. Drackley, J.K. (2005). Interorgan lipid and fatty acid metabolism in growing ruminants. In: D.G. Burrin and H.J. Mersmann (eds.) Biology of Metabolism in Growing Animals. Elsevier Limited, Edinburgh, UK. pp 323-350.
29. Drackley, J.K., D.C. Beitz & J.W. Young (1991a). Regulation of in vitro palmitate oxidation in liver from dairy cows in early lactation. Journal of Dairy Science, 74, 1884-1892.
30. Drackley, J.K., D.C. Beitz & J.W. Young (1991b). Regulation of in vitro metabolism of palmitate by carnitine and propionate in liver from dairy cows. Journal of Dairy Science, 74, 3014-3024.
31. Drackley, J.K., T.R. Overton & G.N. Douglas (2001). Adaptations of glucose and long-chain fatty acid metabolism in liver of dairy cows during the periparturient period. Journal of Dairy Science, 84 (E Supplement), E100-E112.
32. Drynan, L., P.A. Quant & V.A. Zammit (1996). Flux control exerted by mitochondrial outer membrane carnitine palmitoyltransferase over ß-oxidation, ketogenesis and tricarboxylic acid cycle activity in hepatocytes isolated from rats in different metabolic states. Biochemical Journal, 317, 791-795.
33. Dunshea, F.R., A.W. Bell & T.E. Trigg (1989). Relations between plasma non-esterified fatty acid metabolism and body fat mobilization in primiparous lactating goats. British Journal of Nutrition, 62, 51-61.
34. Dusserre, E., P. Moulin & H. Vidal (2000). Differences in mRNA expression of the proteins secreted by the adipocytes in human subcutaneous and visceral adipose tissues. Biochimica et Biophysica Acta, 1500, 88-96.
35. Eaton, S., D.M. Turnbull & K. Bartlett (1994). Redox control of ß-oxidation in rat liver mitochondria. European Journal of Biochemistry, 220, 671-681.
36. Emery, R.S., J.S. Liesman & T.H. Herdt (1992). Metabolism of long chain fatty acids by ruminant liver. Journal of Nutrition, 122, 832-837.
37. Freeman, C.P. (1969). Properties of fatty acids in dispersions of emulsified lipid and bile salt and the significance of these properties in fat absorption in the pig and the sheep. British Journal of Nutrition, 23, 249-263.
38. Freetly, H.C. & C.L. Ferrell (2000). Net flux of nonesterified fatty acids, cholesterol, triacylglycerol, and glycerol across the portal-drained viscera and liver of pregnant ewes. Journal of Animal Science, 78, 1380-1388.
39. Fronk,T.J., L.H. Schultz & A.R. Hardie (1980). Effect of dry period overconditioning on subsequent metabolic disorders and performance of dairy cows. Journal of Dairy Science, 63, 1080-1090.
40. Gabriely, I., X.H. Ma, X.M. Yang, G. Atzmon, M.W. Rajala, A.H. Berg, P. Scherer, L. Rossetti & N. Barzilai (2002). Removal of visceral fat prevents insulin resistance and glucose intolerance of aging. An adipokine-mediated process? Diabetes, 51, 2951-2958.
41. Gasteyger, C. & A. Tremblay (2002). Metabolic impact of body fat distribution. Journal of Endocrinological Investigation, 25, 876-883.
42. Gibbons, G.F., D. Wiggins, A.-M. Brown & A.-M. Hebbachi (2004). Synthesis and function of hepatic verylow-density lipoprotein. Biochemical Society Transactions, 32, 59-64.
43. Gilham, D., S. Ho, M. Rasouli, P. Martres, D.E. Vance & R. Lehner (2003). Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion. FASEB Journal, 17, 1685-1687.
44. Graulet, B., D. Gruffat, D. Durand & D. Bauchart (1998). Fatty acid metabolism and very low density lipoprotein secretion in liver slices from rats and preruminant calves. Journal of Biochemistry, 124, 1212-1219.
45. Graulet, B., D. Gruffat-Mouty, D. Durand & D. Bauchart (2000). Effects of milk diets containing beef tallow or coconut oil on the fatty acid metabolism of liver slices from preruminant calves. British Journal of Nutrition, 84, 309-318.
46. Gruffat, D., D. Durand, Y. Chilliard, P. Williams & D. Bauchart (1997). Hepatic gene expression of apolipoprotein B100 during early lactation in underfed, high producing dairy cows. Journal of Dairy Science, 80, 657-666.
47. Gruffat, D., D. Durand, B. Graulet & D. Bauchart (1996). Regulation of VLDL synthesis and secretion in the liver. Reproduction, Nutrition, and Development, 36, 375-389.
48. Gruffat-Mouty, D., B. Graulet, D. Durand, M.E. Samson-Bouma & D. Bauchart (1999). Apolipoprotein B production and very low density lipoprotein secretion by calf liver slices. Journal of Biochemistry, 126, 188-193.
49. Grum, D.E., J.K. Drackley & J.H. Clark (2002). Fatty acid metabolism in liver of dairy cows fed supplemental fat and nicotinic acid during an entire lactation. Journal of Dairy Science, 85, 3026-3034.
50. Grum, D E., J.K. Drackley, R.S. Younker, D.W. LaCount & J.J. Veenhuizen (1996). Nutrition during the dry period and hepatic lipid metabolism of periparturient dairy cows. Journal of Dairy Science, 79, 1850-1864.
51. Grum, D.E., L.R. Hansen & J.K. Drackley (1994). Peroxisomal ß-oxidation of fatty acids in bovine and rat liver. Comparative Biochemistry and Phyiology, 109B, 281-292.
52. Grummer, R.R. (1993). Etiology of lipid-related metabolic disorders in periparturient dairy cows. Journal of Dairy Science, 76, 3882-3896.
53. Hanigan, M.D., L.A. Crompton, C.K. Reynolds, D. Wray-Cahen, M.A. Lomax & J. France (2004). An integrative model of amino acid metabolism in the liver of the lactating dairy cow. Journal of Theoretical Biology, 228, 271-289.
54. Hansen, L.R., J.K. Drackley, L.L. Berger, D.E. Grum,. J.D. Cremin, Jr., X. Lin & J. Odle (1995). Prenatal androgenization of lambs: II. Metabolism in adipose tissue and liver. Journal of Animal Science, 73, 1701-1712.
55. Harfoot, C.G. (1978). Lipid metabolism in the rumen. Progress in Lipid Research, 17, 21-54.
56. Hegardt, F.G. (1999). Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis. Biochemical Journal, 338, 569-582.
57. Heitmann, R.N., D.J. Dawes & S.C. Sensenig (1987). Hepatic ketogenesis and peripheral ketone body utilization in the ruminant. Journal of Nutrition, 117, 1174-1180.
58. Heitmann, R.N., S.C. Sensenig, C.K. Reynolds, J.M. Fernandez & D.J. Dawes (1986). Changes in energy metabolite and regulatory hormone concentrations and net fluxes across splanchnic and peripheral tissues in fed and progressively fasted ewes. Journal of Nutrition, 116, 2516-2524.
59. Herdt, T.H. (2000). Ruminant adaptation to negative energy balance. Influences on the etiology of ketosis and fatty liver. Veterinary Clinics of North America, Food Animal Practice, 16, 215-230.
60. Hippen, A.R., P. She, J.W. Young, D.C. Beitz, G.L. Lindberg, L.F. Richardson & R.W. Tucker (1999). Alleviation of fatty liver in dairy cows with 14-day intravenous infusions of glucagon. Journal of Dairy Science, 82, 1139-1152.
61. Hocquette, J.F. & D. Bauchart (1999). Intestinal absorption, blood transport and hepatic and muscle metabolism of fatty acids in preruminant and ruminant animals. Reproduction, Nutrition, and Development, 39, 27-48.
62. Holtenius, K., S. Agenäs, C. Delavaud & Y. Chilliard (2003). Effects of feeding intensity during the dry period. 2. Metabolic and hormonal responses. Journal of Dairy Science, 86, 883-891.
63. Holtenius, P. & K. Holtenius (1996). New aspects of ketone bodies in energy metabolism of dairy cows: a review. Journal of Veterinay Medicine A, 43, 579-587.
64. Huntington, G.B., J.H. Eisemann & J.M. Whitt (1990). Portal blood flow in beef steers: comparison of techniques and relation to hepatic blood flow, cardiac output and oxygen uptake. Journal of Animal Science, 68, 1666-1673.
65. Janovick, N.A., J.J. Loor, H.M. Dann, H.A. Lewin & J.K. Drackley (2004). Characterization of changes in hepatic expression of inflammation-associated genes during the periparturient period in multiparous Holstein cows using quantitative real time-PCR (RT-PCR). Journal of Dairy Science, 87 (Supplement 1), 460. (Abstract)
66. Jenkins, K.J. & J.K.G. Kramer (1986). Influence of low linoleic and linolenic acids in milk replacers on calf performance and lipids in blood plasma, heart, and liver. Journal of Dairy Science, 69, 1374-1386.
67. Jesse, B.W., R.S. Emery & J.W. Thomas (1986a). Control of bovine hepatic fatty acid oxidation. Journal of Dairy Science, 69, 2290-2297.
68. Jesse, B.W., R.S. Emery & J.W. Thomas (1986b). Aspects of the regulation of long-chain fatty acid oxidation in bovine liver. Journal of Dairy Science, 69, 2298-2303.
69. Jorritsma, R., T. Wensing, T.A.M. Kruip, P.L.A.M. Vos, and J.P.T.M. Noordhuizen (2003). Metabolic changes in early lactation and impaired reproductive performance in dairy cows. Veterinary Research, 34, 11-26.
70. Kabir, M., K.J. Catalano, S. Ananthnarayan, S.P. Kim, G.W. Van Citters, M.K. Dea & R.N. Bergman (2005). Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance. American Journal of Physiology, 288, E454-E461.
71. Katoh, N. (2002). Relevance of apolipoproteins in the development of fatty liver and fatty liver-related peripartum diseases in dairy cows. Journal of Veterinary Medical Science, 64, 293-307.
72. Khovidhunkit, W., M.S. Kim, R.A. Memon, J.K. Shigenaga, A.H. Moser, K.R. Feingold & C. Grunfeld (2004). Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. Journal of Lipid Research, 45, 1169-1196.
73. Kleppe, B.B., R.J. Aiello, R.R. Grummer & L.E. Armentano (1988). Triglyceride accumulation and very low density lipoprotein secretion by rat and goat hepatocytes in vitro. Journal of Dairy Science, 71, 1813-1822.
74. Knowles, S.E., I.G. Jarrett, O.W. Filsell & F.J. Ballard (1974). Production and utilization of acetate in mammals. Biochemical Journal, 142, 401-411.
75. Lehner, R., Z. Cui & D.E. Vance (1999). Subcellular localization, developmental expression and characterization of a liver triacylglycerol hydrolase. Biochemical Journal, 338, 761-768.
76. Leplaix-Charlat, L., D. Durand & D. Bauchart (1996). Effects of diets containing tallow and soybean oil with or without cholesterol on hepatic metabolism of lipids and lipoproteins in the preruminant calf. Journal of Dairy Science, 79, 1826-1835.
77. Litherland, N.B., H.M. Dann, A.S. Hansen & J.K. Drackley (2003). Prepartum nutrient intake alters metabolism by liver slices from peripartal dairy cows. Journal of Dairy Science, 86 (Supplement 1), 105-106. (Abstract)
78. Loor, J.J., N.A. Janovick, H.M. Dann, R.E. Everts, S.L. Rodriguez-Zas, H.A. Lewin, and J.K. Drackley (2004a). Microarray analysis of hepatic gene expression from dry-off through early lactation in dairy cows fed at two intakes during the dry period. Journal of Dairy Science, 87 (Supplement 1), 196. (Abstract)
79. Loor, J.J., N.A. Janovick, R.E. Everts, S.L. Rodriguez-Zas, H.A. Lewin & J.K. Drackley (2004b). Adipose, mammary, and hepatic gene expression profiling in lactating dairy cows using a bovine cDNA microarray. Journal of Dairy Science, 87 (Supplement 1), 196-197. (Abstract)
80. Lyle, R.R., G. deBoer, R.O. Harrison & J.W. Young (1984). Plasma and liver metabolites and glucose kinetics as affected by prolonged ketonemia-glucosuria and fasting in steers. Journal of Dairy Science, 67, 2274-2282.
81. Mandard, S., M. Muller & S. Kersten (2004). Peroxisome proliferator-activated receptor α target genes. Cellular and Molecular Life Sciences, 61, 393-416.
82. Marcos, E., A. Mazur, P. Cardot & Y. Rayssiguier (1990). Serum apolipoproteins B and A-I and naturally occurring fatty liver in dairy cows. Lipids, 25, 575-577.
83. Mashek, D.G., S.J. Bertics & R.R. Grummer (2002). Metabolic fate of long-chain unsaturated fatty acids and their effects on palmitic acid metabolism and gluconeogenesis in bovine hepatocytes. Journal of Dairy Science, 85, 2283-2289.
84. Mashek, D.G., and R.R. Grummer (2003). Effects of long chain fatty acids on lipid and glucose metabolism in monolayer cultures of bovine hepatocytes. Journal of Dairy Science, 86, 2390-2396.
85. McGarry, J.D. & N.F. Brown (1997). The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. European Journal of Biochemisty, 244, 1-14.
86. Monzon, J.R., R. Basile, S. Heneghan, V. Udupi & A. Green (2002). Lipolysis in adipocytes isolated from deep and superficial subcutaneous adipose tissue. Obesity Research, 10, 266-269.
87. Morrow, D.A. (1976). Fat cow syndrome. Journal of Dairy Science, 59, 1625-1629.
88. Mu, H. & C.E. Hoy (2004). The digestion of dietary triacylglycerols. Progress in Lipid Research, 43, 105-133.
89. Murondoti, A., R. Jorritsma, A.C. Beynen, T. Wensing & M.J. Geelen (2004). Unrestricted feed intake during the dry period impairs the postpartum oxidation and synthesis of fatty acids in the liver of dairy cows. Journal of Dairy Science, 87, 672-679.
90. Nakamura, M.T., Y. Cheon, Y. Li & T.Y. Nara (2004). Mechanisms of regulation of gene expression by fatty acids. Lipids, 39, 1077-1083.
91. Noble, R.C. (1978). Digestion, absorption and transport of lipids in ruminant animals. Progress in Lipid Research, 17, 55-91.
92. Osmundsen, H.J., J. Bremer & J.I. Pedersen (1991). Metabolic aspects of peroxisomal beta-oxidation. Biochimica et Biophysica Acta, 1085, 141-158.
93. Overton, T.R. & M.R. Waldron (2004). Nutritional management of transition dairy cows: strategies to optimize metabolic health. Journal of Dairy Science, 87, E105-E119.
94. Palmquist, D.L. & H.R. Conrad (1971). Origin of plasma fatty acids in lactating cows fed high grain or high fat diets. Journal of Dairy Science, 54, 1025-1033.
95. Palmquist, D.L. & W. Mattos (1978). Turnover of lipoproteins and transfer to milk fat of dietary (1-carbon-14) linoleic acid in lactating cows. Journal of Dairy Science, 61, 561-565.
96. Pethick, D.W., D.B. Lindsay, P.J. Barker & A.J. Northrop (1981). Acetate supply and utilization by the tissues of sheep in vivo. British Journal of Nutrition, 46, 97-110.
97. Phan, C.T., and P. Tso (2001). Intestinal lipid absorption and transport. Frontiers in Bioscience, 6, 299-319.
98. Piepenbrink, M.S. & T.R. Overton (2003). Liver metabolism and production of cows fed increasing amounts of rumen-protected choline during the periparturient period. Journal of Dairy Science, 86:1722-1733.
99. Piot, C., J.F. Hocquette, J.H. Veerkamp, D. Durand & D. Bauchart (1999). Effects of dietary coconut oil on fatty acid oxidative capacity of the liver, the heart, and skeletal muscles in the preruminant calf. British Journal of Nutrition, 82, 299-308.
100. Pullen, D.L., R.S. Emery & N.K. Ames (1988). Turnover of hepatic and plasma triacylglycerol in sheep. Journal of Animal Science, 66, 1538-1547.
101. Pullen, D.L., J.S. Liesman & R.S. Emery (1990). A species comparison of liver slice synthesis and secretion of triacylglycerol from nonesterified fatty acids in media. Journal of Animal Science, 68, 1395-1399.
102. Pullen, D.L., D.L. Palmquist & R.S. Emery (1989). Effect of days of lactation and methionine hydroxyl analog on incorporation of plasma fatty acids into plasma triglycerides. Journal of Dairy Science, 72, 49-58.
103. Reid, I.M., R.A. Collins, G.D. Baird, C.J. Roberts & H.W. Symonds (1979). Lipid production rates and pathogenesis of fatty liver in fasted cows. Journal of Agricultural Science (Cambridge), 93, 253-256.
104. Reid, I.M., C.J. Roberts, R.J. Treacher & L.A. Williams (1986). Effect of body condition at calving on tissue mobilization, development of fatty liver and blood chemistry of dairy cows. Animal Production, 43, 7-15.
105. Reynolds, C.K., P.C. Aikman, B. Lupoli, D.J. Humphries & D.E. Beever (2003). Splanchnic metabolism of dairy cows during the transition from late gestation through early lactation. Journal of Dairy Science, 86, 1201-1217.
106. Reynolds, C.K., B. Durst, B. Lupoli, D.J. Humphries & D.E. Beever (2004). Visceral tissue mass and rumen volume in dairy cows during the transition from late gestation to early lactation. Journal of Dairy Science, 87, 961-971.
107. Ruderman, N.B., A.K. Saha, D. Vavvas & L.A. Witters (1999). Malonyl-CoA, fuel sensing, and insulin resistance. American Journal of Physiology, 276, E1-E18.
108. Rukkwamsuk, T., T.A. Kruip & T. Wensing (1999). Relationship between overfeeding and overconditioning in the dry period and the problems of high producing dairy cows during the postparturient period. Veterinary Quarterly, 21, 71-77.
109. Selberg, K.T., C.R. Staples, N.D. Luchini & L. Badinga (2005). Dietary trans octadecenoic acids upregulate the liver gene encoding peroxisome proliferator-activated receptor-α in transition dairy cows. Journal of Dairy Research, 72, 107-114.
110. Shelness, G.S. & J.A. Sellers (2001). Very-low-density lipoprotein assembly and secretion. Current Opinion in Lipidology, 12, 151-157.
111. Trayhurn, P. & I.S. Wood (2004). Adipokines: inflammation and the pleiotropic role of white adipose tissue. British Journal of Nutrition, 92, 347-355.
112. Trickett, J.I, D.D. Patel, B.L. Knight, E.D. Saggerson, G.F. Gibbons & R.J. Pease (2001). Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation. Journal of Biological Chemistry, 276, 39533-39532.
113. Underwood, J.P. (2003). Protein nutrition of dairy cows during the transition period. Ph.D. dissertation, University of Illinois, Urbana.
114. Van Den Branden, C. & J. Vamecq (2003). Metabolic regulation of peroxisomal and mitochondrial fatty acid oxidation. Advances in Experimental Medicine and Biology, 544, 307-314.
115. Van Den Top, A.M., M.J.H. Geelen, T. Wensing, G.H. Wentink, A.T. Van 't Klooster & A.C. Beynen (1996). Higher postpartum hepatic triacylglycerol concentrations in dairy cows with free rather than restricted access to feed during the dry period are associated with lower activities of hepatic glycerolphosphate acyltransferase. Journal of Nutrition, 126, 76-85.
116. Vernon, R.G. (1992). Effects of diet on lipolysis and its regulation. Proceedings of the Nutrition Society, 51, 397-408.
117. Waldron, M.R., T. Nishida, B.J. Nonnecke & T.R. Overton (2003). Effect of lipopolysaccharide on indices of peripheral and hepatic metabolism in lactating cows. Journal of Dairy Science, 86, 3447-3459.
118. Wanders, R.J. (2004). Peroxisomes, lipid metabolism, and peroxisomal disorders. Molecular Genetics and Metabolism, 83, 16-27.
119. Yao, Z. & D.E. Vance (1988). The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. Journal of Biological Chemistry, 263, 2998-3004.
120. Zammit, V.A. (1990). Ketogenesis in the liver of ruminants-adaptations to a challenge. Journal of Agricultural Science (Cambridge), 115, 155-162.
121. Zammit, V.A. (1999a). Carnitine acyltransferases: functional significance of subcellular distribution and membrane topology. Progress in Lipid Research, 38, 199-224.
122. Zammit, V.A. (1999b). The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function. Biochemical Journal, 343, 505-515.